Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2) - Rat Genome Database

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Gene: Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2) Rattus norvegicus
Analyze
Symbol: Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RGD ID: 1307865
Description: Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase inhibitor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of TOR signaling. Predicted to act upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DEP domain containing 2; Depdc2; LOC312912; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8512,720,683 - 13,036,077 (-)NCBIGRCr8
mRatBN7.257,937,692 - 8,253,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx510,093,176 - 10,412,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0511,732,115 - 12,051,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0511,427,833 - 11,746,816 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.057,622,668 - 7,941,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl57,627,771 - 7,941,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0512,446,043 - 12,761,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.457,404,475 - 7,693,459 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.157,366,703 - 7,728,758 (-)NCBI
Celera57,493,673 - 7,724,174 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Prex2Ratcholangiocarcinoma sexual_dimorphismISORGD:1317307151665188DNA:substitutions, insertion/deletions: (human)RGD 
Prex2Rathepatitis B  ISORGD:1317307151665185associated with hepatocellular carcinoma;mRNA:increased expression:liver (human)RGD 
Prex2Rathepatocellular carcinoma  ISORGD:1317307151665343mRNA:increased expression:liver (human)RGD 
Prex2Rathepatocellular carcinoma exacerbatesISORGD:1317307151665186protein:increased expression:liver (human)RGD 
Prex2Rathepatocellular carcinoma  ISORGD:1317307151665188mRNA:decreased expression:liver (human)RGD 
Prex2Rathepatocellular carcinoma exacerbatesISORGD:1317307151665185mRNA:increased expression:liver (human)RGD 
Prex2RatKlatskin's tumor  ISORGD:1317307126848756DNA:substitutions, insertion/deletions: (human)RGD 
Prex2RatKlatskin's tumor sexual_dimorphismISORGD:13173079068941DNA:substitutions, insertion/deletions: (human)RGDPMID:33387086|REF_RGD_ID:126848756
Prex2Ratlung non-small cell carcinoma  ISORGD:1317307151665187mRNA:increased expression:lung (human)RGD 
Prex2Ratlung squamous cell carcinoma  ISORGD:1317307151665184mRNA:increased expression:lung (human)RGD 
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Original Reference(s)
Prex2Ratarteriovenous malformations of the brain  ISORGD:13173078554872ClinVar Annotator: match by term: Cerebral arteriovenous malformationClinVarPMID:25741868
Prex2Rathead and neck squamous cell carcinoma  ISORGD:13173078554872ClinVar Annotator: match by term: Lip and oral cavity carcinomaClinVarPMID:26614431
Prex2Ratprostate cancer  ISORGD:13173078554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383

1 to 20 of 71 rows

  
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Original Reference(s)
Prex2Rat1,2-dichloroethane decreases expressionISORGD:16182836480464ethylene dichloride results in decreased expression of PREX2 mRNACTDPMID:28189721|PMID:28960355
Prex2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PREX2 mRNACTDPMID:32145629
Prex2Rat17beta-estradiol decreases expressionISORGD:16182836480464Estradiol results in decreased expression of PREX2 mRNACTDPMID:39298647
Prex2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PREX2 mRNACTDPMID:32109520
Prex2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PREX2 mRNACTDPMID:34747641
Prex2Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642,3,7,8-tetrachlorodibenzofuran results in decreased expression of PREX2 mRNACTDPMID:32109520
Prex2Rat4,4'-sulfonyldiphenol multiple interactionsISORGD:16182836480464[bisphenol S co-treated with Tretinoin] results in increased expression of PREX2 mRNACTDPMID:30951980
Prex2Rat4,4'-sulfonyldiphenol decreases expressionISORGD:16182836480464bisphenol S results in decreased expression of PREX2 mRNACTDPMID:39298647
Prex2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of PREX2 mRNACTDPMID:24780913
Prex2Rataflatoxin B1 affects methylationISORGD:13173076480464Aflatoxin B1 affects the methylation of PREX2 intronCTDPMID:30157460
Prex2Ratall-trans-retinoic acid multiple interactionsISORGD:16182836480464[bisphenol A co-treated with Tretinoin] results in increased expression of PREX2 mRNA; [bisphenol F co-treated more ...CTDPMID:30951980
Prex2Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of PREX2 geneCTDPMID:28931070
Prex2Ratbenzo[a]pyrene increases expressionISORGD:16182836480464Benzo(a)pyrene results in increased expression of PREX2 mRNACTDPMID:32417428
Prex2Ratbenzo[a]pyrene increases methylationISORGD:13173076480464Benzo(a)pyrene results in increased methylation of PREX2 exon; Benzo(a)pyrene results in increased methylation of PREX2 more ...CTDPMID:27901495
Prex2RatBenzo[ghi]perylene decreases expressionISORGD:161828364804641,12-benzoperylene results in decreased expression of PREX2 mRNACTDPMID:26377693
Prex2Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PREX2 mRNACTDPMID:25181051|PMID:30816183|PMID:32145629|PMID:32528016|PMID:34947998
Prex2Ratbisphenol A decreases expressionISORGD:16182836480464bisphenol A results in decreased expression of PREX2 mRNACTDPMID:32156529
Prex2Ratbisphenol A multiple interactionsISORGD:16182836480464[bisphenol A co-treated with Tretinoin] results in increased expression of PREX2 mRNACTDPMID:30951980
Prex2Ratbisphenol F multiple interactionsISORGD:16182836480464[bisphenol F co-treated with Tretinoin] results in increased expression of PREX2 mRNACTDPMID:30951980
Prex2Ratbisphenol F increases expressionISORGD:16182836480464bisphenol F results in increased expression of PREX2 mRNACTDPMID:38685157

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Biological Process

  
Object Symbol
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Reference
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Original Reference(s)
Prex2Ratadult locomotory behavior acts_upstream_of_or_withinISORGD:16182831624291MGI:3783295 PMID:18334636RGDPMID:18334636
Prex2Ratdendrite morphogenesis acts_upstream_of_or_withinISORGD:16182831624291MGI:3783295 PMID:18334636RGDPMID:18334636
Prex2RatG protein-coupled receptor signaling pathway acts_upstream_of_or_withinISORGD:13173071624291 PMID:15304343RGDPMID:15304343
Prex2RatG protein-coupled receptor signaling pathway involved_inIBAMGI:3040696|PANTHER:PTN001107228|UniProtKB:Q70Z351600115GO_REF:0000033GO_CentralGO_REF:0000033
Prex2Ratintracellular signal transduction involved_inIEAInterPro:IPR0005911600115GO_REF:0000002InterProGO_REF:0000002
Prex2Ratintracellular signal transduction involved_inIEAInterPro:IPR000591|InterPro:IPR0013311600115GO_REF:0000002InterProGO_REF:0000002
Prex2Ratnegative regulation of TOR signaling involved_inIBAPANTHER:PTN001107228|UniProtKB:Q8TB451600115GO_REF:0000033GO_CentralGO_REF:0000033
Prex2Ratphosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_of_or_withinISORGD:16182831624291MGI:3856561 PMID:24367090RGDPMID:24367090

Cellular Component

  
Object Symbol
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Original Reference(s)
Prex2Ratplasma membrane is_active_inIBAMGI:1923385|PANTHER:PTN0011072281600115GO_REF:0000033GO_CentralGO_REF:0000033
Prex2Ratplasma membrane located_inISORGD:16182831624291 PMID:24367090RGDPMID:24367090

Molecular Function

  
Object Symbol
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Original Reference(s)
Prex2RatGTPase activator activity enablesISORGD:13173071624291 PMID:15304343RGDPMID:15304343
Prex2RatGTPase activator activity enablesIBAPANTHER:PTN001107227|UniProtKB:Q70Z351600115GO_REF:0000033GO_CentralGO_REF:0000033
Prex2Ratguanyl-nucleotide exchange factor activity enablesISORGD:13173071624291 PMID:15304343RGDPMID:15304343
Prex2Ratguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR000219|InterPro:IPR001331|InterPro:IPR0373671600115GO_REF:0000002InterProGO_REF:0000002
Prex2Ratguanyl-nucleotide exchange factor activity enablesIEAUniProtKB-KW:KW-03441600115GO_REF:0000043UniProtGO_REF:0000043
Prex2Ratguanyl-nucleotide exchange factor activity enablesIBAPANTHER:PTN001107227|UniProtKB:Q70Z351600115GO_REF:0000033GO_CentralGO_REF:0000033
Prex2Ratguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR0373671600115GO_REF:0000002InterProGO_REF:0000002
Prex2Ratprotein serine/threonine kinase inhibitor activity enablesIBAPANTHER:PTN001107227|UniProtKB:Q8TB451600115GO_REF:0000033GO_CentralGO_REF:0000033


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Reference Title
Reference Citation
1. Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients. Feng F, etal., Int J Clin Oncol. 2021 Apr;26(4):717-727. doi: 10.1007/s10147-020-01846-z. Epub 2021 Jan 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2. Lan X, etal., J Mol Histol. 2014 Dec;45(6):689-96. doi: 10.1007/s10735-014-9593-0. Epub 2014 Aug 24.
4. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Li CH, etal., Int J Cancer. 2017 May 15;140(10):2284-2297. doi: 10.1002/ijc.30652.
5. MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. Liao Z, etal., Oncol Res. 2020 Mar 27;28(2):147-159. doi: 10.3727/096504019X15732109856009. Epub 2019 Nov 11.
6. Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues. Liao Z, etal., Sci Rep. 2016 Dec 21;6:39655. doi: 10.1038/srep39655.
7. Leveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma. Liu L, etal., Oncol Lett. 2020 Jul;20(1):193-200. doi: 10.3892/ol.2020.11564. Epub 2020 Apr 22.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340. Yu J, etal., Hum Cell. 2020 Jan;33(1):148-158. doi: 10.1007/s13577-019-00303-y. Epub 2019 Nov 27.
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PMID:15304343   PMID:18334636   PMID:21700703   PMID:24367090  



Prex2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8512,720,683 - 13,036,077 (-)NCBIGRCr8
mRatBN7.257,937,692 - 8,253,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx510,093,176 - 10,412,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0511,732,115 - 12,051,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0511,427,833 - 11,746,816 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.057,622,668 - 7,941,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl57,627,771 - 7,941,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0512,446,043 - 12,761,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.457,404,475 - 7,693,459 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.157,366,703 - 7,728,758 (-)NCBI
Celera57,493,673 - 7,724,174 (-)NCBICelera
Cytogenetic Map5q11NCBI
PREX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,952,046 - 68,237,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl867,952,046 - 68,237,032 (+)EnsemblGRCh38hg38GRCh38
GRCh37868,864,281 - 69,149,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36869,027,157 - 69,306,451 (+)NCBINCBI36Build 36hg18NCBI36
Build 34869,027,156 - 69,180,208NCBI
Celera864,857,879 - 65,137,147 (+)NCBICelera
Cytogenetic Map8q13.2NCBI
HuRef864,357,585 - 64,636,285 (+)NCBIHuRef
CHM1_1868,920,457 - 69,199,336 (+)NCBICHM1_1
T2T-CHM13v2.0868,378,485 - 68,663,734 (+)NCBIT2T-CHM13v2.0
Prex2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39111,063,496 - 11,373,907 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl111,063,689 - 11,373,905 (+)EnsemblGRCm39 Ensembl
GRCm38110,993,273 - 11,303,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,993,465 - 11,303,681 (+)EnsemblGRCm38mm10GRCm38
MGSCv37110,983,546 - 11,293,763 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36111,243,254 - 11,284,089 (+)NCBIMGSCv36mm8
MGSCv36111,320,283 - 11,360,870 (+)NCBIMGSCv36mm8
Celera110,967,661 - 11,280,694 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.57NCBI
Prex2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544411,154,318 - 11,414,075 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544411,154,318 - 11,414,680 (-)NCBIChiLan1.0ChiLan1.0
PREX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2783,684,537 - 83,969,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1859,324,320 - 59,611,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0864,489,817 - 64,769,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1866,150,970 - 66,434,518 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl866,215,974 - 66,430,138 (+)Ensemblpanpan1.1panPan2
PREX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12917,458,098 - 17,738,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2917,458,281 - 17,735,170 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2917,773,929 - 18,057,994 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02917,543,026 - 17,827,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2917,542,889 - 17,905,693 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12917,589,003 - 17,873,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02917,666,595 - 17,943,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02917,936,353 - 18,212,814 (+)NCBIUU_Cfam_GSD_1.0
Prex2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530368,501,144 - 68,796,617 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364966,008,277 - 6,284,346 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364966,005,410 - 6,284,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl466,715,237 - 66,996,044 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1466,712,412 - 66,996,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2472,703,372 - 72,929,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PREX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1863,781,892 - 64,061,222 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl863,781,948 - 64,060,864 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603977,434,955 - 77,723,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prex2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474422,946,979 - 23,172,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474422,941,194 - 23,208,987 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Prex2
2739 total Variants


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 8177387 8177388 A T snv LEXF10A/StmMcwi (2020) View more Information

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:140
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000064774
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat

1 to 10 of 10 rows
D5Rat120  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8512,970,480 - 12,970,624 (+)Marker Load Pipeline
mRatBN7.258,187,501 - 8,187,645 (+)MAPPERmRatBN7.2
Rnor_6.057,875,611 - 7,875,754NCBIRnor6.0
Rnor_5.0512,694,705 - 12,694,848UniSTSRnor5.0
Celera57,724,876 - 7,725,019UniSTS
SHRSP x BN Map52.3599RGD
SHRSP x BN Map52.3599UniSTS
Cytogenetic Map5q11UniSTS
D5Got262  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.258,208,478 - 8,208,579 (+)MAPPERmRatBN7.2
Rnor_6.057,897,065 - 7,897,163NCBIRnor6.0
Rnor_5.0512,716,827 - 12,716,925UniSTSRnor5.0
RGSC_v3.457,684,535 - 7,684,633UniSTSRGSC3.4
Celera57,745,828 - 7,745,926UniSTS
Cytogenetic Map5q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000064774   ⟹   ENSRNOP00000063421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,942,795 - 8,186,800 (-)Ensembl
Rnor_6.0 Ensembl57,627,771 - 7,874,909 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079917   ⟹   ENSRNOP00000075213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,950,811 - 8,253,068 (-)Ensembl
Rnor_6.0 Ensembl57,628,238 - 7,941,822 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108148   ⟹   ENSRNOP00000096523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,950,811 - 8,186,800 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108865   ⟹   ENSRNOP00000095390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116125   ⟹   ENSRNOP00000080155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl57,942,795 - 8,252,926 (-)Ensembl
RefSeq Acc Id: NM_001393795   ⟹   NP_001380724
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8512,720,683 - 13,036,077 (-)NCBI
mRatBN7.257,937,692 - 8,253,112 (-)NCBI
Protein RefSeqs NP_001380724 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11540 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063421.1
  ENSRNOP00000075213.2
  ENSRNOP00000080155.1
  ENSRNOP00000095390.1
  ENSRNOP00000096523.1
  ENSRNOP00000099324
Ensembl Acc Id: ENSRNOP00000075213   ⟸   ENSRNOT00000079917
Ensembl Acc Id: ENSRNOP00000063421   ⟸   ENSRNOT00000064774
Ensembl Acc Id: ENSRNOP00000080155   ⟸   ENSRNOT00000116125
Ensembl Acc Id: ENSRNOP00000096523   ⟸   ENSRNOT00000108148
Ensembl Acc Id: ENSRNOP00000095390   ⟸   ENSRNOT00000108865
DEP   DH   PDZ   PH

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KA11-F1-model_v2 AlphaFold A0A0G2KA11 1-1598 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 52 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42220 BioCyc
Ensembl Genes ENSRNOG00000005391 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064774.4 UniProtKB/TrEMBL
  ENSRNOT00000079917.2 UniProtKB/TrEMBL
  ENSRNOT00000108148.1 UniProtKB/TrEMBL
  ENSRNOT00000108865.1 UniProtKB/TrEMBL
  ENSRNOT00000116125.1 UniProtKB/TrEMBL
  ENSRNOT00000126928 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  mTOR-Rac_regulators UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rex2_DEP_1 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 312912 ENTREZGENE
PANTHER DEP DOMAIN PROTEIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 2 PROTEIN UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Prex2 PhenoGen
PROSITE DEP UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005391 RatGTEx
SMART DEP UniProtKB/TrEMBL
1 to 40 of 52 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-08-25 Prex2  phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2  Depdc2  DEP domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Depdc2  DEP domain containing 2   Depdc2_predicted  DEP domain containing 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Depdc2_predicted  DEP domain containing 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED