Cyp39a1 (cytochrome P450, family 39, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp39a1 (cytochrome P450, family 39, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
RGD ID: 1307471
Description: Predicted to enable oxysterol 7-alpha-hydroxylase activity and steroid 7-alpha-hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cholesterol catabolic process. Predicted to be located in membrane. Orthologous to human CYP39A1 (cytochrome P450 family 39 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 24-hydroxycholesterol 7-alpha-hydroxylase; LOC301264
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2917,230,455 - 17,306,775 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,230,455 - 17,306,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,813,887 - 25,896,692 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0930,888,426 - 30,971,232 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0929,177,662 - 29,260,471 (-)NCBIRnor_WKY
Rnor_6.0919,804,079 - 19,880,346 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,804,079 - 19,880,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,681,949 - 18,758,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4912,926,125 - 13,002,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1912,924,912 - 12,999,586 (-)NCBI
Celera914,954,224 - 15,030,308 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(24S)-24-hydroxycholesterol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10748047  


Genomics

Comparative Map Data
Cyp39a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2917,230,455 - 17,306,775 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,230,455 - 17,306,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx925,813,887 - 25,896,692 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0930,888,426 - 30,971,232 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0929,177,662 - 29,260,471 (-)NCBIRnor_WKY
Rnor_6.0919,804,079 - 19,880,346 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,804,079 - 19,880,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,681,949 - 18,758,013 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4912,926,125 - 13,002,576 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1912,924,912 - 12,999,586 (-)NCBI
Celera914,954,224 - 15,030,308 (-)NCBICelera
Cytogenetic Map9q13NCBI
CYP39A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,549,580 - 46,652,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl646,549,580 - 46,652,830 (-)EnsemblGRCh38hg38GRCh38
GRCh37646,517,317 - 46,620,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,625,404 - 46,728,482 (-)NCBINCBI36Build 36hg18NCBI36
Build 34646,625,404 - 46,728,482NCBI
Celera648,069,986 - 48,173,038 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,240,326 - 46,343,851 (-)NCBIHuRef
CHM1_1646,520,541 - 46,624,016 (-)NCBICHM1_1
T2T-CHM13v2.0646,387,235 - 46,490,468 (-)NCBIT2T-CHM13v2.0
Cyp39a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,978,263 - 44,062,322 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,978,316 - 44,062,322 (+)EnsemblGRCm39 Ensembl
GRCm381743,667,372 - 43,751,431 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,667,425 - 43,751,431 (+)EnsemblGRCm38mm10GRCm38
MGSCv371743,804,374 - 43,888,380 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,130,480 - 43,214,486 (+)NCBIMGSCv36mm8
Celera1747,090,227 - 47,177,420 (+)NCBICelera
Cytogenetic Map17B3NCBI
LOC102006164
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,444,220 - 11,497,084 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,444,780 - 11,497,268 (-)NCBIChiLan1.0ChiLan1.0
CYP39A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1647,404,969 - 47,507,600 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,404,969 - 47,507,600 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0646,132,584 - 46,235,578 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CYP39A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,728,289 - 14,818,264 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,729,063 - 14,867,888 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,759,739 - 14,849,550 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,228,042 - 15,318,048 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,228,045 - 15,317,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,744,051 - 14,833,700 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,832,622 - 14,922,602 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01214,929,415 - 15,019,242 (-)NCBIUU_Cfam_GSD_1.0
LOC101972335
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,141,095 - 50,298,692 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,697,583 - 13,819,109 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647613,697,598 - 13,819,362 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP39A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl741,344,804 - 41,425,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1741,345,011 - 41,425,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2747,585,570 - 47,666,631 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP39A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,621,297 - 25,726,055 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,621,305 - 25,728,617 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604446,561,483 - 46,671,274 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101717854
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,980,354 - 14,034,098 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,980,180 - 14,033,591 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp39a1
775 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:145
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000014051
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat

Markers in Region
D9Got20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,304,458 - 17,304,622 (+)MAPPERmRatBN7.2
Rnor_6.0919,878,030 - 19,878,193NCBIRnor6.0
Rnor_5.0918,755,697 - 18,755,860UniSTSRnor5.0
RGSC_v3.4913,000,259 - 13,000,423RGDRGSC3.4
RGSC_v3.4913,000,260 - 13,000,423UniSTSRGSC3.4
RGSC_v3.1912,997,582 - 12,997,745RGD
Celera915,027,992 - 15,028,155UniSTS
RH 3.4 Map9111.7UniSTS
RH 3.4 Map9111.7RGD
RH 2.0 Map9102.0RGD
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 21 21
Low 2 43 33 20 9 20 8 10 69 35 41 11 8
Below cutoff 1 3 9 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014051   ⟹   ENSRNOP00000014051
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl917,230,455 - 17,306,775 (-)Ensembl
Rnor_6.0 Ensembl919,804,079 - 19,880,346 (-)Ensembl
RefSeq Acc Id: NM_001106893   ⟹   NP_001100363
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2917,230,455 - 17,306,775 (-)NCBI
Rnor_6.0919,804,079 - 19,880,346 (-)NCBI
Rnor_5.0918,681,949 - 18,758,013 (-)NCBI
RGSC_v3.4912,926,125 - 13,002,576 (-)RGD
Celera914,954,224 - 15,030,308 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100363 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18705 (Get FASTA)   NCBI Sequence Viewer  
  EDM18706 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100363   ⟸   NM_001106893
- UniProtKB: D4AE09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014051   ⟸   ENSRNOT00000014051

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE09-F1-model_v2 AlphaFold D4AE09 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696554
Promoter ID:EPDNEW_R7078
Type:initiation region
Name:Cyp39a1_1
Description:cytochrome P450, family 39, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0919,880,100 - 19,880,160EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307471 AgrOrtholog
BioCyc Gene G2FUF-28121 BioCyc
Ensembl Genes ENSRNOG00000010519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014051 ENTREZGENE
  ENSRNOP00000014051.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014051 ENTREZGENE
  ENSRNOT00000014051.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report rno:301264 UniProtKB/TrEMBL
NCBI Gene 301264 ENTREZGENE
PANTHER 24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 7 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PharmGKB CYP39A1 RGD
PhenoGen Cyp39a1 PhenoGen
PRINTS EP450IV UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt D4AE09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyp39a1  cytochrome P450, family 39, subfamily a, polypeptide 1   Cyp39a1_predicted  cytochrome P450, family 39, subfamily a, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyp39a1_predicted  cytochrome P450, family 39, subfamily a, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED