Pitx2 (paired-like homeodomain 2) - Rat Genome Database

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Gene: Pitx2 (paired-like homeodomain 2) Rattus norvegicus
Analyze
Symbol: Pitx2
Name: paired-like homeodomain 2
RGD ID: 3331
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad development; positive regulation of transcription by RNA polymerase II; and response to vitamin A. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Biomarker of autosomal dominant polycystic kidney disease and hypothyroidism. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 1; anterior segment dysgenesis 4; and ring dermoid of cornea. Orthologous to human PITX2 (paired like homeodomain 2); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeobox protein PITX2; homeodomain transcription factor 2; paired-like homeodomain transcription factor 2; pituitary homeobox 2; Pitx-2; Pitx2c; Ptx2; rPtx2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,391,417 - 220,411,588 (+)NCBIGRCr8
mRatBN7.22217,717,738 - 217,737,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,717,693 - 217,737,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,392,106 - 225,411,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,291,763 - 223,311,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,149,443 - 218,168,994 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,602,732 - 233,621,129 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IBA,ISO)
animal organ morphogenesis  (IEA,ISO)
atrial cardiac muscle tissue morphogenesis  (ISO)
atrioventricular valve development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle tissue development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell proliferation involved in outflow tract morphogenesis  (ISO)
deltoid tuberosity development  (ISO)
determination of left/right symmetry  (ISO)
digestive system development  (ISO)
embryonic camera-type eye development  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic heart tube left/right pattern formation  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endodermal digestive tract morphogenesis  (ISO)
extraocular skeletal muscle development  (ISO)
female gonad development  (IEP)
heart development  (ISO)
hypothalamus cell migration  (ISO)
in utero embryonic development  (ISO)
iris morphogenesis  (ISO)
left lung morphogenesis  (ISO)
left/right axis specification  (ISO)
lung development  (ISO)
male gonad development  (IEP)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (IEP)
neuron migration  (ISO)
odontogenesis  (ISO)
odontogenesis of dentin-containing tooth  (IEP)
outflow tract morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
pulmonary myocardium development  (ISO)
pulmonary vein morphogenesis  (ISO)
regulation of cell migration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to hormone  (IEP)
response to vitamin A  (IEP)
skeletal muscle tissue development  (ISO)
spleen development  (ISO)
subthalamic nucleus development  (ISO)
superior vena cava morphogenesis  (ISO)
system development  (IEA)
vascular associated smooth muscle cell differentiation  (ISO)
vasculogenesis  (ISO)
ventricular cardiac muscle cell development  (ISO)
ventricular septum morphogenesis  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Arts syndrome is caused by loss-of-function mutations in PRPS1. de Brouwer AP, etal., Am J Hum Genet. 2007 Sep;81(3):507-18. Epub 2007 Aug 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Involvement of Pitx2, a homeodomain transcription factor, in hypothyroidism associated reproductive disorders. Ghosh P, etal., Cell Physiol Biochem. 2007;20(6):887-98.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Ito Y, etal., Development. 2003 Nov;130(21):5269-80.
6. A novel PITX2 mutation and a polymorphism in a 5-generation family with Axenfeld-Rieger anomaly and coexisting Fuchs' endothelial dystrophy. Kniestedt C, etal., Ophthalmology. 2006 Oct;113(10):1791.e1-8. Epub 2006 Jul 31.
7. Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Kriangkrai R, etal., Anat Embryol (Berl). 2006 Mar;211(2):101-8. Epub 2006 Jan 17.
8. Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling. Kugita M, etal., Am J Physiol Renal Physiol. 2011 Jan;300(1):F177-88. Epub 2010 Oct 6.
9. A novel PITX2 mutation in a Chinese family with Axenfeld-Rieger syndrome. Li D, etal., Mol Vis. 2008;14:2205-10. Epub 2008 Dec 5.
10. Regulated expression of the homeobox gene, rPtx2, in the developing rat. Lindberg C, etal., Brain Res Dev Brain Res 1998 Oct 1;110(2):215-26.
11. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Lu MF, etal., Nature 1999 Sep 16;401(6750):276-8.
12. Pitx2-mediated cardiac outflow tract remodeling. Ma HY, etal., Dev Dyn. 2013 May;242(5):456-68. doi: 10.1002/dvdy.23934. Epub 2013 Mar 12.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Expression of PITX2 homeodomain transcription factor during rat gonadal development in a sexually dimorphic manner. Nandi SS, etal., Cell Physiol Biochem. 2011;27(2):159-70. Epub 2011 Feb 11.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter. Quentien MH, etal., J Biol Chem 2002 Nov 15;277(46):44408-16.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. GABAergic lineage differentiation of AF5 neural progenitor cells in vitro. Sanchez JF, etal., Cell Tissue Res. 2006 Apr;324(1):1-8. Epub 2006 Jan 12.
22. The temporal requirement for vitamin A in the developing eye: mechanism of action in optic fissure closure and new roles for the vitamin in regulating cell proliferation and adhesion in the embryonic retina. See AW and Clagett-Dame M, Dev Biol. 2009 Jan 1;325(1):94-105. Epub 2008 Oct 14.
23. Analysis of three Ptx2 splice variants on transcriptional activity and differential expression pattern in the brain. Smidt MP, etal., J Neurochem. 2000 Nov;75(5):1818-25.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9437321   PMID:9618168   PMID:9685346   PMID:9708732   PMID:10498698   PMID:10499586   PMID:10572050   PMID:10822271   PMID:11157981   PMID:11301317   PMID:11493526   PMID:12397115  
PMID:12464179   PMID:12612071   PMID:14630904   PMID:15385555   PMID:15466416   PMID:15475956   PMID:16449236   PMID:16556915   PMID:16638982   PMID:16836994   PMID:16958127   PMID:17234970  
PMID:17767158   PMID:17823370   PMID:18022758   PMID:18158920   PMID:18206388   PMID:18231602   PMID:18292603   PMID:18312615   PMID:18458156   PMID:19174163   PMID:19251162   PMID:19531352  
PMID:20816801   PMID:21035439   PMID:21550054   PMID:23131154   PMID:23975681   PMID:24091014   PMID:24908044   PMID:35639924  


Genomics

Comparative Map Data
Pitx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,391,417 - 220,411,588 (+)NCBIGRCr8
mRatBN7.22217,717,738 - 217,737,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,717,693 - 217,737,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,392,106 - 225,411,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,291,763 - 223,311,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,149,443 - 218,168,994 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,602,732 - 233,621,129 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
PITX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,617,423 - 110,642,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,617,423 - 110,642,123 (-)EnsemblGRCh38hg38GRCh38
GRCh374111,538,579 - 111,563,279 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,758,028 - 111,777,957 (-)NCBINCBI36Build 36hg18NCBI36
Build 344111,896,185 - 111,916,112NCBI
Celera4108,832,403 - 108,852,329 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,270,120 - 107,294,817 (-)NCBIHuRef
CHM1_14111,515,486 - 111,540,182 (-)NCBICHM1_1
T2T-CHM13v2.04113,919,284 - 113,943,981 (-)NCBIT2T-CHM13v2.0
Pitx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393128,993,527 - 129,013,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3128,993,527 - 129,013,240 (+)EnsemblGRCm39 Ensembl
GRCm383129,199,878 - 129,219,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,199,878 - 129,219,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv373128,902,836 - 128,922,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,191,965 - 129,211,613 (+)NCBIMGSCv36mm8
Celera3135,706,515 - 135,726,130 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.84NCBI
Pitx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545715,803,219 - 15,823,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545715,803,493 - 15,823,193 (+)NCBIChiLan1.0ChiLan1.0
PITX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,707,912 - 108,728,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14109,000,309 - 109,020,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04103,112,624 - 103,137,356 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,676,846 - 113,696,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PITX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,710,161 - 30,730,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,710,685 - 30,730,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,306,508 - 11,326,539 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,931,178 - 30,951,191 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,931,702 - 30,947,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,916,988 - 30,937,021 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,667,533 - 30,687,592 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,167,168 - 9,187,192 (+)NCBIUU_Cfam_GSD_1.0
Pitx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,214,001 - 10,237,701 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,698,757 - 111,723,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,697,364 - 111,723,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,906,708 - 119,926,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PITX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,501,669 - 58,526,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,501,559 - 58,507,318 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603737,182,289 - 37,203,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,871,511 - 4,886,384 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248384,872,279 - 4,889,780 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pitx2
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:776
Count of miRNA genes:218
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000044232, ENSRNOT00000051009
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat

Markers in Region
PITX2_380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,736,443 - 217,737,300 (+)MAPPERmRatBN7.2
Rnor_6.02233,620,206 - 233,621,062NCBIRnor6.0
Rnor_5.02252,947,330 - 252,948,186UniSTSRnor5.0
RGSC_v3.42226,600,470 - 226,601,326UniSTSRGSC3.4
Celera2210,032,743 - 210,033,599UniSTS
Cytogenetic Map2q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 14 4 4 4 16 7
Low 1 23 10 10 10 8 11 24 33 19 7 8
Below cutoff 5 20 17 7 17 26 2 9 1

Sequence


RefSeq Acc Id: ENSRNOT00000044232   ⟹   ENSRNOP00000043402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,717,693 - 217,737,288 (+)Ensembl
Rnor_6.0 Ensembl2233,602,732 - 233,621,051 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000051009   ⟹   ENSRNOP00000046259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,731,928 - 217,737,293 (+)Ensembl
Rnor_6.0 Ensembl2233,615,739 - 233,621,129 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111851   ⟹   ENSRNOP00000084208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,721,648 - 217,737,293 (+)Ensembl
RefSeq Acc Id: NM_001042505   ⟹   NP_001035970
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,406,223 - 220,411,588 (+)NCBI
mRatBN7.22217,731,928 - 217,737,293 (+)NCBI
Rnor_6.02233,615,690 - 233,621,055 (+)NCBI
Rnor_5.02252,929,195 - 252,948,179 (+)NCBI
RGSC_v3.42226,581,170 - 226,601,319 (+)RGD
Celera2210,028,227 - 210,033,592 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019334   ⟹   NP_062207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,392,034 - 220,411,584 (+)NCBI
mRatBN7.22217,717,738 - 217,737,289 (+)NCBI
Rnor_6.02233,602,732 - 233,621,051 (+)NCBI
Rnor_5.02252,929,195 - 252,948,179 (+)NCBI
RGSC_v3.42226,581,170 - 226,601,319 (+)RGD
Celera2210,013,296 - 210,033,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063282420   ⟹   XP_063138490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,391,417 - 220,411,588 (+)NCBI
RefSeq Acc Id: NP_062207   ⟸   NM_019334
- Peptide Label: isoform 2
- UniProtKB: A6HVN3 (UniProtKB/TrEMBL),   A0A8I5ZYF1 (UniProtKB/TrEMBL),   A6HVN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001035970   ⟸   NM_001042505
- Peptide Label: isoform 1
- UniProtKB: Q9R0W1 (UniProtKB/Swiss-Prot),   A6HVN4 (UniProtKB/TrEMBL),   A0A8I5ZYF1 (UniProtKB/TrEMBL),   A6HVN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046259   ⟸   ENSRNOT00000051009
RefSeq Acc Id: ENSRNOP00000043402   ⟸   ENSRNOT00000044232
RefSeq Acc Id: ENSRNOP00000084208   ⟸   ENSRNOT00000111851
RefSeq Acc Id: XP_063138490   ⟸   XM_063282420
- Peptide Label: isoform X1
Protein Domains
Homeobox   OAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0W1-F1-model_v2 AlphaFold Q9R0W1 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3331 AgrOrtholog
BioCyc Gene G2FUF-51248 BioCyc
Ensembl Genes ENSRNOG00000010681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026980 UniProtKB/Swiss-Prot
  ENSRNOG00060003311 UniProtKB/Swiss-Prot
  ENSRNOG00065014191 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044232 ENTREZGENE
  ENSRNOT00000044232.7 UniProtKB/Swiss-Prot
  ENSRNOT00000051009 ENTREZGENE
  ENSRNOT00000051009.5 UniProtKB/Swiss-Prot
  ENSRNOT00000111851.1 UniProtKB/TrEMBL
  ENSRNOT00055046617 UniProtKB/Swiss-Prot
  ENSRNOT00060005436 UniProtKB/Swiss-Prot
  ENSRNOT00065023428 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Homeobox_Pitx/unc30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54284 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54284 ENTREZGENE
PANTHER PITUITARY HOMEOBOX 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PITUITARY HOMEOBOX HOMOLOG PTX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PITX2 RGD
PhenoGen Pitx2 PhenoGen
PIRSF Homeobox_protein_Pitx/Unc30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010681 RatGTEx
  ENSRNOG00055026980 RatGTEx
  ENSRNOG00060003311 RatGTEx
  ENSRNOG00065014191 RatGTEx
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207548
UniProt A0A8I5ZYF1 ENTREZGENE, UniProtKB/TrEMBL
  A6HVN2 ENTREZGENE, UniProtKB/TrEMBL
  A6HVN3 ENTREZGENE, UniProtKB/TrEMBL
  A6HVN4 ENTREZGENE, UniProtKB/TrEMBL
  PITX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Pitx2  paired-like homeodomain 2  Pitx2  paired-like homeodomain transcription factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pitx2  paired-like homeodomain transcription factor 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function involved in basal and hormone-regulated activity of the prolactin promoter 633538
gene_physical_interaction binds to the prolactin promoter 633538
gene_product member of the paired-like class of homeobox genes 69931