Pitx2 (paired like homeodomain 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pitx2 (paired like homeodomain 2) Heterocephalus glaber
Analyze
Symbol: Pitx2
Name: paired like homeodomain 2
RGD ID: 18916391
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); animal organ morphogenesis (ortholog); atrial cardiac muscle tissue morphogenesis (ortholog); ASSOCIATED WITH anterior segment dysgenesis (ortholog); anterior segment dysgenesis 1 (ortholog); anterior segment dysgenesis 4 (ortholog); FOUND IN nucleoplasm (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pituitary homeobox 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248384,872,279 - 4,889,780 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248384,871,511 - 4,886,384 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2713,618,095 - 13,631,864 (-)Ensembl
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
atrial cardiac muscle tissue morphogenesis  (ISO)
atrioventricular valve development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle tissue development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell proliferation involved in outflow tract morphogenesis  (ISO)
deltoid tuberosity development  (ISO)
determination of left/right symmetry  (ISO)
digestive system development  (ISO)
embryonic camera-type eye development  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic heart tube left/right pattern formation  (ISO)
embryonic hindlimb morphogenesis  (ISO)
endodermal digestive tract morphogenesis  (ISO)
extraocular skeletal muscle development  (ISO)
female gonad development  (ISO)
heart development  (ISO)
hypothalamus cell migration  (ISO)
in utero embryonic development  (ISO)
iris morphogenesis  (ISO)
left lung morphogenesis  (ISO)
left/right axis specification  (ISO)
lung development  (ISO)
male gonad development  (ISO)
myoblast fusion  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (ISO)
neuron migration  (ISO)
odontogenesis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
outflow tract morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pulmonary myocardium development  (ISO)
pulmonary vein morphogenesis  (ISO)
regulation of cell migration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to hormone  (ISO)
response to vitamin A  (ISO)
skeletal muscle tissue development  (ISO)
spleen development  (ISO)
subthalamic nucleus development  (ISO)
superior vena cava morphogenesis  (ISO)
system development  (IEA)
vascular associated smooth muscle cell differentiation  (ISO)
vasculogenesis  (ISO)
ventricular cardiac muscle cell development  (ISO)
ventricular septum morphogenesis  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pitx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248384,872,279 - 4,889,780 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248384,871,511 - 4,886,384 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2713,618,095 - 13,631,864 (-)Ensembl
PITX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,617,423 - 110,642,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,617,423 - 110,642,182 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh374111,538,579 - 111,563,279 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,758,028 - 111,777,957 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344111,896,185 - 111,916,112NCBI
Celera4108,832,403 - 108,852,329 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,270,120 - 107,294,817 (-)NCBIHuRef
CHM1_14111,515,486 - 111,540,182 (-)NCBICHM1_1
T2T-CHM13v2.04113,919,284 - 113,943,981 (-)NCBIT2T-CHM13v2.0
Pitx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393128,993,527 - 129,013,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3128,993,527 - 129,013,240 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383129,199,878 - 129,219,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,199,878 - 129,219,591 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv373128,902,836 - 128,922,509 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363129,191,965 - 129,211,613 (+)NCBIMGSCv36mm8
Celera3135,706,515 - 135,726,130 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.84NCBI
Pitx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,391,417 - 220,411,588 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2220,391,888 - 220,411,591 (+)EnsemblGRCr8
mRatBN7.22217,717,738 - 217,737,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,717,693 - 217,737,293 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2225,392,106 - 225,411,651 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,291,763 - 223,311,312 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,149,443 - 218,168,994 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2220,218,130 - 220,237,640 (+)NCBI
Lyon_Normotensive2220,414,712 - 220,434,223 (+)NCBI
Lyon_Hypertensive2220,030,374 - 220,049,886 (+)NCBI
F344_StmMcwi2220,088,117 - 220,107,631 (+)NCBI
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,602,732 - 233,621,129 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2210,013,296 - 210,033,592 (+)NCBICelera
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Cytogenetic Map2q42NCBI
Pitx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545715,803,219 - 15,823,310 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495545715,803,493 - 15,823,193 (+)NCBIChiLan1.0ChiLan1.0
PITX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,707,912 - 108,728,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14109,000,309 - 109,020,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04103,112,624 - 103,137,356 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,676,846 - 113,696,518 (-)NCBIPanPan1.1PanPan1.1panPan2
PITX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,710,161 - 30,730,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,710,685 - 30,730,273 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3211,306,508 - 11,326,539 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03230,931,178 - 30,951,191 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,931,702 - 30,947,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,916,988 - 30,937,021 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,667,533 - 30,687,592 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,167,168 - 9,187,192 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pitx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1993,468,460 - 93,488,094 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440530110,214,001 - 10,237,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365631,713,288 - 1,732,449 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,698,757 - 111,723,298 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.18111,697,364 - 111,723,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,906,708 - 119,926,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PITX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1762,110,083 - 62,130,414 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603737,182,289 - 37,203,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1758,501,669 - 58,526,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,501,559 - 58,507,318 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Pitx2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1330,098,939 - 30,118,584 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000007943   ⟹   ENSHGLP00000007855
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248384,871,511 - 4,886,384 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000007944   ⟹   ENSHGLP00000007856
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248384,871,511 - 4,876,829 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000007945   ⟹   ENSHGLP00000007857
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248384,872,935 - 4,886,214 (-)Ensembl
Naked mole-rat maternal Ensembl2713,618,095 - 13,631,392 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000071833   ⟹   ENSHGLP00000053989
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
Naked mole-rat maternal Ensembl2713,618,095 - 13,631,864 (-)Ensembl
RefSeq Acc Id: XM_004867586   ⟹   XP_004867643
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248384,872,279 - 4,876,962 (-)NCBI
RefSeq Acc Id: XM_021246644   ⟹   XP_021102303
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248384,872,279 - 4,889,780 (-)NCBI
RefSeq Acc Id: XM_021246645   ⟹   XP_021102304
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248384,872,279 - 4,886,353 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004867643 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102303 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007855
  ENSHGLP00000007856
GenBank Protein JAO02751 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021102303   ⟸   XM_021246644
- Peptide Label: isoform X2
- UniProtKB: A0AAX6S0E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102304   ⟸   XM_021246645
- Peptide Label: isoform X2
- UniProtKB: A0AAX6S0E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867643   ⟸   XM_004867586
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JE95 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000007857   ⟸   ENSHGLT00000007945
Ensembl Acc Id: ENSHGLP00000007855   ⟸   ENSHGLT00000007943
Ensembl Acc Id: ENSHGLP00000007856   ⟸   ENSHGLT00000007944
Ensembl Acc Id: ENSHGLP00000053989   ⟸   ENSHGLT00000071833


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005694 Ensembl, ENTREZGENE
  ENSHGLG00000047113 Ensembl
Ensembl Transcript ENSHGLT00000007943 ENTREZGENE
  ENSHGLT00000007944 ENTREZGENE
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro HD_metazoa UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_Pitx/unc30 UniProtKB/TrEMBL
  OAR_dom UniProtKB/TrEMBL
KEGG Report hgl:101722303 UniProtKB/TrEMBL
NCBI Gene Pitx2 ENTREZGENE
PANTHER PITUITARY HOMEOBOX 2 UniProtKB/TrEMBL
  PITUITARY HOMEOBOX HOMOLOG PTX1 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
PIRSF Homeobox_protein_Pitx/Unc30 UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0P6JE95 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S0E1 ENTREZGENE, UniProtKB/TrEMBL