Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) - Rat Genome Database

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Gene: Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) Mus musculus
Analyze
Symbol: Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
RGD ID: 732614
MGI Page MGI
Description: Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; lung cancer (multiple); nicotine dependence; and stomach cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: (a); (a)3; A730007P14Rik; Ac; Acr; Acra-3; Acra3; alpha 3; neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)Ensembl
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBImm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-anabasine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
atracurium  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbachol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
cisatracurium  (ISO)
cocaine  (ISO)
cytisine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epibatidine  (EXP,ISO)
EPTC  (ISO)
ethanol  (EXP)
fenoxycarb  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
fonofos  (ISO)
genistein  (EXP)
Hexamethonium  (ISO)
imidacloprid  (ISO)
Licochalcone B  (ISO)
Mecamylamine  (EXP,ISO)
mercury dichloride  (ISO)
methyllycaconitine  (EXP,ISO)
Mivacurium  (ISO)
N'-Nitrosonornicotine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
pancuronium  (ISO)
panobinostat  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rocuronium  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
thapsigargin  (ISO)
toluene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tubocurarine  (ISO)
valproic acid  (EXP,ISO)
varenicline  (ISO)
vecuronium bromide  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Adams MR, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):67-79.
2. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
3. Amos CI, etal., J Natl Cancer Inst. 2010 Aug 4;102(15):1199-205. doi: 10.1093/jnci/djq232. Epub 2010 Jun 16.
4. Balassiano K, etal., Cancer Lett. 2011 Dec 1;311(1):85-95. doi: 10.1016/j.canlet.2011.06.038. Epub 2011 Jul 14.
5. Chikova A, etal., Life Sci. 2012 Nov 27;91(21-22):1103-8. doi: 10.1016/j.lfs.2011.12.023. Epub 2012 Jan 17.
6. Falvella FS, etal., Clin Cancer Res. 2009 Mar 1;15(5):1837-42. doi: 10.1158/1078-0432.CCR-08-2107. Epub 2009 Feb 17.
7. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
8. He P, etal., Int J Mol Sci. 2014 Mar 28;15(4):5446-57. doi: 10.3390/ijms15045446.
9. Improgo MR, etal., Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.
10. Jin G, etal., J Thorac Oncol. 2012 May;7(5):808-14. doi: 10.1097/JTO.0b013e31824c7d7c.
11. Kaur-Knudsen D, etal., Eur Respir J. 2012 Dec;40(6):1538-44. doi: 10.1183/09031936.00176811. Epub 2012 Mar 22.
12. Kim WJ, etal., Respiration. 2013;86(2):117-22. doi: 10.1159/000342976. Epub 2012 Nov 27.
13. Kupiainen H, etal., COPD. 2016 Aug;13(4):464-70. doi: 10.3109/15412555.2015.1049260. Epub 2016 Jan 11.
14. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
15. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
16. MGD and Homologene mouse data transfer
17. MGD data from the GO Consortium
18. MGD IEA
19. Ochi S, etal., Neurosci Lett. 2014 May 21;569:33-7. doi: 10.1016/j.neulet.2014.03.054. Epub 2014 Apr 2.
20. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline
22. Pipeline to import SMPDB annotations from SMPDB into RGD
23. Pérez-Morales R, etal., Ann Hum Genet. 2018 Nov;82(6):415-424. doi: 10.1111/ahg.12264. Epub 2018 Jul 11.
24. Ren JH, etal., J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):897-901. doi: 10.1007/s11596-013-1218-4. Epub 2013 Dec 13.
25. RGD automated import pipeline
26. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. RGD automated import pipeline for gene-chemical interactions
28. Saccone NL, etal., Cancer Res. 2009 Sep 1;69(17):6848-56. doi: 10.1158/0008-5472.CAN-09-0786. Epub 2009 Aug 25.
29. Shen B, etal., Mol Med Rep. 2012 Dec;6(6):1389-92. doi: 10.3892/mmr.2012.1101. Epub 2012 Sep 26.
30. Sun Y, etal., Oncotarget. 2017 Dec 20;9(2):2435-2444. doi: 10.18632/oncotarget.23459. eCollection 2018 Jan 5.
31. Tseng TS, etal., PLoS One. 2014 Sep 18;9(9):e107268. doi: 10.1371/journal.pone.0107268. eCollection 2014.
32. Verbois SL, etal., J Neurotrauma. 2002 Dec;19(12):1569-85.
33. Wassenaar CA, etal., J Natl Cancer Inst. 2011 Sep 7;103(17):1342-6. doi: 10.1093/jnci/djr237. Epub 2011 Jul 11.
34. Wu C, etal., Cancer Res. 2009 Jun 15;69(12):5065-72. doi: 10.1158/0008-5472.CAN-09-0081. Epub 2009 Jun 2.
35. Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.
36. Yang L, etal., PLoS One. 2012;7(10):e46071. doi: 10.1371/journal.pone.0046071. Epub 2012 Oct 3.
Additional References at PubMed
PMID:1505988   PMID:2004777   PMID:2338144   PMID:8563774   PMID:8630490   PMID:8748389   PMID:8838678   PMID:9023306   PMID:10095079   PMID:10318955   PMID:10349636   PMID:10771006  
PMID:11027228   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11923417   PMID:12079404   PMID:12225896   PMID:12438103   PMID:12477932   PMID:15275829   PMID:15681842   PMID:16141072  
PMID:16141073   PMID:16162937   PMID:16602821   PMID:17434683   PMID:17504758   PMID:18279314   PMID:18568021   PMID:18826434   PMID:19186169   PMID:19474315   PMID:19640321   PMID:19906978  
PMID:20128845   PMID:20496163   PMID:20620869   PMID:21267068   PMID:21873635   PMID:22378897   PMID:22380605   PMID:22647603   PMID:23213462   PMID:23416040   PMID:23613527   PMID:24049141  
PMID:24750073   PMID:24799426   PMID:24952961   PMID:24966386   PMID:25031416   PMID:25105141   PMID:25131634   PMID:25816313   PMID:25948261   PMID:26265139   PMID:27452274   PMID:29241539  
PMID:29617653   PMID:29791835   PMID:30953718   PMID:31171666   PMID:32776643   PMID:33380469  


Genomics

Comparative Map Data
Chrna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)Ensembl
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBImm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
CHRNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,593,052 - 78,620,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1578,593,052 - 78,621,295 (-)EnsemblGRCh38hg38GRCh38
GRCh371578,885,394 - 78,913,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,674,706 - 76,700,377 (-)NCBINCBI36hg18NCBI36
Build 341576,674,706 - 76,700,377NCBI
Celera1555,821,707 - 55,849,902 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1555,642,483 - 55,671,504 (-)NCBIHuRef
CHM1_11579,003,962 - 79,032,196 (-)NCBICHM1_1
T2T-CHM13v2.01576,455,721 - 76,484,482 (-)NCBI
Chrna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2855,401,981 - 55,415,012 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)Ensembl
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Celera854,888,972 - 54,929,562 (-)NCBICelera
Cytogenetic Map8q24NCBI
Chrna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450977,075 - 1,011,372 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955450979,630 - 1,011,316 (-)NCBIChiLan1.0ChiLan1.0
CHRNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11576,486,416 - 76,513,899 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,487,710 - 76,512,044 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01557,523,553 - 57,550,228 (-)NCBIMhudiblu_PPA_v0panPan3
CHRNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,330,287 - 38,343,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,328,814 - 38,346,246 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,289,178 - 38,306,359 (+)NCBI
ROS_Cfam_1.01338,802,608 - 38,819,775 (+)NCBI
ROS_Cfam_1.0 Ensembl1338,802,250 - 38,833,013 (+)Ensembl
UMICH_Zoey_3.11338,493,778 - 38,510,924 (+)NCBI
UNSW_CanFamBas_1.01338,603,187 - 38,616,744 (+)NCBI
UU_Cfam_GSD_1.01339,078,181 - 39,095,376 (+)NCBI
Chrna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,579,566 - 118,599,906 (+)NCBI
SpeTri2.0NW_00493647136,427,598 - 36,447,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,361,778 - 47,384,303 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,787,929 - 52,806,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,721,145 - 4,747,694 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBIVero_WHO_p1.0
Chrna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,324,501 - 2,357,723 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248942,324,480 - 2,357,389 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
BE108721  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,012,498 - 55,012,719UniSTSGRCm38
MGSCv37954,860,305 - 54,860,526UniSTSGRCm37
Celera952,255,906 - 52,256,130UniSTS
Cytogenetic Map9BUniSTS
Chrna3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9BUniSTS
cM Map951.0UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:411
Count of miRNA genes:299
Interacting mature miRNAs:343
Transcripts:ENSMUST00000034851
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034851   ⟹   ENSMUSP00000034851
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,917,395 - 54,933,846 (-)Ensembl
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214204   ⟹   ENSMUSP00000150636
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,921,514 - 54,933,814 (-)Ensembl
GRCm38.p6 Ensembl955,014,230 - 55,026,530 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238862   ⟹   ENSMUSP00000158914
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,918,627 - 54,933,843 (-)Ensembl
GRCm38.p6 Ensembl955,011,343 - 55,026,559 (-)Ensembl
RefSeq Acc Id: NM_145129   ⟹   NP_660111
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,917,401 - 54,933,846 (-)NCBI
GRCm38955,010,117 - 55,026,562 (-)NCBI
MGSCv37954,859,150 - 54,874,366 (-)RGD
Celera952,254,751 - 52,269,961 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_660111   ⟸   NM_145129
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSMUSP00000034851   ⟸   ENSMUST00000034851
RefSeq Acc Id: ENSMUSP00000158914   ⟸   ENSMUST00000238862
RefSeq Acc Id: ENSMUSP00000150636   ⟸   ENSMUST00000214204
Protein Domains
Neur_chan_LBD   Neur_chan_memb

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4G9-F1-model_v2 AlphaFold Q8R4G9 1-499 view protein structure

Promoters
RGD ID:8669658
Promoter ID:EPDNEW_M12860
Type:initiation region
Name:Chrna3_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38955,026,532 - 55,026,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87887 AgrOrtholog
Ensembl Genes ENSMUSG00000032303 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034851 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000150636 UniProtKB/TrEMBL
  ENSMUSP00000158914 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034851 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000214204 UniProtKB/TrEMBL
  ENSMUST00000238862 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87887 ENTREZGENE
NCBI Gene 110834 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA3 RGD
PhenoGen Chrna3 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SU72_MOUSE UniProtKB/TrEMBL
  ACHA3_MOUSE UniProtKB/Swiss-Prot
  Q0VBK4_MOUSE UniProtKB/TrEMBL
  Q8R4G9 ENTREZGENE
  Q8VHH6_MOUSE UniProtKB/TrEMBL
  Q8VI11_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BV44 UniProtKB/Swiss-Prot