Cdkl3 (cyclin-dependent kinase-like 3) - Rat Genome Database

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Gene: Cdkl3 (cyclin-dependent kinase-like 3) Rattus norvegicus
Analyze
Symbol: Cdkl3
Name: cyclin-dependent kinase-like 3
RGD ID: 619874
Description: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within dendrite extension; negative regulation of axon extension; and positive regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Orthologous to human CDKL3 (cyclin dependent kinase like 3); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,4-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103693326; LOC103694901; Nkiatre; Nkiatreb; serine/threonine kinase NKIATRE; serine/threonine kinase NKIATRE beta; serine/threonine protein kinase NKIATRE; uncharacterized LOC103693326
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,755,413 - 36,850,197 (+)NCBIGRCr8
mRatBN7.21036,263,212 - 36,349,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,961,446 - 40,985,530 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,451,416 - 40,475,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,955,138 - 35,979,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,458,397 - 37,510,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,227,962 - 37,315,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,527,865 - 37,552,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1035,621,986 - 35,646,386 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
nucleus  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NKIATRE is a novel conserved cdc2-related kinase. Haq R, etal., Genomics 2001 Jan 15;71(2):131-41.
3. Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis. Liu Z, etal., Neurobiol Dis. 2010 Sep;39(3):242-51. doi: 10.1016/j.nbd.2010.03.015. Epub 2010 Mar 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:15057822  


Genomics

Comparative Map Data
Cdkl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,755,413 - 36,850,197 (+)NCBIGRCr8
mRatBN7.21036,263,212 - 36,349,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,961,446 - 40,985,530 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,451,416 - 40,475,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,955,138 - 35,979,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,458,397 - 37,510,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,227,962 - 37,315,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,527,865 - 37,552,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1035,621,986 - 35,646,386 (+)NCBICelera
Cytogenetic Map10q22NCBI
CDKL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,283,345 - 134,371,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,286,350 - 134,371,047 (-)EnsemblGRCh38hg38GRCh38
GRCh375133,634,115 - 133,706,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,671,591 - 133,730,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 345133,671,590 - 133,730,113NCBI
Celera5129,757,884 - 129,826,544 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,818,996 - 128,887,557 (-)NCBIHuRef
CHM1_15133,066,750 - 133,135,396 (-)NCBICHM1_1
T2T-CHM13v2.05134,806,646 - 134,895,410 (-)NCBIT2T-CHM13v2.0
Cdkl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,891,694 - 51,980,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,895,048 - 51,980,611 (+)EnsemblGRCm39 Ensembl
GRCm381152,000,842 - 52,089,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,004,221 - 52,089,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,817,723 - 51,898,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,847,745 - 51,881,588 (+)NCBIMGSCv36mm8
Celera1156,572,516 - 56,652,949 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.85NCBI

Variants

.
Variants in Cdkl3
269 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000059040
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat

Markers in Region
RH132769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,267,163 - 36,267,366 (+)MAPPERmRatBN7.2
Rnor_6.01037,458,677 - 37,458,879NCBIRnor6.0
Rnor_5.01037,231,787 - 37,231,989UniSTSRnor5.0
RGSC_v3.41037,528,052 - 37,528,254UniSTSRGSC3.4
Celera1035,622,173 - 35,622,375UniSTS
RH 3.4 Map10390.5UniSTS
Cytogenetic Map10q22UniSTS
RH133033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,302,574 - 36,302,768 (+)MAPPERmRatBN7.2
Rnor_6.01037,494,122 - 37,494,315NCBIRnor6.0
Rnor_5.01037,268,701 - 37,268,894UniSTSRnor5.0
RGSC_v3.41037,564,834 - 37,565,027UniSTSRGSC3.4
Celera1035,657,659 - 35,657,852UniSTS
RH 3.4 Map10387.2UniSTS
Cytogenetic Map10q22UniSTS
AU049026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,280,983 - 36,281,214 (+)MAPPERmRatBN7.2
Rnor_6.01037,472,495 - 37,472,725NCBIRnor6.0
Rnor_5.01037,245,886 - 37,246,117NCBIRnor5.0
RGSC_v3.41037,541,870 - 37,542,100UniSTSRGSC3.4
Celera1035,635,961 - 35,636,191UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 19 13 2 12 2 118 29 58 12
Below cutoff 6 60 61 43 20 43 10 12 11 40 20 9 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_597993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07024291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01063836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01063837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01063838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW523244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI296078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000079411   ⟹   ENSRNOP00000072310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,302,432 (+)Ensembl
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085895   ⟹   ENSRNOP00000073449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087152   ⟹   ENSRNOP00000068841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,304,109 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098640   ⟹   ENSRNOP00000091215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,344,571 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099737   ⟹   ENSRNOP00000084767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,984 - 36,302,946 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102740   ⟹   ENSRNOP00000082633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,310,602 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113693   ⟹   ENSRNOP00000096533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,310,602 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120278   ⟹   ENSRNOP00000094552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,266,977 - 36,296,776 (+)Ensembl
RefSeq Acc Id: NM_021772   ⟹   NP_068540
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,908 - 36,792,231 (+)NCBI
mRatBN7.21036,266,977 - 36,291,302 (+)NCBI
Rnor_6.01037,458,490 - 37,482,849 (+)NCBI
Rnor_5.01037,227,962 - 37,315,393 (+)NCBI
RGSC_v3.41037,527,865 - 37,552,851 (+)RGD
Celera1035,621,986 - 35,646,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773883   ⟹   XP_008772105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,889 - 36,311,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773884   ⟹   XP_008772106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,891 - 36,311,827 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773885   ⟹   XP_008772107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,888 - 36,311,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773886   ⟹   XP_008772108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,833,314 (+)NCBI
mRatBN7.21036,266,889 - 36,311,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773889   ⟹   XP_008772111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,803,875 (+)NCBI
mRatBN7.21036,266,892 - 36,301,301 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602529   ⟹   XP_017458018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,850,197 (+)NCBI
mRatBN7.21036,266,891 - 36,349,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602531   ⟹   XP_017458020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,783,505 - 36,833,314 (+)NCBI
mRatBN7.21036,282,568 - 36,312,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086735   ⟹   XP_038942663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,426 - 36,833,314 (+)NCBI
mRatBN7.21036,263,525 - 36,311,829 (+)NCBI
RefSeq Acc Id: XM_039086737   ⟹   XP_038942665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,679 - 36,833,314 (+)NCBI
mRatBN7.21036,263,742 - 36,311,829 (+)NCBI
RefSeq Acc Id: XM_039086738   ⟹   XP_038942666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,755,413 - 36,833,314 (+)NCBI
mRatBN7.21036,263,212 - 36,311,829 (+)NCBI
RefSeq Acc Id: XM_039086739   ⟹   XP_038942667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,795,881 (+)NCBI
mRatBN7.21036,266,884 - 36,295,034 (+)NCBI
RefSeq Acc Id: XM_063269754   ⟹   XP_063125824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,679 - 36,833,314 (+)NCBI
RefSeq Acc Id: XM_063269756   ⟹   XP_063125826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269757   ⟹   XP_063125827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,848,400 (+)NCBI
RefSeq Acc Id: XM_063269758   ⟹   XP_063125828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269759   ⟹   XP_063125829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,292 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269760   ⟹   XP_063125830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,755,413 - 36,803,875 (+)NCBI
RefSeq Acc Id: XM_063269762   ⟹   XP_063125832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,292 - 36,848,400 (+)NCBI
RefSeq Acc Id: XM_063269763   ⟹   XP_063125833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,819 - 36,799,663 (+)NCBI
RefSeq Acc Id: XR_005489935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,797,376 (+)NCBI
mRatBN7.21036,266,890 - 36,296,453 (+)NCBI
RefSeq Acc Id: XR_005489936
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,795,881 (+)NCBI
mRatBN7.21036,266,885 - 36,294,922 (+)NCBI
RefSeq Acc Id: XR_010055232
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,767,820 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055233
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,755,413 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055234
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,683 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055235
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,764,426 - 36,850,197 (+)NCBI
RefSeq Acc Id: XR_010055236
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,797,376 (+)NCBI
RefSeq Acc Id: XR_597993
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,766,507 - 36,850,197 (+)NCBI
mRatBN7.21036,266,893 - 36,349,268 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_068540 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772105 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772106 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772107 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772108 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772111 (Get FASTA)   NCBI Sequence Viewer  
  XP_017458018 (Get FASTA)   NCBI Sequence Viewer  
  XP_017458020 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942663 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942665 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942666 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942667 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125824 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125826 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125827 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125828 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125829 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125830 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125832 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF34870 (Get FASTA)   NCBI Sequence Viewer  
  AAF34871 (Get FASTA)   NCBI Sequence Viewer  
  EDM04342 (Get FASTA)   NCBI Sequence Viewer  
  EDM04343 (Get FASTA)   NCBI Sequence Viewer  
  EDM04344 (Get FASTA)   NCBI Sequence Viewer  
  EDM04345 (Get FASTA)   NCBI Sequence Viewer  
  EDM04346 (Get FASTA)   NCBI Sequence Viewer  
  EDM04347 (Get FASTA)   NCBI Sequence Viewer  
  EDM04348 (Get FASTA)   NCBI Sequence Viewer  
  EDM04349 (Get FASTA)   NCBI Sequence Viewer  
  EDM04350 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068841.2
  ENSRNOP00000072310.2
  ENSRNOP00000073449
  ENSRNOP00000073449.2
  ENSRNOP00000082633
  ENSRNOP00000082633.1
  ENSRNOP00000084767
  ENSRNOP00000084767.1
  ENSRNOP00000091215
  ENSRNOP00000091215.1
  ENSRNOP00000094552.1
  ENSRNOP00000096533.1
  ENSRNOP00055006450
  ENSRNOP00060036323
  ENSRNOP00065005577
GenBank Protein Q9JM01 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068540   ⟸   NM_021772
- UniProtKB: A6HE95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072310   ⟸   ENSRNOT00000079411
RefSeq Acc Id: XP_038942666   ⟸   XM_039086738
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942663   ⟸   XM_039086735
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942665   ⟸   XM_039086737
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942667   ⟸   XM_039086739
- Peptide Label: isoform X11
RefSeq Acc Id: XP_008772107   ⟸   XM_008773885
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772105   ⟸   XM_008773883
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772108   ⟸   XM_008773886
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017458018   ⟸   XM_017602529
- Peptide Label: isoform X2
- UniProtKB: A6HE87 (UniProtKB/TrEMBL),   A0A0G2K5J4 (UniProtKB/TrEMBL),   A6HE88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772106   ⟸   XM_008773884
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772111   ⟸   XM_008773889
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZYS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017458020   ⟸   XM_017602531
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: ENSRNOP00000073449   ⟸   ENSRNOT00000085895
RefSeq Acc Id: ENSRNOP00000084767   ⟸   ENSRNOT00000099737
RefSeq Acc Id: ENSRNOP00000091215   ⟸   ENSRNOT00000098640
RefSeq Acc Id: ENSRNOP00000096533   ⟸   ENSRNOT00000113693
RefSeq Acc Id: ENSRNOP00000094552   ⟸   ENSRNOT00000120278
RefSeq Acc Id: ENSRNOP00000068841   ⟸   ENSRNOT00000087152
RefSeq Acc Id: ENSRNOP00000082633   ⟸   ENSRNOT00000102740
RefSeq Acc Id: XP_063125830   ⟸   XM_063269760
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063125832   ⟸   XM_063269762
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063125829   ⟸   XM_063269759
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063125824   ⟸   XM_063269754
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063125826   ⟸   XM_063269756
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063125827   ⟸   XM_063269757
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063125828   ⟸   XM_063269758
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063125833   ⟸   XM_063269763
- Peptide Label: isoform X9
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM01-F1-model_v2 AlphaFold Q9JM01 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697167
Promoter ID:EPDNEW_R7692
Type:multiple initiation site
Name:Cdkl3_1
Description:cyclin-dependent kinase-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01037,458,470 - 37,458,530EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619874 AgrOrtholog
BioCyc Gene G2FUF-25178 BioCyc
Ensembl Genes ENSRNOG00000054806 UniProtKB/TrEMBL
  ENSRNOG00000059485 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005280 UniProtKB/Swiss-Prot
  ENSRNOG00060025117 UniProtKB/Swiss-Prot
  ENSRNOG00065005389 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079411.2 UniProtKB/TrEMBL
  ENSRNOT00000085895 UniProtKB/TrEMBL
  ENSRNOT00000085895.2 UniProtKB/Swiss-Prot
  ENSRNOT00000087152.2 UniProtKB/TrEMBL
  ENSRNOT00000098640.1 UniProtKB/TrEMBL
  ENSRNOT00000099737.1 UniProtKB/TrEMBL
  ENSRNOT00000102740.1 UniProtKB/TrEMBL
  ENSRNOT00000113693.1 UniProtKB/TrEMBL
  ENSRNOT00000120278.1 UniProtKB/TrEMBL
  ENSRNOT00055008499 UniProtKB/Swiss-Prot
  ENSRNOT00060043779 UniProtKB/Swiss-Prot
  ENSRNOT00065007990 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60396 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 60396 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE-LIKE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdkl3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054806 RatGTEx
  ENSRNOG00000059485 RatGTEx
  ENSRNOG00055005280 RatGTEx
  ENSRNOG00060025117 RatGTEx
  ENSRNOG00065005389 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2N2_RAT UniProtKB/TrEMBL
  A0A0G2K5J4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYS3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQU1_RAT UniProtKB/TrEMBL
  A0A8I6GKT9_RAT UniProtKB/TrEMBL
  A0A8L2R015_RAT UniProtKB/TrEMBL
  A6HE87 ENTREZGENE, UniProtKB/TrEMBL
  A6HE88 ENTREZGENE, UniProtKB/TrEMBL
  A6HE90_RAT UniProtKB/TrEMBL
  A6HE93_RAT UniProtKB/TrEMBL
  A6HE95 ENTREZGENE, UniProtKB/TrEMBL
  CDKL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JM02 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cdkl3  cyclin-dependent kinase-like 3  LOC103693326  uncharacterized LOC103693326  Data merged from RGD:9397746 737654 PROVISIONAL
2015-02-13 Cdkl3  cyclin-dependent kinase-like 3  LOC103694901  cyclin-dependent kinase-like 3  Data merged from RGD:9243578 737654 APPROVED
2014-08-25 LOC103694901  cyclin-dependent kinase-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-08-25 LOC103693326  uncharacterized LOC103693326      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cdkl3  cyclin-dependent kinase-like 3  Nkiatreb  serine/threonine kinase NKIATRE beta  Symbol and Name updated 1299863 APPROVED
2002-08-07 Nkiatreb  serine/threonine kinase NKIATRE beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a cyclin-binding domain 633468
gene_protein contains two isoforms, of which one has a nuclear localization signal 633468