Pitx2 (paired like homeodomain 2) - Rat Genome Database

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Gene: Pitx2 (paired like homeodomain 2) Ictidomys tridecemlineatus
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Symbol: Pitx2
Name: paired like homeodomain 2
RGD ID: 12468276
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); animal organ morphogenesis (ortholog); atrial cardiac muscle tissue morphogenesis (ortholog); ASSOCIATED WITH anterior segment dysgenesis (ortholog); anterior segment dysgenesis 1 (ortholog); anterior segment dysgenesis 4 (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: paired like homeodomain 2, transcript variant X1; paired like homeodomain 2, transcript variant X2; paired like homeodomain 2, transcript variant X3; pituitary homeobox 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,214,001 - 10,237,701 (+)NCBI
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (ISO)
animal organ morphogenesis  (ISO)
atrial cardiac muscle tissue morphogenesis  (ISO)
atrioventricular valve development  (ISO)
brain development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle tissue development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell proliferation involved in outflow tract morphogenesis  (ISO)
deltoid tuberosity development  (ISO)
determination of left/right symmetry  (ISO)
digestive system development  (ISO)
embryonic camera-type eye development  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic heart tube left/right pattern formation  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endodermal digestive tract morphogenesis  (ISO)
extraocular skeletal muscle development  (ISO)
female gonad development  (ISO)
heart development  (ISO)
hypothalamus cell migration  (ISO)
in utero embryonic development  (ISO)
iris morphogenesis  (ISO)
left lung morphogenesis  (ISO)
left/right axis specification  (ISO)
lung development  (ISO)
male gonad development  (ISO)
myoblast fusion  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
odontogenesis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
pituitary gland development  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
pulmonary myocardium development  (ISO)
pulmonary vein morphogenesis  (ISO)
regulation of cell migration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to hormone  (ISO)
response to vitamin A  (ISO)
skeletal muscle tissue development  (ISO)
spleen development  (ISO)
subthalamic nucleus development  (ISO)
superior vena cava morphogenesis  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
vasculogenesis  (ISO)
ventricular cardiac muscle cell development  (ISO)
ventricular septum morphogenesis  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Pitx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,214,001 - 10,237,701 (+)NCBI
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4110,617,423 - 110,642,123 (-)EnsemblGRCh38hg38GRCh38
GRCh384110,617,423 - 110,642,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374111,538,579 - 111,563,279 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,758,028 - 111,777,957 (-)NCBINCBI36hg18NCBI36
Build 344111,896,185 - 111,916,112NCBI
Celera4108,832,403 - 108,852,329 (-)NCBI
Cytogenetic Map4q25NCBI
HuRef4107,270,120 - 107,294,817 (-)NCBIHuRef
CHM1_14111,515,486 - 111,540,182 (-)NCBICHM1_1
Pitx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393128,993,527 - 129,013,243 (+)NCBIGRCm39mm39
GRCm39 Ensembl3128,993,527 - 129,013,240 (+)Ensembl
GRCm383129,199,878 - 129,219,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,199,878 - 129,219,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv373128,902,836 - 128,922,509 (+)NCBIGRCm37mm9NCBIm37
MGSCv363129,191,965 - 129,211,613 (+)NCBImm8
Celera3135,706,515 - 135,726,130 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.84NCBI
Pitx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22217,717,738 - 217,737,293 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2217,717,693 - 217,737,293 (+)Ensembl
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,602,732 - 233,621,129 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
Pitx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545715,803,219 - 15,823,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545715,803,493 - 15,823,193 (+)NCBIChiLan1.0ChiLan1.0
PITX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14113,676,846 - 113,696,518 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v04103,112,624 - 103,137,356 (-)NCBIMhudiblu_PPA_v0panPan3
PITX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,710,161 - 30,730,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,710,685 - 30,730,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,306,508 - 11,326,539 (+)NCBI
ROS_Cfam_1.03230,931,178 - 30,951,191 (-)NCBI
UMICH_Zoey_3.13230,916,988 - 30,937,021 (-)NCBI
UNSW_CanFamBas_1.03230,667,533 - 30,687,592 (-)NCBI
UU_Cfam_GSD_1.0329,167,168 - 9,187,192 (+)NCBI
PITX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,698,664 - 111,723,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,697,364 - 111,723,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,906,708 - 119,926,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PITX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,501,669 - 58,526,413 (-)NCBI
ChlSab1.1 Ensembl758,501,559 - 58,507,318 (-)Ensembl
Vero_WHO_p1.0NW_02366603737,182,289 - 37,203,030 (-)NCBI
Pitx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248384,872,279 - 4,889,780 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005330097   ⟹   XP_005330154
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530110,232,495 - 10,237,701 (+)NCBI
SpeTri2.0NW_0049365631,713,294 - 1,718,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330098   ⟹   XP_005330155
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530110,218,205 - 10,237,701 (+)NCBI
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005330100   ⟹   XP_005330157
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530110,218,223 - 10,237,701 (+)NCBI
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040292993   ⟹   XP_040148927
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530110,214,003 - 10,237,701 (+)NCBI
RefSeq Acc Id: XM_040292994   ⟹   XP_040148928
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440530110,214,001 - 10,237,701 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005330157   ⟸   XM_005330100
- Peptide Label: isoform X3
- UniProtKB: A0A287D303 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005330155   ⟸   XM_005330098
- Peptide Label: isoform X2
- UniProtKB: A0A287CSU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005330154   ⟸   XM_005330097
- Peptide Label: isoform X1
- UniProtKB: I3NES5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040148928   ⟸   XM_040292994
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040148927   ⟸   XM_040292993
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025728 ENTREZGENE
Ensembl Protein ENSSTOP00000022872 ENTREZGENE
  ENSSTOP00000024361 ENTREZGENE
  ENSSTOP00000027909 ENTREZGENE
NCBI Gene Pitx2 ENTREZGENE
UniProt A0A287CSU1 ENTREZGENE
  A0A287D303 ENTREZGENE
  I3NES5 ENTREZGENE