RGD Reference Report - LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340. - Rat Genome Database

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LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340.

Authors: Yu, Junfeng  Ou, Zhejian  Lei, Yangyang  Chen, Liuhua  Su, Qiao  Zhang, Kunsong 
Citation: Yu J, etal., Hum Cell. 2020 Jan;33(1):148-158. doi: 10.1007/s13577-019-00303-y. Epub 2019 Nov 27.
RGD ID: 151665343
Pubmed: PMID:31776854   (View Abstract at PubMed)
DOI: DOI:10.1007/s13577-019-00303-y   (Journal Full-text)

Hepatocellular carcinoma (HCC) remains one of the most common and aggressive human cancers worldwide. Accumulating evidences indicate that non-coding RNAs are critical regulators implicated in various physiological processes including HCC development. Long non-coding RNA (lncRNA) MYCN opposite-strand (MYCNOS) was reported to be up-regulated in several human cancers, yet its role in HCC progression is still elusive. In the present study, MYCNOS was up-regulated in both HCC tissues and cell lines, and elevated MYCNOS expression was correlated to shorter survival time of HCC patients. We knocked down MYCNOS expression using short hairpin RNAs specifically targeting MYCNOS. MYCNOS knockdown significantly inhibited proliferation in HCC cells in vitro accompanied by exacerbated cell apoptosis; it also suppressed tumor growth in mouse model in vivo. Besides, the migration and invasion of HCC cells were remarkably inhibited after MYCNOS knockdown. In addition, MYCNOS acted as a negative regulator of miR-340 in HCC cells, and all effects of MYCNOS knockdown were abrogated by further miR-340 inhibition. We also discovered that oncogene phosphatidylinositol-3, 4, 5-trisphosphate-dependent Rac exchange factor 2 (PREX2) was a downstream target of miR-340, and PREX2 expression was positively correlated to that of MYCNOS in HCC tissues. In conclusion, our findings demonstrated that MYCNOS knockdown inhibited HCC progression through regulating miR-340.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PREX2Humanhepatocellular carcinoma  IEP mRNA:increased expression:liver (human)RGD 
Prex2Rathepatocellular carcinoma  ISOPREX2 (Homo sapiens)mRNA:increased expression:liver (human)RGD 
Prex2Mousehepatocellular carcinoma  ISOPREX2 (Homo sapiens)mRNA:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prex2  (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)

Genes (Mus musculus)
Prex2  (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)

Genes (Homo sapiens)
PREX2  (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2)


Additional Information