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Gene: Shisa4 (shisa family member 4) Rattus norvegicus
Analyze
Symbol:
Shisa4
Name:
shisa family member 4
RGD ID:
1312041
Description:
Predicted to localize to integral component of membrane. Orthologous to human SHISA4 (shisa family member 4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC360848; Prmp; proline rich membrane protein; protein shisa-4; RGD1312041; shisa homolog 4; shisa homolog 4 (Xenopus laevis); similar to scotin; Tmem58; transmembrane protein 58
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SHISA4 (shisa family member 4)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Shisa4 (shisa family member 4)
HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Shisa4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SHISA4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SHISA4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Shisa4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SHISA4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SHISA4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Shisa4 (shisa family member 4)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SHISA4 (shisa family member 4)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Shisa4 (shisa family member 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
shisa4 (shisa family member 4)
Alliance
DIOPT (PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 13 46,800,487 - 46,803,703 (-) NCBI Rnor_6.0 Ensembl 13 52,193,989 - 52,197,205 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 13 52,193,989 - 52,197,205 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 13 57,244,749 - 57,248,270 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 48,368,910 - 48,372,126 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 48,382,485 - 48,386,271 (-) NCBI Celera 13 47,120,498 - 47,123,714 (-) NCBI Celera Cytogenetic Map 13 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dimethylhydrazine increases expression ISO RGD:1617455 6480464 1, 2-Dimethylhydrazine results in increased expression of SHISA4 mRNA CTD PMID:22206623 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of SHISA4 mRNA CTD PMID:20068009 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SHISA4 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1323817 6480464 Tetrachlorodibenzodioxin results in increased expression of SHISA4 mRNA CTD PMID:27913140 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1323817 6480464 Tetrachlorodibenzodioxin affects the expression of SHISA4 mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1617455 6480464 Tetrachlorodibenzodioxin affects the expression of SHISA4 mRNA CTD PMID:21570461 2-hydroxypropanoic acid decreases expression ISO RGD:1323817 6480464 Lactic Acid results in decreased expression of SHISA4 mRNA CTD PMID:30851411 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of SHISA4 mRNA CTD PMID:28959563 aflatoxin B1 increases methylation ISO RGD:1323817 6480464 Aflatoxin B1 results in increased methylation of SHISA4 intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:1323817 6480464 aflatoxin B2 results in increased methylation of SHISA4 intron CTD PMID:30157460 atrazine increases expression ISO RGD:1323817 6480464 Atrazine results in increased expression of SHISA4 mRNA CTD PMID:22378314 benzo[a]pyrene affects methylation ISO RGD:1323817 6480464 Benzoapyrene affects the methylation of SHISA4 promoter CTD PMID:27901495 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1617455 6480464 Diethylhexyl Phthalate results in decreased expression of SHISA4 mRNA CTD PMID:28085963 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SHISA4 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases methylation ISO RGD:1617455 6480464 bisphenol A results in increased methylation of SHISA4 promoter CTD PMID:27312807 calcitriol increases expression ISO RGD:1323817 6480464 Calcitriol results in increased expression of SHISA4 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1323817 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of SHISA4 mRNA CTD PMID:21592394 carbon nanotube increases expression ISO RGD:1617455 6480464 Nanotubes more ... CTD PMID:25554681 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of SHISA4 mRNA, Copper results in increased expression of SHISA4 mRNA CTD PMID:26033743 , PMID:30556269 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of SHISA4 mRNA, Copper results in increased expression of SHISA4 mRNA CTD PMID:26033743 , PMID:30556269 decabromodiphenyl ether affects expression ISO RGD:1323817 6480464 decabromobiphenyl ether affects the expression of SHISA4 mRNA CTD PMID:24834073 dioxygen multiple interactions ISO RGD:1617455 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SHISA4 mRNA CTD PMID:30529165 doxorubicin decreases expression ISO RGD:1323817 6480464 Doxorubicin results in decreased expression of SHISA4 mRNA CTD PMID:29803840 lead(0) affects expression ISO RGD:1323817 6480464 Lead affects the expression of SHISA4 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1323817 6480464 Lead affects the expression of SHISA4 mRNA CTD PMID:28903495 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of SHISA4 mRNA CTD PMID:23665939 pirinixic acid multiple interactions ISO RGD:1323817 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SHISA4 mRNA CTD PMID:19710929 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of SHISA4 mRNA CTD PMID:27225895 pravastatin increases expression ISO RGD:1617455 6480464 Pravastatin results in increased expression of SHISA4 mRNA CTD PMID:27225895 rac-lactic acid decreases expression ISO RGD:1323817 6480464 Lactic Acid results in decreased expression of SHISA4 mRNA CTD PMID:30851411 sunitinib decreases expression ISO RGD:1323817 6480464 Sunitinib results in decreased expression of SHISA4 mRNA CTD PMID:31533062 testosterone multiple interactions ISO RGD:1323817 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of SHISA4 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:1323817 6480464 Testosterone results in increased expression of SHISA4 mRNA CTD PMID:21592394 titanium dioxide decreases expression ISO RGD:1617455 6480464 titanium dioxide results in decreased expression of SHISA4 mRNA CTD PMID:29264374 trichloroethene affects expression ISO RGD:1617455 6480464 Trichloroethylene affects the expression of SHISA4 mRNA CTD PMID:21135412 vancomycin decreases expression ISO RGD:1617455 6480464 Vancomycin results in decreased expression of SHISA4 mRNA CTD PMID:18930951 zaragozic acid A increases expression ISO RGD:1617455 6480464 squalestatin 1 results in increased expression of SHISA4 mRNA CTD PMID:27225895 zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of SHISA4 mRNA CTD PMID:27225895
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 1 107975663 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 1 107975663 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 1 107975663 Rat 1581554 Pur11 Proteinuria QTL 11 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 9016906 82995569 Rat 1581573 Uae36 Urinary albumin excretion QTL 36 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 9016906 82995569 Rat 1581570 Eae17 Experimental allergic encephalomyelitis QTL 17 4.1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 12193394 108478121 Rat 9589141 Insul28 Insulin level QTL 28 10.82 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 13 14096330 59096330 Rat 7411662 Foco29 Food consumption QTL 29 20.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 13 14096330 59096330 Rat 2317040 Aia21 Adjuvant induced arthritis QTL 21 2.75 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 13 14624631 59624631 Rat 2317046 Aia8 Adjuvant induced arthritis QTL 8 3.9700000286102295 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 13 14624631 59624631 Rat 631645 Bp121 Blood pressure QTL 121 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 19810814 64810814 Rat 9589164 Gluco66 Glucose level QTL 66 6.67 0.001 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 13 20052477 65052477 Rat 1331784 Bp222 Blood pressure QTL 222 2.944 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 21482481 58537177 Rat 7207885 Glom27 Glomerulus QTL 27 3.9 kidney glomerulus integrity trait (VT:0010546) kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139) 13 24502279 108770533 Rat 61391 Bp5 Blood pressure QTL 5 5.6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 28008338 73008338 Rat 70170 Eae14 Experimental allergic encephalomyelitis QTL 14 0.0024 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 28584452 73584452 Rat 1558644 Cm45 Cardiac mass QTL 45 3.6 0.002 heart mass (VT:0007028) heart wet weight (CMO:0000069) 13 29076934 74076934 Rat 6893338 Cm76 Cardiac mass QTL 76 0 0.99 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 13 29076934 74076934 Rat 1354621 Rf47 Renal function QTL 47 3.7 kidney renin amount (VT:0010559) kidney renin level (CMO:0002166) 13 35301263 107975663 Rat 2301962 Cm72 Cardiac mass QTL 72 4.12 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) 13 36147533 64868393 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 36147533 99968921 Rat 2303563 Bw89 Body weight QTL 89 6 body mass (VT:0001259) body weight (CMO:0000012) 13 37346348 82346348 Rat 61340 Bp25 Blood pressure QTL 25 4.2 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39372927 84372927 Rat 10755495 Bp387 Blood pressure QTL 387 3.78 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39501300 93652524 Rat 4889861 Pur29 Proteinuria QTL 29 13.8 0.005 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 13 42310744 86833540 Rat 1331750 Bp220 Blood pressure QTL 220 2.98 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 42310744 87310744 Rat 70220 Bp55 Blood pressure QTL 55 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 42508345 87508345 Rat 61349 Bp31 Blood pressure QTL 31 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 42508345 87508345 Rat 1549897 Stresp12 Stress response QTL 12 3.35 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 13 43575717 88575717 Rat 619615 Bp80 Blood pressure QTL 80 0.0354 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 45676629 90676629 Rat 4145117 Mcs27 Mammary carcinoma susceptibility QTL 27 0.0001 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 13 48776655 53264877 Rat 6893344 Cm79 Cardiac mass QTL 79 1.5 0.04 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 13 49058507 67207219 Rat 12879472 Bp399 Blood pressure QTL 399 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 50609228 53264877 Rat 12879441 Bp396 Blood pressure QTL 396 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 51080989 96080989 Rat 1298066 Bp159 Blood pressure QTL 159 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 51569248 96569248 Rat 71119 Thym2 Thymus enlargement QTL 2 3.8 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) 13 51577824 90675199 Rat