Mcm6 (minichromosome maintenance complex component 6) - Rat Genome Database

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Gene: Mcm6 (minichromosome maintenance complex component 6) Rattus norvegicus
Analyze
Symbol: Mcm6
Name: minichromosome maintenance complex component 6
RGD ID: 61967
Description: Predicted to enable identical protein binding activity. Predicted to contribute to DNA helicase activity and single-stranded DNA binding activity. Predicted to be involved in DNA duplex unwinding; DNA replication initiation; and regulation of DNA-templated DNA replication initiation. Predicted to act upstream of or within DNA unwinding involved in DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and MCM complex. Orthologous to human MCM6 (minichromosome maintenance complex component 6); PARTICIPATES IN cell cycle pathway, mitotic; DNA replication pathway; INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA replication licensing factor MCM6; intestinal DNA replication protein; Mcmd6; mini chromosome maintenance deficient 6; mini chromosome maintenance deficient 6 (S. cerevisiae); minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21339,826,745 - 39,851,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,826,763 - 39,851,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,420,624 - 42,445,691 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01343,708,729 - 43,733,794 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01340,962,569 - 40,987,646 (-)NCBIRnor_WKY
Rnor_6.01345,042,882 - 45,068,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,042,882 - 45,068,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,127,492 - 50,152,683 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,045,677 - 41,070,868 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,059,886 - 41,073,893 (-)NCBI
Celera1340,200,796 - 40,225,972 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (ISO)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etoposide  (ISO)
folic acid  (ISO)
furan  (EXP,ISO)
genistein  (EXP,ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (EXP)
Nonylphenol  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
CMG complex  (IEA,ISO,ISS)
MCM complex  (IBA,IEA,ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Rat intestinal crypt-cell replication factor with homology to early S-phase proteins required for cell division. Sykes DE and Weiser MM, Gene 1995 Oct 3;163(2):243-7.
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:9305914   PMID:10611160   PMID:11555636   PMID:12477932   PMID:12915462   PMID:12947022   PMID:15232106   PMID:15917436   PMID:16189514   PMID:16899510   PMID:17296731  
PMID:18064521   PMID:19135898   PMID:31505169  


Genomics

Comparative Map Data
Mcm6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21339,826,745 - 39,851,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1339,826,763 - 39,851,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,420,624 - 42,445,691 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01343,708,729 - 43,733,794 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01340,962,569 - 40,987,646 (-)NCBIRnor_WKY
Rnor_6.01345,042,882 - 45,068,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,042,882 - 45,068,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,127,492 - 50,152,683 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,045,677 - 41,070,868 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,059,886 - 41,073,893 (-)NCBI
Celera1340,200,796 - 40,225,972 (-)NCBICelera
Cytogenetic Map13q13NCBI
MCM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382135,839,626 - 135,876,443 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2135,839,626 - 135,876,443 (-)EnsemblGRCh38hg38GRCh38
GRCh372136,597,196 - 136,634,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,313,666 - 136,350,481 (-)NCBINCBI36Build 36hg18NCBI36
Build 342136,430,929 - 136,467,743NCBI
Celera2130,307,953 - 130,344,734 (-)NCBICelera
Cytogenetic Map2q21.3NCBI
HuRef2128,590,433 - 128,627,241 (-)NCBIHuRef
CHM1_12136,602,596 - 136,639,440 (-)NCBICHM1_1
T2T-CHM13v2.02136,284,082 - 136,320,862 (-)NCBIT2T-CHM13v2.0
Mcm6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,259,312 - 128,287,442 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,259,327 - 128,287,401 (-)EnsemblGRCm39 Ensembl
GRCm381128,331,575 - 128,359,705 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,331,590 - 128,359,664 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,228,168 - 130,256,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,159,137 - 130,187,202 (-)NCBIMGSCv36mm8
Celera1130,958,472 - 130,988,007 (-)NCBICelera
Cytogenetic Map1E3NCBI
cM Map155.8NCBI
Mcm6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554403,200,803 - 3,234,437 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554403,200,803 - 3,234,437 (-)NCBIChiLan1.0ChiLan1.0
MCM6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B139,911,909 - 139,947,687 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B139,911,909 - 139,947,687 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B23,986,278 - 24,023,045 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MCM6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11938,627,154 - 38,660,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1938,627,183 - 38,660,280 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1938,870,097 - 38,903,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01940,072,481 - 40,105,667 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1940,072,480 - 40,105,669 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11938,714,459 - 38,747,626 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01938,874,063 - 38,907,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01940,106,781 - 40,139,971 (-)NCBIUU_Cfam_GSD_1.0
Mcm6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303101,558,149 - 101,602,839 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646940,014,863 - 40,059,580 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493646940,014,892 - 40,059,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1515,923,681 - 15,985,405 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11515,923,638 - 15,978,587 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MCM6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11020,053,726 - 20,089,571 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1020,051,138 - 20,089,545 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660612,374,233 - 2,412,670 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473235,179,488 - 35,217,391 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473235,179,488 - 35,217,437 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcm6
110 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:45
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000004969
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 38 27 19 27 1 1 59 22 39 9 1
Low 15 19 14 14 7 10 15 13 2 2 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004969   ⟹   ENSRNOP00000004969
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,826,763 - 39,851,960 (-)Ensembl
Rnor_6.0 Ensembl1345,042,882 - 45,068,077 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115806   ⟹   ENSRNOP00000088984
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1339,827,329 - 39,851,960 (-)Ensembl
RefSeq Acc Id: NM_017287   ⟹   NP_058983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21339,826,745 - 39,851,937 (-)NCBI
Rnor_6.01345,042,882 - 45,068,073 (-)NCBI
Rnor_5.01350,127,492 - 50,152,683 (-)NCBI
RGSC_v3.41341,045,677 - 41,070,868 (-)RGD
Celera1340,200,796 - 40,225,972 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058983   ⟸   NM_017287
- UniProtKB: A9CMB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004969   ⟸   ENSRNOT00000004969
RefSeq Acc Id: ENSRNOP00000088984   ⟸   ENSRNOT00000115806
Protein Domains
MCM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62724-F1-model_v2 AlphaFold Q62724 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698780
Promoter ID:EPDNEW_R9305
Type:initiation region
Name:Mcm6_1
Description:minichromosome maintenance complex component 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01345,068,051 - 45,068,111EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61967 AgrOrtholog
BioCyc Gene G2FUF-18409 BioCyc
Ensembl Genes ENSRNOG00000003703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004969 ENTREZGENE
  ENSRNOP00000004969.4 UniProtKB/TrEMBL
  ENSRNOP00000088984.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004969 ENTREZGENE
  ENSRNOT00000004969.7 UniProtKB/TrEMBL
  ENSRNOT00000115806.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8369193 IMAGE-MGC_LOAD
InterPro MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM6 UniProtKB/TrEMBL
  Mcm6_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29685 UniProtKB/TrEMBL
MGC_CLONE MGC:188701 IMAGE-MGC_LOAD
NCBI Gene 29685 ENTREZGENE
PANTHER PTHR11630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM6_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
PhenoGen Mcm6 PhenoGen
PRINTS MCMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCMPROTEIN6 UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MCM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Nucleic_acid_OB UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218880
UniProt A0A8I6A784_RAT UniProtKB/TrEMBL
  A9CMB8 ENTREZGENE, UniProtKB/TrEMBL
  A9CMC9_RAT UniProtKB/TrEMBL
  MCM6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Mcm6  minichromosome maintenance complex component 6  Mcm6  minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mcm6  minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)  Mcmd6  mini chromosome maintenance deficient 6 (S. cerevisiae)   Symbol and Name updated 1299863 APPROVED
2002-06-10 Mcmd6  mini chromosome maintenance deficient 6 (S. cerevisiae)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in intestinal crypt cells 61660