Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) - Rat Genome Database

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Gene: Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) Mus musculus
Analyze
Symbol: Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
RGD ID: 732614
MGI Page MGI
Description: Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within several processes, including behavioral response to nicotine; chemical synaptic transmission; and regulation of acetylcholine secretion, neurotransmission. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; lung cancer (multiple); nicotine dependence; and stomach cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
Previously known as: (a); (a)3; A730007P14Rik; Ac; acetylcholine receptor alpha 3 neural; Acr; Acra-3; Acra3; alpha 3; neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)EnsemblGRCm39 Ensembl
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBIMGSCv36mm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map951.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-anabasine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atracurium  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
carbachol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
cisatracurium  (ISO)
cocaine  (ISO)
cytisine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epibatidine  (EXP,ISO)
EPTC  (ISO)
ethanol  (EXP)
fenoxycarb  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
fonofos  (ISO)
genistein  (EXP)
glyphosate  (ISO)
Hexamethonium  (ISO)
imidacloprid  (ISO)
Licochalcone B  (ISO)
Mecamylamine  (EXP,ISO)
mercury dichloride  (ISO)
methyllycaconitine  (EXP,ISO)
Mivacurium  (ISO)
N'-Nitrosonornicotine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
pancuronium  (ISO)
panobinostat  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rocuronium  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
toluene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tubocurarine  (ISO)
valproic acid  (EXP,ISO)
varenicline  (ISO)
vecuronium bromide  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. In vitro and in vivo effects of an alpha3 neuronal nicotinic acetylcholine receptor antisense oligonucleotide. Adams MR, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):67-79.
2. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
3. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. Amos CI, etal., J Natl Cancer Inst. 2010 Aug 4;102(15):1199-205. doi: 10.1093/jnci/djq232. Epub 2010 Jun 16.
4. Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Balassiano K, etal., Cancer Lett. 2011 Dec 1;311(1):85-95. doi: 10.1016/j.canlet.2011.06.038. Epub 2011 Jul 14.
5. New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer. Chikova A, etal., Life Sci. 2012 Nov 27;91(21-22):1103-8. doi: 10.1016/j.lfs.2011.12.023. Epub 2012 Jan 17.
6. Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Falvella FS, etal., Clin Cancer Res. 2009 Mar 1;15(5):1837-42. doi: 10.1158/1078-0432.CCR-08-2107. Epub 2009 Feb 17.
7. Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors. Greenbaum L, etal., Hum Psychopharmacol. 2010 Nov;25(7-8):536-42. doi: 10.1002/hup.1149. Epub 2010 Oct 25.
8. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Haller G, etal., Hum Mol Genet. 2012 Feb 1;21(3):647-55. doi: 10.1093/hmg/ddr498. Epub 2011 Oct 31.
9. Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. Haller G, etal., Hum Mol Genet. 2014 Feb 1;23(3):810-9. doi: 10.1093/hmg/ddt463. Epub 2013 Sep 20.
10. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
11. CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population. He P, etal., Int J Mol Sci. 2014 Mar 28;15(4):5446-57. doi: 10.3390/ijms15045446.
12. ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Improgo MR, etal., Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.
13. A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer. Jin G, etal., J Thorac Oncol. 2012 May;7(5):808-14. doi: 10.1097/JTO.0b013e31824c7d7c.
14. CHRNA3 genotype, nicotine dependence, lung function and disease in the general population. Kaur-Knudsen D, etal., Eur Respir J. 2012 Dec;40(6):1538-44. doi: 10.1183/09031936.00176811. Epub 2012 Mar 22.
15. CHRNA3 variant for lung cancer is associated with chronic obstructive pulmonary disease in Korea. Kim WJ, etal., Respiration. 2013;86(2):117-22. doi: 10.1159/000342976. Epub 2012 Nov 27.
16. CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers. Kupiainen H, etal., COPD. 2016 Aug;13(4):464-70. doi: 10.3109/15412555.2015.1049260. Epub 2016 Jan 11.
17. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
18. Expression of acetylcholine receptors by experimental rat renal allografts. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
19. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. The nicotinic cholinergic system is affected in rats with delayed carbon monoxide encephalopathy. Ochi S, etal., Neurosci Lett. 2014 May 21;569:33-7. doi: 10.1016/j.neulet.2014.03.054. Epub 2014 Apr 2.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population. Pérez-Morales R, etal., Ann Hum Genet. 2018 Nov;82(6):415-424. doi: 10.1111/ahg.12264. Epub 2018 Jul 11.
27. Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: a case-control study. Ren JH, etal., J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):897-901. doi: 10.1007/s11596-013-1218-4. Epub 2013 Dec 13.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems. Richmond-Rakerd LS, etal., Nicotine Tob Res. 2017 Apr 1;19(4):426-434. doi: 10.1093/ntr/ntw260.
32. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Saccone NL, etal., Cancer Res. 2009 Sep 1;69(17):6848-56. doi: 10.1158/0008-5472.CAN-09-0786. Epub 2009 Aug 25.
33. Correlation between polymorphisms of nicotine acetylcholine acceptor subunit CHRNA3 and lung cancer susceptibility. Shen B, etal., Mol Med Rep. 2012 Dec;6(6):1389-92. doi: 10.3892/mmr.2012.1101. Epub 2012 Sep 26.
34. Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the associated with the risk of non-small cell lung cancer. Sun Y, etal., Oncotarget. 2017 Dec 20;9(2):2435-2444. doi: 10.18632/oncotarget.23459. eCollection 2018 Jan 5.
35. Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. Tseng TS, etal., PLoS One. 2014 Sep 18;9(9):e107268. doi: 10.1371/journal.pone.0107268. eCollection 2014.
36. Time-dependent changes in rat brain cholinergic receptor expression after experimental brain injury. Verbois SL, etal., J Neurotrauma. 2002 Dec;19(12):1569-85.
37. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. Wassenaar CA, etal., J Natl Cancer Inst. 2011 Sep 7;103(17):1342-6. doi: 10.1093/jnci/djr237. Epub 2011 Jul 11.
38. Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Wu C, etal., Cancer Res. 2009 Jun 15;69(12):5065-72. doi: 10.1158/0008-5472.CAN-09-0081. Epub 2009 Jun 2.
39. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.
40. Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. Yang L, etal., PLoS One. 2012;7(10):e46071. doi: 10.1371/journal.pone.0046071. Epub 2012 Oct 3.

Genomics

Comparative Map Data
Chrna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,917,401 - 54,933,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,917,395 - 54,933,846 (-)EnsemblGRCm39 Ensembl
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBIMGSCv36mm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map951.0NCBI
CHRNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,593,052 - 78,620,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,593,052 - 78,621,295 (-)EnsemblGRCh38hg38GRCh38
GRCh371578,885,394 - 78,913,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,674,706 - 76,700,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 341576,674,706 - 76,700,377NCBI
Celera1555,821,707 - 55,849,902 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,642,483 - 55,671,504 (-)NCBIHuRef
CHM1_11579,003,962 - 79,032,196 (-)NCBICHM1_1
T2T-CHM13v2.01576,455,721 - 76,484,482 (-)NCBIT2T-CHM13v2.0
Chrna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,297,755 - 64,311,251 (-)NCBIGRCr8
mRatBN7.2855,401,668 - 55,415,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,401,702 - 55,415,165 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,943,296 - 60,956,354 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,222,294 - 59,235,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,086,538 - 57,099,598 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Celera854,888,972 - 54,929,562 (-)NCBICelera
Cytogenetic Map8q24NCBI
Chrna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450977,075 - 1,011,372 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955450979,630 - 1,011,316 (-)NCBIChiLan1.0ChiLan1.0
CHRNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,807,750 - 67,835,101 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,973,644 - 72,000,975 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,523,553 - 57,550,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,486,416 - 76,513,899 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,487,710 - 76,512,044 (-)Ensemblpanpan1.1panPan2
CHRNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,330,287 - 38,343,142 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,328,814 - 38,346,246 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,289,178 - 38,306,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,802,608 - 38,819,775 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,802,250 - 38,833,013 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,493,778 - 38,510,924 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,603,187 - 38,616,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,078,181 - 39,095,376 (+)NCBIUU_Cfam_GSD_1.0
Chrna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,579,566 - 118,599,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,427,495 - 36,457,758 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,427,598 - 36,447,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,361,899 - 47,384,303 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,361,710 - 47,382,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,787,929 - 52,806,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,721,145 - 4,747,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,722,489 - 4,737,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,048,285 - 137,075,017 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,324,501 - 2,357,723 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248942,324,480 - 2,357,389 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrna3
351 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:411
Count of miRNA genes:299
Interacting mature miRNAs:343
Transcripts:ENSMUST00000034851
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse

Markers in Region
BE108721  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,012,498 - 55,012,719UniSTSGRCm38
MGSCv37954,860,305 - 54,860,526UniSTSGRCm37
Celera952,255,906 - 52,256,130UniSTS
Cytogenetic Map9BUniSTS
Chrna3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9BUniSTS
cM Map951.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034851   ⟹   ENSMUSP00000034851
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,917,395 - 54,933,846 (-)Ensembl
GRCm38.p6 Ensembl955,010,111 - 55,026,562 (-)Ensembl
Ensembl Acc Id: ENSMUST00000214204   ⟹   ENSMUSP00000150636
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,921,514 - 54,933,814 (-)Ensembl
GRCm38.p6 Ensembl955,014,230 - 55,026,530 (-)Ensembl
Ensembl Acc Id: ENSMUST00000238862   ⟹   ENSMUSP00000158914
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,918,627 - 54,933,843 (-)Ensembl
GRCm38.p6 Ensembl955,011,343 - 55,026,559 (-)Ensembl
RefSeq Acc Id: NM_145129   ⟹   NP_660111
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,917,401 - 54,933,846 (-)NCBI
GRCm38955,010,117 - 55,026,562 (-)NCBI
MGSCv37954,859,150 - 54,874,366 (-)RGD
Celera952,254,751 - 52,269,961 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Ensembl Protein ENSMUSP00000034851.6
  ENSMUSP00000150636.3
  ENSMUSP00000158914.2
RefSeq Acc Id: NP_660111   ⟸   NM_145129
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSMUSP00000034851   ⟸   ENSMUST00000034851
Ensembl Acc Id: ENSMUSP00000158914   ⟸   ENSMUST00000238862
Ensembl Acc Id: ENSMUSP00000150636   ⟸   ENSMUST00000214204
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4G9-F1-model_v2 AlphaFold Q8R4G9 1-499 view protein structure

Promoters
RGD ID:8669658
Promoter ID:EPDNEW_M12860
Type:initiation region
Name:Chrna3_1
Description:Mus musculus cholinergic receptor, nicotinic, alpha polypeptide3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38955,026,532 - 55,026,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87887 AgrOrtholog
Ensembl Genes ENSMUSG00000032303 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034851.7 UniProtKB/Swiss-Prot
  ENSMUST00000214204.3 UniProtKB/TrEMBL
  ENSMUST00000238862.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87887 ENTREZGENE
NCBI Gene Chrna3 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNA3 RGD
PhenoGen Chrna3 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SU72_MOUSE UniProtKB/TrEMBL
  ACHA3_MOUSE UniProtKB/Swiss-Prot
  Q0VBK4_MOUSE UniProtKB/TrEMBL
  Q8VHH6_MOUSE UniProtKB/TrEMBL
  Q8VI11_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BV44 UniProtKB/Swiss-Prot