Plekha2 (pleckstrin homology domain containing A2) - Rat Genome Database

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Gene: Plekha2 (pleckstrin homology domain containing A2) Rattus norvegicus
Analyze
Symbol: Plekha2
Name: pleckstrin homology domain containing A2
RGD ID: 1586710
Description: Predicted to enable several functions, including PDZ domain binding activity; fibronectin binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and membrane. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC684785; pleckstrin homology domain-containing family A member 2; pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2; similar to pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,641,338 - 73,704,068 (+)NCBIGRCr8
mRatBN7.21666,938,684 - 67,000,661 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,939,109 - 66,999,395 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01671,725,649 - 71,784,432 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,738,718 - 71,787,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,376,494 - 71,434,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1664,845,382 - 64,902,600 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aristolochic acid A  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
niclosamide  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiram  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
membrane  (IBA,ISO)
protein-containing complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11001876   PMID:14516276   PMID:19786618  


Genomics

Comparative Map Data
Plekha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,641,338 - 73,704,068 (+)NCBIGRCr8
mRatBN7.21666,938,684 - 67,000,661 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,939,109 - 66,999,395 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01671,725,649 - 71,784,432 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,738,718 - 71,787,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01671,376,494 - 71,434,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1664,845,382 - 64,902,600 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
PLEKHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,901,346 - 38,973,912 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,901,235 - 38,973,912 (+)EnsemblGRCh38hg38GRCh38
GRCh37838,758,864 - 38,831,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,877,910 - 38,950,588 (+)NCBINCBI36Build 36hg18NCBI36
Build 34838,877,985 - 38,945,341NCBI
Celera837,712,048 - 37,783,032 (+)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef837,326,687 - 37,364,593 (+)NCBIHuRef
HuRef837,294,194 - 37,310,707 (+)NCBIHuRef
CHM1_1838,960,620 - 39,033,491 (+)NCBICHM1_1
T2T-CHM13v2.0839,178,051 - 39,251,053 (+)NCBIT2T-CHM13v2.0
Plekha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,529,160 - 25,594,684 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,529,160 - 25,592,392 (-)EnsemblGRCm39 Ensembl
GRCm38825,039,144 - 25,104,679 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,039,144 - 25,102,376 (-)EnsemblGRCm38mm10GRCm38
MGSCv37826,149,616 - 26,212,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,506,385 - 26,567,277 (-)NCBIMGSCv36mm8
Celera826,506,205 - 26,568,790 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map813.7NCBI
Plekha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,462,875 - 14,525,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,462,875 - 14,525,174 (+)NCBIChiLan1.0ChiLan1.0
PLEKHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2757,463,091 - 57,536,307 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1833,180,577 - 33,253,791 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0838,202,121 - 38,275,316 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1835,377,105 - 35,445,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl835,377,105 - 35,446,938 (+)Ensemblpanpan1.1panPan2
PLEKHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11626,570,466 - 26,644,971 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1626,572,641 - 26,629,495 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,090,002 - 27,165,475 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01628,401,507 - 28,476,061 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1628,400,081 - 28,476,115 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11626,693,773 - 26,769,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,270,483 - 27,346,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,308,791 - 27,384,846 (-)NCBIUU_Cfam_GSD_1.0
Plekha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,180,691 - 49,250,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367102,223,941 - 2,276,792 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367102,210,683 - 2,280,522 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1547,626,110 - 47,697,603 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11547,626,107 - 47,697,238 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21554,710,304 - 54,731,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,901,552 - 36,989,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,918,990 - 36,992,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660524,986,349 - 5,077,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekha2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247804,633,007 - 4,683,162 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247804,633,487 - 4,695,555 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plekha2
514 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:96
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000022097
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH139097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,953,628 - 66,953,838 (+)MAPPERmRatBN7.2
Rnor_6.01671,740,222 - 71,740,431NCBIRnor6.0
Rnor_5.01671,391,279 - 71,391,488UniSTSRnor5.0
Celera1664,859,841 - 64,860,050UniSTS
RH 3.4 Map16632.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 15 15 19 4 7 7 19 25 11 4
Low 28 42 41 41 4 4 67 16 15 4
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000022097   ⟹   ENSRNOP00000022097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1671,738,718 - 71,787,787 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097592   ⟹   ENSRNOP00000084363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,939,109 - 66,999,395 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119625   ⟹   ENSRNOP00000082311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,939,109 - 66,999,395 (+)Ensembl
RefSeq Acc Id: NM_001427342   ⟹   NP_001414271
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,641,722 - 73,704,068 (+)NCBI
RefSeq Acc Id: XM_039095213   ⟹   XP_038951141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,641,338 - 73,704,068 (+)NCBI
mRatBN7.21666,938,684 - 67,000,661 (+)NCBI
RefSeq Acc Id: XM_039095214   ⟹   XP_038951142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,643,022 - 73,704,068 (+)NCBI
mRatBN7.21666,940,604 - 67,000,661 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414271 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951141 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951142 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09049 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082311.1
  ENSRNOP00000084363.1
RefSeq Acc Id: ENSRNOP00000022097   ⟸   ENSRNOT00000022097
RefSeq Acc Id: XP_038951141   ⟸   XM_039095213
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTX1 (UniProtKB/TrEMBL),   A6IW22 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951142   ⟸   XM_039095214
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTX1 (UniProtKB/TrEMBL),   A6IW22 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084363   ⟸   ENSRNOT00000097592
RefSeq Acc Id: ENSRNOP00000082311   ⟸   ENSRNOT00000119625
RefSeq Acc Id: NP_001414271   ⟸   NM_001427342
- UniProtKB: A6IW22 (UniProtKB/TrEMBL),   A0A8I5ZTX1 (UniProtKB/TrEMBL)
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LXA9-F1-model_v2 AlphaFold F1LXA9 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586710 AgrOrtholog
BioCyc Gene G2FUF-10954 BioCyc
Ensembl Genes ENSRNOG00000038365 Ensembl
  ENSRNOG00000066109 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097592.1 UniProtKB/TrEMBL
  ENSRNOT00000119625.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene 684785 ENTREZGENE
PANTHER PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 2 UniProtKB/TrEMBL
  TANDEM PH DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PhenoGen Plekha2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038365 RatGTEx
  ENSRNOG00000066109 RatGTEx
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8I5ZTX1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBR3_RAT UniProtKB/TrEMBL
  A6IW22 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Plekha2  pleckstrin homology domain containing A2  Plekha2  pleckstrin homology domain containing A2  Data merged from RGD:149736380 737654 PROVISIONAL
2021-08-09 Plekha2  pleckstrin homology domain containing A2      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-11-30 Plekha2  pleckstrin homology domain containing A2  Plekha2  pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-26 Plekha2  pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2   LOC684785  similar to pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC684785  similar to pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2      Symbol and Name status set to provisional 70820 PROVISIONAL