Gene: Pitx2 (paired-like homeodomain 2) Rattus norvegicus
Symbol: Pitx2
Name: paired-like homeodomain 2
Description: ENCODES a protein that exhibits RNA polymerase II proximal promoter sequence-specific DNA binding; transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; chromatin binding (ortholog); INVOLVED IN brain development; female gonad development; male gonad development; PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH Hypothyroidism; Polycystic Kidney, Autosomal Dominant; Anterior Segment Dysgenesis 5 (ortholog); FOUND IN nucleus; cytoplasm (ortholog); transcription factor complex (ortholog); INTERACTS WITH 1,3-dinitrobenzene; all-trans-retinoic acid; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein PITX2; homeodomain transcription factor 2; paired-like homeodomain transcription factor 2; pituitary homeobox 2; Pitx-2; Pitx2c; Ptx2; rPtx2
Homo sapiens (human) : PITX2 (paired like homeodomain 2)  HGNC  AGR
Mus musculus (house mouse) : Pitx2 (paired-like homeodomain transcription factor 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Pitx2 (paired like homeodomain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PITX2 (paired like homeodomain 2)
Canis lupus familiaris (dog) : PITX2 (paired like homeodomain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pitx2 (paired like homeodomain 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pitx2
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3331
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-31
Status: ACTIVE