RGD Reference Report - A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer. - Rat Genome Database

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A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer.

Authors: Jin, Guang  Bae, Eun Young  Yang, Enyue  Lee, Eung Bae  Lee, Won-Kee  Choi, Jin Eun  Jeon, Hyo-Sung  Yoo, Seung Soo  Lee, Shin Yup  Lee, Jaehee  Cha, Sung Ick  Kim, Chang Ho  Cho, Sukki  Jheon, Sanghoon  Park, Jae Yong 
Citation: Jin G, etal., J Thorac Oncol. 2012 May;7(5):808-14. doi: 10.1097/JTO.0b013e31824c7d7c.
RGD ID: 151347532
Pubmed: PMID:22722785   (View Abstract at PubMed)
DOI: DOI:10.1097/JTO.0b013e31824c7d7c   (Journal Full-text)


INTRODUCTION: The 15q25 region has been associated with lung-cancer risk and might also be associated with the prognosis of lung cancer. This study was conducted to determine the impact of a functional polymorphism in the CHRNA3 gene on chromosome 15q25 in the survival of patients with early-stage non-small-cell lung cancer (NSCLC).
METHODS: Five hundred and eighty-three consecutive patients with surgically resected NSCLC were enrolled. The rs6495309C > T polymorphism in the promoter of the CHRNA3 gene was investigated. The association between genotype and overall survival (OS) and disease-free survival (DFS) was analyzed.
RESULTS: Patients with the rs6495309 CT or TT genotype had a significantly better OS and DFS than the rs6495309 CC genotype (adjusted hazard ratio for OS = 0.56, 95% confidence interval = 0.41-0.75, p = 0.0001; and adjusted hazard ratio for DFS = 0.61, 95% confidence interval = 0.48-0.79, p = 0.0001). An association between the rs6495309C > T polymorphism and survival outcome was demonstrated in smokers and never-smokers, and in squamous-cell carcinomas and adenocarcinomas.
CONCLUSION: The CHRNA3 rs6495309C > T polymorphism may affect survival in patients with early-stage NSCLC. Analysis of the rs6495309C > T polymorphism can help identify patients at high risk of a poor disease outcome.




  
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Original Reference(s)
CHRNA3Humanlung non-small cell carcinoma disease_progressionIAGP DNA:SNP: :rs6495309(human)RGD 
Chrna3Ratlung non-small cell carcinoma disease_progressionISORGD:732613DNA:SNP: :rs6495309(human)RGD 
Chrna3Mouselung non-small cell carcinoma disease_progressionISORGD:732613DNA:SNP: :rs6495309(human)RGD 


Genes (Rattus norvegicus)
Chrna3  (cholinergic receptor nicotinic alpha 3 subunit)

Genes (Mus musculus)
Chrna3  (cholinergic receptor, nicotinic, alpha polypeptide 3)

Genes (Homo sapiens)
CHRNA3  (cholinergic receptor nicotinic alpha 3 subunit)