Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of KLC4 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | Klc4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of KLC4 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | ISO | Klc4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KLC4 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of KLC4 mRNA | CTD | PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLC4 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KLC4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLC4 mRNA | CTD | PMID:21215274 and PMID:32109520 | 2,4,6-tribromophenol | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of KLC4 mRNA | CTD | PMID:21346803 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:32119087 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of KLC4 protein | CTD | PMID:31675489 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of KLC4 protein | CTD | PMID:34915118 | 4-hydroxyphenyl retinamide | increases expression | ISO | Klc4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of KLC4 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KLC4 mRNA | CTD | PMID:30047161 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of KLC4 mRNA | CTD | PMID:28959563 | aflatoxin B1 | affects expression | ISO | KLC4 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of KLC4 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of KLC4 mRNA | CTD | PMID:22100608 | antirheumatic drug | increases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of KLC4 mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | KLC4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KLC4 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | KLC4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of KLC4 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | KLC4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of KLC4 gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of KLC4 mRNA | CTD | PMID:22316170 and PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | KLC4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KLC4 exon | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | KLC4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of KLC4 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | KLC4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of KLC4 5' UTR and Benzo(a)pyrene results in decreased methylation of KLC4 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KLC4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | KLC4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of KLC4 protein | CTD | PMID:37567409 | bisphenol A | increases expression | ISO | Klc4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KLC4 mRNA | CTD | PMID:34585602 | bisphenol A | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of KLC4 protein | CTD | PMID:31675489 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KLC4 mRNA | CTD | PMID:30816183 more ... | bisphenol A | affects expression | ISO | KLC4 (Homo sapiens) | 6480464 | bisphenol A affects the expression of KLC4 mRNA | CTD | PMID:30903817 | cadmium atom | multiple interactions | ISO | Klc4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KLC4 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Klc4 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KLC4 mRNA | CTD | PMID:37325564 | caffeine | affects phosphorylation | ISO | KLC4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of KLC4 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Klc4 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of KLC4 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | KLC4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KLC4 gene] | CTD | PMID:28238834 | clofibrate | decreases expression | ISO | Klc4 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of KLC4 mRNA | CTD | PMID:17585979 | copper(II) sulfate | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of KLC4 mRNA | CTD | PMID:19549813 | Cuprizon | multiple interactions | ISO | KLC4 (Homo sapiens) | 6480464 | [Cuprizone co-treated with Haloperidol] results in increased expression of KLC4 protein | CTD | PMID:34122009 | cyclosporin A | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of KLC4 mRNA | CTD | PMID:20106945 and PMID:25562108 | decabromodiphenyl ether | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of KLC4 protein | CTD | PMID:31675489 | doxorubicin | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of KLC4 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | KLC4 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KLC4 protein | CTD | PMID:23301498 | fenthion | increases expression | ISO | Klc4 (Mus musculus) | 6480464 | Fenthion results in increased expression of KLC4 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Klc4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KLC4 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | KLC4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of KLC4 protein | CTD | PMID:37730182 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of KLC4 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of KLC4 mRNA | CTD | PMID:24136188 | haloperidol | multiple interactions | ISO | KLC4 (Homo sapiens) | 6480464 | [Cuprizone co-treated with Haloperidol] results in increased expression of KLC4 protein | CTD | PMID:34122009 | leflunomide | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of KLC4 mRNA | CTD | PMID:28988120 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of KLC4 mRNA | CTD | PMID:30047161 | N-Nitrosopyrrolidine | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of KLC4 mRNA | CTD | PMID:32234424 | nickel atom | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Nickel results in decreased expression of KLC4 mRNA | CTD | PMID:25583101 | niclosamide | increases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of KLC4 mRNA | CTD | PMID:36318118 | O-methyleugenol | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of KLC4 mRNA | CTD | PMID:32234424 | oxycodone | increases expression | EXP | | 6480464 | Oxycodone results in increased expression of KLC4 mRNA | CTD | PMID:23439660 | p-toluidine | increases expression | EXP | | 6480464 | 4-toluidine results in increased expression of KLC4 mRNA | CTD | PMID:27638505 | paracetamol | affects expression | ISO | Klc4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of KLC4 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of KLC4 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of KLC4 mRNA | CTD | PMID:22230336 and PMID:29067470 | perfluorononanoic acid | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of KLC4 mRNA | CTD | PMID:32588087 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Klc4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of KLC4 mRNA | CTD | PMID:36331819 | quercetin | increases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Quercetin results in increased expression of KLC4 mRNA | CTD | PMID:19729006 | quercetin | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of KLC4 mRNA | CTD | PMID:21632981 | silicon dioxide | decreases expression | ISO | KLC4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of KLC4 mRNA | CTD | PMID:25895662 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of KLC4 mRNA | CTD | PMID:30047161 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of KLC4 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of KLC4 mRNA] | CTD | PMID:31150632 | thapsigargin | decreases expression | EXP | | 6480464 | Thapsigargin results in decreased expression of KLC4 protein | CTD | PMID:35544339 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of KLC4 mRNA | CTD | PMID:34492290 | tungsten | decreases expression | ISO | Klc4 (Mus musculus) | 6480464 | Tungsten results in decreased expression of KLC4 mRNA | CTD | PMID:30912803 | |