Ptprg (protein tyrosine phosphatase, receptor type, G) - Rat Genome Database
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Gene: Ptprg (protein tyrosine phosphatase, receptor type, G) Rattus norvegicus
Analyze
Symbol: Ptprg
Name: protein tyrosine phosphatase, receptor type, G
RGD ID: 620774
Description: Predicted to have identical protein binding activity and protein tyrosine phosphatase activity. Involved in brain development and negative regulation of neuron projection development. Localizes to extracellular space. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4-tert-Octylphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: protein tyrosine phosphatase gamma; Protein tyrosine phosphatase, gamma (provisional HGM11 symbol); Ptpg; receptor-like protein tyrosine phosphatase gamma; receptor-type tyrosine-protein phosphatase gamma; RPTP gamma; RPTP gamma A; RPTP gamma B; RPTP gamma C; RPTP gamma S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21512,872,284 - 13,552,186 (-)NCBI
Rnor_6.0 Ensembl1512,926,167 - 13,228,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01512,926,056 - 13,633,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01516,953,275 - 17,647,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41514,449,352 - 15,130,760 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11514,449,351 - 14,966,931 (-)NCBI
Celera1512,868,965 - 13,547,381 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP,ISO)
melphalan  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosomorpholine  (EXP)
nickel sulfate  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
tetraphene  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:15978577   PMID:19167335   PMID:20014386   PMID:21724833   PMID:23376485   PMID:23533145   PMID:23716698  


Genomics

Comparative Map Data
Ptprg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21512,872,284 - 13,552,186 (-)NCBI
Rnor_6.0 Ensembl1512,926,167 - 13,228,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01512,926,056 - 13,633,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01516,953,275 - 17,647,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41514,449,352 - 15,130,760 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11514,449,351 - 14,966,931 (-)NCBI
Celera1512,868,965 - 13,547,381 (-)NCBICelera
Cytogenetic Map15p16NCBI
PTPRG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl361,561,569 - 62,297,609 (+)EnsemblGRCh38hg38GRCh38
GRCh38361,561,571 - 62,297,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37361,547,245 - 62,283,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36361,522,285 - 62,254,738 (+)NCBINCBI36hg18NCBI36
Build 34361,522,284 - 62,254,737NCBI
Celera361,560,149 - 62,297,663 (+)NCBI
Cytogenetic Map3p14.2NCBI
HuRef361,645,865 - 62,378,614 (+)NCBIHuRef
CHM1_1361,497,665 - 62,231,710 (+)NCBICHM1_1
Ptprg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391410,227,722 - 10,916,341 (-)NCBIGRCm39mm39
GRCm381411,553,440 - 12,242,041 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1411,553,532 - 12,242,041 (+)EnsemblGRCm38mm10GRCm38
MGSCv371412,386,067 - 13,074,553 (+)NCBIGRCm37mm9NCBIm37
MGSCv361410,347,279 - 11,031,196 (+)NCBImm8
Celera147,168,551 - 7,867,137 (+)NCBICelera
Celera1415,457,844 - 15,462,854 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map146.33NCBI
Ptprg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555173,676,342 - 4,352,909 (-)NCBIChiLan1.0ChiLan1.0
PTPRG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1362,876,655 - 63,608,175 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl362,877,232 - 63,604,275 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0361,487,734 - 62,221,149 (+)NCBIMhudiblu_PPA_v0panPan3
PTPRG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2028,778,386 - 29,481,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12028,777,306 - 29,481,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptprg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366374,126,058 - 4,248,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1343,548,770 - 43,869,270 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11343,132,786 - 43,869,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21347,543,401 - 47,873,302 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12222,652,375 - 23,370,973 (+)NCBI
ChlSab1.1 Ensembl2223,061,935 - 23,370,960 (+)Ensembl
Ptprg
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248228,378,048 - 8,942,342 (+)NCBI

Position Markers
D15Rat136  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01512,982,697 - 12,982,878NCBIRnor6.0
Rnor_5.01517,009,983 - 17,010,164UniSTSRnor5.0
RGSC_v3.41514,506,878 - 14,507,060RGDRGSC3.4
RGSC_v3.41514,506,879 - 14,507,060UniSTSRGSC3.4
RGSC_v3.11514,506,878 - 14,507,060RGD
Celera1512,925,256 - 12,925,437UniSTS
SHRSP x BN Map159.5698UniSTS
SHRSP x BN Map159.5698RGD
Cytogenetic Map15p16-p15UniSTS
D15Got18  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01513,500,629 - 13,500,755NCBIRnor6.0
Rnor_5.01517,516,160 - 17,516,286UniSTSRnor5.0
RGSC_v3.41515,012,985 - 15,013,112RGDRGSC3.4
RGSC_v3.41515,012,986 - 15,013,112UniSTSRGSC3.4
RGSC_v3.11515,012,986 - 15,013,112RGD
Celera1513,429,108 - 13,429,234UniSTS
RH 3.4 Map15110.0RGD
RH 3.4 Map15110.0UniSTS
RH 2.0 Map1562.3RGD
Cytogenetic Map15p16-p15UniSTS
D15Kyo1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01513,602,281 - 13,602,425NCBIRnor6.0
Rnor_5.01517,616,068 - 17,616,212UniSTSRnor5.0
RGSC_v3.41515,099,202 - 15,099,346UniSTSRGSC3.4
Celera1513,515,813 - 13,515,957UniSTS
Cytogenetic Map15p16-p15UniSTS
RH133004  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01517,198,751 - 17,199,159NCBIRnor5.0
RGSC_v3.41514,701,554 - 14,701,954UniSTSRGSC3.4
Celera1513,116,466 - 13,116,866UniSTS
Cytogenetic Map15p16-p15UniSTS
BE102252  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01513,629,831 - 13,630,004NCBIRnor6.0
Rnor_5.01517,643,618 - 17,643,791UniSTSRnor5.0
RGSC_v3.41515,126,752 - 15,126,925UniSTSRGSC3.4
Celera1513,543,373 - 13,543,546UniSTS
RH 3.4 Map1596.6UniSTS
Cytogenetic Map15p16-p15UniSTS
BE116836  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01513,398,010 - 13,398,199NCBIRnor6.0
Rnor_5.01517,413,541 - 17,413,730UniSTSRnor5.0
RGSC_v3.41514,910,301 - 14,910,490UniSTSRGSC3.4
Celera1513,326,770 - 13,326,959UniSTS
RH 3.4 Map15109.3UniSTS
Cytogenetic Map15p16-p15UniSTS
BF390487  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01513,453,254 - 13,453,423NCBIRnor6.0
Rnor_5.01517,468,785 - 17,468,954UniSTSRnor5.0
RGSC_v3.41514,965,611 - 14,965,780UniSTSRGSC3.4
Celera1513,381,733 - 13,381,902UniSTS
RH 3.4 Map1596.9UniSTS
Cytogenetic Map15p16-p15UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15110589015828368Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:22
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000042010
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 34 14 5 2 5 2 2 74 35 34 11 2
Low 2 9 43 36 17 36 6 9 7 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042010   ⟹   ENSRNOP00000039045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1512,926,167 - 13,228,607 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088214   ⟹   ENSRNOP00000073305
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1512,926,167 - 13,228,607 (-)Ensembl
RefSeq Acc Id: NM_134356   ⟹   NP_599183
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21512,872,284 - 13,552,186 (-)NCBI
Rnor_6.01512,926,056 - 13,633,839 (-)NCBI
Rnor_5.01516,953,275 - 17,647,626 (-)NCBI
RGSC_v3.41514,449,352 - 15,130,760 (-)RGD
Celera1512,868,965 - 13,547,381 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB02231 (Get FASTA)   NCBI Sequence Viewer  
  AAN72429 (Get FASTA)   NCBI Sequence Viewer  
  AAN72430 (Get FASTA)   NCBI Sequence Viewer  
  AAN72431 (Get FASTA)   NCBI Sequence Viewer  
  AAN72432 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_599183   ⟸   NM_134356
- UniProtKB: Q8CIN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000039045   ⟸   ENSRNOT00000042010
RefSeq Acc Id: ENSRNOP00000073305   ⟸   ENSRNOT00000088214
Protein Domains
Alpha-carbonic anhydrase   Fibronectin type-III   TYR_PHOSPHATASE_2   Tyrosine-protein phosphatase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620774 AgrOrtholog
Ensembl Genes ENSRNOG00000009419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039045 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073305 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042010 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000088214 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.10.200.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro alpha_CARP_receptor-type UniProtKB/TrEMBL
  Carbonic_anhydrase_a UniProtKB/TrEMBL
  Carbonic_anhydrase_a_sf UniProtKB/TrEMBL
  Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:171357 UniProtKB/TrEMBL
NCBI Gene 171357 ENTREZGENE
Pfam Carb_anhydrase UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PharmGKB PTPRG RGD
PhenoGen Ptprg PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE ALPHA_CA_2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP Euk_COanhd UniProtKB/TrEMBL
  FN_III-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2K561_RAT UniProtKB/TrEMBL
  F1LP13_RAT UniProtKB/TrEMBL
  Q8CIN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ptprg  protein tyrosine phosphatase, receptor type, G      Symbol and Name updated 629477 APPROVED
2003-03-06 Ptprg  protein tyrosine phosphatase, receptor type, G  Ptpg  Protein tyrosine phosphatase, gamma (provisional HGM11 symbol)  Data Merged 628472 PROVISIONAL
2002-08-07 Ptprg  protein tyrosine phosphatase, receptor type, G      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ptpg  Protein tyrosine phosphatase, gamma (provisional HGM11 symbol)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain, kidney, lung, and heart 633859