Gpr75 (G protein-coupled receptor 75) - Rat Genome Database

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Gene: Gpr75 (G protein-coupled receptor 75) Rattus norvegicus
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Symbol: Gpr75
Name: G protein-coupled receptor 75
RGD ID: 1566385
Description: Predicted to enable C-C chemokine receptor activity. Predicted to be involved in chemokine-mediated signaling pathway. Predicted to be active in plasma membrane. Orthologous to human GPR75 (G protein-coupled receptor 75); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor GPR75; LOC498434; probable G-protein coupled receptor 75; RGD1566385; similar to G protein-coupled receptor GPR75
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,810,462 - 108,821,926 (+)NCBIGRCr8
mRatBN7.214104,609,542 - 104,618,885 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,611,089 - 104,620,370 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14108,928,518 - 108,931,127 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,161,479 - 110,164,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,633,916 - 106,636,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014115,270,452 - 115,278,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,275,894 - 115,278,503 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014114,928,115 - 114,936,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414112,004,037 - 112,006,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera14103,454,448 - 103,457,057 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17001303   PMID:23979485  


Genomics

Comparative Map Data
Gpr75
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,810,462 - 108,821,926 (+)NCBIGRCr8
mRatBN7.214104,609,542 - 104,618,885 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,611,089 - 104,620,370 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14108,928,518 - 108,931,127 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,161,479 - 110,164,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,633,916 - 106,636,525 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014115,270,452 - 115,278,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,275,894 - 115,278,503 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014114,928,115 - 114,936,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414112,004,037 - 112,006,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera14103,454,448 - 103,457,057 (+)NCBICelera
Cytogenetic Map14q22NCBI
GPR75
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38253,852,912 - 53,859,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl253,852,912 - 53,859,967 (-)EnsemblGRCh38hg38GRCh38
GRCh37254,080,049 - 54,087,104 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36253,933,554 - 53,940,572 (-)NCBINCBI36Build 36hg18NCBI36
Build 34253,991,700 - 53,998,719NCBI
Celera253,920,904 - 53,927,988 (-)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef253,814,122 - 53,821,237 (-)NCBIHuRef
CHM1_1254,010,915 - 54,018,039 (-)NCBICHM1_1
T2T-CHM13v2.0253,849,132 - 53,856,193 (-)NCBIT2T-CHM13v2.0
Gpr75
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,834,636 - 30,846,090 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,835,358 - 30,843,729 (+)EnsemblGRCm39 Ensembl
GRCm381130,884,633 - 30,896,090 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,885,358 - 30,893,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv371130,791,097 - 30,792,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,791,097 - 30,792,719 (+)NCBIMGSCv36mm8
Celera1133,296,506 - 33,298,128 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.16NCBI
Gpr75
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544119,576,967 - 19,578,571 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544119,576,490 - 19,579,447 (-)NCBIChiLan1.0ChiLan1.0
GPR75
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21272,498,538 - 72,509,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A72,502,488 - 72,513,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A53,996,008 - 54,003,134 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A54,908,210 - 54,915,172 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A54,908,736 - 54,910,358 (-)Ensemblpanpan1.1panPan2
GPR75
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,858,380 - 54,862,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1054,813,033 - 54,815,018 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01055,860,403 - 55,862,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1055,860,403 - 55,861,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11055,553,039 - 55,554,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,839,677 - 55,841,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,126,156 - 56,128,140 (-)NCBIUU_Cfam_GSD_1.0
Gpr75
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629228,171,339 - 28,180,452 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491391,144 - 400,001 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936491391,022 - 400,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR75
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl387,341,345 - 87,350,637 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1387,341,562 - 87,350,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,492,876 - 92,499,138 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR75
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11453,112,773 - 53,119,964 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1453,117,915 - 53,119,537 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604558,583,166 - 58,590,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr75
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248338,026,168 - 8,033,382 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248338,023,796 - 8,033,355 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr75
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:205
Interacting mature miRNAs:240
Transcripts:ENSRNOT00000033437
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat

Markers in Region
RH144409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.214104,618,470 - 104,618,675 (+)MAPPERmRatBN7.2
Rnor_6.014115,278,096 - 115,278,300NCBIRnor6.0
Rnor_5.014114,935,599 - 114,935,803UniSTSRnor5.0
RGSC_v3.414112,006,239 - 112,006,443UniSTSRGSC3.4
Celera14103,456,650 - 103,456,854UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13
Low 2 17 10 2 55 16 27 11
Below cutoff 1 25 13 9 15 9 8 10 6 19 13 8

Sequence


RefSeq Acc Id: ENSRNOT00000033437   ⟹   ENSRNOP00000029471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl14104,611,089 - 104,620,370 (+)Ensembl
Rnor_6.0 Ensembl14115,275,894 - 115,278,503 (+)Ensembl
RefSeq Acc Id: NM_001109096   ⟹   NP_001102566
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,817,185 - 108,819,794 (+)NCBI
mRatBN7.214104,616,269 - 104,618,878 (+)NCBI
Rnor_6.014115,275,894 - 115,278,503 (+)NCBI
Rnor_5.014114,928,115 - 114,936,013 (+)NCBI
RGSC_v3.414112,004,037 - 112,006,646 (+)RGD
Celera14103,454,448 - 103,457,057 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251616   ⟹   XP_006251678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,810,462 - 108,821,926 (+)NCBI
mRatBN7.214104,609,542 - 104,618,885 (+)NCBI
Rnor_6.014115,270,452 - 115,278,510 (+)NCBI
Rnor_5.014114,928,115 - 114,936,013 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102566 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98049 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029471
  ENSRNOP00000029471.4
RefSeq Acc Id: NP_001102566   ⟸   NM_001109096
- UniProtKB: D3Z826 (UniProtKB/TrEMBL),   A6JQD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251678   ⟸   XM_006251616
- Peptide Label: isoform X1
- UniProtKB: D3Z826 (UniProtKB/TrEMBL),   A6JQD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029471   ⟸   ENSRNOT00000033437
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z826-F1-model_v2 AlphaFold D3Z826 1-540 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566385 AgrOrtholog
BioCyc Gene G2FUF-14627 BioCyc
Ensembl Genes ENSRNOG00000022176 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033437.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:498434 UniProtKB/TrEMBL
NCBI Gene 498434 ENTREZGENE
PANTHER B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 75-RELATED UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr75 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022176 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6JQD2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z826 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Gpr75  G protein-coupled receptor 75  RGD1566385_predicted  similar to G protein-coupled receptor GPR75 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566385_predicted  similar to G protein-coupled receptor GPR75 (predicted)  LOC498434  similar to G protein-coupled receptor GPR75  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498434  similar to G protein-coupled receptor GPR75      Symbol and Name status set to provisional 70820 PROVISIONAL