P2ry6 (pyrimidinergic receptor P2Y6) - Rat Genome Database

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Gene: P2ry6 (pyrimidinergic receptor P2Y6) Rattus norvegicus
Analyze
Symbol: P2ry6
Name: pyrimidinergic receptor P2Y6
RGD ID: 620269
Description: Predicted to enable G protein-coupled ADP receptor activity; G protein-coupled UDP receptor activity; and G protein-coupled UTP receptor activity. Involved in several processes, including cellular response to pyrimidine ribonucleotide; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; and positive regulation of smooth muscle cell migration. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: P2Y ATP receptor 6; P2Y purinoceptor 6; P2y6; pyrimidinergic receptor P2Y, G-protein coupled, 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,707,188 - 164,742,689 (-)NCBIGRCr8
mRatBN7.21155,295,110 - 155,330,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,295,111 - 155,330,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,280,542 - 163,305,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,460,651 - 170,485,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,344,864 - 163,369,750 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,972,439 - 166,008,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,169,438 - 172,204,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,381,127 - 158,406,783 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,460,144 - 158,485,800 (-)NCBI
Celera1153,376,657 - 153,401,528 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
quercitrin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
UDP  (ISO)
urethane  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and functional analysis of a novel P2 nucleotide receptor. Chang K, etal., J Biol Chem 1995 Nov 3;270(44):26152-8.
2. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Koizumi S, etal., Nature. 2007 Apr 26;446(7139):1091-5. doi: 10.1038/nature05704. Epub 2007 Apr 4.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Nucleotide receptors involved in UTP-induced rat arterial smooth muscle cell migration. Pillois X, etal., Circ Res 2002 Apr 5;90(6):678-81.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8670200   PMID:11259526   PMID:14764443   PMID:15489334   PMID:15722352   PMID:18250478   PMID:21317391   PMID:21323829   PMID:21879346   PMID:22728100   PMID:23479225   PMID:23941325  
PMID:24269631   PMID:24886406   PMID:25449358   PMID:28277742   PMID:31106899   PMID:31638262   PMID:35349212  


Genomics

Comparative Map Data
P2ry6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,707,188 - 164,742,689 (-)NCBIGRCr8
mRatBN7.21155,295,110 - 155,330,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,295,111 - 155,330,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,280,542 - 163,305,882 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,460,651 - 170,485,989 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,344,864 - 163,369,750 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,972,439 - 166,008,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,169,438 - 172,204,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,381,127 - 158,406,783 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,460,144 - 158,485,800 (-)NCBI
Celera1153,376,657 - 153,401,528 (-)NCBICelera
Cytogenetic Map1q32NCBI
P2RY6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,264,506 - 73,298,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,264,498 - 73,305,103 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,975,551 - 73,009,670 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,653,218 - 72,687,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 341172,658,586 - 72,686,497NCBI
Celera1170,280,653 - 70,314,752 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBIHuRef
CHM1_11172,859,110 - 72,893,227 (+)NCBICHM1_1
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBIT2T-CHM13v2.0
P2ry6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,586,837 - 100,628,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,586,837 - 100,623,856 (-)EnsemblGRCm39 Ensembl
GRCm387100,937,630 - 100,975,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,937,630 - 100,974,649 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,086,148 - 108,112,880 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,811,721 - 100,838,449 (-)NCBIMGSCv36mm8
Celera7101,288,708 - 101,316,203 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.46NCBI
P2ry6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,177,406 - 18,215,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,177,406 - 18,215,428 (-)NCBIChiLan1.0ChiLan1.0
P2RY6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,210,309 - 74,243,682 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,253,497 - 75,286,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,341,722 - 68,375,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11171,562,990 - 71,595,540 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,594,250 - 71,595,236 (+)Ensemblpanpan1.1panPan2
P2RY6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,929,502 - 24,966,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,929,771 - 24,930,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,693,846 - 24,731,202 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02125,136,107 - 25,173,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2125,136,107 - 25,173,442 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,929,647 - 24,967,004 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02125,130,680 - 25,168,052 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02125,045,964 - 25,083,341 (-)NCBIUU_Cfam_GSD_1.0
P2ry6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,868,422 - 60,901,890 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364982,500,128 - 2,501,114 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364982,468,020 - 2,501,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,749,375 - 7,759,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,708,452 - 7,759,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,538,019 - 8,554,097 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,508,959 - 64,543,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,541,221 - 64,542,207 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604361,343,922 - 61,369,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,648,829 - 3,671,852 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,648,829 - 3,672,051 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2ry6
294 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:511
Count of miRNA genes:265
Interacting mature miRNAs:328
Transcripts:ENSRNOT00000050227
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1150452391168228760Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000050227   ⟹   ENSRNOP00000049439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,295,111 - 155,320,042 (-)Ensembl
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107101   ⟹   ENSRNOP00000088558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,295,900 - 155,302,013 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108172   ⟹   ENSRNOP00000081429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,295,779 - 155,321,998 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111790   ⟹   ENSRNOP00000094637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,295,813 - 155,312,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116084   ⟹   ENSRNOP00000087971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,295,801 - 155,330,808 (-)Ensembl
RefSeq Acc Id: NM_057124   ⟹   NP_476465
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,188 - 164,732,117 (-)NCBI
mRatBN7.21155,295,110 - 155,320,042 (-)NCBI
Rnor_6.01165,972,439 - 165,997,751 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
RGSC_v3.41158,381,127 - 158,406,783 (-)RGD
Celera1153,376,657 - 153,401,528 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229712   ⟹   XP_006229774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,732,209 (-)NCBI
mRatBN7.21155,295,871 - 155,320,178 (-)NCBI
Rnor_6.01165,973,200 - 165,999,087 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229713   ⟹   XP_006229775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,742,689 (-)NCBI
mRatBN7.21155,295,871 - 155,330,610 (-)NCBI
Rnor_6.01165,973,200 - 166,008,348 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229715   ⟹   XP_006229777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,732,209 (-)NCBI
mRatBN7.21155,295,871 - 155,320,178 (-)NCBI
Rnor_6.01165,973,200 - 165,999,087 (-)NCBI
Rnor_5.01172,169,438 - 172,204,831 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078872   ⟹   XP_038934800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,742,607 (-)NCBI
mRatBN7.21155,295,871 - 155,330,533 (-)NCBI
RefSeq Acc Id: XM_063268010   ⟹   XP_063124080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81164,707,953 - 164,717,139 (-)NCBI
RefSeq Acc Id: NP_476465   ⟸   NM_057124
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229775   ⟸   XM_006229713
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229774   ⟸   XM_006229712
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229777   ⟸   XM_006229715
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049439   ⟸   ENSRNOT00000050227
RefSeq Acc Id: XP_038934800   ⟸   XM_039078872
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081429   ⟸   ENSRNOT00000108172
Ensembl Acc Id: ENSRNOP00000088558   ⟸   ENSRNOT00000107101
Ensembl Acc Id: ENSRNOP00000087971   ⟸   ENSRNOT00000116084
Ensembl Acc Id: ENSRNOP00000094637   ⟸   ENSRNOT00000111790
RefSeq Acc Id: XP_063124080   ⟸   XM_063268010
- Peptide Label: isoform X1
- UniProtKB: Q63371 (UniProtKB/Swiss-Prot),   A6I6S4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63371-F1-model_v2 AlphaFold Q63371 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690251
Promoter ID:EPDNEW_R776
Type:single initiation site
Name:P2ry6_1
Description:pyrimidinergic receptor P2Y6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,997,727 - 165,997,787EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620269 AgrOrtholog
BioCyc Gene G2FUF-58310 BioCyc
Ensembl Genes ENSRNOG00000019270 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028219 UniProtKB/Swiss-Prot
  ENSRNOG00060002963 UniProtKB/Swiss-Prot
  ENSRNOG00065021749 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050227.3 UniProtKB/Swiss-Prot
  ENSRNOT00000107101.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108172.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111790.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116084.1 UniProtKB/Swiss-Prot
  ENSRNOT00055048830 UniProtKB/Swiss-Prot
  ENSRNOT00055048838 UniProtKB/Swiss-Prot
  ENSRNOT00055048848 UniProtKB/Swiss-Prot
  ENSRNOT00055048860 UniProtKB/Swiss-Prot
  ENSRNOT00055048866 UniProtKB/Swiss-Prot
  ENSRNOT00060004828 UniProtKB/Swiss-Prot
  ENSRNOT00060004831 UniProtKB/Swiss-Prot
  ENSRNOT00060004836 UniProtKB/Swiss-Prot
  ENSRNOT00060004839 UniProtKB/Swiss-Prot
  ENSRNOT00060004842 UniProtKB/Swiss-Prot
  ENSRNOT00065036970 UniProtKB/Swiss-Prot
  ENSRNOT00065036981 UniProtKB/Swiss-Prot
  ENSRNOT00065037005 UniProtKB/Swiss-Prot
  ENSRNOT00065037011 UniProtKB/Swiss-Prot
  ENSRNOT00065037016 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105972 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y6_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91535 IMAGE-MGC_LOAD
NCBI Gene 117264 ENTREZGENE
PANTHER P2Y PURINOCEPTOR 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2ry6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y6PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019270 RatGTEx
  ENSRNOG00055028219 RatGTEx
  ENSRNOG00060002963 RatGTEx
  ENSRNOG00065021749 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I6S4 ENTREZGENE, UniProtKB/TrEMBL
  P2RY6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry6  pyrimidinergic receptor P2Y6  P2ry6  pyrimidinergic receptor P2Y, G-protein coupled, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 P2ry6  pyrimidinergic receptor P2Y, G-protein coupled, 6      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_process mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_regulation activated only by UDP 628452