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Gene: Nkx2-1 (NK2 homeobox 1) Rattus norvegicus
Symbol: Nkx2-1
Name: NK2 homeobox 1
RGD ID: 3866
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; TBP-class protein binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to leptin stimulus; embryonic lung development; and hyperosmotic salinity response. Localizes to nucleoplasm. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH acetylsalicylic acid; all-trans-retinoic acid; all-trans-retinol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein Nkx-2.1; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; Thyroid transcription factor 1 TTF-1 NK-2 (Drosophila) homolog A (thyroid nuclear factor); thyroid-specific transcription factor 1; Titf1; TTF-1; TTF1
Homo sapiens (human) : NKX2-1 (NK2 homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Nkx2-1 (NK2 homeobox 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-1 (NK2 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-1 (NK2 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-1 (NK2 homeobox 1)
Sus scrofa (pig) : NKX2-1 (NK2 homeobox 1)
Chlorocebus sabaeus (African green monkey) : NKX2-1 (NK2 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Nkx2-1 (NK2 homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0677,418,096 - 77,423,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl677,418,096 - 77,421,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0686,945,224 - 86,950,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4676,916,943 - 76,920,133 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1676,920,108 - 76,923,259 (-)NCBI
Celera672,803,847 - 72,807,046 (-)NCBICelera
Cytogenetic Map6q23NCBI
RH 3.4 Map6523.61RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nkx2-1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3866
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.