RGD Reference Report - TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. - Rat Genome Database

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TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.

Authors: Zannini, M  Avantaggiato, V  Biffali, E  Arnone, MI  Sato, K  Pischetola, M  Taylor, BA  Phillips, SJ  Simeone, A  Di Lauro, R 
Citation: Zannini M, etal., EMBO J 1997 Jun 2;16(11):3185-97.
RGD ID: 632682
Pubmed: PMID:9214635   (View Abstract at PubMed)
PMCID: PMC1169936   (View Article at PubMed Central)
DOI: DOI:10.1093/emboj/16.11.3185   (Journal Full-text)

Expression of thyroglobulin (Tg) and thyroperoxidase (TPO) genes in thyroid follicular cells occurs in the mouse at embryonic day (E)14.5. Two transcription factors, TTF-1 and Pax-8, have been implicated in transcriptional activation of Tg and TPO, even though the onset of their expression is at E9.5, suggesting that additional events are necessary for transcriptional activation of Tg and TPO genes. We report in this paper the cloning of TTF-2, a DNA binding protein that recognizes sites on both Tg and TPO promoters. TTF-2 is a new forkhead domain-containing protein whose expression is restricted to the endodermal lining of the foregut and to the ectoderm that will give rise to the anterior pituitary. TTF-2 shows transient expression in the developing thyroid and anterior pituitary. In the thyroid, TTF-2 expression is down-regulated just before the onset of Tg and TPO gene expression, suggesting that this transcription factor plays the role in development of a negative controller of thyroid-specific gene expression.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nkx2-1Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIDA PMID:9214635MGI 
Pax8Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIDA PMID:9214635MGI 
Foxe1Ratregulation of DNA-templated transcription  TAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Foxe1RatDNA-binding transcription factor activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Foxe1  (forkhead box E1)
Nkx2-1  (NK2 homeobox 1)
Pax8  (paired box 8)

Objects referenced in this article
Gene Foxe1 forkhead box E1 Mus musculus
Gene Nkx2-1 NK2 homeobox 1 Mus musculus
Gene Orm1 orosomucoid 1 Mus musculus
Gene Pax8 paired box 8 Mus musculus
Gene Xpa xeroderma pigmentosum, complementation group A Mus musculus

Additional Information