Fgfr4 (fibroblast growth factor receptor 4) - Rat Genome Database

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Gene: Fgfr4 (fibroblast growth factor receptor 4) Rattus norvegicus
Analyze
Symbol: Fgfr4
Name: fibroblast growth factor receptor 4
RGD ID: 2612
Description: Predicted to enable fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and heparin binding activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell-cell junction. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach cancer. Orthologous to human FGFR4 (fibroblast growth factor receptor 4); PARTICIPATES IN fibroblast growth factor signaling pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGFR-4; MGC116290
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,461,541 - 9,476,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,477,854 - 9,492,597 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01711,007,466 - 11,022,178 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0179,474,258 - 9,489,006 (-)NCBIRnor_WKY
Rnor_6.0179,990,072 - 10,004,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,099,383 - 12,113,637 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,512,144 - 15,527,348 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,512,146 - 15,523,432 (-)NCBI
Celera179,540,006 - 9,554,750 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
flusilazole  (EXP)
flutamide  (EXP)
furosemide  (EXP)
gossypol  (ISO)
GW 4064  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (EXP)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
taurocholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma. da Costa Andrade VC, etal., Exp Mol Pathol. 2007 Feb;82(1):53-7. doi: 10.1016/j.yexmp.2006.05.003. Epub 2006 Nov 3.
2. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Desnoyers LR, etal., Oncogene. 2008 Jan 3;27(1):85-97. doi: 10.1038/sj.onc.1210623. Epub 2007 Jun 25.
3. FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung. Falvella FS, etal., Int J Cancer. 2009 Jun 15;124(12):2880-5. doi: 10.1002/ijc.24302.
4. FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer. Fang HM, etal., Acta Pharmacol Sin. 2013 Apr;34(4):549-54. doi: 10.1038/aps.2012.206. Epub 2013 Mar 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Cloning, expression and tissue distribution of the gene encoding rat fibroblast growth factor receptor subtype 4. Horlick RA, etal., Gene 1992 Oct 21;120(2):291-5.
8. The prognostic significance of fibroblast growth factor receptor 4 in non-small-cell lung cancer. Huang HP, etal., Onco Targets Ther. 2015 May 22;8:1157-64. doi: 10.2147/OTT.S81659. eCollection 2015.
9. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. Konishi M, etal., J Biol Chem. 2000 Apr 21;275(16):12119-22.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction. Quintanal-Villalonga Á, etal., Sci Rep. 2018 Feb 5;8(1):2394. doi: 10.1038/s41598-018-20570-3.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma. Sheu MJ, etal., PLoS One. 2015 Apr 10;10(4):e0122961. doi: 10.1371/journal.pone.0122961. eCollection 2015.
18. High Expression of FGFR4 Enhances Tumor Growth and Metastasis in Nasopharyngeal Carcinoma. Shi S, etal., J Cancer. 2015 Oct 20;6(12):1245-54. doi: 10.7150/jca.12825. eCollection 2015.
19. The Prognostic Significance of FGFR4 Gly388 Polymorphism in Esophageal Squamous Cell Carcinoma after Concurrent Chemoradiotherapy. Shim HJ, etal., Cancer Res Treat. 2016 Jan;48(1):71-9. doi: 10.4143/crt.2015.018. Epub 2015 May 14.
20. Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors. Sootome H, etal., Cancer Res. 2020 Nov 15;80(22):4986-4997. doi: 10.1158/0008-5472.CAN-19-2568. Epub 2020 Sep 24.
21. Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. Spinola M, etal., J Clin Oncol. 2005 Oct 10;23(29):7307-11. doi: 10.1200/JCO.2005.17.350. Epub 2005 Aug 1.
22. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
23. FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. Tanuma J, etal., Oncol Rep. 2010 Mar;23(3):739-44.
24. The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Wang J, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6169-78. doi: 10.1158/1078-0432.CCR-04-0408.
25. Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma. Yamauchi M, etal., Clin Transl Gastroenterol. 2020 May;11(5):e00179. doi: 10.14309/ctg.0000000000000179.
26. The fibroblast growth factor receptor-4 Arg388 allele is associated with gastric cancer progression. Ye Y, etal., Ann Surg Oncol. 2010 Dec;17(12):3354-61. doi: 10.1245/s10434-010-1323-6. Epub 2010 Sep 16.
27. Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. Ye Y, etal., Tumour Biol. 2016 Mar;37(3):3185-95. doi: 10.1007/s13277-015-4100-0. Epub 2015 Oct 2.
28. Fibroblast growth factor receptor 4 regulates proliferation and antiapoptosis during gastric cancer progression. Ye YW, etal., Cancer. 2011 Dec 1;117(23):5304-13. doi: 10.1002/cncr.26207. Epub 2011 May 12.
Additional References at PubMed
PMID:8663044   PMID:9716527   PMID:10525310   PMID:10809780   PMID:12477932   PMID:15489334   PMID:15576401   PMID:17623664   PMID:17627937   PMID:17664243   PMID:18061161   PMID:18187602  
PMID:18480409   PMID:19085950   PMID:20683963   PMID:20798051   PMID:20876804   PMID:21561999   PMID:21653700   PMID:24259513   PMID:28339837  


Genomics

Comparative Map Data
Fgfr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,461,541 - 9,476,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,477,854 - 9,492,597 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01711,007,466 - 11,022,178 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0179,474,258 - 9,489,006 (-)NCBIRnor_WKY
Rnor_6.0179,990,072 - 10,004,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01712,099,383 - 12,113,637 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,512,144 - 15,527,348 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,512,146 - 15,523,432 (-)NCBI
Celera179,540,006 - 9,554,750 (-)NCBICelera
Cytogenetic Map17p14NCBI
FGFR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,086,915 - 177,098,144 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5177,086,905 - 177,098,144 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,513,916 - 176,525,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,446,527 - 176,457,733 (+)NCBINCBI36Build 36hg18NCBI36
Build 345176,446,526 - 176,457,730NCBI
Celera5171,976,184 - 171,987,401 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5171,435,609 - 171,446,679 (+)NCBIHuRef
CHM1_15175,946,753 - 175,957,892 (+)NCBICHM1_1
T2T-CHM13v2.05177,630,123 - 177,641,352 (+)NCBIT2T-CHM13v2.0
Fgfr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,300,631 - 55,316,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,300,453 - 55,316,572 (+)EnsemblGRCm39 Ensembl
GRCm381355,152,818 - 55,168,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,152,640 - 55,168,759 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,254,179 - 55,270,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,162,497 - 55,178,362 (+)NCBIMGSCv36mm8
Celera1356,213,486 - 56,229,296 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.8NCBI
Fgfr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,370,468 - 29,383,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,370,480 - 29,383,531 (+)NCBIChiLan1.0ChiLan1.0
FGFR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15179,454,995 - 179,466,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,454,995 - 179,467,605 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05172,386,443 - 172,400,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FGFR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,243,689 - 36,254,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,244,220 - 36,252,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha436,209,722 - 36,220,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,607,886 - 36,618,835 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,607,906 - 36,618,801 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,434,871 - 36,445,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,622,022 - 36,632,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,130,265 - 37,141,210 (-)NCBIUU_Cfam_GSD_1.0
Fgfr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,360,727 - 122,372,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,385,624 - 1,397,758 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365971,388,394 - 1,397,731 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,841,536 - 80,853,796 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,841,536 - 80,853,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,414,997 - 82,427,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,095,031 - 79,106,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,097,429 - 79,105,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,259,717 - 10,291,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,964,746 - 12,976,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,964,893 - 12,979,198 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgfr4
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000042394
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 31 2 31 30 6 11
Low 3 32 17 10 11 10 8 11 44 5 27 8
Below cutoff 11 9 6 30 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042394   ⟹   ENSRNOP00000050988
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)Ensembl
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082836   ⟹   ENSRNOP00000069871
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,461,547 - 9,473,596 (-)Ensembl
Rnor_6.0 Ensembl179,990,078 - 10,001,901 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118916   ⟹   ENSRNOP00000094461
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)Ensembl
RefSeq Acc Id: NM_001109904   ⟹   NP_001103374
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,461,541 - 9,476,242 (-)NCBI
Rnor_6.0179,990,072 - 10,004,321 (-)NCBI
Rnor_5.01712,099,383 - 12,113,637 (-)NCBI
RGSC_v3.41715,512,144 - 15,527,348 (-)RGD
Celera179,540,006 - 9,554,750 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253606   ⟹   XP_006253668
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,461,541 - 9,476,268 (-)NCBI
Rnor_6.0179,990,072 - 10,004,339 (-)NCBI
Rnor_5.01712,099,383 - 12,113,637 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095374   ⟹   XP_038951302
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,461,541 - 9,470,316 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001103374   ⟸   NM_001109904
- Peptide Label: precursor
- UniProtKB: Q498D6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253668   ⟸   XM_006253606
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QQB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069871   ⟸   ENSRNOT00000082836
RefSeq Acc Id: ENSRNOP00000050988   ⟸   ENSRNOT00000042394
RefSeq Acc Id: XP_038951302   ⟸   XM_039095374
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000094461   ⟸   ENSRNOT00000118916
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498D6-F1-model_v2 AlphaFold Q498D6 1-800 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700313
Promoter ID:EPDNEW_R10837
Type:multiple initiation site
Name:Fgfr4_1
Description:fibroblast growth factor receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01710,004,305 - 10,004,365EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2612 AgrOrtholog
BioCyc Gene G2FUF-10193 BioCyc
Ensembl Genes ENSRNOG00000016763 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050988 ENTREZGENE
  ENSRNOP00000050988.4 UniProtKB/TrEMBL
  ENSRNOP00000069871 ENTREZGENE
  ENSRNOP00000069871.2 UniProtKB/TrEMBL
  ENSRNOP00000094461.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042394 ENTREZGENE
  ENSRNOT00000042394.5 UniProtKB/TrEMBL
  ENSRNOT00000082836 ENTREZGENE
  ENSRNOT00000082836.2 UniProtKB/TrEMBL
  ENSRNOT00000118916.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096119 IMAGE-MGC_LOAD
  IMAGE:7100540 IMAGE-MGC_LOAD
InterPro FGF_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25114 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116290 IMAGE-MGC_LOAD
  MGC:93687 IMAGE-MGC_LOAD
NCBI Gene 25114 ENTREZGENE
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Fgfr4 PhenoGen
PIRSF FGFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ANB5_RAT UniProtKB/TrEMBL
  A0A8L2QQB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UPP9_RAT UniProtKB/TrEMBL
  FGFR4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgfr4  fibroblast growth factor receptor 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may have a role in breast and ovarian tumorigenesis 69837
gene_expression overexpressed in gynecological tumor samples 69837
gene_function receptor for acidic fibroblast growth factor 69837