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Gene: Gpr75 (G protein-coupled receptor 75) Rattus norvegicus

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Symbol:

Gpr75

Name:

G protein-coupled receptor 75

RGD ID:

1566385

Description:

Predicted to enable C-C chemokine receptor activity. Predicted to be involved in chemokine-mediated signaling pathway. Predicted to be active in plasma membrane. Orthologous to human GPR75 (G protein-coupled receptor 75); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G protein-coupled receptor GPR75; LOC498434; probable G-protein coupled receptor 75; RGD1566385; similar to G protein-coupled receptor GPR75

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR75 (G protein-coupled receptor 75)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr75 (G protein-coupled receptor 75)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GPR75 (G protein-coupled receptor 75)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr75 (G protein-coupled receptor 75)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpr75 (G protein-coupled receptor 75)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr75	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	108,810,462 - 108,821,926 (+)	NCBI		GRCr8
mRatBN7.2	14	104,609,542 - 104,618,885 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	104,611,089 - 104,620,370 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	108,928,518 - 108,931,127 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	110,161,479 - 110,164,088 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	106,633,916 - 106,636,525 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	115,270,452 - 115,278,510 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	115,275,894 - 115,278,503 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	112,004,037 - 112,006,646 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	103,454,448 - 103,457,057 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gpr75	Rat	1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene	multiple interactions	ISO	Gpr75 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
Gpr75	Rat	17beta-estradiol	increases expression	ISO	GPR75 (Homo sapiens)	6480464	Estradiol results in increased expression of GPR75 mRNA	CTD	PMID:23019147 and PMID:31614463
Gpr75	Rat	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	Gpr75 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
Gpr75	Rat	2,2',5,5'-tetrachlorobiphenyl	multiple interactions	ISO	Gpr75 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
Gpr75	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of GPR75 mRNA	CTD	PMID:33387578
Gpr75	Rat	2,4,4'-trichlorobiphenyl	multiple interactions	ISO	Gpr75 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
Gpr75	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	Gpr75 (Mus musculus)	6480464	bisphenol S results in increased expression of GPR75 mRNA	CTD	PMID:33297965
Gpr75	Rat	aristolochic acid A	increases expression	ISO	GPR75 (Homo sapiens)	6480464	aristolochic acid I results in increased expression of GPR75 mRNA	CTD	PMID:33212167
Gpr75	Rat	benzo[a]pyrene	increases expression	ISO	GPR75 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased expression of GPR75 mRNA	CTD	PMID:32234424
Gpr75	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of GPR75 mRNA	CTD	PMID:25181051
Gpr75	Rat	bisphenol A	decreases expression	ISO	Gpr75 (Mus musculus)	6480464	bisphenol A results in decreased expression of GPR75 mRNA	CTD	PMID:32156529
Gpr75	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of GPR75 mRNA	CTD	PMID:30816183 and PMID:32528016
Gpr75	Rat	CGP 52608	multiple interactions	ISO	GPR75 (Homo sapiens)	6480464	CGP 52608 promotes the reaction [RORA protein binds to GPR75 gene]	CTD	PMID:28238834
Gpr75	Rat	cisplatin	multiple interactions	ISO	GPR75 (Homo sapiens)	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of GPR75 mRNA	CTD	PMID:27392435
Gpr75	Rat	crocidolite asbestos	increases expression	ISO	Gpr75 (Mus musculus)	6480464	Asbestos and Crocidolite results in increased expression of GPR75 mRNA	CTD	PMID:29279043
Gpr75	Rat	Dibutyl phosphate	affects expression	ISO	GPR75 (Homo sapiens)	6480464	di-n-butylphosphoric acid affects the expression of GPR75 mRNA	CTD	PMID:37042841
Gpr75	Rat	dicrotophos	increases expression	ISO	GPR75 (Homo sapiens)	6480464	dicrotophos results in increased expression of GPR75 mRNA	CTD	PMID:28302478
Gpr75	Rat	dimethyl sulfoxide	affects expression	ISO	GPR75 (Homo sapiens)	6480464	Dimethyl Sulfoxide affects the expression of GPR75 mRNA	CTD	PMID:24834073
Gpr75	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of GPR75 mRNA	CTD	PMID:33387578
Gpr75	Rat	niclosamide	decreases expression	ISO	GPR75 (Homo sapiens)	6480464	Niclosamide results in decreased expression of GPR75 mRNA	CTD	PMID:36318118
Gpr75	Rat	nitrogen dioxide	multiple interactions	ISO	GPR75 (Homo sapiens)	6480464	[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Nitrogen Dioxide] which affects the methylation of GPR75 gene	CTD	PMID:38573328
Gpr75	Rat	okadaic acid	increases expression	ISO	GPR75 (Homo sapiens)	6480464	Okadaic Acid results in increased expression of GPR75 mRNA	CTD	PMID:38832940
Gpr75	Rat	ozone	multiple interactions	ISO	Gpr75 (Mus musculus)	6480464	[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of GPR75 mRNA	CTD	PMID:27106289
Gpr75	Rat	PCB138	multiple interactions	ISO	Gpr75 (Mus musculus)	6480464	[2 more ...	CTD	PMID:25510870
Gpr75	Rat	potassium chloride	multiple interactions	ISO	GPR75 (Homo sapiens)	6480464	[Dronabinol results in decreased susceptibility to Potassium Chloride] which results in increased expression of GPR75 mRNA	CTD	PMID:29691375
Gpr75	Rat	titanium dioxide	increases expression	ISO	Gpr75 (Mus musculus)	6480464	titanium dioxide results in increased expression of GPR75 mRNA	CTD	PMID:29264374
Gpr75	Rat	triclosan	decreases expression	ISO	GPR75 (Homo sapiens)	6480464	Triclosan results in decreased expression of GPR75 mRNA	CTD	PMID:30510588
Gpr75	Rat	urethane	increases expression	ISO	GPR75 (Homo sapiens)	6480464	Urethane results in increased expression of GPR75 mRNA	CTD	PMID:28818685

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gpr75	Rat	chemokine-mediated signaling pathway	involved_in	ISO	Gpr75 (Mus musculus)	1624291	PMID:17001303	RGD	PMID:17001303
Gpr75	Rat	chemokine-mediated signaling pathway	involved_in	IEA	UniProtKB:Q6X632 and ensembl:ENSMUSP00000105057	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gpr75	Rat	G protein-coupled receptor signaling pathway	involved_in	ISO	Gpr75 (Mus musculus)	1624291	PMID:17001303 and PMID:23979485	RGD	PMID:17001303 and PMID:23979485
Gpr75	Rat	G protein-coupled receptor signaling pathway	involved_in	IEA	UniProtKB:Q6X632 and ensembl:ENSMUSP00000105057	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gpr75	Rat	G protein-coupled receptor signaling pathway	involved_in	IEA	UniProtKB-KW:KW-0297	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gpr75	Rat	G protein-coupled receptor signaling pathway	involved_in	IEA	InterPro:IPR000276	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gpr75	Rat	G protein-coupled receptor signaling pathway	involved_in	IBA	FB:FBgn0025631 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gpr75	Rat	signal transduction	involved_in	IEA	UniProtKB-KW:KW-0807	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gpr75	Rat	membrane	located_in	IEA	InterPro:IPR000276 and InterPro:IPR017452	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gpr75	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gpr75	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Gpr75	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gpr75	Rat	plasma membrane	is_active_in	IBA	MGI:87964 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gpr75	Rat	C-C chemokine receptor activity	enables	ISO	Gpr75 (Mus musculus)	1624291	PMID:17001303	RGD	PMID:17001303
Gpr75	Rat	C-C chemokine receptor activity	enables	IEA	UniProtKB:Q6X632 and ensembl:ENSMUSP00000105057	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gpr75	Rat	C-C chemokine receptor activity	enables	IBA	MGI:2441843 and PANTHER:PTN002796002	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gpr75	Rat	G protein-coupled receptor activity	enables	ISO	Gpr75 (Mus musculus)	1624291	PMID:17001303	RGD	PMID:17001303
Gpr75	Rat	G protein-coupled receptor activity	enables	IEA	UniProtKB:Q6X632 and ensembl:ENSMUSP00000105057	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gpr75	Rat	G protein-coupled receptor activity	enables	IEA	InterPro:IPR000276	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gpr75	Rat	G protein-coupled receptor activity	enables	IEA	UniProtKB-KW:KW-0297	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:17001303	PMID:23979485

Gpr75
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	108,810,462 - 108,821,926 (+)	NCBI		GRCr8
mRatBN7.2	14	104,609,542 - 104,618,885 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	104,611,089 - 104,620,370 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	108,928,518 - 108,931,127 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	110,161,479 - 110,164,088 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	106,633,916 - 106,636,525 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	115,270,452 - 115,278,510 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	115,275,894 - 115,278,503 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	112,004,037 - 112,006,646 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	103,454,448 - 103,457,057 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

GPR75
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	53,852,912 - 53,859,967 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	53,852,912 - 53,859,967 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	54,080,049 - 54,087,104 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	53,933,554 - 53,940,572 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	53,991,700 - 53,998,719	NCBI
Celera	2	53,920,904 - 53,927,988 (-)	NCBI		Celera
Cytogenetic Map	2	p16.2	NCBI
HuRef	2	53,814,122 - 53,821,237 (-)	NCBI		HuRef
CHM1_1	2	54,010,915 - 54,018,039 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	53,849,132 - 53,856,193 (-)	NCBI		T2T-CHM13v2.0

Gpr75
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	30,834,636 - 30,846,090 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	30,835,358 - 30,843,729 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	30,884,633 - 30,896,090 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	30,885,358 - 30,893,729 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	30,791,097 - 30,792,719 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	30,791,097 - 30,792,719 (+)	NCBI		MGSCv36	mm8
Celera	11	33,296,506 - 33,298,128 (+)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI
cM Map	11	18.16	NCBI

Gpr75
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	19,576,967 - 19,578,571 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	19,576,490 - 19,579,447 (-)	NCBI	ChiLan1.0	ChiLan1.0

GPR75
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	72,498,538 - 72,509,305 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	72,502,488 - 72,513,270 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	53,996,008 - 54,003,134 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	54,908,210 - 54,915,172 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	54,908,736 - 54,910,358 (-)	Ensembl	panpan1.1		panPan2

GPR75
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	54,858,380 - 54,862,734 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	54,813,033 - 54,815,018 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	55,860,403 - 55,862,384 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	55,860,403 - 55,861,929 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	55,553,039 - 55,554,936 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	55,839,677 - 55,841,765 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	56,126,156 - 56,128,140 (-)	NCBI		UU_Cfam_GSD_1.0

Gpr75
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	28,171,339 - 28,180,452 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	391,144 - 400,001 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	391,022 - 400,394 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR75
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	87,341,345 - 87,350,637 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	87,341,562 - 87,350,664 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	92,492,876 - 92,499,138 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR75
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	53,112,773 - 53,119,964 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	53,117,915 - 53,119,537 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	58,583,166 - 58,590,309 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr75
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624833	8,026,168 - 8,033,382 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624833	8,023,796 - 8,033,355 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Gpr75
46 total Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain	Variant Page
14	114934333	114934334	A	T	snv	DOB/Oda (KyushuU)	View more Information

Predicted Target Of

	Summary Value
Count of predictions:	322
Count of miRNA genes:	205
Interacting mature miRNAs:	240
Transcripts:	ENSRNOT00000033437
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat

RH144409

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	104,618,470 - 104,618,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	115,278,096 - 115,278,300	NCBI	Rnor6.0
Rnor_5.0	14	114,935,599 - 114,935,803	UniSTS	Rnor5.0
RGSC_v3.4	14	112,006,239 - 112,006,443	UniSTS	RGSC3.4
Celera	14	103,456,650 - 103,456,854	UniSTS
Cytogenetic Map	14	q22	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	48	113	56	55	26	23	26	6	181	93	93	45	59	29


RefSeq Transcripts	NM_001109096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033437 ⟹ ENSRNOP00000029471

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	104,611,089 - 104,620,370 (+)	Ensembl
Rnor_6.0 Ensembl	14	115,275,894 - 115,278,503 (+)	Ensembl

RefSeq Acc Id:

NM_001109096 ⟹ NP_001102566

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	108,817,185 - 108,819,794 (+)	NCBI
mRatBN7.2	14	104,616,269 - 104,618,878 (+)	NCBI
Rnor_6.0	14	115,275,894 - 115,278,503 (+)	NCBI
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI
RGSC_v3.4	14	112,004,037 - 112,006,646 (+)	RGD
Celera	14	103,454,448 - 103,457,057 (+)	RGD

Sequence:

show sequence

ATGAATTCAAGTGCCCCGCTTCAGAATGTTCCCAATGCCACCTTGCTATACACACCTCCCCTGCAGGGAGGAAATAACACTTCTCTCCAGGAGGGTCTTCGAGATTTTATCCACACAGCCACCTTGGT
GACCTGCACGGTCCTGCTTGCCATCATCTTCTGTCTAGGCTCTTATGGAAATTTTATTGTCTTCTTGTCTTTCTTTGACCCGGCCTTCAGAAAGTTCAGAACTAACTTTGATTTCATGATCTTGAACC
TGTCTTTCTGTGATCTGTTCATCTGTGGGGCCACAGCCCCCATGTTCACCTTTGTGCTGTTCTTCAGCTCAGCCAGGAGCATCCCAGACAGTTTCTGCTTCACCTTCCACCTTACCAGCTCAGGTTTC
ATCATCATGTCCCTCAAGATGGTAGCTGTGATTGCCCTGCACCGGCTCCGGATGGTGATGGGGAAGCAGCCTAATTGCACCGCTTCCTTTTCCTGCATCTTGCTCCTTACCCTTCTTCTCTGGGCCAC
CAGCTTTACACTTGCCACCTTGGCTACACTGAGAACCAGTAAGTCCCACCTGTGTCTCCCCATGTCCAGTCTTATGGACGGGGAAGGGAAGGCCATTCTGTCTCTGTATGTTGTTGACTTTACCTTCT
GTGTGGCCGTGGTGTCTGTCTCTTATATCATGATTGCTCAAACCCTTCGGAAGAATGCCCAAGTAAAAAAGTGCCCCCCTGTGATCACAGTTGATGCTTCCAGACCACAGCCATTCATGGGGGCCTCT
GTGAAGGGAAATGGAGATCCCATCCAGTGCACCATGCCAGCTCTGTATAGGAACCAGAATTATAACAAACTGCAGCACAATCAAACTCATGGATACACTAAGAATGCCAACCAGATGCCAATCCCCTC
AGCCAGTCGGCTCCAGCTGGTATCAGCGGTCAACCTCTCTACTGCCAAGGATTCCAAAGCTGTGGTCACCTGCATGGTCATCGTGTTGTCGGTTCTAGTGTGCTGTCTTCCTCTGGGGATTTCCCTGC
TGCAAGTGGTTCTGTCTGACAGTGGCAGCTTCATCCTTTACCAGTTTGAGTTATTTGGATTTACTCTGATATTTTTCAAGTCAGGATTAAATCCTTTTATATATTCTCGGAACAGTGCTGGGCTGAGA
AGGAAAGTGCTCTGGTGCCTGCGATACACTGGCCTGGGCTTCCTCTGCTGCAAACAGAAAACTCGACTTCGGGCCATGGGGAAAGGGAACCTTGAAATCAATAGAAACAAATCCTCCCATCATGAGAC
AAACTCTGCCTACATGCTGTCTCCAAAACCACAGAAGAAATTTGTAGACCAGGCTTGTGGCCCAAGTCATTCAAAAGAAAGTGTAGCAAGTCCCAAAGTCTCTGCTGGACATCACCCCTGTGGGCAGA
GCAGCTCGACACCCATCAACACTCGGATTGAACCTTACTATAGCATCTATAACAGCAGCCCGTCCCAGCAGGAGAGCAGCCCAGCAAACCTGCAGCCAGTGAACTCTTTTGGTTTCGCCAGTTCCTAC
ATCGCCATGCACTATTACACCACCAATGACTTGATGCAGGACTATGACAGCACGTCGGCAAAACAGATCCCTATCCCTTCTGTTTAATACAGCCAGAGAATCTGGAGGGAATGGTTTTCTCTCTGGAC
TGAACAAACCTTTAAAAGAGCTTGAGTTCCATGGCAAAACAAAACCTGGAATCAACTGAAGACTTGACTTTCTTTCACCTGAAGTATTAGTATCCGGGTTGGCTTCATGGTTTCTTGACATTTTAAGA
TTTAGTGTAAAAGTTTAGTTCAATTTATACTCTGACCCATGTCCCAATACTTTATACTAAACTGCTAAAAAGATGTCAGGGACTATTCTATTAATGACACCCTTTTAAGTCAGTATTATGGGATTTTA
GATATGTATTGACTACATTTTCTTTCTTTCCACTAATTTATTTATTTATTCACTTTACATCCCGATTGAAGCCCCACCTCTCCTCCCAGTACTCCCTCTCATGGTCCCTCTCCCAATTTCTCCTCCCC
TTTATTTCTGAGGAGGAGGAGGTCCCTCCTGGGGAAACAACCTTCCTCAAGTCACTGAAGGACTAGGTACATCCTCTGCCACTGAGGCCAGACGTGCTAGCCCAATTAGGAGCAGGATTCACAGACAG
GAAACAGTCAGGGACAGTCAGCACTCTACTCATTGGGGGACCCATATAAAGACCAAGCTGCACCTCTGTTACAAATGTGCTGGTGGGCCTAGGACCAGCCTCTTTGGCTAGTGGTTCAGTACCTGGGA
GCCTTCAAGGATCCAGGTTAGTTGGTATTCTGAAGGAGTACCTGTTCCCTCCAGGTTCCTCTATCCTTTCTCCAACCCTTCCACAAGACTTCCCAAGCTCCAGTCTAATGTTTGGCTGTGGGACTGCA
TTTGTTTCTGTCAACTGCTGTAATTTGGCTACATTTTTAAAATGGTGTTTGAAAAAAATTATCTTTCTGAAGTGTTATTTTTATAAAAATATGGAATTAGTGTCTTTGAAGTACTGAAACAGCAAACA
GTGTACTTTTTTGGTGGCAAGTGGTTTAAATAAAAAACTTACTGTTAAAA

hide sequence

RefSeq Acc Id:

XM_006251616 ⟹ XP_006251678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	108,810,462 - 108,821,926 (+)	NCBI
mRatBN7.2	14	104,609,542 - 104,618,885 (+)	NCBI
Rnor_6.0	14	115,270,452 - 115,278,510 (+)	NCBI
Rnor_5.0	14	114,928,115 - 114,936,013 (+)	NCBI

Sequence:

show sequence

TATCAGCGGCCAGTTCTCCGGCAGCCCTGGCAGGTCTGAGTGCACACCCACCAGGCTGAGGCCC
GCAGGCAGGGAGGGTGACGACAGGCGGGGCGGCCACGGTCAGAGGGAGGGGCTGCGCCCCGGGTTCTGTGACTGCGCCGCCGGCCCGGCTCGCCTAGGCTCCCGGGATGCGTGGAGGCGGCGGCGATG
ACGGTGATGACTCTAGCCCGGCAGCATCCAGGCCACCGGGCGCAGATAGGGTCGAGCATCCAGGCCACCGGGCGCAGATAGGGTCGCTGCTGCGACATGGAGGAGGAAGGGCGGCGCTGCGGCCAGCT
GGCAGGCTTATCTTCCTCCGCCATACATGCCCATCGTCTGTGAGCTGAGATCCTGACTCTCTTCCTGCTGATGTTTTTAAAACACAAGAGACACTTCTCTGAAGATGAATTCAAGTGCCCCGCTTCAG
AATGTTCCCAATGCCACCTTGCTATACACACCTCCCCTGCAGGGAGGAAATAACACTTCTCTCCAGGAGGGTCTTCGAGATTTTATCCACACAGCCACCTTGGTGACCTGCACGGTCCTGCTTGCCAT
CATCTTCTGTCTAGGCTCTTATGGAAATTTTATTGTCTTCTTGTCTTTCTTTGACCCGGCCTTCAGAAAGTTCAGAACTAACTTTGATTTCATGATCTTGAACCTGTCTTTCTGTGATCTGTTCATCT
GTGGGGCCACAGCCCCCATGTTCACCTTTGTGCTGTTCTTCAGCTCAGCCAGGAGCATCCCAGACAGTTTCTGCTTCACCTTCCACCTTACCAGCTCAGGTTTCATCATCATGTCCCTCAAGATGGTA
GCTGTGATTGCCCTGCACCGGCTCCGGATGGTGATGGGGAAGCAGCCTAATTGCACCGCTTCCTTTTCCTGCATCTTGCTCCTTACCCTTCTTCTCTGGGCCACCAGCTTTACACTTGCCACCTTGGC
TACACTGAGAACCAGTAAGTCCCACCTGTGTCTCCCCATGTCCAGTCTTATGGACGGGGAAGGGAAGGCCATTCTGTCTCTGTATGTTGTTGACTTTACCTTCTGTGTGGCCGTGGTGTCTGTCTCTT
ATATCATGATTGCTCAAACCCTTCGGAAGAATGCCCAAGTAAAAAAGTGCCCCCCTGTGATCACAGTTGATGCTTCCAGACCACAGCCATTCATGGGGGCCTCTGTGAAGGGAAATGGAGATCCCATC
CAGTGCACCATGCCAGCTCTGTATAGGAACCAGAATTATAACAAACTGCAGCACAATCAAACTCATGGATACACTAAGAATGCCAACCAGATGCCAATCCCCTCAGCCAGTCGGCTCCAGCTGGTATC
AGCGGTCAACCTCTCTACTGCCAAGGATTCCAAAGCTGTGGTCACCTGCATGGTCATCGTGTTGTCGGTTCTAGTGTGCTGTCTTCCTCTGGGGATTTCCCTGCTGCAAGTGGTTCTGTCTGACAGTG
GCAGCTTCATCCTTTACCAGTTTGAGTTATTTGGATTTACTCTGATATTTTTCAAGTCAGGATTAAATCCTTTTATATATTCTCGGAACAGTGCTGGGCTGAGAAGGAAAGTGCTCTGGTGCCTGCGA
TACACTGGCCTGGGCTTCCTCTGCTGCAAACAGAAAACTCGACTTCGGGCCATGGGGAAAGGGAACCTTGAAATCAATAGAAACAAATCCTCCCATCATGAGACAAACTCTGCCTACATGCTGTCTCC
AAAACCACAGAAGAAATTTGTAGACCAGGCTTGTGGCCCAAGTCATTCAAAAGAAAGTGTAGCAAGTCCCAAAGTCTCTGCTGGACATCACCCCTGTGGGCAGAGCAGCTCGACACCCATCAACACTC
GGATTGAACCTTACTATAGCATCTATAACAGCAGCCCGTCCCAGCAGGAGAGCAGCCCAGCAAACCTGCAGCCAGTGAACTCTTTTGGTTTCGCCAGTTCCTACATCGCCATGCACTATTACACCACC
AATGACTTGATGCAGGACTATGACAGCACGTCGGCAAAACAGATCCCTATCCCTTCTGTTTAATACAGCCAGAGAATCTGGAGGGAATGGTTTTCTCTCTGGACTGAACAAACCTTTAAAAGAGCTTG
AGTTCCATGGCAAAACAAAACCTGGAATCAACTGAAGACTTGACTTTCTTTCACCTGAAGTATTAGTATCCGGGTTGGCTTCATGGTTTCTTGACATTTTAAGATTTAGTGTAAAAGTTTAGTTCAAT
TTATACTCTGACCCATGTCCCAATACTTTATACTAAACTGCTAAAAAGATGTCAGGGACTATTCTATTAATGACACCCTTTTAAGTCAGTATTATGGGATTTTAGATATGTATTGACTACATTTTCTT
TCTTTCCACTAATTTATTTATTTATTCACTTTACATCCCGATTGAAGCCCCACCTCTCCTCCCAGTACTCCCTCTCATGGTCCCTCTCCCAATTTCTCCTCCCCTTTATTTCTGAGGAGGAGGAGGTC
CCTCCTGGGGAAACAACCTTCCTCAAGTCACTGAAGGACTAGGTACATCCTCTGCCACTGAGGCCAGACGTGCTAGCCCAATTAGGAGCAGGATTCACAGACAGGAAACAGTCAGGGACAGTCAGCAC
TCTACTCATTGGGGGACCCATATAAAGACCAAGCTGCACCTCTGTTACAAATGTGCTGGTGGGCCTAGGACCAGCCTCTTTGGCTAGTGGTTCAGTACCTGGGAGCCTTCAAGGATCCAGGTTAGTTG
GTATTCTGAAGGAGTACCTGTTCCCTCCAGGTTCCTCTATCCTTTCTCCAACCCTTCCACAAGACTTCCCAAGCTCCAGTCTAATGTTTGGCTGTGGGACTGCATTTGTTTCTGTCAACTGCTGTAAT
TTGGCTACATTTTTAAAATGGTGTTTGAAAAAAATTATCTTTCTGAAGTGTTATTTTTATAAAAATATGGAATTAGTGTCTTTGAAGTACTGAAACAGCAAACAGTGTACTTTTTTGGTGGCAAGTGG
TTTAAATAAAAAACTTACTGTTAAAACAGAAAA

hide sequence


Protein RefSeqs	NP_001102566	(Get FASTA)	NCBI Sequence Viewer
	XP_006251678	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98049	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029471
	ENSRNOP00000029471.4

RefSeq Acc Id:

NP_001102566 ⟸ NM_001109096

- UniProtKB:

D3Z826 (UniProtKB/TrEMBL), A6JQD2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNSSAPLQNVPNATLLYTPPLQGGNNTSLQEGLRDFIHTATLVTCTVLLAIIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGATAPMFTFVLFFSSARSIPDSFCFTFHLTSSGF
IIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTSKSHLCLPMSSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGAS
VKGNGDPIQCTMPALYRNQNYNKLQHNQTHGYTKNANQMPIPSASRLQLVSAVNLSTAKDSKAVVTCMVIVLSVLVCCLPLGISLLQVVLSDSGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLR
RKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQKKFVDQACGPSHSKESVASPKVSAGHHPCGQSSSTPINTRIEPYYSIYNSSPSQQESSPANLQPVNSFGFASSY
IAMHYYTTNDLMQDYDSTSAKQIPIPSV

hide sequence

RefSeq Acc Id:	XP_006251678 ⟸ XM_006251616
- Peptide Label:	isoform X1
- UniProtKB:	D3Z826 (UniProtKB/TrEMBL), A6JQD2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNSSAPLQNVPNATLLYTPPLQGGNNTSLQEGLRDFIHTATLVTCTVLLAIIFCLGSYGNFIVF LSFFDPAFRKFRTNFDFMILNLSFCDLFICGATAPMFTFVLFFSSARSIPDSFCFTFHLTSSGFIIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTSKSHLCLPM SSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYRNQNYNKLQHNQTHGYTKNANQMPIPSASRLQLVSAVNLSTAKDSKAV VTCMVIVLSVLVCCLPLGISLLQVVLSDSGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQKKFVDQACGP SHSKESVASPKVSAGHHPCGQSSSTPINTRIEPYYSIYNSSPSQQESSPANLQPVNSFGFASSYIAMHYYTTNDLMQDYDSTSAKQIPIPSV hide sequence

Ensembl Acc Id:

ENSRNOP00000029471 ⟸ ENSRNOT00000033437

Protein Domains

G-protein coupled receptors family 1 profile

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z826-F1-model_v2	AlphaFold	D3Z826	1-540	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-14627	BioCyc
Ensembl Genes	ENSRNOG00000022176	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033437	ENTREZGENE
	ENSRNOT00000033437.5	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
KEGG Report	rno:498434	UniProtKB/TrEMBL
NCBI Gene	498434	ENTREZGENE
PANTHER	B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR	UniProtKB/TrEMBL
	G-PROTEIN COUPLED RECEPTOR 75-RELATED	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Gpr75	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022176	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A6JQD2	ENTREZGENE, UniProtKB/TrEMBL
	D3Z826	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Gpr75	G protein-coupled receptor 75	RGD1566385_predicted	similar to G protein-coupled receptor GPR75 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1566385_predicted	similar to G protein-coupled receptor GPR75 (predicted)	LOC498434	similar to G protein-coupled receptor GPR75	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498434	similar to G protein-coupled receptor GPR75			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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