Bcorl1 (BCL6 co-repressor-like 1) - Rat Genome Database

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Gene: Bcorl1 (BCL6 co-repressor-like 1) Rattus norvegicus
Analyze
Symbol: Bcorl1
Name: BCL6 co-repressor-like 1
RGD ID: 1566108
Description: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome. Orthologous to human BCORL1 (BCL6 corepressor like 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCL-6 corepressor-like protein 1; LOC302810; RGD1566108; similar to BCL6 co-repressor-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,394,703 - 132,462,414 (+)NCBIGRCr8
mRatBN7.2X127,516,504 - 127,584,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,537,538 - 127,584,087 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,663,301 - 129,709,882 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,234,075 - 133,280,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,760,466 - 130,807,048 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X135,187,468 - 135,233,859 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,187,468 - 135,233,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,258,329 - 135,311,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,755,840 - 134,802,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX126,486,590 - 126,533,223 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1. Xu Q, etal., Biomed Pharmacother. 2018 Jul;103:645-652. doi: 10.1016/j.biopha.2018.04.037. Epub 2018 Apr 24.
5. BCORL1 is an independent prognostic marker and contributes to cell migration and invasion in human hepatocellular carcinoma. Yin G, etal., BMC Cancer. 2016 Feb 15;16:103. doi: 10.1186/s12885-016-2154-z.
6. [Expression and clinical significance of BCL6 corepressor-like 1 in non-small cell lung cancer]. Zhao X, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015 Dec;31(12):1677-81.

Genomics

Comparative Map Data
Bcorl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,394,703 - 132,462,414 (+)NCBIGRCr8
mRatBN7.2X127,516,504 - 127,584,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,537,538 - 127,584,087 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,663,301 - 129,709,882 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,234,075 - 133,280,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,760,466 - 130,807,048 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X135,187,468 - 135,233,859 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,187,468 - 135,233,839 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,258,329 - 135,311,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,755,840 - 134,802,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX126,486,590 - 126,533,223 (+)NCBICelera
Cytogenetic MapXq36NCBI
BCORL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X129,980,313 - 130,058,071 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX129,981,107 - 130,058,071 (+)EnsemblGRCh38hg38GRCh38
GRCh37X129,114,955 - 129,192,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,944,350 - 129,019,282 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X128,842,203 - 128,917,136NCBI
CeleraX129,525,724 - 129,578,619 (+)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX118,537,901 - 118,589,904 (+)NCBIHuRef
CHM1_1X129,050,337 - 129,103,226 (+)NCBICHM1_1
T2T-CHM13v2.0X128,299,075 - 128,376,871 (+)NCBIT2T-CHM13v2.0
Bcorl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,430,235 - 47,496,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,430,235 - 47,496,926 (+)EnsemblGRCm39 Ensembl
GRCm38X48,341,358 - 48,408,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,341,358 - 48,408,049 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X45,694,535 - 45,759,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X44,585,985 - 44,651,355 (+)NCBIMGSCv36mm8
CeleraX35,844,530 - 35,908,298 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX25.64NCBI
Bcorl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554734,989,366 - 5,054,925 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554734,990,974 - 5,054,829 (-)NCBIChiLan1.0ChiLan1.0
BCORL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X129,401,630 - 129,477,387 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X129,405,942 - 129,482,415 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X119,108,049 - 119,185,165 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X129,402,314 - 129,479,302 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX129,403,888 - 129,479,297 (+)Ensemblpanpan1.1panPan2
BCORL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X101,153,952 - 101,215,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX101,154,823 - 101,214,175 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX87,328,963 - 87,393,319 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X103,007,034 - 103,068,542 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX103,009,422 - 103,066,883 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X100,425,537 - 100,489,175 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X102,271,127 - 102,335,455 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X102,049,188 - 102,113,572 (+)NCBIUU_Cfam_GSD_1.0
Bcorl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,381,148 - 99,449,640 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364791,538,051 - 1,606,344 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364791,539,676 - 1,605,647 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCORL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,549,139 - 106,612,894 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,547,754 - 106,613,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,316,202 - 122,381,574 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCORL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X105,238,616 - 105,314,326 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX105,240,043 - 105,314,553 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606542,660,158 - 42,737,626 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcorl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247979,240,209 - 9,282,020 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247979,211,625 - 9,283,435 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcorl1
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:407
Count of miRNA genes:232
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000006805
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
BF397401  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X127,584,237 - 127,584,473 (+)MAPPERmRatBN7.2
Rnor_6.0X135,233,994 - 135,234,229NCBIRnor6.0
Rnor_5.0X135,305,469 - 135,305,704UniSTSRnor5.0
RGSC_v3.4X134,802,474 - 134,802,709UniSTSRGSC3.4
CeleraX126,533,358 - 126,533,593UniSTS
RH 3.4 MapX900.5UniSTS
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006805   ⟹   ENSRNOP00000006805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,537,538 - 127,584,087 (+)Ensembl
Rnor_6.0 EnsemblX135,187,468 - 135,233,839 (+)Ensembl
RefSeq Acc Id: NM_001191587   ⟹   NP_001178516
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,415,425 - 132,461,992 (+)NCBI
mRatBN7.2X127,537,538 - 127,584,103 (+)NCBI
Rnor_6.0X135,187,468 - 135,233,859 (+)NCBI
Rnor_5.0X135,258,329 - 135,311,922 (+)NCBI
CeleraX126,486,590 - 126,533,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099669   ⟹   XP_038955597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,395,387 - 132,462,414 (+)NCBI
mRatBN7.2X127,517,491 - 127,584,529 (+)NCBI
RefSeq Acc Id: XM_039099670   ⟹   XP_038955598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,394,703 - 132,462,414 (+)NCBI
mRatBN7.2X127,516,504 - 127,584,529 (+)NCBI
RefSeq Acc Id: XM_039099671   ⟹   XP_038955599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,396,613 - 132,462,414 (+)NCBI
mRatBN7.2X127,518,701 - 127,584,529 (+)NCBI
RefSeq Acc Id: XM_039099672   ⟹   XP_038955600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,397,219 - 132,462,414 (+)NCBI
mRatBN7.2X127,519,332 - 127,584,529 (+)NCBI
RefSeq Acc Id: XM_039099673   ⟹   XP_038955601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,397,408 - 132,462,414 (+)NCBI
mRatBN7.2X127,520,002 - 127,584,529 (+)NCBI
RefSeq Acc Id: XM_039099674   ⟹   XP_038955602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,398,767 - 132,462,414 (+)NCBI
mRatBN7.2X127,520,873 - 127,584,529 (+)NCBI
RefSeq Acc Id: NP_001178516   ⟸   NM_001191587
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006805   ⟸   ENSRNOT00000006805
RefSeq Acc Id: XP_038955598   ⟸   XM_039099670
- Peptide Label: isoform X1
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955597   ⟸   XM_039099669
- Peptide Label: isoform X1
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955599   ⟸   XM_039099671
- Peptide Label: isoform X1
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955600   ⟸   XM_039099672
- Peptide Label: isoform X1
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955601   ⟸   XM_039099673
- Peptide Label: isoform X1
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955602   ⟸   XM_039099674
- Peptide Label: isoform X1
- UniProtKB: F1LYC7 (UniProtKB/TrEMBL)
Protein Domains
BCL-6 corepressor PCGF1 binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LYC7-F1-model_v2 AlphaFold F1LYC7 1-1788 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566108 AgrOrtholog
BioCyc Gene G2FUF-1133 BioCyc
Ensembl Genes ENSRNOG00000005076 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006805.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.10.260.40 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  BCOR-like UniProtKB/TrEMBL
  PUFD UniProtKB/TrEMBL
  PUFD_som_sf UniProtKB/TrEMBL
KEGG Report rno:302810 UniProtKB/TrEMBL
NCBI Gene 302810 ENTREZGENE
PANTHER AGAP007537-PB UniProtKB/TrEMBL
  BCL-6 COREPRESSOR-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  PUFD UniProtKB/TrEMBL
PhenoGen Bcorl1 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005076 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt F1LYC7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Bcorl1  BCL6 co-repressor-like 1  RGD1566108_predicted  similar to BCL6 co-repressor-like 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566108_predicted  similar to BCL6 co-repressor-like 1 (predicted)  LOC302810  similar to BCL6 co-repressor-like 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302810  similar to BCL6 co-repressor-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL