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Gene: Ccnb3 (cyclin B3) Rattus norvegicus

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Symbol:

Ccnb3

Name:

cyclin B3

RGD ID:

1564367

Description:

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CCNB3 (cyclin B3); PARTICIPATES IN cell cycle pathway, mitotic; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G2/mitotic-specific cyclin-B3; LOC317389; RGD1564367; similar to cyclin B3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCNB3 (cyclin B3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ccnb3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ccnb3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCNB3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCNB3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ccnb3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCNB3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CCNB3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ccnb3 (cyclin B3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC16A9 (solute carrier family 16 member 9)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CCNB3 (cyclin B3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ccnb3 (cyclin B3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ccnb3 (cyclin B3)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	CLB6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	CLB1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	CLB2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	CLB5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CycB3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	cyb-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ccnb3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	18,149,915 - 18,214,801 (+)	NCBI		GRCr8
mRatBN7.2	X	15,478,050 - 15,543,292 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	15,478,065 - 15,542,885 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	20,294,337 - 20,358,758 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	19,724,545 - 19,788,967 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	15,989,504 - 16,053,924 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	16,300,752 - 16,402,206 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	16,337,102 - 16,402,202 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	17,122,155 - 17,187,194 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	27,565,661 - 27,623,293 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	15,515,387 - 15,617,162 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	autistic disorder		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106 and PMID:30208311
Ccnb3	Rat	congenital disorder of glycosylation type IIm		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 22	ClinVar	PMID:28492532
Ccnb3	Rat	Habitual Abortions		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pregnancy loss more ...	ClinVar
Ccnb3	Rat	immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Insulin-dependent diabetes mellitus secretory diarrhea syndrome	ClinVar	PMID:11137992 more ...
Ccnb3	Rat	neurodegeneration with brain iron accumulation 5		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Beta-propeller protein-associated neurodegeneration	ClinVar	PMID:28492532
Ccnb3	Rat	Stocco Dos Santos type X-linked intellectual disability		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: X-linked intellectual disability and Stocco dos Santos type	ClinVar	PMID:25670966
Ccnb3	Rat	syndromic X-linked intellectual disability Lubs type		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868
Ccnb3	Rat	Thrombocytopenia 1		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Thrombocytopenia and X-linked	ClinVar	PMID:28492532
Ccnb3	Rat	Wiskott-Aldrich syndrome		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: WISKOTT-ALDRICH SYNDROME 1	ClinVar	PMID:28492532
Ccnb3	Rat	X-linked epilepsy with variable learning disabilities and behavior disorders		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:28492532
Ccnb3	Rat	X-linked severe congenital neutropenia		ISO	CCNB3 (Homo sapiens)	8554872	ClinVar Annotator: match by term: X-linked severe congenital neutropenia	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	osteosarcoma		ISO	CCNB3 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:22387997

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of CCNB3 mRNA	CTD	PMID:33387578
Ccnb3	Rat	atrazine	affects methylation	EXP		6480464	Atrazine affects the methylation of CCNB3 gene	CTD	PMID:35440735
Ccnb3	Rat	benzo[a]pyrene	decreases methylation	ISO	CCNB3 (Homo sapiens)	6480464	Benzo(a)pyrene results in decreased methylation of CCNB3 3' UTR and Benzo(a)pyrene results in decreased methylation of CCNB3 promoter	CTD	PMID:27901495
Ccnb3	Rat	benzo[a]pyrene	affects methylation	ISO	CCNB3 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of CCNB3 5' UTR	CTD	PMID:27901495
Ccnb3	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of CCNB3 mRNA	CTD	PMID:25181051
Ccnb3	Rat	bisphenol A	affects expression	ISO	CCNB3 (Homo sapiens)	6480464	bisphenol A affects the expression of CCNB3 mRNA	CTD	PMID:35628146
Ccnb3	Rat	CGP 52608	multiple interactions	ISO	CCNB3 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to CCNB3 gene]	CTD	PMID:28238834
Ccnb3	Rat	FR900359	increases phosphorylation	ISO	CCNB3 (Homo sapiens)	6480464	FR900359 results in increased phosphorylation of CCNB3 protein	CTD	PMID:37730182
Ccnb3	Rat	lipopolysaccharide	multiple interactions	ISO	CCNB3 (Homo sapiens)	6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CCNB3 mRNA	CTD	PMID:35811015
Ccnb3	Rat	N-Nitrosopyrrolidine	decreases expression	ISO	CCNB3 (Homo sapiens)	6480464	N-Nitrosopyrrolidine results in decreased expression of CCNB3 mRNA	CTD	PMID:32234424
Ccnb3	Rat	niclosamide	decreases expression	ISO	CCNB3 (Homo sapiens)	6480464	Niclosamide results in decreased expression of CCNB3 mRNA	CTD	PMID:36318118
Ccnb3	Rat	paracetamol	affects expression	ISO	Ccnb3 (Mus musculus)	6480464	Acetaminophen affects the expression of CCNB3 mRNA	CTD	PMID:17562736
Ccnb3	Rat	potassium dichromate	increases expression	ISO	Ccnb3 (Mus musculus)	6480464	Potassium Dichromate results in increased expression of CCNB3 mRNA	CTD	PMID:23608068
Ccnb3	Rat	rotenone	increases expression	ISO	CCNB3 (Homo sapiens)	6480464	Rotenone results in increased expression of CCNB3 mRNA	CTD	PMID:29955902
Ccnb3	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	CCNB3 (Homo sapiens)	6480464	[S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CCNB3 mRNA	CTD	PMID:35811015
Ccnb3	Rat	sodium arsenite	decreases expression	ISO	CCNB3 (Homo sapiens)	6480464	sodium arsenite results in decreased expression of CCNB3 mRNA	CTD	PMID:25879800
Ccnb3	Rat	sunitinib	decreases expression	ISO	CCNB3 (Homo sapiens)	6480464	Sunitinib results in decreased expression of CCNB3 mRNA	CTD	PMID:31533062
Ccnb3	Rat	tetracycline	increases expression	ISO	Ccnb3 (Mus musculus)	6480464	Tetracycline results in increased expression of CCNB3 mRNA	CTD	PMID:16917069
Ccnb3	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of CCNB3 mRNA	CTD	PMID:33387578
Ccnb3	Rat	triptonide	increases expression	ISO	Ccnb3 (Mus musculus)	6480464	triptonide results in increased expression of CCNB3 mRNA	CTD	PMID:33045310
Ccnb3	Rat	valproic acid	affects expression	ISO	CCNB3 (Homo sapiens)	6480464	Valproic Acid affects the expression of CCNB3 mRNA	CTD	PMID:25979313
Ccnb3	Rat	valproic acid	increases expression	ISO	CCNB3 (Homo sapiens)	6480464	Valproic Acid results in increased expression of CCNB3 mRNA	CTD	PMID:28001369

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	cell division	involved_in	IEA	UniProtKB-KW:KW-0132	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ccnb3	Rat	G1/S transition of mitotic cell cycle	involved_in	IBA	CGD:CAL0000185532 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	cyclin-dependent protein kinase holoenzyme complex	part_of	IBA	MGI:108042 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ccnb3	Rat	cytoplasm	is_active_in	IBA	FB:FBgn0000404 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ccnb3	Rat	nucleoplasm	located_in	ISO	CCNB3 (Homo sapiens) and UniProtKB:Q8WWL7-1	1624291		RGD	GO_REF:0000052
Ccnb3	Rat	nucleus	is_active_in	IBA	FB:FBgn0000404 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ccnb3	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ccnb3	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	cyclin-dependent protein serine/threonine kinase regulator activity	enables	IBA	CGD:CAL0000175354 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ccnb3	Rat	protein binding	enables	ISO	CCNB3 (Homo sapiens)	1624291	UniProtKB:A8UKE6 more ...	RGD	PMID:12185076 and PMID:17174311
Ccnb3	Rat	protein kinase binding	enables	IEA	ARBA:ARBA00028598	1600115	GO_REF:0000117	UniProt	GO_REF:0000117

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ccnb3	Rat	cell cycle pathway, mitotic		IEA		6907045		KEGG	rno:04110
Ccnb3	Rat	p53 signaling pathway		IEA		6907045		KEGG	rno:04115

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Ccnb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	18,149,915 - 18,214,801 (+)	NCBI		GRCr8
mRatBN7.2	X	15,478,050 - 15,543,292 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	15,478,065 - 15,542,885 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	20,294,337 - 20,358,758 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	19,724,545 - 19,788,967 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	15,989,504 - 16,053,924 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	16,300,752 - 16,402,206 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	16,337,102 - 16,402,202 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	17,122,155 - 17,187,194 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	27,565,661 - 27,623,293 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	15,515,387 - 15,617,162 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

CCNB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	50,202,713 - 50,351,914 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	50,202,713 - 50,351,914 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	49,969,416 - 50,094,913 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	50,044,280 - 50,111,653 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	49,860,575 - 49,927,945	NCBI
Celera	X	54,071,225 - 54,138,495 (+)	NCBI		Celera
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	47,471,841 - 47,539,060 (+)	NCBI		HuRef
CHM1_1	X	50,107,188 - 50,174,744 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	49,520,371 - 49,623,348 (+)	NCBI		T2T-CHM13v2.0

Ccnb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	6,845,890 - 6,907,894 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	6,845,891 - 6,907,858 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	6,979,652 - 7,041,635 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	6,979,652 - 7,041,619 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	6,556,778 - 6,618,745 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	6,136,611 - 6,198,578 (-)	NCBI		MGSCv36	mm8
Celera	X	4,421,565 - 4,483,832 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	3.13	NCBI

Ccnb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955543	1,377,932 - 1,444,327 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCNB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	51,622,770 - 51,724,853 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	51,626,146 - 51,728,152 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	42,409,954 - 42,511,811 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	50,157,122 - 50,223,759 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	50,157,122 - 50,223,547 (+)	Ensembl	panpan1.1		panPan2

CCNB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	42,951,030 - 43,041,616 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	42,949,558 - 43,012,122 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	17,340,549 - 17,389,577 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	43,102,335 - 43,180,933 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	43,088,724 - 43,151,391 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	43,088,178 - 43,137,193 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	43,075,470 - 43,124,516 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	43,170,367 - 43,219,386 (+)	NCBI		UU_Cfam_GSD_1.0

Ccnb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	35,485,077 - 35,542,195 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936721	1,729,979 - 1,782,399 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCNB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	43,922,804 - 43,990,929 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	43,922,729 - 43,988,939 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	48,849,863 - 48,916,024 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCNB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	47,059,747 - 47,142,911 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	47,085,605 - 47,142,788 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666086	642,635 - 731,855 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccnb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624893	1,788,915 - 1,862,015 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624893	1,775,726 - 1,861,925 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Ccnb3
223 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	33
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000003954
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	5	23	71	44	34	18	14	18	3	122	55	54	41	59	16


RefSeq Transcripts	NM_001401153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001064448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010061199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010061200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HQ634292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003954 ⟹ ENSRNOP00000003954

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	15,478,065 - 15,542,885 (+)	Ensembl
Rnor_6.0 Ensembl	X	16,337,102 - 16,402,202 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094271 ⟹ ENSRNOP00000093786

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	15,478,065 - 15,542,837 (+)	Ensembl

RefSeq Acc Id:

NM_001401153 ⟹ NP_001388082

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	18,149,915 - 18,214,801 (+)	NCBI
mRatBN7.2	X	15,478,050 - 15,542,938 (+)	NCBI

RefSeq Acc Id:

XM_063280057 ⟹ XP_063136127

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	18,149,919 - 18,214,801 (+)	NCBI

RefSeq Acc Id:

XR_010061199

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	18,149,915 - 18,203,737 (+)	NCBI

RefSeq Acc Id:

XR_010061200

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	18,149,915 - 18,199,305 (+)	NCBI


Protein RefSeqs	NP_001388082	(Get FASTA)	NCBI Sequence Viewer
	XP_063136127	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ADX01544	(Get FASTA)	NCBI Sequence Viewer
	EDL83865	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003954
	ENSRNOP00000003954.6
	ENSRNOP00000093786.1

Ensembl Acc Id:

ENSRNOP00000003954 ⟸ ENSRNOT00000003954

Ensembl Acc Id:

ENSRNOP00000093786 ⟸ ENSRNOT00000094271

RefSeq Acc Id:	NP_001388082 ⟸ NM_001401153
- UniProtKB:	K7NAQ4 (UniProtKB/TrEMBL), F1LVT0 (UniProtKB/TrEMBL), A0A8I6AMG1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136127 ⟸ XM_063280057
- Peptide Label:	isoform X1
- UniProtKB:	F1LVT0 (UniProtKB/TrEMBL), K7NAQ4 (UniProtKB/TrEMBL), A0A8I6AMG1 (UniProtKB/TrEMBL)

Protein Domains

Cyclin C-terminal Cyclin-like

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LVT0-F1-model_v2	AlphaFold	F1LVT0	1-1404	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13701757

Promoter ID:

EPDNEW_R12277

Type:

single initiation site

Name:

Ccnb3_1

Description:

cyclin B3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	16,337,090 - 16,337,150	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-2875	BioCyc
Ensembl Genes	ENSRNOG00000002951	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003954	ENTREZGENE
	ENSRNOT00000003954.7	UniProtKB/TrEMBL
	ENSRNOT00000094271.1	UniProtKB/TrEMBL
Gene3D-CATH	Cyclin-like	UniProtKB/TrEMBL
InterPro	Cyclin	UniProtKB/TrEMBL
	Cyclin-like	UniProtKB/TrEMBL
	Cyclin-like_sf	UniProtKB/TrEMBL
	Cyclin_C	UniProtKB/TrEMBL
	Cyclin_N	UniProtKB/TrEMBL
	Cyclins_cyclin-box	UniProtKB/TrEMBL
NCBI Gene	317389	ENTREZGENE
PANTHER	PTHR10177	UniProtKB/TrEMBL
Pfam	Cyclin_C	UniProtKB/TrEMBL
	Cyclin_N	UniProtKB/TrEMBL
PhenoGen	Ccnb3	PhenoGen
PROSITE	CYCLINS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002951	RatGTEx
SMART	CYCLIN	UniProtKB/TrEMBL
	Cyclin_C	UniProtKB/TrEMBL
Superfamily-SCOP	Cyclin_like	UniProtKB/TrEMBL
UniProt	A0A8I6AMG1	ENTREZGENE, UniProtKB/TrEMBL
	F1LVT0	ENTREZGENE, UniProtKB/TrEMBL
	K7NAQ4	ENTREZGENE
UniProt Secondary	K7NAQ4	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ccnb3	cyclin B3	Ccnb3_predicted	cyclin B3 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Ccnb3_predicted	cyclin B3 (predicted)	RGD1564367_predicted	similar to cyclin B3 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1564367_predicted	similar to cyclin B3 (predicted)	LOC317389	similar to cyclin B3	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC317389	similar to cyclin B3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)