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Gene: Nkx2-1 (NK2 homeobox 1) Mus musculus
Symbol: Nkx2-1
Name: NK2 homeobox 1
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region DNA binding activity. Involved in several processes, including animal organ development; neurogenesis; and regulation of transcription by RNA polymerase II. Localizes to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human NKX2-1 (NK2 homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV026640; homeobox protein Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; tinman; Titf1; Ttf-1
Homo sapiens (human) : NKX2-1 (NK2 homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nkx2-1 (NK2 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-1 (NK2 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-1 (NK2 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-1 (NK2 homeobox 1)
Sus scrofa (pig) : NKX2-1 (NK2 homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [13 Feb 2013]
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1256,531,958 - 56,536,908 (-)Ensembl
GRCm381256,531,935 - 56,536,908 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371257,632,922 - 57,637,895 (-)NCBIGRCm37mm9NCBIm37
MGSCv361257,449,970 - 57,454,920 (-)NCBImm8
Celera1257,681,286 - 57,686,296 (-)NCBICelera
Cytogenetic Map12 C1NCBI
cM Map1224.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nkx2-1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11420
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.