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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:salicylamide
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Accession:CHEBI:32114 term browser browse the term
Definition:The simplest member of the class of salicylamides derived from salicylic acid.
Synonyms:related_synonym: 2-Carbamoylphenol;   2-Carboxamidophenol;   2-Hydroxybenzamide;   Formula=C7H7NO2;   InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10);   InChIKey=SKZKKFZAGNVIMN-UHFFFAOYSA-N;   OHB;   SMILES=NC(=O)c1ccccc1O;   Salicylic Acid amide;   o-Hydroxybenzamide;   salicilamida;   salicylamidum
 xref: Beilstein:742439;   CAS:65-45-2;   DrugBank:DB08797;   Drug_Central:2415;   Gmelin:142521;   KEGG:D01811
 xref_mesh: MESH:C031060
 xref: PDBeChem:OHB;   PMID:14729655;   PMID:1650428;   PMID:22530891;   Reaxys:742439;   Wikipedia:Salicylamide


show annotations for term's descendants           Sort by:
 
salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] CTD PMID:14729655 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:14729655, PMID:27286660 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:14729655 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:14729655 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [salicylamide co-treated with Glucose] binds to PPARA protein; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO
EXP
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of salicylamide] CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
3,3',4',5-tetrachlorosalicylanilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression ISO 3,3',4',5-tetrachlorosalicylanilide results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 3,3',4',5-tetrachlorosalicylanilide results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO 3,3',4',5-tetrachlorosalicylanilide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ar androgen receptor multiple interactions ISO nitazoxanide binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]
nitazoxanide results in increased expression of ATF4 protein
CTD PMID:19664635 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Dock8 dedicator of cytokinesis 8 affects response to substance ISO DOCK8 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 1:242,934,685...243,153,472
Ensembl chr 1:242,959,488...243,153,465
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation
ISO IFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO nitazoxanide results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:19,924,200...20,517,918
Ensembl chr10:20,320,878...20,518,518
JBrowse link
G Susd6 sushi domain containing 6 affects response to substance ISO SUSD6 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 6:104,437,104...104,532,522
Ensembl chr 6:104,437,159...104,530,403
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          analgesic 13061
            non-narcotic analgesic 11980
              salicylamide 18
                acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 9
                acetic acid [2-[[(6,6-dimethoxy-3-oxo-1-cyclohexa-1,4-dienyl)amino]-oxomethyl]phenyl] ester 0
                exalamide 0
                salicylanilides + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  arenecarboxamide 6507
                                                    benzamides 6507
                                                      salicylamides 39
                                                        salicylamide 18
                                                          acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 9
                                                          acetic acid [2-[[(6,6-dimethoxy-3-oxo-1-cyclohexa-1,4-dienyl)amino]-oxomethyl]phenyl] ester 0
                                                          exalamide 0
                                                          salicylanilides + 3
paths to the root

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