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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1618193 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of METRNL mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1618193 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of METRNL mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | RGD:1348183 | 6480464 | Estradiol results in increased expression of METRNL mRNA | CTD | PMID:20106945 | 17beta-estradiol | multiple interactions | ISO | RGD:1348183 | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of METRNL mRNA, Estradiol promotes the reaction [ESR2 protein affects the expression of METRNL mRNA] | CTD | PMID:20404318 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1618193 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of METRNL mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1618193 | 6480464 | [Tetrachlorodibenzodioxin affects the methylation of METRNL intron] which results in increased expression of METRNL mRNA | CTD | PMID:33017471 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of METRNL mRNA | CTD | PMID:22298810 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of METRNL mRNA | CTD | PMID:21346803 | 2-deoxy-D-glucose | multiple interactions | ISO | RGD:1618193 | 6480464 | METRNL protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose] | CTD | PMID:30213948 | 2-hydroxypropanoic acid | decreases expression | ISO | RGD:1348183 | 6480464 | Lactic Acid results in decreased expression of METRNL mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:1348183 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of METRNL mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases expression | ISO | RGD:1618193 | 6480464 | bis4-hydroxyphenylsulfone results in increased expression of METRNL mRNA | CTD | PMID:30951980 | 8-Br-cAMP | increases expression | ISO | RGD:1348183 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of METRNL mRNA | CTD | PMID:22079614 | acetyl-CoA | multiple interactions | ISO | RGD:1618193 | 6480464 | METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] | CTD | PMID:30213948 | aflatoxin B1 | affects expression | ISO | RGD:1348183 | 6480464 | Aflatoxin B1 affects the expression of METRNL protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:1348183 | 6480464 | Aflatoxin B1 results in increased expression of METRNL mRNA | CTD | PMID:21641981 more ... | Aroclor 1254 | increases expression | ISO | RGD:1618193 | 6480464 | Chlorodiphenyl 54% Chlorine results in increased expression of METRNL mRNA | CTD | PMID:23650126 | arsane | multiple interactions | ISO | RGD:1348183 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of METRNL mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | RGD:1348183 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of METRNL mRNA | CTD | PMID:32525701 | ATP | multiple interactions | ISO | RGD:1618193 | 6480464 | METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Adenosine Triphosphate] | CTD | PMID:30213948 | azathioprine | increases expression | ISO | RGD:1348183 | 6480464 | Azathioprine results in increased expression of METRNL mRNA | CTD | PMID:22623647 | benzo[a]pyrene | increases expression | ISO | RGD:1348183 | 6480464 | Benzoapyrene results in increased expression of METRNL mRNA | CTD | PMID:21632981 more ... | benzo[a]pyrene | decreases methylation | ISO | RGD:1348183 | 6480464 | Benzoapyrene results in decreased methylation of METRNL promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | increases expression | ISO | RGD:1348183 | 6480464 | 7 more ... | CTD | PMID:26238291 | Benzo[k]fluoranthene | decreases expression | ISO | RGD:1618193 | 6480464 | benzokfluoranthene results in decreased expression of METRNL mRNA | CTD | PMID:26377693 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of METRNL mRNA | CTD | PMID:25181051 | bisphenol A | affects expression | ISO | RGD:1348183 | 6480464 | bisphenol A affects the expression of METRNL mRNA | CTD | PMID:30903817 | bisphenol A | increases expression | ISO | RGD:1618193 | 6480464 | bisphenol A results in increased expression of METRNL mRNA | CTD | PMID:30951980 | bisphenol F | multiple interactions | ISO | RGD:1348183 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of METRNL mRNA | CTD | PMID:28628672 | bisphenol F | increases expression | ISO | RGD:1618193 | 6480464 | bisphenol F results in increased expression of METRNL mRNA | CTD | PMID:30951980 | butanal | increases expression | ISO | RGD:1348183 | 6480464 | butyraldehyde results in increased expression of METRNL mRNA | CTD | PMID:26079696 | calcitriol | increases expression | ISO | RGD:1348183 | 6480464 | Calcitriol results in increased expression of METRNL mRNA | CTD | PMID:16002434 | carbon nanotube | increases expression | ISO | RGD:1618193 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | copper(II) sulfate | increases expression | ISO | RGD:1348183 | 6480464 | Copper Sulfate results in increased expression of METRNL mRNA | CTD | PMID:19549813 | crocidolite asbestos | increases expression | ISO | RGD:1348183 | 6480464 | Asbestos, Crocidolite results in increased expression of METRNL mRNA | CTD | PMID:29523930 | cyclosporin A | increases expression | ISO | RGD:1618193 | 6480464 | Cyclosporine results in increased expression of METRNL mRNA | CTD | PMID:19770486 | cyclosporin A | decreases expression | ISO | RGD:1348183 | 6480464 | Cyclosporine results in decreased expression of METRNL mRNA | CTD | PMID:27989131 | cyclosporin A | increases expression | ISO | RGD:1348183 | 6480464 | Cyclosporine results in increased expression of METRNL mRNA | CTD | PMID:20106945 more ... | dexamethasone | decreases expression | ISO | RGD:1348183 | 6480464 | Dexamethasone results in decreased expression of METRNL mRNA | CTD | PMID:25047013 | dexamethasone | multiple interactions | ISO | RGD:1348183 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of METRNL mRNA | CTD | PMID:28628672 | dioxygen | increases expression | ISO | RGD:1348183 | 6480464 | Oxygen deficiency results in increased expression of METRNL mRNA | CTD | PMID:26516004 | dorsomorphin | multiple interactions | ISO | RGD:1348183 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... | CTD | PMID:27188386 | ethyl methanesulfonate | increases expression | ISO | RGD:1348183 | 6480464 | Ethyl Methanesulfonate results in increased expression of METRNL mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | RGD:1618193 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of METRNL mRNA | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | RGD:1348183 | 6480464 | Formaldehyde results in increased expression of METRNL mRNA | CTD | PMID:18045764, PMID:23649840 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of METRNL mRNA | CTD | PMID:27387713 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of METRNL mRNA | CTD | PMID:22061828 | hydrogen peroxide | affects expression | ISO | RGD:1348183 | 6480464 | Hydrogen Peroxide affects the expression of METRNL mRNA | CTD | PMID:20044591 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of METRNL mRNA | CTD | PMID:21396975 | indometacin | multiple interactions | ISO | RGD:1348183 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of METRNL mRNA | CTD | PMID:28628672 | methyl methanesulfonate | increases expression | ISO | RGD:1348183 | 6480464 | Methyl Methanesulfonate results in increased expression of METRNL mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | RGD:1348183 | 6480464 | methylmercuric chloride results in increased expression of METRNL mRNA | CTD | PMID:28001369 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:1348183 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of METRNL mRNA | CTD | PMID:24810058 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of METRNL mRNA | CTD | PMID:25380136 | obeticholic acid | decreases expression | ISO | RGD:1348183 | 6480464 | obeticholic acid results in decreased expression of METRNL mRNA | CTD | PMID:27939613 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of METRNL mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of METRNL mRNA | CTD | PMID:25729387 | panobinostat | multiple interactions | ISO | RGD:1348183 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of METRNL mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | RGD:1348183 | 6480464 | panobinostat results in increased expression of METRNL mRNA | CTD | PMID:26272509 | paracetamol | increases expression | ISO | RGD:1348183 | 6480464 | Acetaminophen results in increased expression of METRNL mRNA | CTD | PMID:21420995, PMID:29067470 | pentanal | increases expression | ISO | RGD:1348183 | 6480464 | pentanal results in increased expression of METRNL mRNA | CTD | PMID:26079696 | perfluorononanoic acid | increases expression | ISO | RGD:1348183 | 6480464 | perfluorononanoic acid results in increased expression of METRNL mRNA | CTD | PMID:32588087 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of METRNL mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | RGD:1348183 | 6480464 | Phenobarbital affects the expression of METRNL mRNA | CTD | PMID:19159669 | phenylmercury acetate | increases expression | ISO | RGD:1348183 | 6480464 | Phenylmercuric Acetate results in increased expression of METRNL mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1348183 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of METRNL mRNA | CTD | PMID:27188386 | propanal | increases expression | ISO | RGD:1348183 | 6480464 | propionaldehyde results in increased expression of METRNL mRNA | CTD | PMID:26079696 | quercetin | increases expression | ISO | RGD:1348183 | 6480464 | Quercetin results in increased expression of METRNL mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | ISO | RGD:1348183 | 6480464 | Lactic Acid results in decreased expression of METRNL mRNA | CTD | PMID:30851411 | resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of METRNL mRNA | CTD | PMID:25905778 | rotenone | increases expression | ISO | RGD:1348183 | 6480464 | Rotenone results in increased expression of METRNL mRNA | CTD | PMID:29955902 | SB 431542 | multiple interactions | ISO | RGD:1348183 | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | RGD:1348183 | 6480464 | Silicon Dioxide analog results in increased expression of METRNL mRNA | CTD | PMID:25895662 | silicon dioxide | increases expression | ISO | RGD:1618193 | 6480464 | Silicon Dioxide results in increased expression of METRNL mRNA | CTD | PMID:19073995 | silver atom | decreases expression | ISO | RGD:1618193 | 6480464 | Silver results in decreased expression of METRNL mRNA | CTD | PMID:27131904 | silver atom | increases expression | ISO | RGD:1348183 | 6480464 | Silver results in increased expression of METRNL mRNA | CTD | PMID:26014281 | silver(0) | increases expression | ISO | RGD:1348183 | 6480464 | Silver results in increased expression of METRNL mRNA | CTD | PMID:26014281 | silver(0) | decreases expression | ISO | RGD:1618193 | 6480464 | Silver results in decreased expression of METRNL mRNA | CTD | PMID:27131904 | sodium arsenate | multiple interactions | ISO | RGD:1348183 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of METRNL mRNA | CTD | PMID:32525701 | sunitinib | increases expression | ISO | RGD:1348183 | 6480464 | Sunitinib results in increased expression of METRNL mRNA | CTD | PMID:31533062 | T-2 toxin | decreases expression | ISO | RGD:1348183 | 6480464 | T-2 Toxin results in decreased expression of METRNL mRNA | CTD | PMID:31863870 | tetrachloromethane | increases expression | ISO | RGD:1618193 | 6480464 | Carbon Tetrachloride results in increased expression of METRNL mRNA | CTD | PMID:27339419, PMID:31919559 | titanium dioxide | increases expression | ISO | RGD:1618193 | 6480464 | titanium dioxide analog results in increased expression of METRNL mRNA | CTD | PMID:25111187 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of METRNL mRNA | CTD | PMID:25729387 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of METRNL mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | RGD:1348183 | 6480464 | trichostatin A results in increased expression of METRNL mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | affects expression | ISO | RGD:1348183 | 6480464 | trichostatin A affects the expression of METRNL mRNA | CTD | PMID:28542535 | trichostatin A | multiple interactions | ISO | RGD:1348183 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of METRNL mRNA | CTD | PMID:27188386 | tris(2-butoxyethyl) phosphate | affects expression | ISO | RGD:1348183 | 6480464 | tris2-butoxyethyl phosphate affects the expression of METRNL mRNA | CTD | PMID:29024780 | urethane | increases expression | ISO | RGD:1348183 | 6480464 | Urethane results in increased expression of METRNL mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | RGD:1618193 | 6480464 | Valproic Acid affects the expression of METRNL mRNA | CTD | PMID:17963808 | valproic acid | increases expression | ISO | RGD:1348183 | 6480464 | Valproic Acid results in increased expression of METRNL mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | RGD:1348183 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of METRNL mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | RGD:1348183 | 6480464 | Valproic Acid affects the expression of METRNL mRNA | CTD | PMID:25979313 | valproic acid | increases methylation | ISO | RGD:1348183 | 6480464 | Valproic Acid results in increased methylation of METRNL gene | CTD | PMID:29154799 | zinc atom | multiple interactions | ISO | RGD:1348183 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of METRNL mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1348183 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of METRNL mRNA | CTD | PMID:18593933 | zoledronic acid | decreases expression | ISO | RGD:1348183 | 6480464 | zoledronic acid results in decreased expression of METRNL mRNA | CTD | PMID:24714768 | |