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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:salicylamide
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Accession:CHEBI:32114 term browser browse the term
Definition:The simplest member of the class of salicylamides derived from salicylic acid.
Synonyms:related_synonym: 2-Carbamoylphenol;   2-Carboxamidophenol;   2-Hydroxybenzamide;   Formula=C7H7NO2;   InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10);   InChIKey=SKZKKFZAGNVIMN-UHFFFAOYSA-N;   OHB;   SMILES=NC(=O)c1ccccc1O;   Salicylic Acid amide;   o-Hydroxybenzamide;   salicilamida;   salicylamidum
 xref: Beilstein:742439;   CAS:65-45-2;   DrugBank:DB08797;   Drug_Central:2415;   Gmelin:142521;   KEGG:D01811
 xref_mesh: MESH:C031060
 xref: PDBeChem:OHB;   PMID:14729655;   PMID:1650428;   PMID:22530891;   Reaxys:742439;   Wikipedia:Salicylamide



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salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] CTD PMID:14729655 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:14729655 PMID:27286660 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CTD PMID:14729655 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO salicylamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:14729655 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [salicylamide co-treated with Glucose] binds to PPARA protein; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO
EXP
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of salicylamide] CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
3,3',4',5-tetrachlorosalicylanilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression ISO 3,3',4',5-tetrachlorosalicylanilide results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 3,3',4',5-tetrachlorosalicylanilide results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO 3,3',4',5-tetrachlorosalicylanilide inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO 3,3',4',5-tetrachlorosalicylanilide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Ar androgen receptor multiple interactions ISO nitazoxanide binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]
nitazoxanide results in increased expression of ATF4 protein
CTD PMID:19664635 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Dock8 dedicator of cytokinesis 8 affects response to substance ISO DOCK8 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 1:222,649,309...222,842,474
Ensembl chr 1:222,649,309...222,842,474
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions
increases phosphorylation
ISO IFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] CTD PMID:19664635 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO nitazoxanide results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Slit3 slit guidance ligand 3 affects response to substance ISO SLIT3 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
JBrowse link
G Susd6 sushi domain containing 6 affects response to substance ISO SUSD6 gene SNP affects the susceptibility to nitazoxanide CTD PMID:25622337 NCBI chr 6:100,437,826...100,531,621
Ensembl chr 6:100,437,642...100,531,606
JBrowse link
tribromosalicylanilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iyd iodotyrosine deiodinase multiple interactions ISO tribromsalan inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        pharmacological role 18852
          analgesic 13303
            non-narcotic analgesic 12008
              salicylamide 19
                acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 9
                acetic acid [2-[[(6,6-dimethoxy-3-oxo-1-cyclohexa-1,4-dienyl)amino]-oxomethyl]phenyl] ester 0
                exalamide 0
                salicylanilides + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                monocarboxylic acid amide 15012
                                                  arenecarboxamide 7267
                                                    benzamides 7267
                                                      salicylamides 50
                                                        salicylamide 19
                                                          acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester 9
                                                          acetic acid [2-[[(6,6-dimethoxy-3-oxo-1-cyclohexa-1,4-dienyl)amino]-oxomethyl]phenyl] ester 0
                                                          exalamide 0
                                                          salicylanilides + 4
paths to the root