lung non-small cell carcinoma - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	lung non-small cell carcinoma	go back to main search page
Accession:	DOID:3908	browse the term
Definition:	A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. (DO)
Synonyms:	exact_synonym:	NSCLC; non-small cell lung cancer; non-small-cell lung carcinomas; nonsmall cell lung cancer
	related_synonym:	NONSMALL CELL LUNG CANCER SUPPRESSOR; nonsmall cell lung cancer, resistance to tyrosine kinase inhibitor in; nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic
	primary_id:	MESH:D002289; OMIM:603040; RDO:0008878
	alt_id:	DOID:9000424
	xref:	EFO:0003060; NCI:C2926
For additional species annotation, visit the Alliance of Genome Resources.

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Rat (635) Mouse (641) Human (3630) Chinchilla (583) Bonobo (600) Dog (632) Squirrel (582) Pig (621) Green Monkey (588) Naked Mole-rat (571) All
Genes (635)

lung non-small cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

treatment

DNA:SNPs: :2677G>T, 3435C>T(human)
ClinVar Annotator: match by term: Non-small cell lung cancer
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:10716719 PMID:11502320 PMID:12686700 PMID:15452305 PMID:15452306 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

treatment

DNA:SNPs: :-24C>T, 3972C>T(human)

RGD

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

treatment

human cells in mouse model

RGD

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

activin A receptor type 1B

susceptibility

DNA:SNP:intron:rs12809597(human)

RGD

NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673

G

adenosine deaminase

protein:decreased expression:lymphocyte,erythrocyte:

RGD

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase domain 28

treatment

DNA:hypermethylation:promoter

RGD

PMID:22354764 PMID:21429053

RGD:153297789, RGD:153298914

NCBI chr15:43,774,463...43,840,726
Ensembl chr15:42,944,467...43,840,672

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

advanced glycosylation end product-specific receptor

mRNA, protein:decreased expression:lung (human)

RGD

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aldo-keto reductase family 1, member C1

CTD Direct Evidence: marker/mechanism

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

AKT serine/threonine kinase 1

ameliorates
treatment

ClinVar Annotator: match by term: Non-small cell lung cancer
human cells in mouse model

PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More...

RGD:5133243, RGD:151357000, RGD:150404268

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:21479466 PMID:25157968 PMID:28492532

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

disease_progression

RGD

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

albumin

disease_progression

RGD

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:17625570 PMID:18923525 PMID:20979469 PMID:20979473 PMID:21030459 More...

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

adenosylmethionine decarboxylase 1

disease_progression

DNA:SNP: :rs1279590(human)

RGD

NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476

G

apoptotic peptidase activating factor 1

mRNA:decreased expression:lung

RGD

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

APC regulator of WNT signaling pathway

CTD Direct Evidence: marker/mechanism

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

A-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:24569458 PMID:26619011

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

amphiregulin

CTD Direct Evidence: marker/mechanism

PMID:15496427 PMID:16230376

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

AT-rich interaction domain 1A

disease_progression
treatment

protein:decreased expression:lung (human)
DNA:mutations

RGD

PMID:24566899 PMID:32791957

RGD:126848781, RGD:126848874

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

AT-rich interaction domain 1B

treatment

DNA:mutations

RGD

NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493

G

actin related protein 2/3 complex, subunit 5

mRNA:increased expression:lung (human)

RGD

NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410

G

activating transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATM serine/threonine kinase

susceptibility
treatment

DNA:SNPs,haplotypes:intron: (rs227060, rs170548) (human)
human cells in mouse model

RGD

PMID:17582598 PMID:23632475

RGD:150383340, RGD:150404268

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

apoptosis and caspase activation inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634

G

axin 1

disease_progression

protein:decreased expression:lung (human)

RGD

NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615

G

Axl receptor tyrosine kinase

CTD Direct Evidence: therapeutic

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

BCL2-associated agonist of cell death

disease_progression

protein:decreased expression:lung

RGD

PMID:21918885 PMID:24092988

RGD:13432584, RGD:13434906

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 6

susceptibility

DNA:SNP: :rs3117582(human)

RGD

NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657

G

BMP and activin membrane-bound inhibitor

mRNA,protein:increased expression:lung:

RGD

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BRCA1 associated RING domain 1

disease_progression

RGD

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BCL2 associated X, apoptosis regulator

treatment

human cells in mouse model

RGD

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

treatment

human cells in mouse model

RGD

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL11 transcription factor A

severity

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

G

BCL6 co-repressor-like 1

severity

RGD

NCBI chr X:127,516,504...127,584,529
Ensembl chr X:127,537,538...127,584,087

G

BEN domain containing 4

CTD Direct Evidence: marker/mechanism

NCBI chr14:40,753,048...40,788,686
Ensembl chr14:40,753,077...40,783,504

G

baculoviral IAP repeat-containing 2

exacerbates

protein:increased expression:lung (human)

RGD

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

exacerbates
ameliorates

protein:increased expression:lung (human)
DNA:SNP:intron: (rs11225211) (human)

RGD

PMID:27737687 PMID:32905523 PMID:20959404

RGD:152998985, RGD:153297804, RGD:152999005

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

CTD Direct Evidence: marker/mechanism

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Non-small cell lung cancer | ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:2102266 PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 More...

RGD:5133243, RGD:5133242

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BRCA1, DNA repair associated

disease_progression
treatment

DNA:hypermethylation:promoter

RGD

PMID:23128816 PMID:23335114 PMID:24443257 PMID:21575522

RGD:126925968, RGD:127229949, RGD:127229948, RGD:127229935

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

bromodomain containing 7

disease_progression

protein:increased expression:lung:

RGD

NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494

G

Bruton tyrosine kinase

ameliorates

mRNA:increased expression:lung (human)

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

calreticulin

ameliorates

protein:increased expression:lung (human)
mRNA, protein:increased expression:lung (human)

RGD

PMID:26842877 PMID:29228584

RGD:150521685, RGD:150521696

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

carbonic anhydrase 12

disease_progression

RGD

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 9

disease_progression

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:30381462 PMID:23910904

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

caspase 3

DNA:SNP: :77G>A (human)
mRNA:increased expression:lung

RGD

PMID:20661084 PMID:16231180

RGD:13434908, RGD:13434909

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

mRNA:increased expression:lung

RGD

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

DNA:SNP: :rs2227310 (human)

RGD

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

no_association

DNA, mRNA:SNP, decreased expression:exon, lung:rs1052576 (human)
mRNA:increased expression:lung
mRNA:splice variant:lung
DNA:SNP: :rs4645981 (human)
DNA:SNP:exon:rs1052571 (human)

RGD

PMID:17285546 PMID:16231180 PMID:20972334 PMID:20661084 PMID:17285546

RGD:13434907, RGD:13434909, RGD:9999427, RGD:13434908, RGD:13434907

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene

DNA:missense mutations, loss of heterozygosity:multiple (human)

RGD

NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176

G

Cbl proto-oncogene B

disease_progression
treatment
no_association

DNA:SNPs: :rs2305035, rs9657904 (human)
DNA:SNP,haplotype: :rs2305035(human)
DNA:SNPs: :rs3772534 (human)

RGD

PMID:29707316 PMID:26732495 PMID:29707316

RGD:126925239, RGD:150540334, RGD:126925239

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

cyclin B1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

disease_progression
treatment

DNA:amplification
mRNA:splice variant
DNA:SNP: :870A>G (human)

RGD

PMID:26055143 PMID:9462706 PMID:18715616 PMID:16406195

RGD:11052612, RGD:13434928, RGD:13434926, RGD:13434924

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

mRNA:increased expression:lung
protein:increased expression:lung

RGD

PMID:31253987 PMID:30227870

RGD:151665100, RGD:151665108

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

disease_progression

RGD

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin H

CTD Direct Evidence: marker/mechanism

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

G

CD74 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD9 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

cytidine deaminase

DNA:snp:cds:p.K27Q (human)

RGD

NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231

G

cadherin 13

DNA:hypermethylation:promoter
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18337602 PMID:11389090

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cyclin-dependent kinase 4

disease_progression
treatment

RGD

PMID:24959380 PMID:24496383

RGD:13464275, RGD:13464276

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

treatment

RGD

PMID:27874949 PMID:23591808

RGD:13464321, RGD:13464324

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

treatment

human cells in mouse model

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

disease_progression

RGD

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

PMID:18337602 PMID:19375815

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2B

disease_progression

DNA:hypermethylation:promoter

RGD

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

centromere protein A

severity

mRNA:increased expression:lung (human)

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

ceramide transporter 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:27,882,546...27,987,090
Ensembl chr 2:27,882,555...27,987,074

G

checkpoint with forkhead and ring finger domains

CTD Direct Evidence: marker/mechanism

NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014

G

chromogranin A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

chitinase 3 like 1

severity

protein:increased secretion:serum (human)

RGD

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

cholinergic receptor nicotinic alpha 3 subunit

disease_progression
susceptibility

DNA:SNP: :rs6495309(human)
DNA:SNP:exon: (rs1051730) (human)

RGD

PMID:22722785 PMID:21747048

RGD:151347532, RGD:151660346

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 5 subunit

disease_progression

DNA:SNP: :rs667282(human)

RGD

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic alpha 7 subunit

ameliorates

RGD

PMID:19151195 PMID:19326440

RGD:151667906, RGD:151667908

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 4 subunit

severity

RGD

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

CLPTM1-like

disease_progression
no_association

CTD Direct Evidence: marker/mechanism
DNA:SNPs: :rs4975616,rs401681(human)
DNA:SNP: :rs31490(human)
DNA:SNPs:: rs401681,rs4975616(human)

CTD
RGD

PMID:22675468 PMID:24679952 PMID:27982019 PMID:24175795

RGD:150530644, RGD:150530632, RGD:150530500

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

cytidine/uridine monophosphate kinase 1

severity

DNA:snps:intron:IVS1+1057C>A rs4492666, IVS1-928C>A rs11211524 (human)

RGD

NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830

G

collagen type VII alpha 1 chain

CTD Direct Evidence: marker/mechanism

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

coronin 1C

CTD Direct Evidence: marker/mechanism

NCBI chr12:42,713,024...42,785,179
Ensembl chr12:42,712,991...42,785,179

G

colony stimulating factor 1 receptor

ameliorates
severity

human cells in a mouse model
mRNA,protein:increased expression:lung (human)
mRNA:decreased expression:lung (human)
DNA:missense mutation:CDS:p.H362R (rs10079250) (human)

RGD

PMID:27486763 PMID:33428598 PMID:24451080 PMID:28449811

RGD:150524288, RGD:150524295, RGD:150524294, RGD:150524292

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 3

CTD Direct Evidence: therapeutic

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cystatin E/M

CTD Direct Evidence: marker/mechanism

NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030

G

CTD small phosphatase like

mRNA:decreased expression:lung (human)

RGD

NCBI chr 8:118,642,729...118,767,238
Ensembl chr 8:118,642,672...118,767,117

G

cut-like homeobox 1

exacerbates

mRNA:increased expression:lung (human)

RGD

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866

G

C-X-C motif chemokine receptor 4

disease_progression

protein:increased expression:lung (human)

RGD

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome c, somatic

severity
treatment

protein:decreased expression:serum

RGD

PMID:25578497 PMID:25578497

RGD:13792769, RGD:13792769

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

CYLD lysine 63 deubiquitinase

CTD Direct Evidence: marker/mechanism

NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658

G

cytochrome P450, family 24, subfamily a, polypeptide 1

exacerbates
susceptibility
disease_progression

mRNA:increased expression:lung (human)
DNA:SNPs:multiple (human)
DNA:SNPs:CDS, 3' utr: (rs6068816, rs4809957) (human)
DNA:SNP:exon, intron: (rs6068816, rs2181874) (human)
DNA:SNP:intron 4: (rs3787554) (human)

RGD

PMID:29250167 PMID:29726119 PMID:17671213 PMID:25544771 PMID:27669215 More...

RGD:151361179, RGD:151708739, RGD:151708738, RGD:151665789, RGD:151665175, RGD:151361185, RGD:151361182

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily e, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DAB2 interacting protein

disease_progression

protein:decreased expression:lung (human)

RGD

NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280

G

death associated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

discoidin domain receptor tyrosine kinase 1

disease_progression

RGD

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

discoidin domain receptor tyrosine kinase 2

mRNA:decreased expression:lung
ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:18938156 PMID:22328973 PMID:23932362 PMID:25741868 PMID:26206333 More...

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

deuterosome assembly protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:12,380,300...12,442,649
Ensembl chr 8:12,380,302...12,442,199

G

diablo, IAP-binding mitochondrial protein

mRNA:increased expression:lung

RGD

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dynein axonemal intermediate chain 7

ameliorates

RGD

NCBI chr 4:178,143,499...178,179,871
Ensembl chr 4:178,143,500...178,179,980

G

DNA methyltransferase 1

treatment

RGD

PMID:32211850 PMID:32211850

RGD:126848780, RGD:126848780

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dual specificity phosphatase 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962

G

E2F transcription factor 1

treatment
disease_progression
severity

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:29754146 PMID:28498400 PMID:12358350 PMID:12237873 PMID:23543735

RGD:13464333, RGD:13464343, RGD:13464342, RGD:9590260

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 3

disease_progression

DNA:SNP: :rs3806116 (human)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:29754146 PMID:27557513

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

E2F transcription factor 6

CTD Direct Evidence: marker/mechanism

NCBI chr 6:39,592,224...39,608,685
Ensembl chr 6:39,592,228...39,608,683

G

E2F transcription factor 7

CTD Direct Evidence: marker/mechanism

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

CTD Direct Evidence: marker/mechanism

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

eukaryotic translation elongation factor 2

disease_progression

protein:increased expression:blood serum (human)

RGD

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor

treatment

RGD

PMID:26927662 PMID:25992884

RGD:13464348, RGD:13464350

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

ameliorates
severity
treatment
susceptibility

ClinVar Annotator: match by term: Non-small cell lung cancer | ClinVar Annotator: match by term: Non-small cell lung carcinoma | ClinVar Annotator: match by term: Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic
human cells in mouse model
CTD Direct Evidence: marker/mechanism
protein:decreased expression:tumor (human)
DNA:deletion:cds:2240del18 (human)

ClinVar
CTD
RGD

PMID:2302402 PMID:11423618 PMID:15118073 PMID:15118125 PMID:15272417 More...

RGD:5133242, RGD:153344584, RGD:151357000, RGD:126790479, RGD:13464349, RGD:5131629, RGD:5131640, RGD:1601010, RGD:5133241

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

resistance

mRNA:increased expression:tumor (human)

RGD

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4E binding protein 1

treatment

human cells in mouse model

RGD

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

EMAP like 4

CTD Direct Evidence: marker/mechanism

PMID:17625570 PMID:21757253 PMID:21767331 PMID:22568572 PMID:22617245 More...

NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879

G

enolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

enolase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

endothelial PAS domain protein 1

treatment

RGD

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

epoxide hydrolase 1

disease_progression

RGD

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erb-b2 receptor tyrosine kinase 2

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:15457249 PMID:15753357 PMID:16638863 PMID:16863509 PMID:18334834 More...

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

treatment
disease_progression

RGD

PMID:20364069 PMID:11789762

RGD:126790478, RGD:126790479

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

ERCC excision repair 1, endonuclease non-catalytic subunit

treatment
disease_progression
severity

CTD Direct Evidence: marker/mechanism
DNA:SNPs:multiple (human)
DNA:silent mutation:cds:p.N118N (human)
protein:decreased expression:lung (human)

CTD
RGD

PMID:21553054 PMID:23912706 PMID:28924235 PMID:23549037 PMID:24443257 More...

RGD:153323316, RGD:127229950, RGD:127229948, RGD:13207428, RGD:13207308

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 2, TFIIH core complex helicase subunit

disease_progression
treatment

DNA:polymorphism:cds:p.K751Q(human)
DNA:SNPs:multiple (human)
ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:19434073 PMID:19470925 PMID:24033266 PMID:24728327 PMID:25741868 More...

RGD:12880391, RGD:153323316

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 3, TFIIH core complex helicase subunit

treatment

DNA:snp:intron:c.2064+741T>C (rs3738948) (human)

RGD

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

ERCC excision repair 5, endonuclease

treatment

DNA:SNPs:multiple (human)

RGD

PMID:24782167 PMID:28924235

RGD:151347410, RGD:153323316

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

ERCC excision repair 6, chromatin remodeling factor

treatment

DNA:SNP:intron: (rs4253002) (human)

RGD

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

ERGIC and golgi 3

CTD Direct Evidence: marker/mechanism

NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813

G

estrogen receptor 1

DNA:hypermethylation: :lung

RGD

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

disease_progression

RGD

PMID:21539681 PMID:23300840

RGD:126781700, RGD:126781715

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

fibroblast activation protein, alpha

disease_progression

RGD

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

Fas ligand

CTD Direct Evidence: marker/mechanism

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FAT atypical cadherin 1

treatment

CTD Direct Evidence: therapeutic

CTD
RGD

PMID:34390292 PMID:31085721

NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107

G

F-box protein 11

treatment

RGD

NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662

G

fibroblast growth factor 9

severity

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung (human)

PMID:19358281 PMID:24239165 PMID:31884893

RGD:152177524, RGD:152177912

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

Fibroblast growth factor receptor 1

disease_progression

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22286583 PMID:27794399 PMID:23806793

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 4

disease_progression
severity

mRNA, protein:increased expression:lung (human)
DNA:SNP:exon 9: p.G3888R (rs351855) (human)

RGD

PMID:26045670 PMID:23524567

RGD:150429970, RGD:150429982

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

fumarate hydratase

severity

DNA:SNP: (rs1414493) (human)

RGD

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

fragile histidine triad diadenosine triphosphatase

disease_progression

CTD Direct Evidence: marker/mechanism
DNA:loss of heterozygosity:intron:

CTD
RGD

PMID:11788890 PMID:9635574 PMID:9850082

RGD:13792815, RGD:13792770

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

FOS like 2, AP-1 transcription factor subunit

disease_progression

protein:increased expression:lung (human)

RGD

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box A1

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung

CTD
RGD

PMID:32717239 PMID:26658322 PMID:26909612

RGD:11554787, RGD:151665747

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box A2

mRNA:decreased expression:lung

RGD

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box L2

DNA:hypermethylation: (human)

RGD

NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427

G

forkhead box M1

CTD Direct Evidence: marker/mechanism

PMID:18345025 PMID:19672312

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box O3

CTD Direct Evidence: marker/mechanism

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P1

mRNA:decreased expression:lung (human)

RGD

NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258

G

frizzled-related protein

DNA:hypermethylation:exon 1

RGD

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

glutamate-cysteine ligase, catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

gastric inhibitory polypeptide receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462

G

G protein subunit alpha q

disease_progression

RGD

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

G protein-coupled receptor 135

CTD Direct Evidence: marker/mechanism

NCBI chr 6:90,627,533...90,630,661
Ensembl chr 6:90,629,178...90,630,551

G

glutathione peroxidase 1

treatment
onset

DNA:SNP: (human)
mRNA:increased expression:leukocyte (human)

RGD

PMID:19347979 PMID:33474835

RGD:152998881, RGD:152998904

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor kainate type subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

gastrin releasing peptide

disease_progression

protein:increased expression:serum (human)

RGD

NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061

G

glutathione S-transferase mu 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP: :p.A114V (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:exon:p.I105V (human)

CTD
RGD

PMID:17094902 PMID:18258609 PMID:19174490

RGD:4140950, RGD:4140944

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H19 imprinted maternally expressed transcript

disease_progression

mRNA:increased expression:lung (human)

RGD

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

histone deacetylase 3

RGD

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

hes family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hypoxia inducible factor 1 subunit alpha

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:30381462 PMID:21812995

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heterogeneous nuclear ribonucleoprotein A1

protein:increased expression:lung (human)

RGD

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

heterogeneous nuclear ribonucleoprotein A2/B1

susceptibility

antibody 703D4 recognizes Hnrnpa2b1 protein (RGD:9685415);protein:increased expression:sputum (human)

RGD

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:2674130 PMID:3004741 PMID:3283542 PMID:3304147 PMID:6287572 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heparan sulfate-glucosamine 3-sulfotransferase 2

DNA:hypermethylation

RGD

NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399

G

HtrA serine peptidase 1

exacerbates

protein:decreased expression:lung (human)

RGD

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

intercellular adhesion molecule 1

disease_progression

progression-free survival; protein:increased secretion:serum (human)

RGD

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

isocitrate dehydrogenase (NADP(+)) 2

severity

DNA:SNP: (rs11540478) (human)

RGD

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

IKAROS family zinc finger 2

exacerbates

protein:decreased expression:venous blood, lung, regulatory T cell (human)

RGD

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

IKAROS family zinc finger 3

exacerbates

protein:increased expression:lung (human)

RGD

NCBI chr10:83,460,564...83,553,591
Ensembl chr10:83,465,745...83,553,591

G

interleukin 10

CTD Direct Evidence: marker/mechanism

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

protein:increased expression:serum

RGD

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

DNA:SNPs: :

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

susceptibility

DNA:polymorphism: :-31T>C (human)

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

susceptibility

DNA:polymorphism (human)

RGD

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 7

disease_progression

RGD

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

interleukin 7 receptor

disease_progression
susceptibility

DNA:SNPs:: rs1494555,rs7737000(human)

RGD

PMID:21159243 PMID:19505916

RGD:151347686, RGD:4142793

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

IQ motif and Sec7 domain ArfGEF 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr 4:123,168,719...123,488,300
Ensembl chr 4:123,168,719...123,488,172

G

interferon regulatory factor 1

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:10395927 PMID:10395927

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

insulin receptor substrate 4

protein:increased expression:lung (human)

RGD

NCBI chr X:105,344,020...105,360,004

G

integrin subunit alpha 9

mRNA:decreased expression:lung (human)

RGD

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

G

integrin subunit beta 1

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung

CTD
RGD

PMID:21478906 PMID:28537888

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 3

RGD

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

integrin subunit beta 4

CTD Direct Evidence: marker/mechanism

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

Janus kinase 1

disease_progression

protein:increased phosphorylation:lung

RGD

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

treatment

human cells in mouse model

RGD

PMID:25869210 PMID:21325979

RGD:149735332, RGD:149735342

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

JunB proto-oncogene, AP-1 transcription factor subunit

severity

RNA:increased expression:lung (human)

RGD

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lysine acetyltransferase 2A

disease_progression

RGD

NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166

G

lysine demethylase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319

G

lysine demethylase 2A

severity

mRNA:increased expression:stomach (human)
human gene in a mouse model

RGD

PMID:24200691 PMID:24482232

RGD:9588263, RGD:9588265

NCBI chr 1:201,612,427...201,682,359
Ensembl chr 1:201,612,453...201,680,787

G

lysine demethylase 3B

DNA:amplification:lung, peripheral blood mononuclear cell (human)

RGD

NCBI chr18:26,380,859...26,436,701
Ensembl chr18:26,380,964...26,436,628

G

lysine demethylase 5A

severity

protein:increased expression:lung (human)

RGD

NCBI chr 4:153,565,909...153,643,912
Ensembl chr 4:153,565,846...153,642,422

G

lysine demethylase 6A

exacerbates

human cells in a mouse model

RGD

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

kinase insert domain receptor

disease_progression
treatment

DNA:CNVs
protein:increased expression:plasma
DNA:SNP:promoter:��906T>C (rs2071559) (human)
DNA, protein:CNVs, increased expression:lung

RGD

PMID:21724587 PMID:21481963 PMID:25975224 PMID:12415261 PMID:16697074 More...

RGD:126908001, RGD:126925199, RGD:126925198, RGD:126925192, RGD:126925189, RGD:126925188

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kinesin family member 5B

CTD Direct Evidence: marker/mechanism

NCBI chr17:51,489,904...51,527,508
Ensembl chr17:51,489,944...51,527,508

G

KIT proto-oncogene receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:7530509 PMID:9438854 PMID:11276010 PMID:15790786 PMID:16731599 More...

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lysine methyltransferase 2C

disease_progression

RGD

NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539

G

lysine methyltransferase 2D

disease_progression

DNA, protein:missense mutations, nonsense mutations, frameshift mutation, increased expression:lung

RGD

PMID:29627316 PMID:33665490 PMID:25112956

RGD:150523767, RGD:150523771, RGD:150523769

NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Non-small cell lung cancer | ClinVar Annotator: match by term: Non-small cell lung carcinoma
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:2278970 PMID:2547513 PMID:3122217 PMID:3627975 PMID:6320174 More...

NCBI chr 4:178,185,418...178,218,484

G

L1 cell adhesion molecule

disease_progression

RGD

NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857

G

laminin subunit beta 3

mRNA:increased expression:lung:

RGD

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

G

laminin subunit gamma 2

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:lung:

CTD
RGD

PMID:30381462 PMID:26180921 PMID:10964684

RGD:13793367, RGD:13793368

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

leptin

protein:increased expression:serum

RGD

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

LDL receptor related protein 1B

ameliorates

DNA:mutations:multiple: (human)

RGD

NCBI chr 3:24,594,302...26,715,037
Ensembl chr 3:24,594,991...26,715,505

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:2674130 PMID:3004741 PMID:3283542 PMID:3304147 PMID:6287572 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

leucine rich repeat containing 59

CTD Direct Evidence: marker/mechanism

NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533

G

lymphotoxin alpha

protein:increased expression:lung

RGD

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

lactotransferrin

RGD

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

macrophage immunometabolism regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 9:98,420,760...98,440,818
Ensembl chr 9:98,420,376...98,441,733

G

mesencephalic astrocyte-derived neurotrophic factor

susceptibility

RGD

NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438

G

mitogen activated protein kinase kinase 1

ameliorates

ClinVar Annotator: match by term: Non-small cell lung cancer | ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:7651428 PMID:17704260 PMID:18060073 PMID:18632602 PMID:19344873 More...

RGD:5133242, RGD:150530476, RGD:5133243

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

ameliorates

RGD

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase kinase 4

ameliorates

associated with Postoperative Complications;DNA:SNP:intron: (rs12452497)(human)

RGD

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase kinase 7

susceptibility
exacerbates

DNA:SNP:3' utr: (rs3679) (human)

RGD

PMID:27861856 PMID:21317887

RGD:155230827, RGD:155249848

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 1

severity

DNA:SNPs:5'-UTR, intron 1: (rs17661089, rs16886403, rs726501) (human)

RGD

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen-activated protein kinase kinase kinase 8

disease_progression

RGD

PMID:28393206 PMID:23533274

RGD:151356965, RGD:151356978

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

MCL1 apoptosis regulator, BCL2 family member

disease_progression
ameliorates
severity

protein:increased expression:lung, cytoplasm (human)
human cells in mouse model
protein:increased expression:lung (human)
DNA:mutations:multiple

PMID:24469836 PMID:31662324 PMID:32945371 PMID:29567880 PMID:32276600 More...

RGD:151356906 RGD:151356915 RGD:151356931, RGD:151356750, RGD:151357000, RGD:151356758

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

CTD Direct Evidence: marker/mechanism

PMID:19941079 PMID:21268124

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mesenchyme homeobox 1

CTD Direct Evidence: therapeutic

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

MET proto-oncogene, receptor tyrosine kinase

disease_progression

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21623265 PMID:21815704 PMID:22787409 PMID:24688052 PMID:20519133 More...

RGD:5133241, RGD:13434906, RGD:5133243, RGD:5133242

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

macrophage migration inhibitory factor

RGD

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504

G

microRNA 107

mRNA:decreased expression:lung (human)

RGD

NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853

G

microRNA 126a

CTD Direct Evidence: therapeutic

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

G

microRNA 136

ameliorates

RNA:decreased expression:lung (human)
human cells in mouse model

RGD

PMID:31059060 PMID:34556984

RGD:153344623, RGD:153344608

NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177

G

microRNA 145

CTD Direct Evidence: therapeutic

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

microRNA 146a

ameliorates
severity

RGD

PMID:27494902 PMID:27494902

RGD:151665165, RGD:151665165

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 154

treatment
disease_progression

human cells in mouse model
RNA:decreased expression:lung (human)

RGD

PMID:30780105 PMID:25846246

RGD:152995466, RGD:152995468

NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030

G

microRNA 193a

ameliorates

miRNA:decreased expression:lung (human)
human cells in mouse model

RGD

PMID:26655272 PMID:31205511

RGD:11085320, RGD:153344584

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 205

CTD Direct Evidence: marker/mechanism

NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985

G

microRNA 21

disease_progression

RNA:increased expression:lung (human)
RNA:increased expression:blood serum (human)

RGD

PMID:20956945 PMID:20223231 PMID:25477028 PMID:22956424 PMID:33467964 More...

RGD:41404697, RGD:152998901, RGD:152998899, RGD:152998889, RGD:152998886, RGD:152998885

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 222

disease_progression

RGD

PMID:24955421 PMID:30233216

RGD:151708732, RGD:151708743

NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006

G

microRNA 223

severity
treatment

RGD

PMID:29615147 PMID:29615147

RGD:21408562, RGD:21408562

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

G

microRNA 29a

CTD Direct Evidence: marker/mechanism

NCBI chr 4:59,650,608...59,650,695

G

microRNA 29b-1

treatment

RGD

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

microRNA 301a

CTD Direct Evidence: marker/mechanism

NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435

G

microRNA 30c-1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325

G

microRNA 31

miRNA:increased expression:sputum (human)

RGD

NCBI chr 5:103,599,038...103,599,143

G

microRNA 346

CTD Direct Evidence: marker/mechanism

NCBI chr16:10,218,118...10,218,215
Ensembl chr16:10,218,118...10,218,215

G

microRNA 377

miRNA:decreased expression:lung

RGD

NCBI chr 6:128,755,051...128,755,122

G

microRNA 381

treatment

RGD

NCBI chr 6:128,740,976...128,741,036

G

microRNA 484

disease_progression

mRNA:increased expression:lung
mRNA:decreased expression:lung

RGD

PMID:28982084 PMID:28982084

RGD:13703106, RGD:13703106

NCBI chr10:887,684...887,760
Ensembl chr10:887,684...887,760

G

microRNA 497

miRNA:decreased expression:lung

RGD

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

microRNA 665

disease_progression

associated with metastasis; mRNA:increased expression:lung (human)

RGD

PMID:32269632 PMID:32269632

RGD:151361291, RGD:151361291

NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533

G

microRNA 671

severity

RGD

NCBI chr 4:10,580,747...10,580,827
Ensembl chr 4:10,580,738...10,580,835

G

marker of proliferation Ki-67

ameliorates

human cells in mouse model

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

severity

RGD

PMID:32211850 PMID:18370958

RGD:126848780, RGD:126848801

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 11

CTD Direct Evidence: marker/mechanism

NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628

G

matrix metallopeptidase 2

severity

protein:increased expression, increased activity:lung

RGD

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

mRNA:increased expression:lung

RGD

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

disease_progression

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21789004 PMID:20704821

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

membrane spanning 4-domains A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512

G

mutS homolog 2

treatment

protein:decreased expression:lung
DNA:SNP: :rs6544991 (human)

RGD

PMID:32211850 PMID:20458443 PMID:16783774 PMID:20145178 PMID:28093084

RGD:126848780, RGD:126848800, RGD:126848791, RGD:126848789, RGD:126848786

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 3

treatment

DNA:SNPs: :rs6151627, rs6151670, rs7709909 (human)

RGD

NCBI chr 2:23,444,326...23,585,777

G

mutS homolog 5

treatment

DNA:SNPs: :rs805304, rs707939 (human)

RGD

NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336

G

metallothionein 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

mechanistic target of rapamycin kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

disease_progression

protein:increased expression:lung (human)
DNA:hypomethylation:promoter (human)

RGD

PMID:31432177 PMID:32010578

RGD:150519919, RGD:150524328

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

N-acetyltransferase 1

susceptibility

DNA:polymorphism: :

RGD

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

non-SMC condensin I complex, subunit H

protein:decreased expression:lung (human)

RGD

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

nuclear receptor coactivator 2

DNA:SNPs:introns: (rs2926702, rs11993276) (human)

RGD

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nuclear receptor coactivator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

NDC80 kinetochore complex component

disease_progression

RGD

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NIMA-related kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

neurofibromin 1

mRNA:increased expression:lung (human)

RGD

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

RGD

NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism

PMID:22684020 PMID:26482881 PMID:33148531

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

susceptibility

DNA:polymorphism:rs28362491(human)
protein:increased expression:nucleus

RGD

PMID:26221384 PMID:17899287

RGD:13793390, RGD:13793391

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

neuronatin

CTD Direct Evidence: marker/mechanism

NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834

G

notch receptor 1

ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:20007775 PMID:25741868 PMID:28492532

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

NAD(P)H quinone dehydrogenase 1

disease_progression

DNA:polymorphism: :
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:cds: 609 C>T (human)

CTD
RGD

PMID:9865924 PMID:21479364 PMID:21479364 PMID:19596483

RGD:5133265, RGD:5133268

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

disease_progression

protein:increased expression:lung

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Non-small cell lung cancer | ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

neuropilin 1

disease_progression

DNA, protein:CNVs, increased expression:lung

RGD

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

nuclear receptor binding SET domain protein 2

mRNA:increased expression:lung (human)

RGD

NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641

G

NUF2 component of NDC80 kinetochore complex

disease_progression

RGD

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

OIP5 antisense RNA 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:106,578,309...106,591,845

G

oncostatin M receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262

G

oxytocin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674

G

polyamine oxidase

susceptibility

DNA:SNPs: :rs7316, rs1046175(human)

RGD

NCBI chr 1:194,919,655...194,928,498
Ensembl chr 1:194,903,273...194,928,504

G

polybromo 1

disease_progression

RGD

NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780

G

3-phosphoinositide dependent protein kinase-1

disease_progression

mRNA:increased expression:blood serum

RGD

NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623

G

platelet and endothelial cell adhesion molecule 1

treatment

human cells in mouse model

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

phosphoglycerate mutase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

phosphoglycerate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

pleckstrin homology-like domain, family A, member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: Non-small cell lung cancer | ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

RGD:5133243, RGD:5133242

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

plasminogen activator, urokinase

RGD

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phospholipase B domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277

G

phospholipase C, gamma 1

treatment

human cell line in a mouse model

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

DNA polymerase epsilon, catalytic subunit

ameliorates

DNA:mutations:multiple (human)

RGD

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

G

peptidylprolyl isomerase A

CTD Direct Evidence: marker/mechanism

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

PRAME like, X-linked 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:98,567,994...98,574,654
Ensembl chr X:98,569,415...98,572,096

G

PR/SET domain 14

disease_progression

DNA:hypermethylation

RGD

PMID:23690269 PMID:27777637

RGD:150530468, RGD:152998954

NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712

G

peroxiredoxin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

mRNA:increased expression:lung (human)

RGD

NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068

G

protein kinase AMP-activated catalytic subunit alpha 1

treatment

human cells in mouse model

RGD

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, beta

DNA:hypermethylation:promoter:lung

RGD

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

proline rich 13

CTD Direct Evidence: marker/mechanism

NCBI chr 7:133,592,511...133,595,817
Ensembl chr 7:133,592,490...133,601,005

G

phosphoserine aminotransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Non-small cell lung cancer
mRNA:decreased expression:lung (human)
DNA:loss of heterozygosity:cds: (human)

PMID:1336932 PMID:9140396 PMID:9241266 PMID:9259288 PMID:9399897 More...

RGD:5133242, RGD:152998901, RGD:152998889, RGD:12832745

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E synthase

severity

protein:increased expression:lung

RGD

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin I2 synthase

severity

protein:decreased expression:lung (human)

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 2

severity

protein:increased expression:lung
DNA:SNP: :929G>C(human)

RGD

PMID:20592629 PMID:20016751

RGD:5135302, RGD:5135471

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

CTD Direct Evidence: therapeutic

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

protein tyrosine phosphatase, receptor type, B

disease_progression

human cells in mouse model
mRNA:decreased expression:lung (human)

RGD

PMID:27314562 PMID:27314562

RGD:151361281, RGD:151361281

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

paxillin

CTD Direct Evidence: marker/mechanism

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

PYD and CARD domain containing

CTD Direct Evidence: marker/mechanism

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAD21 cohesin complex component

susceptibility
exacerbates

DNA:SNP:intron: (rs1374297) (human)
mRNA:increased expression:lung (human)

PMID:32178590 PMID:28977903

RGD:150520031, RGD:150520036

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

RAD52 homolog, DNA repair protein

susceptibility

DNA:SNPs,haplotype:multiple

RGD

NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207

G

Raf-1 proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

retinoic acid receptor, beta

DNA:hypermethylation:lung

RGD

PMID:23599765 PMID:18349282

RGD:13503323, RGD:13503324

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

Ras association domain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

Ras association domain family member 5

RGD

NCBI chr13:42,637,513...42,703,024
Ensembl chr13:42,637,549...42,703,024

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 7

CTD Direct Evidence: marker/mechanism

NCBI chr 8:48,831,894...48,838,399
Ensembl chr 8:48,831,894...48,838,411

G

reversion-inducing-cysteine-rich protein with kazal motifs

CTD Direct Evidence: marker/mechanism

NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502

G

RELA proto-oncogene, NF-kB subunit

RGD

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

Ras homolog, mTORC1 binding

CTD Direct Evidence: marker/mechanism

NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160

G

ring finger protein 168

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277

G

roundabout guidance receptor 1

mRNA:altered expression:lung

RGD

NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203

G

ROS proto-oncogene 1 , receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:22215748 PMID:22585869 PMID:22617245 PMID:22919003

NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

CTD Direct Evidence: marker/mechanism

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

ribonucleotide reductase catalytic subunit M1

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21496433 PMID:19002265

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

treatment

RGD

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

RUNX family transcription factor 1

disease_progression

mRNA:alternative form:lung

RGD

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 2

human cells in mouse model

RGD

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

RUNX family transcription factor 3

DNA:hypermethylation:promoter

RGD

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

retinoid X receptor gamma

DNA:hypermethylation:promoter

RGD

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

secretoglobin, family 3A, member 2

RGD

NCBI chr18:35,932,840...35,935,762
Ensembl chr18:35,932,840...35,935,762

G

syndecan 4

CTD Direct Evidence: marker/mechanism

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

succinate dehydrogenase complex flavoprotein subunit A

susceptibility

DNA:SNP: 3'utr (rs13173911) (human)

RGD

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

succinate dehydrogenase complex subunit C

exacerbates

DNA:SNP: 3'utr (rs12064957) (human)

RGD

NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253

G

selenoprotein S

CTD Direct Evidence: marker/mechanism

NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833

G

serpin family F member 1

protein:increased expression:serum, pleural effusion (human)

RGD

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

surfactant protein B

susceptibility

DNA:SNPs: :rs7316, rs9752 (human)

RGD

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein D

disease_progression

RGD

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

serine hydroxymethyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236

G

solute carrier family 22, member 18

disease_progression

mRNA:increased expression:lung (human)
protein:increased expression:lung (human)

RGD

PMID:25498886 PMID:22237119

RGD:150557424, RGD:150557425

NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975

G

solute carrier family 22 member 22

CTD Direct Evidence: marker/mechanism

NCBI chr 7:88,720,425...88,750,111
Ensembl chr 7:88,720,427...88,750,111

G

solute carrier family 34 member 2

CTD Direct Evidence: marker/mechanism

PMID:22617245 PMID:22919003

NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436

G

solute carrier family 3 member 2

disease_progression
severity
sexual_dimorphism

DNA:SNP:5'utr: (rs105929) (human)
protein:increased expression:lung (human)

RGD

PMID:22110199 PMID:24782339 PMID:25084765

RGD:151361206, RGD:152995443, RGD:152995442

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 7 member 5

disease_progression
treatment

RGD

PMID:21187458 PMID:22110199

RGD:151361159, RGD:151361206

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

SMAD family member 3

protein:increased expression:lung (human)

RGD

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

RGD

NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975

G

synaptosome associated protein 47

CTD Direct Evidence: marker/mechanism

NCBI chr10:44,192,886...44,234,435
Ensembl chr10:44,191,218...44,234,424

G

suppressor of cytokine signaling 1

disease_progression

RGD

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

suppressor of cytokine signaling 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

PMID:11731445 PMID:17094902

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 30

disease_progression

RGD

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRY-box transcription factor 4

severity

RGD

NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665

G

speckle type BTB/POZ protein

ameliorates

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955

G

secreted phosphoprotein 1

RGD

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

serine and arginine rich splicing factor 1

severity

protein:increased expression:lung (human)

RGD

PMID:20682707 PMID:23071587

RGD:11038729, RGD:150429662

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 2

protein:increased expression:lung epithelium,nucleus

RGD

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

signal transducer and activator of transcription 3

severity

CTD Direct Evidence: marker/mechanism
protein:increased phosphorylation:lung (human)

CTD
RGD

PMID:21549414 PMID:22977534

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5B

disease_progression

mRNA,protein:increased expression:lung (human)

RGD

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

stromal interaction molecule 1

mRNA:increased expression:blood plasma (human)

RGD

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Non-small cell lung carcinoma

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

synaptophysin

CTD Direct Evidence: marker/mechanism

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

TGF-beta activated kinase 1/MAP3K7 binding protein 2

mRNA:increased expression:lung (human)

RGD

NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756

G

terminal nucleotidyltransferase 5A

susceptibility

DNA:repeats: :

RGD

NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045

G

telomerase reverse transcriptase

disease_progression

CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs2736098(human)
DNA:SNPs, haplotype: :rs2853669,rs2736108(human)

CTD
RGD

PMID:21252717 PMID:24679952 PMID:27982019

RGD:150530644, RGD:150530632

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tet methylcytosine dioxygenase 2

DNA:mutations:multiple

RGD

NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534

G

transforming growth factor alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

thrombomodulin

disease_progression

RGD

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

TIMP metallopeptidase inhibitor 3

disease_progression

RGD

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

thymidine kinase 1

protein:increased expression:serum (human)

RGD

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

toll-like receptor 9

mRNA, protein:increased expression:tumor (human)

RGD

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

transmembrane protein 135

CTD Direct Evidence: marker/mechanism

NCBI chr 1:143,006,343...143,279,824
Ensembl chr 1:143,006,344...143,221,171

G

tumor necrosis factor

DNA:SNPs: :
protein:increased expression:lung

RGD

PMID:19505916 PMID:9669810

RGD:4142793, RGD:4143264

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

disease_progression
severity

protein:increased expression:serum (human)
DNA:snp:5' utr:g.-329G>T rs4149570 (human)

RGD

PMID:20824709 PMID:20422457

RGD:5131156, RGD:5131202

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

treatment

human cells in mouse model
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17290066 PMID:23435014 PMID:24688052 PMID:30381462 PMID:20951313 More...

RGD:5133242, RGD:150404268

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

G

tumor protein p73

treatment

DNA:SNP:intron: (rs3765701) (human)

RGD

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

tRNA methyltransferase 11 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 1:27,054,437...27,109,765
Ensembl chr 1:27,054,420...27,201,610

G

transthyretin

disease_progression

protein:decreased expression:blood serum (human)

RGD

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

thymidine phosphorylase

RGD

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

ubiquitin protein ligase E3 component n-recognin 5

exacerbates

circRNA:decreased expression:lung (human)

RGD

NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903

G

ubiquitin C-terminal hydrolase L1

CTD Direct Evidence: marker/mechanism

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

UDP glucuronosyltransferase family 1 member A1

treatment

DNA:repeat:promoter:(TA)

RGD

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular endothelial growth factor A

disease_progression

CTD Direct Evidence: marker/mechanism
protein:inctreased expression:lung (human)
protein:increased expression:plasma

CTD
RGD

PMID:15956251 PMID:22977534 PMID:21481963

RGD:152023747, RGD:126925199

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

WEE1 G2 checkpoint kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

WD repeat containing, antisense to TP53

disease_progression

RNA:increased expression:lung
DNA:hypermethylation:promoter

RGD

PMID:31281482 PMID:30344734

RGD:21081513, RGD:21081519

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

G

XPC complex subunit, DNA damage recognition and repair factor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

exportin 1

ameliorates
treatment

human cell line in a mouse model

RGD

PMID:31113936 PMID:24946002

RGD:151665798, RGD:151667438

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

exportin 5

severity

DNA:snp, haplotype:3' utr:c.*659A>C (rs11077) (human)

RGD

NCBI chr 9:14,740,182...14,778,171
Ensembl chr 9:14,740,182...14,778,171

G

X-ray repair cross complementing 1

treatment
severity
susceptibility

DNA:missense mutation:p.R399Q (human)
DNA:SNP:3'utr: (rs25487) (human)
DNA:missense mutation:cds: p.R194W (human)
DNA:missense mutations:cds:p.R194W, p.R399Q (human)
ClinVar Annotator: match by term: Non-small cell lung carcinoma

PMID:19157633 PMID:23549037 PMID:15301704 PMID:24446315 PMID:26345972 More...

RGD:127229950, RGD:151347427, RGD:11097268, RGD:11251107, RGD:151347410, RGD:151347402, RGD:151347175, RGD:11538163, RGD:151232297, RGD:151232295

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

zinc finger homeobox 3

ameliorates
exacerbates

DNA:mutations:multiple (human)
mRNA:decreased expression:lung (human)

RGD

PMID:32653938 PMID:23144151

RGD:151361163, RGD:151361164

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

G

zinc finger protein 462

CTD Direct Evidence: marker/mechanism

NCBI chr 5:69,670,085...69,810,729
Ensembl chr 5:69,670,328...69,810,327

bronchiolo-alveolar adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ALX homeobox 4

ameliorates

RGD

NCBI chr 3:79,611,682...79,648,260
Ensembl chr 3:79,611,719...79,648,260

G

cyclin D1

protein:increased expression:lung

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

DNA methyltransferase 1

disease_progression

RGD

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

epidermal growth factor receptor

DNA:snp:cds:p.T790M (human)
protein:increased expression:tumor (human)
DNA:mutations:exons:

RGD

PMID:15737014 PMID:21419590 PMID:26059825

RGD:5131465, RGD:5131630, RGD:11075076

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

mRNA:decreased expression:tumor (human)

RGD

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

glutathione S-transferase pi 1

DNA:hypermethylation:promoter (human)

RGD

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

KRAS proto-oncogene, GTPase

DNA:mutations:cds:

RGD

NCBI chr 4:178,185,418...178,218,484

G

microRNA 130a

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629

G

microRNA 144

CTD Direct Evidence: marker/mechanism

NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430

G

microRNA 19a

CTD Direct Evidence: marker/mechanism

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

G

microRNA 345

CTD Direct Evidence: marker/mechanism

NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122

G

microRNA 497

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

tumor protein p53

DNA:mutations:exons:

RGD

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

large cell neuroendocrine carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 7 member 5

disease_progression

RGD

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

lung adenocarcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily E member 1

severity

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

acyl-CoA synthetase long-chain family member 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

ADAM metallopeptidase domain 19

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 28

exacerbates
disease_progression
treatment

protein:increased expression:lung

RGD

PMID:29882245 PMID:26800504 PMID:30190423 PMID:20112342

RGD:153297792, RGD:11531771, RGD:153297795, RGD:153297794

NCBI chr15:43,774,463...43,840,726
Ensembl chr15:42,944,467...43,840,672

G

ADAMTS-like 3

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986

G

adhesion G protein-coupled receptor G6

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adenosylhomocysteinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member A1

disease_progression

RGD

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

AKT serine/threonine kinase 1

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldolase, fructose-bisphosphate A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:18923525 PMID:20979469 PMID:20979473 PMID:21030459 PMID:21575866 More...

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

arachidonate 12-lipoxygenase, 12R type

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

ALX homeobox 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 7:38,157,626...38,177,220
Ensembl chr 7:38,147,117...38,177,220

G

ALX homeobox 4

disease_progression

RGD

NCBI chr 3:79,611,682...79,648,260
Ensembl chr 3:79,611,719...79,648,260

G

anaphase promoting complex subunit 2

severity

mRNA:decreased expression:lung (human)

RGD

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

acidic nuclear phosphoprotein 32 family member A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

annexin A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1316610 PMID:1338764 PMID:2281069 PMID:8187091 PMID:8381579 More...

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein C3

protein:altered glycosylation::

RGD

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

aquaporin 4

CTD Direct Evidence: marker/mechanism

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

A-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:24569458 PMID:26619011

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

arginase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GTPase activating protein 35

CTD Direct Evidence: marker/mechanism

NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298

G

Rho GTPase activating protein 44

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

ATP synthase peripheral stalk subunit d

CTD Direct Evidence: marker/mechanism

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATRX, chromatin remodeler

disease_progression

RGD

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

axin 2

susceptibility
disease_progression

DNA:SNP:cds:p.P50S(human)
DNA:SNPs::1712 +19 G>A,148 C>T(human)

RGD

PMID:16820935 PMID:30346805

RGD:151356657, RGD:151356655

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

alpha-2-glycoprotein 1, zinc-binding

mRNA,protein:increased expression:lung

RGD

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

beta-2 microglobulin

ClinVar Annotator: match by term: Adenocarcinoma of lung

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

Brca1 associated protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

basic helix-loop-helix family, member e41

mRNA:decreased expression:lung (human)

RGD

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

baculoviral IAP repeat-containing 3

exacerbates

mRNA:increased expression:B cell (human)

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

ameliorates
disease_progression

mRNA:increased expression:lung (human)

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

B-Raf proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

Bruton tyrosine kinase

exacerbates
susceptibility

mRNA:decreased expression:lung (human)

PMID:31803536 PMID:32351880

RGD:151347849, RGD:151347848

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

basic leucine zipper and W2 domains 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628

G

cell adhesion molecule 1

DNA, mRNA:hypermethylation, decreased expression:promoter:liver

RGD

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

calreticulin

treatment

human cells and recombinant gene in a mouse model

RGD

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

capping actin protein, gelsolin like

CTD Direct Evidence: marker/mechanism

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

chromobox 5

disease_progression

mRNA,protein:increased expression:lung:

RGD

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

chromobox 7

mRNA,DNA:decreased expression, loss of heterozygosity:lung:

RGD

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

cyclin D1

disease_progression
treatment

RGD

PMID:26681199 PMID:19355812

RGD:11536846, RGD:13434927

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

disease_progression

RGD

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

chaperonin containing TCP1 subunit 5

CTD Direct Evidence: marker/mechanism

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD163 molecule

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD44 molecule

disease_progression

mRNA:splice variants:lung
mRNA:increased expression:lung (human)

RGD

PMID:18091389 PMID:29537891

RGD:2289345, RGD:149735539

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 73

exacerbates

mRNA:decreased expression:lung (human)

RGD

NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656

G

cadherin 1

DNA:increased methylation

RGD

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 12

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
Ensembl chr10:83,201,211...83,280,888

G

cyclin-dependent kinase 4

protein:increased expression:lung
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:5377176 PMID:7652577 PMID:8528263 PMID:8968104 PMID:9228064 More...

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

protein:increased expression:lung

RGD

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:7780957 PMID:8521414 PMID:9324288 PMID:10491434 PMID:16234564 More...

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

chromodomain helicase DNA binding protein 4

susceptibility
ameliorates

mRNA:increased expression:lung (human)
DNA:missense mutation:CDS:p.D140E (rs7479004) (human)
human cells in a mouse model

PMID:28486105 PMID:29667179 PMID:32228507

RGD:153323299, RGD:151660359, RGD:153323307

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

cholinergic receptor nicotinic alpha 3 subunit

susceptibility

mRNA,protein:decreased expression:lung
associated with smoking; DNA:SNP: :rs1051730(human)
DNA:SNP: :rs8042374(human)
protein:increased expression:lung
DNA:SNPs:multiples:multiples (human)
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:27993330 PMID:19223495 PMID:20554942 PMID:24686516 PMID:24686516 More...

RGD:150524354, RGD:150527848, RGD:151347530, RGD:151347530, RGD:151347535

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 5 subunit

disease_progression
susceptibility

DNA:SNP:cds: p.D398N (rs1696996)(human)
ClinVar Annotator: match by term: Lung adenocarcinoma
mRNA:increased expression:lung
DNA:SNP:cds: p.D398N(human)
associated with smoking; DNA:SNPs: :rs2036527, rs684513, rs667282(human)
DNA:SNP: :rs503464(human)

PMID:27993330 PMID:19223495 PMID:23430818 PMID:19577767 PMID:20554942 More...

RGD:150524354, RGD:150524356, RGD:150524359, RGD:150527848, RGD:150527849, RGD:150527851

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic beta 4 subunit

mRNA:increased expression:lung
DNA:hypomethylation:promoter:

RGD

PMID:20124469 PMID:22945651

RGD:150527851, RGD:151361154

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

CLPTM1-like

susceptibility
no_association
ameliorates

CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs401681(human)
DNA:SNP::rs77518573(human)
DNA:SNP:: rs4975616(human)
DNA:SNP::rs401681(human)
DNA:SNP:: rs31490(human)
mRNA:increased expression:lung

CTD
RGD

PMID:22675468 PMID:24386361 PMID:31935503 PMID:19955392 PMID:24861918 More...

RGD:150537098, RGD:150530635, RGD:150530502, RGD:150530499, RGD:150530498, RGD:150530485, RGD:150530483, RGD:150530483

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

cap methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,190,718...38,197,549
Ensembl chr19:38,190,642...38,197,804

G

collagen type X alpha 1 chain

disease_progression

mRNA:increased expression:lung

PMID:33324550 PMID:33324550

RGD:150429752, RGD:150429752

NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494

G

CREB binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

colony stimulating factor 1 receptor

protein:increased expression:lung (human)

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cysteine and glycine rich protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

catenin beta 1

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 More...

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine receptor 4

exacerbates

protein:increased expression:lung (human)
mRNA:increased expression:lung (human)

RGD

PMID:30103827 PMID:19716197

RGD:152023735, RGD:152177480

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily b, polypeptide 1

protein:increased expression:lung (human)

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

ameliorates

DNA:hypomethylation:promoter (human)
mRNA:decreased expression:lung (human)
human cell line in a mouse model

RGD

PMID:24736069 PMID:25519225 PMID:27793774

RGD:151361181, RGD:151665499, RGD:151665173

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily a, polypeptide 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

discoidin domain receptor tyrosine kinase 2

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:26206333 PMID:27993330

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

delta like canonical Notch ligand 4

treatment

RGD

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

DNA methyltransferase 3 alpha

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:21067377 PMID:21518476 PMID:22160010 PMID:22722925 PMID:22744846 More...

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

susceptibility

DNA:SNPs,haplotype:promoter:-283T >C,-579G>T(human)

RGD

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

docking protein 1

disease_progression

RGD

NCBI chr 4:115,537,453...115,540,464
Ensembl chr 4:115,537,462...115,540,465

G

docking protein 2

disease_progression
exacerbates

mRNA:decreased expression:lung (human)

PMID:20139980 PMID:30475228 PMID:20139980 PMID:24255704

RGD:152177521, RGD:152177492, RGD:152177521, RGD:152177493

NCBI chr15:45,826,984...45,841,409
Ensembl chr15:45,827,398...45,841,402

G

docking protein 3

disease_progression

RGD

NCBI chr17:9,109,633...9,115,188
Ensembl chr17:9,109,597...9,115,188

G

DOT1 like histone lysine methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475

G

E2F transcription factor 1

mRNA:increased expression:lung

RGD

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

RGD

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

eukaryotic translation elongation factor 2

exacerbates

protein:increased expression:lung (human)

RGD

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

eukaryotic elongation factor-2 kinase

ameliorates

Human cells in mouse model

RGD

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

epidermal growth factor

DNA:polymorphism: :p.A61G (human)

RGD

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

disease_progression

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic | ClinVar Annotator: match by term: Lung adenocarcinoma

CTD
ClinVar
RGD

PMID:2302402 PMID:11423618 PMID:15118073 PMID:15118125 PMID:15272417 More...

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

euchromatic histone lysine methyltransferase 2

disease_progression

RGD

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 2B subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601

G

eukaryotic translation initiation factor 2B subunit delta

CTD Direct Evidence: marker/mechanism

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 2B subunit epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419

G

eukaryotic translation initiation factor 3 subunit E

CTD Direct Evidence: marker/mechanism

NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096

G

EMAP like 4

CTD Direct Evidence: marker/mechanism

PMID:22980554 PMID:22999080

NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879

G

empty spiracles homeobox 2

exacerbates

mRNA,protein:decreased expression:lung (human)

RGD

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

enolase 1

CTD Direct Evidence: marker/mechanism

PMID:19381893 PMID:27602772

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

E1A binding protein p300

CTD Direct Evidence: marker/mechanism

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

EPH receptor A5

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317

G

erb-b2 receptor tyrosine kinase 2

disease_progression

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:15457249 PMID:15753357 PMID:16638863 PMID:18334834 PMID:22325357 More...

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

disease_progression

RGD

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

erb-b2 receptor tyrosine kinase 4

disease_progression

RGD

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ERCC excision repair 1, endonuclease non-catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 6, chromatin remodeling factor

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

exacerbates

mRNA:increased expression:lung (human)

RGD

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

ERGIC and golgi 3

ameliorates
disease_progression

mRNA,protein:increased expression:lung (human)

RGD

PMID:27588471 PMID:23374247

RGD:153323314, RGD:151708716

NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813

G

endoplasmic reticulum protein 29

CTD Direct Evidence: marker/mechanism

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

establishment of sister chromatid cohesion N-acetyltransferase 2

ameliorates

RGD

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

disease_progression

RGD

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

Fas cell surface death receptor

mRNA:decreased expression:lung (human)

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

CTD Direct Evidence: marker/mechanism

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillarin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Adenocarcinoma of lung

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

FES proto-oncogene, tyrosine kinase

treatment

human cells in a mouse model

RGD

NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934

G

fibroblast growth factor 10

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 18

mRNA:decreased expression:lung (human)

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 9

disease_progression

protein:increased expression:lung (human)
mRNA:decreased expression:lung (human)

PMID:19296538 PMID:19358281 PMID:20464547

RGD:150429981 RGD:152177688, RGD:152975620

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:17525745 PMID:18552176 PMID:22238366 PMID:23002168 PMID:23908597 More...

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:1908846 PMID:7773297 PMID:8640234 PMID:8858131 PMID:9438390 More...

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

disease_progression
exacerbates

DNA:SNP:exon 9: p.G288R (human)
DNA:SNP:exon 9: p.G388R (rs351855)(human)
human cells in mouse model

RGD

PMID:16061909 PMID:19296538 PMID:29402970

RGD:150429976, RGD:150429981, RGD:150429984

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

FKBP prolyl isomerase 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

Fms related receptor tyrosine kinase 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

forkhead box A1

mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:34254728 PMID:12234996 PMID:29072684

RGD:151665758, RGD:151665822

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box O3

CTD Direct Evidence: marker/mechanism

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P1

mRNA:decreased expression:lung (rat)

RGD

NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258

G

forkhead box P2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

forkhead box P4

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879

G

formyl peptide receptor 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019

G

frizzled-related protein

severity

mRNA:decreased expression:lung (human)

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

far upstream element binding protein 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

glyceraldehyde-3-phosphate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GAR1 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125

G

gap junction protein, beta 2

DNA, mRNA:hypermethylation, decreased expression:lung

RGD

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

GNAS complex locus

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 More...

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit gamma 11

CTD Direct Evidence: marker/mechanism

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

glucosamine-phosphate N-acetyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:18,596,180...18,608,854
Ensembl chr15:18,596,442...18,608,739

G

golgi membrane protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057

G

glucose-6-phosphate isomerase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutathione peroxidase 3

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutamate-rich WD repeat containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201

G

H1.10 linker histone

CTD Direct Evidence: marker/mechanism

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

helicase, lymphoid specific

CTD Direct Evidence: marker/mechanism

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

hexokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 2

CTD Direct Evidence: marker/mechanism

PMID:24366584 PMID:27602772

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

heterogeneous nuclear ribonucleoprotein A1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

homeo box B7

severity

protein:increased expression:lung epithelium (human)

RGD

NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034

G

HRas proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid (17-beta) dehydrogenase 10

CTD Direct Evidence: marker/mechanism

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

heat shock protein 90 beta family member 1

mRNA:increased expression:lung (human)

RGD

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family B (small) member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

5-hydroxytryptamine receptor 4

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321

G

HtrA serine peptidase 1

disease_progression

human cells in mouse model

RGD

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

isocitrate dehydrogenase (NADP(+)) 1

disease_progression

mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Adenocarcinoma of lung
protein:increased expression:blood plasma (human)

PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More...

RGD:149735539, RGD:149735540

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NADP(+)) 2

severity

protein:increased expression:lung (human)
protein:increased expression:blood serum (human)

RGD

PMID:30128035 PMID:29465809

RGD:149735564, RGD:149735567

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

insulin-like growth factor 2 receptor

mRNA:deletions: :c.3698_4902del, c.3366_4902del, c.3817_4697del (rat)

RGD

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

IKAROS family zinc finger 1

exacerbates
ameliorates

protein:increased expression:lung (human)
mRNA:increased expression:lung (human)

PMID:33738286 PMID:32787735

RGD:151347632, RGD:150540324

NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416

G

interleukin 1 receptor type 2

disease_progression
severity

mRNA:altered expression:lung (human)
mRNA:increased expression:lung (human)

RGD

PMID:31921619 PMID:29942094

RGD:152998982, RGD:152998998

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

inosine monophosphate dehydrogenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

importin 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285

G

importin 5

CTD Direct Evidence: marker/mechanism

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

IQ motif and Sec7 domain ArfGEF 1

disease_progression

RGD

NCBI chr 4:123,168,719...123,488,300
Ensembl chr 4:123,168,719...123,488,172

G

interleukin-1 receptor-associated kinase 3

mRNA:increased expression:lung (human)

NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121

G

iron responsive element binding protein 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

G

Janus kinase 2

treatment

human cells in mouse model

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

JunB proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium inwardly-rectifying channel, subfamily J, member 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151

G

KLF transcription factor 5

CTD Direct Evidence: marker/mechanism

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

lysine methyltransferase 2C

disease_progression
onset

RGD

PMID:32867667 PMID:30821106

RGD:151356760, RGD:151356761

NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539

G

karyopherin subunit alpha 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

KRAS proto-oncogene, GTPase

DNA:point mutation:CDS:p.G12C (human)
ClinVar Annotator: match by term: Adenocarcinoma of lung
CTD Direct Evidence: marker/mechanism

ClinVar
CTD
RGD

PMID:2278970 PMID:3122217 PMID:6320174 PMID:8143615 PMID:8425762 More...

NCBI chr 4:178,185,418...178,218,484

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leukocyte cell-derived chemotaxin 2

ameliorates

human cells in mouse model

RGD

NCBI chr17:8,044,759...8,050,983
Ensembl chr17:8,044,759...8,050,983

G

lamin A/C

CTD Direct Evidence: marker/mechanism

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

CTD Direct Evidence: marker/mechanism

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

LDL receptor related protein 1B

disease_progression

DNA:mutations:multiple: (human)

RGD

NCBI chr 3:24,594,302...26,715,037
Ensembl chr 3:24,594,991...26,715,505

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

mitogen activated protein kinase kinase 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma
mRNA:increased expression:lung (human)

CTD
ClinVar
RGD

PMID:18632602 PMID:21383288 PMID:22135231 PMID:22197931 PMID:22588879 More...

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 4

severity

RGD

PMID:21896780 PMID:12231543

RGD:150429783, RGD:150429821

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase kinase 7

exacerbates

human gene in a mouse model

RGD

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 8

exacerbates

RGD

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen-activated protein kinase kinase kinase kinase 4

ameliorates
exacerbates

human cell line in a mouse model
mRNA, protein:increased expression:lung (human)

PMID:22824148 PMID:28306189 PMID:33510968

RGD:151347677, RGD:151347678, RGD:151347681

NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698

G

mitogen activated protein kinase 14

exacerbates

mRNA:increased expression:lung (human)

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

MCL1 apoptosis regulator, BCL2 family member

severity
treatment

mRNA:increased expression:lung (human)
human cells in mouse model

RGD

PMID:31200834 PMID:31200834

RGD:151356911, RGD:151356911

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

mesenchyme homeobox 1

CTD Direct Evidence: therapeutic

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

microRNA 127

treatment

Human cells in mouse model

RGD

NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311

G

microRNA 154

associated with nicotine dependence; RNA:decreased expression:blood serum (human)

RGD

NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030

G

microRNA 20a

RGD

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

G

microRNA 21

disease_progression

RNA:increased expression:lung (human)
miRNA:increased expression:sputum (human)

RGD

PMID:29892003 PMID:27777637

RGD:152998892, RGD:152998954

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 31

severity
disease_progression

RNA:increased expression:lung (human)

RGD

PMID:26657862 PMID:29367106 PMID:23946296 PMID:27215092

RGD:11343268, RGD:152998945, RGD:152998944, RGD:11250998

NCBI chr 5:103,599,038...103,599,143

G

marker of proliferation Ki-67

disease_progression

protein:altered expression:lung (human)

RGD

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:15340264 PMID:17510385 PMID:18307539 PMID:19419416 PMID:22136435 More...

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

MRE11 homolog, double strand break repair nuclease

CTD Direct Evidence: marker/mechanism

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

mitochondrial ribosomal protein L12

CTD Direct Evidence: marker/mechanism

NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913

G

mitochondrial ribosomal protein S5

CTD Direct Evidence: marker/mechanism

NCBI chr 3:114,821,046...114,837,291
Ensembl chr 3:114,821,046...114,837,291

G

membrane spanning 4-domains A1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512

G

mutS homolog 2

no_association

DNA:polymorphisms:introns:IVS10+12A>G, IVS12-6T>C (human)
DNA:polymorphisms:promoter, intron:-118T>C, IVS1+9G>C (human)

RGD

PMID:16614121 PMID:16614121

RGD:11065547, RGD:11065547

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:23,444,326...23,585,777

G

mutS homolog 6

CTD Direct Evidence: marker/mechanism

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

mucin 1, cell surface associated

mRNA:increased expression:lung

RGD

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 4, cell surface associated

disease_progression

protein:increased expression:trachea

RGD

NCBI chr11:68,008,245...68,053,242

G

mucin 5AC, oligomeric mucus/gel-forming

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

human cell line in mouse model
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

CTD
ClinVar
RGD

PMID:25157968 PMID:26619011 PMID:26656844 PMID:27602772 PMID:20033209

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

treatment
ameliorates

mouse cell line in a mouse model

RGD

PMID:32140881 PMID:30712876

RGD:150520172, RGD:150540309

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252

G

NLR family, apoptosis inhibitory protein 6

ameliorates

mRNA:increased expression:lung (human)

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

non-SMC condensin I complex, subunit G

CTD Direct Evidence: marker/mechanism

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

nucleolin

CTD Direct Evidence: marker/mechanism

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

NFE2 like bZIP transcription factor 2

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:26619011 PMID:29018201

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NK2 homeobox 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791

G

NLR family, pyrin domain containing 3

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NOP56 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

NOP58 ribonucleoprotein

CTD Direct Evidence: marker/mechanism

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

notch receptor 1

treatment

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

nucleophosmin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645

G

nucleophosmin/nucleoplasmin, 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

nudix hydrolase 21

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682

G

NUF2 component of NDC80 kinetochore complex

disease_progression

RGD

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

8-oxoguanine DNA glycosylase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

poly(A) binding protein, cytoplasmic 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979

G

parkin coregulated

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:49,882,671...50,305,564
Ensembl chr 1:49,882,630...50,305,430

G

pterin-4 alpha-carbinolamine dehydratase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292

G

phosphatidylinositol glycan anchor biosynthesis, class N

CTD Direct Evidence: marker/mechanism

NCBI chr13:21,659,092...21,812,932
Ensembl chr13:21,662,455...21,806,790

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

mRNA:decreased expression:lung

RGD

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

paired-like homeodomain 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293

G

phospholipase C, gamma 1

exacerbates

protein:decreased expression:lung (human)

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

disease_progression

RGD

NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255

G

DNA polymerase delta 1, catalytic subunit

exacerbates

protein:increased expression:lung (human)

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

RNA polymerase I and III subunit D

CTD Direct Evidence: marker/mechanism

NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624

G

peter pan homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938

G

protein phosphatase 2 scaffold subunit A alpha

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:25741868 PMID:26168268 PMID:26619011 PMID:28492532 PMID:31687265 More...

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 3 catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

PRAME like, X-linked 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr X:98,567,994...98,574,654
Ensembl chr X:98,569,415...98,572,096

G

PR/SET domain 1

exacerbates

RGD

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

parkin RBR E3 ubiquitin protein ligase

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

phosphoserine aminotransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

patched 1

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:27993330 PMID:28492532 PMID:33359005

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: Adenocarcinoma of lung

PMID:26619011 PMID:26822237

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 13

exacerbates
susceptibility

mRNA,protein:decreased expression:lung
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)

RGD

PMID:22245727 PMID:33536603 PMID:19672627

RGD:152176663, RGD:152975626, RGD:152176665

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

protein tyrosine phosphatase, receptor type, B

disease_progression

mRNA:altered expression:lung (human)
mRNA:decreased expression:lung (human)

RGD

PMID:29254206 PMID:7981622

RGD:151665107, RGD:151665112

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

protein tyrosine phosphatase, receptor type, J

susceptibility

DNA:missense mutations:cds:p.R326Q, p.Q276P (human)

RGD

NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260

G

Rac family small GTPase 1

exacerbates
ameliorates

mRNA:increased expression:lung (human)

PMID:31779616 PMID:32366477

RGD:152998910, RGD:153345550

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Raf-1 proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:1760348 PMID:8601312 PMID:10064593 PMID:12077328 PMID:17603482 More...

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAN guanine nucleotide release factor

CTD Direct Evidence: marker/mechanism

NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840

G

retinoic acid receptor, beta

DNA:hypomethylation:lung

RGD

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RAS p21 protein activator 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif protein 10

mRNA, protein:decreased expression:lung
DNA:missense mutations, protein-truncating variants: :multiple

RGD

PMID:29085465 PMID:22980975 PMID:30955253

RGD:151356983, RGD:11097386, RGD:151356984

NCBI chr X:1,540,399...1,572,571
Ensembl chr X:1,540,398...1,572,575

G

RNA terminal phosphate cyclase-like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

replication factor C subunit 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

ras homolog family member A

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Ras and Rab interactor 3

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 6:121,431,776...121,540,956
Ensembl chr 6:121,431,339...121,540,957

G

ribonuclease H2, subunit A

CTD Direct Evidence: marker/mechanism

NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041

G

ring finger protein 43

severity

human cells in a mouse model

RGD

NCBI chr10:72,461,508...72,537,301
Ensembl chr10:72,464,348...72,536,977

G

ROS proto-oncogene 1 , receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:22215748 PMID:23724914 PMID:27993330

NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865

G

ribosomal protein L10A

CTD Direct Evidence: marker/mechanism

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357

G

ribosomal protein L13A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463

G

ribosomal protein L27A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:163,539,732...163,542,771

G

ribosomal protein L36A

CTD Direct Evidence: marker/mechanism

NCBI chr X:97,766,179...97,768,892
Ensembl chr X:97,766,179...97,768,892

G

ribosomal protein SA

CTD Direct Evidence: marker/mechanism

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase catalytic subunit M1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

ribosome biogenesis regulator 1 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140

G

RUNX family transcription factor 1

RGD

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

SATB homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

syndecan 1

mRNA:increased expression:lung (human)

RGD

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

protein:increased expression:cytoplasm

RGD

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

SET domain containing 2, histone lysine methyltransferase

ameliorates
exacerbates
severity

human cells and genes in mouse model
DNA:mutations:multiple (human)

RGD

PMID:33223508 PMID:27687306 PMID:33707235 PMID:28202515

RGD:150429633, RGD:150429649, RGD:150429648, RGD:126848875

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

stratifin

CTD Direct Evidence: marker/mechanism

NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314

G

surfactant protein C

CTD Direct Evidence: marker/mechanism

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

sideroflexin 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

serine hydroxymethyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820

G

solute carrier family 15 member 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 1 member 5

disease_progression

RGD

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22, member 18

disease_progression

mRNA:increased expression:lung (human)
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:27993330 PMID:32726996

NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975

G

solute carrier family 3 member 2

disease_progression

RGD

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 4 member 4

CTD Direct Evidence: marker/mechanism

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 4 member 7

CTD Direct Evidence: marker/mechanism

NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781

G

solute carrier family 7 member 5

disease_progression

RGD

PMID:26279756 PMID:19171406

RGD:151361150, RGD:151361151

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

SMAD family member 4

ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:6604412 PMID:8898652 PMID:9214508 PMID:9285566 PMID:9582123 More...

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

small nucleolar RNA, C/D box 22

CTD Direct Evidence: marker/mechanism

NCBI chr11:9,097,799...9,097,923
Ensembl chr11:9,097,799...9,097,923

G

small nuclear ribonucleoprotein polypeptides B and B1

severity

mRNA:increased expression:lung (human)

RGD

NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339

G

small nuclear ribonucleoprotein polypeptide E

severity

mRNA:increased expression:lung (human)

RGD

NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310

G

small nuclear ribonucleoprotein polypeptide G

CTD Direct Evidence: marker/mechanism

NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SOS Ras/Rac guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:25741868 PMID:26619011 PMID:27158780

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SRY-box transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

SRY-box transcription factor 30

disease_progression

RGD

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRY-box transcription factor 4

protein:increased expression:lung

RGD

NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665

G

speckle type BTB/POZ protein

ameliorates

human gene and cell line in mouse model
mRNA, protein:increased expression:lung (human)

RGD

PMID:30607139 PMID:31105033

RGD:153298920, RGD:153298927

NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955

G

SRC proto-oncogene, non-receptor tyrosine kinase

severity

RGD

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

spermidine synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

serine racemase

CTD Direct Evidence: marker/mechanism

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

serine and arginine rich splicing factor 1

severity

RGD

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 2

severity

RGD

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine/threonine kinase 11

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:10408777 PMID:12865922 PMID:15561763 PMID:15863673 PMID:16287113 More...

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

serine threonine kinase 39

CTD Direct Evidence: marker/mechanism

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

G

spermatid perinuclear RNA binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

succinate-CoA ligase GDP-forming subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

sulfotransferase family 1A member 1

DNA:SNP:exon:p.R213H, 638G>A (human)

RGD

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

telomerase reverse transcriptase

susceptibility

DNA:SNP: :rs2736098(human)
DNA:SNP::rs33963617(human)
DNA:SNP:: rs2736100(human)
DNA:SNPs:: rs2853669,rs2736108(human)

RGD

PMID:23738012 PMID:31935503 PMID:24761905 PMID:19955392 PMID:23908149

RGD:150530485, RGD:150530635, RGD:150530628, RGD:150530502, RGD:150530498

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 2

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

translocase of inner mitochondrial membrane 10

CTD Direct Evidence: marker/mechanism

NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940

G

translocase of inner mitochondrial membrane 8A1

CTD Direct Evidence: marker/mechanism

NCBI chr X:97,717,932...97,722,170
Ensembl chr X:97,717,920...97,721,960

G

TIMP metallopeptidase inhibitor 3

mRNA:decreased expression:lung (human)

RGD

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

thymidine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

toll-like receptor 4

ClinVar Annotator: match by term: Lung adenocarcinoma

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

translocase of outer mitochondrial membrane 40

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Adenocarcinoma of lung | ClinVar Annotator: match by term: Adenocarcinoma of lung, somatic | ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:124622 PMID:253702 PMID:960674 PMID:1349175 PMID:1359493 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p63

CTD Direct Evidence: marker/mechanism

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

triosephosphate isomerase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

Tnf receptor associated factor 4

mRNA:increased expression:lung (human)

RGD

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

transcription termination factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

transthyretin

mRNA,protein:increased expression:lung (human)

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

thymidylate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

U2 small nuclear RNA auxiliary factor 1

ClinVar Annotator: match by term: Lung adenocarcinoma

PMID:22158538 PMID:23029227 PMID:23861105 PMID:24498085 PMID:26619011

NCBI chr20:9,742,904...9,753,840
Ensembl chr20:9,742,905...9,753,832

G

ubiquitin protein ligase E3 component n-recognin 5

ameliorates

human cell line in a mouse model

RGD

NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903

G

uridine-cytidine kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

vav guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937

G

WD repeat containing, antisense to TP53

severity

RGD

NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929

G

XPC complex subunit, DNA damage recognition and repair factor

CTD Direct Evidence: marker/mechanism

PMID:21327329 PMID:27777383

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

exportin 1

exacerbates

circRNA:increased expression:lung (human)

RGD

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

X-ray repair cross complementing 1

susceptibility
severity

DNA:missense mutation:cds: p.R399Q (human)
DNA:missense mutation:exon 10: p.R399Q (rs25487) (human)

RGD

PMID:11104903 PMID:20003463

RGD:151347406, RGD:151347422

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

X-ray repair cross complementing 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762

G

zinc finger homeobox 3

ameliorates

DNA:mutations:multiple (human)

RGD

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

lung large cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho GTPase activating protein 44

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

cholinergic receptor nicotinic alpha 5 subunit

mRNA:increased expression:lung

RGD

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

delta like canonical Notch ligand 4

treatment

RGD

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

notch receptor 1

treatment

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

protein tyrosine phosphatase, non-receptor type 13

mRNA,protein:decreased expression:lung

RGD

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

transthyretin

protein:increased expression:lung (human)

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

lung non-squamous non-small cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

death-domain associated protein

exacerbates

protein:decreased expression:lung (human)

RGD

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

G

TRAF2 and NCK interacting kinase

ameliorates

mRNA,protein:increased expression:lung (human)

NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750

lung squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

ClinVar Annotator: match by term: Squamous cell carcinoma of lung

PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

ALK receptor tyrosine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:24033266 PMID:24728327 PMID:25741868 PMID:28492532

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

Rho GTPase activating protein 44

mRNA:decreased expression:lung (human)

RGD

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

AT-rich interaction domain 1A

exacerbates

protein:decreased expression:lung (human)

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

actin related protein 2/3 complex, subunit 5

mRNA:increased expression:lung (human)

RGD

NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410

G

ATM serine/threonine kinase

susceptibility

DNA:SNP:intron:(rs228589) (human)

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATRX, chromatin remodeler

severity

RGD

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

beta-2 microglobulin

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

baculoviral IAP repeat-containing 5

disease_progression

mRNA:increased expression:lung (human)

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

baculoviral IAP repeat-containing 6

disease_progression

mRNA:increased expression:lung (human)

NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:12068308 PMID:12460918 PMID:12460919 PMID:12960123 PMID:14612909 More...

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

basigin (Ok blood group)

mRNA:increased expression:lung

RGD

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

Cbl proto-oncogene B

disease_progression

RGD

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

cyclin D1

disease_progression

protein:increased expression:lung

RGD

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

DNA:hypermethylation:promoter

RGD

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin-dependent kinase 4

protein:increased expression:lung

RGD

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 2A

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:7777061 PMID:8552400 PMID:8573142 PMID:8595405 PMID:8668202 More...

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

chromodomain helicase DNA binding protein 4

mRNA:increased expression:lung (human)

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

cholinergic receptor nicotinic alpha 5 subunit

susceptibility

DNA:SNP: :rs503464(human)
mRNA:increased expression:lung

RGD

PMID:23314339 PMID:20124469

RGD:150527849, RGD:150527851

NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146

G

cholinergic receptor nicotinic beta 4 subunit

susceptibility

mRNA:increased expression:lung
DNA:hypomethylation:promoter:
DNA:SNP:: (rs7178270) (human)

RGD

PMID:20124469 PMID:22945651 PMID:23397474

RGD:150527851, RGD:151361154, RGD:151361148

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

CLPTM1-like

susceptibility
no_association

mRNA:increased expression:lung
DNA:SNP: :rs401681(human)
DNA:SNP::rs401681(human)
DNA:SNP:: rs31490(human)

RGD

PMID:24366883 PMID:24386361 PMID:24861918 PMID:23908149

RGD:150530483, RGD:150537098, RGD:150530499, RGD:150530498

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

CREB binding protein

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

colony stimulating factor 1 receptor

protein:increased expression:lung (human)

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

catenin beta 1

disease_progression

protein:increased expression:lung

RGD

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome c, somatic

treatment

RGD

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily b, polypeptide 1

susceptibility

Carcinoma, Squamous Cell;DNA:snp:cds:p.A119S (human)

RGD

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

discoidin domain receptor tyrosine kinase 2

severity

ClinVar Annotator: match by term: Squamous cell lung carcinoma
mRNA:increased expression:lung

PMID:22328973 PMID:25741868 PMID:26206333 PMID:28492532 PMID:24885564 More...

RGD:150429702, RGD:150429703

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

E2F transcription factor 1

treatment

RGD

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

RGD

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

eukaryotic translation elongation factor 2

disease_progression

protein:increased expression:lung (human)

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor receptor

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:15118073 PMID:15118125 PMID:15329413 PMID:15623594 PMID:15897572 More...

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

empty spiracles homeobox 2

exacerbates

protein:decreased expression:lung (human)

RGD

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

E1A binding protein p300

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

Eph receptor A2

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:20360610 PMID:25741868 PMID:28492532

NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117

G

ERCC excision repair 6, chromatin remodeling factor

mRNA, protein:increased expression:lung (human)

RGD

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

mRNA:increased expression:lung (human)

RGD

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

fibroblast activation protein, alpha

disease_progression

RGD

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:25741868 PMID:26619011

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

fibroblast growth factor 9

mRNA:decreased expression:lung (human)

RGD

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:9150725 PMID:23786770 PMID:25741868

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:1908846 PMID:7773297 PMID:8589699 PMID:8640234 PMID:8858131 More...

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

disease_progression

human cells in mouse model

RGD

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

frizzled-related protein

protein:decreased expression:lung (human)

RGD

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

far upstream element binding protein 1

mRNA:decreased expression:lung (human)

RGD

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

glutathione peroxidase 1

susceptibility

DNA:missense mutation:CDS:p.P198L (rs1050450) (human)
DNA:missense mutation:CDS:p.P200L (rs1050450) (human)

RGD

PMID:16797832 PMID:18298806

RGD:152995481, RGD:152995507

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:1904555 PMID:3510078 PMID:12835555 PMID:16329078 PMID:16372351 More...

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

isocitrate dehydrogenase (NADP(+)) 1

protein:increased expression:blood plasma (human)

RGD

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NADP(+)) 2

severity
susceptibility

protein:increased expression:lung (human)
protein:increased expression:blood serum (human)
DNA:SNP:CD: (rs11540478) C>T (human)

RGD

PMID:30128035 PMID:29465809 PMID:27649069

RGD:149735564, RGD:149735567, RGD:149735566

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

KIT proto-oncogene receptor tyrosine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lysine methyltransferase 2D

disease_progression

RGD

PMID:24323028 PMID:30885352 PMID:28177435

RGD:150523770, RGD:150523777, RGD:150523776

NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:2278970 PMID:3122217 PMID:6695174 PMID:12460918 PMID:15696205 More...

NCBI chr 4:178,185,418...178,218,484

G

laminin subunit gamma 2

disease_progression

RGD

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:1904555 PMID:3510078 PMID:12835555 PMID:16329078 PMID:16372351 More...

NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172

G

mitogen activated protein kinase kinase 1

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 7

mRNA:decreased expression:lung (human)

RGD

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mediator complex subunit 12

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr X:66,404,807...66,427,775
Ensembl chr X:66,404,760...66,428,387

G

MET proto-oncogene, receptor tyrosine kinase

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microRNA 154

associated with nicotine dependence; RNA:decreased expression:blood serum (human)

RGD

NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030

G

microRNA 193a

exacerbates

DNA:Hypermethylation

RGD

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 20a

RGD

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

G

microRNA 210

miRNA:increased expression:sputum (human)

RGD

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

microRNA 31

severity

RNA:increased expression:blood serum (human)
RNA:increased expression:lung (human)

RGD

PMID:21658006 PMID:21890451

RGD:152998938, RGD:152998950

NCBI chr 5:103,599,038...103,599,143

G

microRNA 497

RGD

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

microRNA 9-3

exacerbates

DNA:Hypermethylation

RGD

NCBI chr 1:133,440,049...133,440,138

G

NFE2 like bZIP transcription factor 2

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:26619011 PMID:29018201

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

platelet derived growth factor receptor alpha

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

DNA polymerase epsilon, catalytic subunit

ameliorates

DNA:mutations:multiple (human)

RGD

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

G

protein phosphatase 6, catalytic subunit

ClinVar Annotator: match by term: Squamous cell lung carcinoma

NCBI chr 3:22,929,816...22,962,123
Ensembl chr 3:22,931,577...22,962,113

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

mRNA:increased expression:lung (human)

RGD

NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068

G

patched 1

disease_progression

DNA:CNVs

RGD

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:1945792 PMID:9467011 PMID:9915974 PMID:10866302 PMID:11051241 More...

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

protein tyrosine kinase 2

severity

RGD

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 11

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:11704759 PMID:12634870 PMID:12717436 PMID:14644997 PMID:14974085 More...

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 13

susceptibility
severity

mRNA,protein:decreased expression:lung
DNA:missense mutations:cds:p.I1522M, p.Y2081D (human)

RGD

PMID:22245727 PMID:19672627 PMID:23906871

RGD:152176663, RGD:152176665, RGD:152176664

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

protein tyrosine phosphatase, receptor type, J

susceptibility

DNA:missense mutations:cds:p.R326Q, p.Q276P (human)

RGD

NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260

G

RAD52 homolog, DNA repair protein

ameliorates
susceptibility

DNA:SNP: (rs6489769) (human)

RGD

PMID:28415565 PMID:22585858

RGD:151660334, RGD:151660345

NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207

G

surfactant protein B

susceptibility

DNA:polymorphism:intron (human)
DNA:variants:intron:

RGD

PMID:16570259 PMID:12107845

RGD:4143389, RGD:151667424

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

solute carrier family 7 member 5

RGD

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

SRY-box transcription factor 30

disease_progression

RGD

NCBI chr10:30,417,499...30,446,441
Ensembl chr10:30,418,473...30,446,453

G

SRC proto-oncogene, non-receptor tyrosine kinase

severity

RGD

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

serine and arginine rich splicing factor 1

protein:increased expression:lung epithelium

RGD

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 2

protein:increased expression:lung epithelium,nucleus

RGD

NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:15800014 PMID:17676035 PMID:19892943 PMID:25741868 PMID:28492532

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

sulfotransferase family 1A member 1

DNA:SNP:exon:p.R213H, 638G>A (human)

RGD

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

telomerase reverse transcriptase

susceptibility

DNA:SNP:: rs2853669(human)
DNA:SNP::rs33963617(human)

RGD

PMID:23908149 PMID:31935503

RGD:150530498, RGD:150530635

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tumor protein p53

ClinVar Annotator: match by term: Squamous cell lung carcinoma
ClinVar Annotator: match by term: Squamous cell carcinoma of lung | ClinVar Annotator: match by term: Squamous cell lung carcinoma

PMID:124622 PMID:960674 PMID:1349175 PMID:1359493 PMID:1565143 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p73

treatment

DNA:SNP:: rs2273953(human)
mRNA:increased expression:lung (human)

PMID:30420492 PMID:27246533

RGD:151347580, RGD:151347584

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

Term paths to the root

Path 1
Term	Annotations
disease	18969
disease of cellular proliferation	7692
cancer	5509
cell type cancer	3760
carcinoma	3201
bronchus carcinoma	672
lung non-small cell carcinoma	635
lung adenocarcinoma +	343
lung large cell carcinoma +	7
lung non-squamous non-small cell carcinoma	2
lung squamous cell carcinoma +	88
Path 2
Term	Annotations
disease	18969
disease of anatomical entity	18249
respiratory system disease	3615
thoracic disease	2003
Thoracic Neoplasms	1473
Respiratory Tract Neoplasms	1022
respiratory system cancer	812
lung cancer	781
bronchus cancer	672
bronchus carcinoma	672
lung non-small cell carcinoma	635
lung adenocarcinoma +	343
lung large cell carcinoma +	7
lung non-squamous non-small cell carcinoma	2
lung squamous cell carcinoma +	88

paths to the root