Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2) - Rat Genome Database

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Gene: Prex2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2) Mus musculus
Analyze
Symbol: Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RGD ID: 1618283
MGI Page MGI
Description: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in plasma membrane. Is expressed in brain ventricular layer and gut. Human ortholog(s) of this gene implicated in Klatskin's tumor and cholangiocarcinoma. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6230420N16Rik; AI316880; AI553603; C030045D06Rik; D430013K02; DEP domain containing 2; DEP domain-containing protein 2; Depdc; Depdc2; P-Rex2; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; ptdIns(3,4,5)-dependent Rac exchanger 2; RIKEN cDNA C030045D06 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39111,063,496 - 11,373,907 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl111,063,689 - 11,373,905 (+)EnsemblGRCm39 Ensembl
GRCm38110,993,273 - 11,303,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,993,465 - 11,303,681 (+)EnsemblGRCm38mm10GRCm38
MGSCv37110,983,546 - 11,293,763 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36111,243,254 - 11,284,089 (+)NCBIMGSCv36mm8
MGSCv36111,320,283 - 11,360,870 (+)NCBIMGSCv36mm8
Celera110,967,661 - 11,280,694 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients. Feng F, etal., Int J Clin Oncol. 2021 Apr;26(4):717-727. doi: 10.1007/s10147-020-01846-z. Epub 2021 Jan 2.
2. The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2. Lan X, etal., J Mol Histol. 2014 Dec;45(6):689-96. doi: 10.1007/s10735-014-9593-0. Epub 2014 Aug 24.
3. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Li CH, etal., Int J Cancer. 2017 May 15;140(10):2284-2297. doi: 10.1002/ijc.30652.
4. MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. Liao Z, etal., Oncol Res. 2020 Mar 27;28(2):147-159. doi: 10.3727/096504019X15732109856009. Epub 2019 Nov 11.
5. Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues. Liao Z, etal., Sci Rep. 2016 Dec 21;6:39655. doi: 10.1038/srep39655.
6. Leveraging methylation to identify the potential causal genes associated with survival in lung adenocarcinoma and lung squamous cell carcinoma. Liu L, etal., Oncol Lett. 2020 Jul;20(1):193-200. doi: 10.3892/ol.2020.11564. Epub 2020 Apr 22.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340. Yu J, etal., Hum Cell. 2020 Jan;33(1):148-158. doi: 10.1007/s13577-019-00303-y. Epub 2019 Nov 27.
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15304343   PMID:15857914  
PMID:16141072   PMID:16141073   PMID:18334636   PMID:20694145   PMID:21178006   PMID:21267068   PMID:21873635   PMID:23844743   PMID:24367090   PMID:24659802   PMID:25538043   PMID:25829446  
PMID:26884185   PMID:27111337   PMID:31040226   PMID:32325033   PMID:35083941   PMID:37839992  


Genomics

Comparative Map Data
Prex2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39111,063,496 - 11,373,907 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl111,063,689 - 11,373,905 (+)EnsemblGRCm39 Ensembl
GRCm38110,993,273 - 11,303,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,993,465 - 11,303,681 (+)EnsemblGRCm38mm10GRCm38
MGSCv37110,983,546 - 11,293,763 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36111,243,254 - 11,284,089 (+)NCBIMGSCv36mm8
MGSCv36111,320,283 - 11,360,870 (+)NCBIMGSCv36mm8
Celera110,967,661 - 11,280,694 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.57NCBI
PREX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,952,046 - 68,237,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl867,952,046 - 68,237,032 (+)EnsemblGRCh38hg38GRCh38
GRCh37868,864,281 - 69,149,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36869,027,157 - 69,306,451 (+)NCBINCBI36Build 36hg18NCBI36
Build 34869,027,156 - 69,180,208NCBI
Celera864,857,879 - 65,137,147 (+)NCBICelera
Cytogenetic Map8q13.2NCBI
HuRef864,357,585 - 64,636,285 (+)NCBIHuRef
CHM1_1868,920,457 - 69,199,336 (+)NCBICHM1_1
T2T-CHM13v2.0868,378,485 - 68,663,734 (+)NCBIT2T-CHM13v2.0
Prex2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8512,720,683 - 13,036,077 (-)NCBIGRCr8
mRatBN7.257,937,692 - 8,253,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl57,942,573 - 8,253,068 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx510,093,176 - 10,412,139 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0511,732,115 - 12,051,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0511,427,833 - 11,746,816 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.057,622,668 - 7,941,715 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl57,627,771 - 7,941,822 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0512,446,043 - 12,761,369 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.457,404,475 - 7,693,459 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.157,366,703 - 7,728,758 (-)NCBI
Celera57,493,673 - 7,724,174 (-)NCBICelera
Cytogenetic Map5q11NCBI
Prex2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544411,154,318 - 11,414,075 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544411,154,318 - 11,414,680 (-)NCBIChiLan1.0ChiLan1.0
PREX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2783,684,537 - 83,969,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1859,324,320 - 59,611,677 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0864,489,817 - 64,769,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1866,150,970 - 66,434,518 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl866,215,974 - 66,430,138 (+)Ensemblpanpan1.1panPan2
PREX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12917,458,098 - 17,738,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2917,458,281 - 17,735,170 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2917,773,929 - 18,057,994 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02917,543,026 - 17,827,957 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2917,542,889 - 17,905,693 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12917,589,003 - 17,873,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02917,666,595 - 17,943,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02917,936,353 - 18,212,814 (+)NCBIUU_Cfam_GSD_1.0
Prex2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530368,501,144 - 68,796,617 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364966,008,277 - 6,284,346 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364966,005,410 - 6,284,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl466,715,237 - 66,996,044 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1466,712,412 - 66,996,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2472,703,372 - 72,929,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PREX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1863,781,892 - 64,061,222 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl863,781,948 - 64,060,864 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603977,434,955 - 77,723,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prex2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474422,946,979 - 23,172,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474422,941,194 - 23,208,987 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prex2
13579 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1622
Count of miRNA genes:699
Interacting mature miRNAs:919
Transcripts:ENSMUST00000027056
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122976684Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125203185Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125203185Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130367747Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse

Markers in Region
RH136147  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38111,303,097 - 11,303,295UniSTSGRCm38
MGSCv37111,293,178 - 11,293,376UniSTSGRCm37
Celera111,280,109 - 11,280,307UniSTS
Cytogenetic Map1A3UniSTS
15.MMHAP9FRE9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38111,036,825 - 11,037,016UniSTSGRCm38
MGSCv37111,026,906 - 11,027,097UniSTSGRCm37
Celera111,007,127 - 11,007,318UniSTS
Cytogenetic Map1A3UniSTS
35.MMHAP94FRD11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38111,297,038 - 11,297,201UniSTSGRCm38
MGSCv37111,287,119 - 11,287,282UniSTSGRCm37
Celera111,274,055 - 11,274,218UniSTS
Cytogenetic Map1A3UniSTS
Whitehead/MRC_RH132.13UniSTS
UniSTS:234068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38111,303,280 - 11,303,449UniSTSGRCm38
MGSCv37111,293,361 - 11,293,530UniSTSGRCm37
Celera111,280,292 - 11,280,461UniSTS
Cytogenetic Map1A3UniSTS
AI553603  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38111,303,489 - 11,303,624UniSTSGRCm38
MGSCv37111,293,570 - 11,293,705UniSTSGRCm37
Celera111,280,501 - 11,280,636UniSTS
Cytogenetic Map1A3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC102529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC102631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI553603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM109952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027056   ⟹   ENSMUSP00000027056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,063,689 - 11,373,905 (+)Ensembl
GRCm38.p6 Ensembl110,993,465 - 11,303,681 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,210,915 - 11,230,820 (+)Ensembl
GRCm38.p6 Ensembl111,140,691 - 11,160,596 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187745   ⟹   ENSMUSP00000140788
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,328,330 - 11,368,229 (+)Ensembl
GRCm38.p6 Ensembl111,258,106 - 11,298,005 (+)Ensembl
RefSeq Acc Id: ENSMUST00000188154   ⟹   ENSMUSP00000140580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,354,217 - 11,368,428 (+)Ensembl
GRCm38.p6 Ensembl111,283,993 - 11,298,204 (+)Ensembl
RefSeq Acc Id: ENSMUST00000188189   ⟹   ENSMUSP00000140621
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,328,291 - 11,368,122 (+)Ensembl
GRCm38.p6 Ensembl111,258,067 - 11,297,898 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189385   ⟹   ENSMUSP00000140863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,334,187 - 11,369,818 (+)Ensembl
GRCm38.p6 Ensembl111,263,963 - 11,299,594 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189822
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,168,754 - 11,220,295 (+)Ensembl
GRCm38.p6 Ensembl111,098,530 - 11,150,071 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190935
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl111,063,742 - 11,066,825 (+)Ensembl
GRCm38.p6 Ensembl110,993,518 - 10,996,601 (+)Ensembl
RefSeq Acc Id: NM_001033636   ⟹   NP_001028808
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39111,334,187 - 11,373,906 (+)NCBI
GRCm38111,263,963 - 11,303,682 (+)NCBI
MGSCv37110,983,546 - 11,293,763 (+)RGD
Celera110,967,661 - 11,280,694 (+)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029525   ⟹   NP_083801
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39111,063,689 - 11,373,906 (+)NCBI
GRCm38110,993,465 - 11,303,682 (+)NCBI
MGSCv37110,983,546 - 11,293,763 (+)RGD
Celera110,967,661 - 11,280,694 (+)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495441   ⟹   XP_006495504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39111,063,499 - 11,373,907 (+)NCBI
GRCm38110,993,273 - 11,303,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153075   ⟹   XP_036008968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39111,151,938 - 11,373,725 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153084   ⟹   XP_036008977
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39111,063,500 - 11,359,548 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004934097
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39111,063,496 - 11,373,907 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001028808   ⟸   NM_001033636
- Peptide Label: isoform 2
- UniProtKB: Q3UWW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_083801   ⟸   NM_029525
- Peptide Label: isoform 1
- UniProtKB: Q3UU18 (UniProtKB/Swiss-Prot),   Q3UQI2 (UniProtKB/Swiss-Prot),   E9QMG3 (UniProtKB/Swiss-Prot),   Q9CXD5 (UniProtKB/Swiss-Prot),   Q3LAC4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006495504   ⟸   XM_006495441
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000027056   ⟸   ENSMUST00000027056
RefSeq Acc Id: ENSMUSP00000140580   ⟸   ENSMUST00000188154
RefSeq Acc Id: ENSMUSP00000140621   ⟸   ENSMUST00000188189
RefSeq Acc Id: ENSMUSP00000140788   ⟸   ENSMUST00000187745
RefSeq Acc Id: ENSMUSP00000140863   ⟸   ENSMUST00000189385
RefSeq Acc Id: XP_036008977   ⟸   XM_036153084
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036008968   ⟸   XM_036153075
- Peptide Label: isoform X2
Protein Domains
DEP   DH   PDZ   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3LAC4-F1-model_v2 AlphaFold Q3LAC4 1-1598 view protein structure

Promoters
RGD ID:6873186
Promoter ID:EPDNEW_M44
Type:initiation region
Name:Prex2_1
Description:Mus musculus phosphatidylinositol-3,4,5-trisphosphate-dependentRac exchange factor 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38110,993,462 - 10,993,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923385 AgrOrtholog
Ensembl Genes ENSMUSG00000048960 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027056 ENTREZGENE
  ENSMUST00000027056.12 UniProtKB/Swiss-Prot
  ENSMUST00000187745.7 UniProtKB/TrEMBL
  ENSMUST00000188154.2 UniProtKB/TrEMBL
  ENSMUST00000188189.7 UniProtKB/TrEMBL
  ENSMUST00000189385.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/Swiss-Prot
  DEP_dom UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Rex2_DEP_1 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:109294 UniProtKB/Swiss-Prot
MGD MGI:1923385 ENTREZGENE
NCBI Gene 109294 ENTREZGENE
PANTHER DEP DOMAIN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 2 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEP UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_6 UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
PhenoGen Prex2 PhenoGen
PROSITE DEP UniProtKB/Swiss-Prot
  DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot
SMART DEP UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF46785 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WRD8_MOUSE UniProtKB/TrEMBL
  A0A087WRG8_MOUSE UniProtKB/TrEMBL
  A0A087WRV5_MOUSE UniProtKB/TrEMBL
  A0A087WS21_MOUSE UniProtKB/TrEMBL
  E9QMG3 ENTREZGENE
  PREX2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UQI2 ENTREZGENE
  Q3UU18 ENTREZGENE
  Q3UWW3 ENTREZGENE, UniProtKB/TrEMBL
  Q8BY00_MOUSE UniProtKB/TrEMBL
  Q9CXD5 ENTREZGENE
UniProt Secondary E9QMG3 UniProtKB/Swiss-Prot
  Q3UQI2 UniProtKB/Swiss-Prot
  Q3UU18 UniProtKB/Swiss-Prot
  Q9CXD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-21 Depdc2  DEP domain containing 2  C030045D06Rik  RIKEN cDNA C030045D06 gene  Data merged from RGD:1623854 737654 APPROVED