Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2) - Rat Genome Database

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Gene: Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2) Rattus norvegicus
Analyze
Symbol: Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RGD ID: 1307865
Description: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase signaling. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DEP domain containing 2; Depdc2; LOC312912; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.257,937,692 - 8,253,112 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)Ensembl
Rnor_6.057,622,668 - 7,941,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl57,627,771 - 7,941,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0512,446,043 - 12,761,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.457,404,475 - 7,693,459 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.157,366,703 - 7,728,758 (-)NCBI
Celera57,493,673 - 7,724,174 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:15304343   PMID:18334636   PMID:21700703   PMID:24367090  


Genomics

Comparative Map Data
Prex2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.257,937,692 - 8,253,112 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)Ensembl
Rnor_6.057,622,668 - 7,941,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl57,627,771 - 7,941,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0512,446,043 - 12,761,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.457,404,475 - 7,693,459 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.157,366,703 - 7,728,758 (-)NCBI
Celera57,493,673 - 7,724,174 (-)NCBICelera
Cytogenetic Map5q11NCBI
PREX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,952,046 - 68,237,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl867,952,046 - 68,237,032 (+)EnsemblGRCh38hg38GRCh38
GRCh37868,864,281 - 69,149,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36869,027,157 - 69,306,451 (+)NCBINCBI36hg18NCBI36
Build 34869,027,156 - 69,180,208NCBI
Celera864,857,879 - 65,137,147 (+)NCBI
Cytogenetic Map8q13.2NCBI
HuRef864,357,585 - 64,636,285 (+)NCBIHuRef
CHM1_1868,920,457 - 69,199,336 (+)NCBICHM1_1
Prex2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39111,063,496 - 11,373,907 (+)NCBIGRCm39mm39
GRCm39 Ensembl111,063,689 - 11,373,905 (+)Ensembl
GRCm38110,993,273 - 11,303,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,993,465 - 11,303,681 (+)EnsemblGRCm38mm10GRCm38
MGSCv37110,983,546 - 11,293,763 (+)NCBIGRCm37mm9NCBIm37
MGSCv36111,243,254 - 11,284,089 (+)NCBImm8
MGSCv36111,320,283 - 11,360,870 (+)NCBImm8
Celera110,967,661 - 11,280,694 (+)NCBICelera
Cytogenetic Map1A2NCBI
Prex2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544411,154,318 - 11,414,075 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544411,154,318 - 11,414,680 (-)NCBIChiLan1.0ChiLan1.0
PREX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1866,150,970 - 66,434,518 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl866,215,974 - 66,430,138 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0864,489,817 - 64,769,602 (+)NCBIMhudiblu_PPA_v0panPan3
PREX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12917,458,098 - 17,738,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2917,458,281 - 17,735,170 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2917,773,929 - 18,057,994 (+)NCBI
ROS_Cfam_1.02917,543,026 - 17,827,957 (+)NCBI
ROS_Cfam_1.0 Ensembl2917,542,889 - 17,905,693 (+)Ensembl
UMICH_Zoey_3.12917,589,003 - 17,873,821 (+)NCBI
UNSW_CanFamBas_1.02917,666,595 - 17,943,382 (+)NCBI
UU_Cfam_GSD_1.02917,936,353 - 18,212,814 (+)NCBI
Prex2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530368,501,144 - 68,796,617 (+)NCBI
SpeTri2.0NW_0049364966,005,410 - 6,284,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl466,715,234 - 67,116,135 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1466,712,412 - 66,996,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2472,703,372 - 72,929,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PREX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1863,781,892 - 64,061,222 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl863,781,948 - 64,060,864 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603977,434,955 - 77,723,163 (-)NCBIVero_WHO_p1.0
Prex2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474422,941,194 - 23,208,987 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D5Rat120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.258,187,501 - 8,187,645 (+)MAPPERmRatBN7.2
Rnor_6.057,875,611 - 7,875,754NCBIRnor6.0
Rnor_5.0512,694,705 - 12,694,848UniSTSRnor5.0
Celera57,724,876 - 7,725,019UniSTS
SHRSP x BN Map52.3599UniSTS
SHRSP x BN Map52.3599RGD
Cytogenetic Map5q11UniSTS
D5Got262  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.258,208,478 - 8,208,579 (+)MAPPERmRatBN7.2
Rnor_6.057,897,065 - 7,897,163NCBIRnor6.0
Rnor_5.0512,716,827 - 12,716,925UniSTSRnor5.0
RGSC_v3.457,684,535 - 7,684,633UniSTSRGSC3.4
Celera57,745,828 - 7,745,926UniSTS
Cytogenetic Map5q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:140
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000064774
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 16 4 12 4 8 8 27 7 11 11 8
Low 3 35 39 35 7 35 2 47 28 29
Below cutoff 2 2 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064774   ⟹   ENSRNOP00000063421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,942,795 - 8,186,800 (-)Ensembl
Rnor_6.0 Ensembl57,627,771 - 7,874,909 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079917   ⟹   ENSRNOP00000075213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,950,811 - 8,253,068 (-)Ensembl
Rnor_6.0 Ensembl57,628,238 - 7,941,822 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108148   ⟹   ENSRNOP00000096523
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,950,811 - 8,186,800 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108865   ⟹   ENSRNOP00000095390
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116125   ⟹   ENSRNOP00000080155
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,942,795 - 8,252,926 (-)Ensembl
RefSeq Acc Id: NM_001107899   ⟹   NP_001101369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.257,942,795 - 8,186,800 (-)NCBI
Rnor_6.057,627,771 - 7,874,909 (-)NCBI
Rnor_5.0512,446,043 - 12,761,369 (-)NCBI
RGSC_v3.457,404,475 - 7,693,459 (-)RGD
Celera57,493,673 - 7,724,174 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237753   ⟹   XP_006237815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.257,937,692 - 8,253,112 (-)NCBI
Rnor_6.057,622,668 - 7,941,715 (-)NCBI
Rnor_5.0512,446,043 - 12,761,369 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101369 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380724 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237815 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11540 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101369   ⟸   NM_001107899
- Sequence:
RefSeq Acc Id: XP_006237815   ⟸   XM_006237753
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KA11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075213   ⟸   ENSRNOT00000079917
RefSeq Acc Id: ENSRNOP00000063421   ⟸   ENSRNOT00000064774
RefSeq Acc Id: ENSRNOP00000080155   ⟸   ENSRNOT00000116125
RefSeq Acc Id: ENSRNOP00000096523   ⟸   ENSRNOT00000108148
RefSeq Acc Id: ENSRNOP00000095390   ⟸   ENSRNOT00000108865
Protein Domains
DEP   DH   PDZ   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KA11-F1-model_v2 AlphaFold A0A0G2KA11 1-1598 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 7865498 7865499 A T snv LEXF10A/StmMcwi (2020)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 12459153 12459154 C T snv BUF/MNa (KyushuU)
5 12627234 12627235 G C snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 7594610 7594611 G C snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 8177387 8177388 A T snv LEXF10A/StmMcwi (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307865 AgrOrtholog
BioCyc Gene G2FUF-42220 BioCyc
Ensembl Genes ENSRNOG00000005391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063421 UniProtKB/TrEMBL
  ENSRNOP00000075213 UniProtKB/TrEMBL
  ENSRNOP00000095390 ENTREZGENE
Ensembl Transcript ENSRNOT00000064774 UniProtKB/TrEMBL
  ENSRNOT00000079917 UniProtKB/TrEMBL
  ENSRNOT00000108865 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rex2_DEP_1 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:312912 UniProtKB/TrEMBL
NCBI Gene 312912 ENTREZGENE
Pfam DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Prex2 PhenoGen
PROSITE DEP UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A0G2KA11 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW14_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-08-25 Prex2  phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2  Depdc2  DEP domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Depdc2  DEP domain containing 2   Depdc2_predicted  DEP domain containing 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Depdc2_predicted  DEP domain containing 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED