Nkx2-1 (NK2 homeobox 1) - Rat Genome Database

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Gene: Nkx2-1 (NK2 homeobox 1) Mus musculus
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Symbol: Nkx2-1
Name: NK2 homeobox 1
RGD ID: 11420
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hypothalamus development; positive regulation of circadian rhythm; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including lung development; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; neural ectoderm; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AV026640; homeobox protein Nkx-2.1; Nkx2.1; T/EB; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; ti; tinman; Titf; Titf1; Ttf-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [13 Feb 2013]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391256,578,741 - 56,583,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1256,578,743 - 56,583,693 (-)EnsemblGRCm39 Ensembl
GRCm381256,531,935 - 56,536,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1256,531,958 - 56,536,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371257,632,922 - 57,637,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361257,449,970 - 57,454,920 (-)NCBIMGSCv36mm8
Celera1257,681,286 - 57,686,296 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IMP)
animal organ morphogenesis  (IMP)
axon guidance  (IMP)
brain development  (IGI,IMP,ISO)
cell differentiation  (IBA)
cellular response to leptin stimulus  (ISO)
cerebral cortex cell migration  (IMP)
cerebral cortex GABAergic interneuron differentiation  (IMP)
cerebral cortex neuron differentiation  (IGI,IMP)
circadian rhythm  (ISO)
club cell differentiation  (IGI)
development of primary female sexual characteristics  (ISO)
developmental induction  (IMP)
embryonic lung development  (ISO)
endoderm development  (IMP)
epithelial tube branching involved in lung morphogenesis  (ISO)
feeding behavior  (ISO)
forebrain development  (ISO)
forebrain dorsal/ventral pattern formation  (IMP)
forebrain neuron differentiation  (IMP)
forebrain neuron fate commitment  (IGI,IMP)
GABAergic neuron differentiation  (IMP)
gene expression  (IMP)
globus pallidus development  (IMP,ISO)
hippocampus development  (IMP)
hypothalamus development  (IMP)
interneuron migration  (IMP)
Leydig cell differentiation  (IMP)
locomotory behavior  (IMP,ISO)
lung development  (IGI,IMP,ISO)
lung saccule development  (IGI)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron fate commitment  (IMP)
neuron migration  (IMP)
oligodendrocyte differentiation  (IGI)
pattern specification process  (IGI)
phospholipid metabolic process  (IGI)
pituitary gland development  (IMP)
positive regulation of circadian rhythm  (IMP)
positive regulation of DNA-templated transcription  (IDA,IGI,ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of DNA-templated transcription  (IDA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA)
response to ethanol  (ISO)
response to hormone  (ISO)
response to lipopolysaccharide  (ISO)
rhythmic process  (IEA)
telencephalon cell migration  (IMP)
telencephalon development  (IMP)
thyroid gland development  (IGI,IMP,ISO)
type II pneumocyte differentiation  (IGI)

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
transcription regulator complex  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis development  (IAGP)
abnormal adrenal cortex morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchus epithelium morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal hypothalamus morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung saccule morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal mesenchymal cell differentiation involved in lung development  (IAGP)
abnormal ovulation  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal pleural cavity morphology  (IAGP)
abnormal pulmonary acinus morphology  (IAGP)
abnormal pulmonary alveolar parenchyma morphology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary alveolus epithelium morphology  (IAGP)
abnormal pulmonary circulation  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland development  (IAGP)
abnormal trachea morphology  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal ventromedial hypothalamic nucleus morphology  (IAGP)
absent alveolar lamellar bodies  (IAGP)
absent infundibular recess of third ventricle  (IAGP)
absent pituitary gland  (IAGP)
absent pituitary infundibular stalk  (IAGP)
absent thyroid gland  (IAGP)
absent type II pneumocytes  (IAGP)
decreased exploration in new environment  (IAGP)
decreased fetal weight  (IAGP)
decreased lung weight  (IAGP)
decreased surfactant secretion  (IAGP)
decreased testes secretion  (IAGP)
decreased testis weight  (IAGP)
decreased tracheal cartilage ring number  (IAGP)
decreased ventromedial hypothalamic nucleus size  (IAGP)
delayed estrous cycle  (IAGP)
delayed sexual maturation  (IAGP)
dilated respiratory conducting tube  (IAGP)
early reproductive senescence  (IAGP)
enhanced coordination  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in respiratory bronchiole morphogenesis  (IAGP)
impaired coordination  (IAGP)
increased adenoma incidence  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased locomotor activity  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
prolonged estrous cycle  (IAGP)
pulmonary hypoplasia  (IAGP)
reduced female fertility  (IAGP)
respiratory failure  (IAGP)
small thyroid gland  (IAGP)
thick lung-associated mesenchyme  (IAGP)
tracheoesophageal fistula  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutations in TITF-1 are associated with benign hereditary chorea. Breedveld GJ, etal., Hum Mol Genet. 2002 Apr 15;11(8):971-9.
2. Nonsense mutation in TITF1 in a Portuguese family with benign hereditary chorea. do Carmo Costa M, etal., Neurogenetics. 2005 Dec;6(4):209-15. Epub 2005 Oct 12.
3. A novel NKX2.1 mutation in a family with hypothyroidism and benign hereditary chorea. Ferrara AM, etal., Thyroid. 2008 Sep;18(9):1005-9. doi: 10.1089/thy.2008.0085.
4. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Kimura S, etal., Genes Dev 1996 Jan 1;10(1):60-9.
5. Benign hereditary chorea, not only chorea: a family case presentation. Koht J, etal., Cerebellum Ataxias. 2016 Feb 2;3:3. doi: 10.1186/s40673-016-0041-7. eCollection 2016.
6. Benign hereditary chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation. Konishi T, etal., J Neurol. 2013 Jan;260(1):207-13. doi: 10.1007/s00415-012-6618-z. Epub 2012 Jul 24.
7. NKX2-1 mutation in a family diagnosed with ataxic dyskinetic cerebral palsy. McMichael G, etal., Eur J Med Genet. 2013 Sep;56(9):506-9. doi: 10.1016/j.ejmg.2013.07.003. Epub 2013 Jul 30.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Identification and functional characterization of a novel mutation in the NKX2-1 gene: comparison with the data in the literature. Nettore IC, etal., Thyroid. 2013 Jun;23(6):675-82. doi: 10.1089/thy.2012.0267.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Qiu M, etal., Genes Dev 1995 Oct 15;9(20):2523-38.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia. Takayasu H, etal., Pediatr Surg Int. 2007 Jan 24;.
19. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. Zannini M, etal., EMBO J 1997 Jun 2;16(11):3185-97.
20. Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers. Zighelboim I, etal., Clin Cancer Res. 2007 May 15;13(10):2882-9.
Additional References at PubMed
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PMID:29939162   PMID:29946134   PMID:29950483   PMID:29972793   PMID:30002193   PMID:30017396   PMID:30022023   PMID:30026494   PMID:30063881   PMID:30146317   PMID:30153454   PMID:30186122  
PMID:30194919   PMID:30217225   PMID:30291164   PMID:30305289   PMID:30332632   PMID:30344048   PMID:30352852   PMID:30377227   PMID:30389913   PMID:30389914   PMID:30397221   PMID:30446499  
PMID:30475207   PMID:30566624   PMID:30571765   PMID:30590426   PMID:30604742   PMID:30679375   PMID:30692221   PMID:30696710   PMID:30699346   PMID:30728831   PMID:30782824   PMID:30843579  
PMID:30846310   PMID:30865900   PMID:30884041   PMID:30886014   PMID:30959515   PMID:31001083   PMID:31038803   PMID:31242446   PMID:31257105   PMID:31548395   PMID:31582725   PMID:31665922  
PMID:31700187   PMID:31758944   PMID:31767619   PMID:31776260   PMID:31811030   PMID:31813798   PMID:32001436   PMID:32059772   PMID:32109363   PMID:32154873   PMID:32156757   PMID:32169553  
PMID:32241942   PMID:32253239   PMID:32273485   PMID:32320667   PMID:32375878   PMID:32414917   PMID:32445470   PMID:32460513   PMID:32515350   PMID:32561725   PMID:32613945   PMID:32633719  
PMID:32778568   PMID:32803714   PMID:32855415   PMID:32855417   PMID:32868762   PMID:32985705   PMID:33060130   PMID:33154347   PMID:33177537   PMID:33184218   PMID:33253712   PMID:33290732  
PMID:33428297   PMID:33431871   PMID:33479483   PMID:33567285   PMID:33576044   PMID:33585465   PMID:33600763   PMID:33711282   PMID:33775695   PMID:33789083   PMID:33821423   PMID:33869166  
PMID:33947861   PMID:34004146   PMID:34121118   PMID:34228108   PMID:34260916   PMID:34261648   PMID:34287339   PMID:34289374   PMID:34321664   PMID:34339499   PMID:34387544   PMID:34463328  
PMID:34494344   PMID:34518367   PMID:34564702   PMID:34611166   PMID:34643182   PMID:34671097   PMID:34838304   PMID:34851738   PMID:34851821   PMID:34932949   PMID:34975747   PMID:34994686  
PMID:35112129   PMID:35132995   PMID:35137631   PMID:35140269   PMID:35175194   PMID:35273083   PMID:35289766   PMID:35294885   PMID:35303432   PMID:35512705   PMID:35544642   PMID:35676931  
PMID:35741102   PMID:35835117   PMID:35853870   PMID:35941210   PMID:35976093   PMID:36046192   PMID:36064547   PMID:36100434   PMID:36115458   PMID:36218069   PMID:36239312   PMID:36302841  
PMID:36375792   PMID:36379611   PMID:36398878   PMID:36433959   PMID:36464171   PMID:36517477   PMID:36595695   PMID:36717694   PMID:36774552   PMID:36805633   PMID:36819097   PMID:37079499  
PMID:37191061   PMID:37254876   PMID:37311756   PMID:37401408   PMID:37524711   PMID:37532091   PMID:37534159   PMID:37566909   PMID:37595582   PMID:37684687   PMID:37738673   PMID:37873566  
PMID:37884508   PMID:37964961   PMID:38114516  


Genomics

Comparative Map Data
Nkx2-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391256,578,741 - 56,583,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1256,578,743 - 56,583,693 (-)EnsemblGRCm39 Ensembl
GRCm381256,531,935 - 56,536,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1256,531,958 - 56,536,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371257,632,922 - 57,637,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361257,449,970 - 57,454,920 (-)NCBIMGSCv36mm8
Celera1257,681,286 - 57,686,296 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.42NCBI
NKX2-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381436,516,397 - 36,520,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1436,516,392 - 36,521,149 (-)EnsemblGRCh38hg38GRCh38
GRCh371436,985,602 - 36,989,437 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361436,055,353 - 36,059,167 (-)NCBINCBI36Build 36hg18NCBI36
Build 341436,055,352 - 36,058,654NCBI
Celera1416,849,149 - 16,852,977 (-)NCBICelera
Cytogenetic Map14q13.3NCBI
HuRef1417,100,276 - 17,104,039 (-)NCBIHuRef
CHM1_11436,984,732 - 36,988,564 (-)NCBICHM1_1
T2T-CHM13v2.01430,705,671 - 30,709,516 (-)NCBIT2T-CHM13v2.0
Nkx2-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8679,731,677 - 79,735,952 (-)NCBIGRCr8
mRatBN7.2673,996,601 - 74,001,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl673,996,601 - 73,999,791 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx674,392,972 - 74,396,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0674,699,372 - 74,702,565 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,126,847 - 74,130,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0677,418,096 - 77,423,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl677,418,096 - 77,421,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0686,945,224 - 86,950,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4676,916,943 - 76,920,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1676,920,108 - 76,923,259 (-)NCBI
Celera672,803,847 - 72,807,046 (-)NCBICelera
RH 3.4 Map6523.61RGD
Cytogenetic Map6q23NCBI
Nkx2-1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540924,612,635 - 24,616,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540924,612,490 - 24,616,360 (+)NCBIChiLan1.0ChiLan1.0
NKX2-1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21537,828,988 - 37,833,255 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11437,045,506 - 37,049,760 (-)NCBINHGRI_mPanPan1
NKX2-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha814,886,591 - 14,888,646 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0815,197,690 - 15,202,516 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl815,197,699 - 15,201,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,896,830 - 14,898,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0814,963,572 - 14,965,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0815,253,618 - 15,255,673 (-)NCBIUU_Cfam_GSD_1.0
Nkx2-1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864047,011,599 - 47,015,298 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649410,517,488 - 10,520,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649410,517,488 - 10,520,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl763,487,807 - 63,491,575 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1763,487,200 - 63,491,580 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2768,395,821 - 68,400,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12413,274,118 - 13,317,533 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2413,310,846 - 13,317,056 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660532,266,777 - 2,311,899 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkx2-1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624838300,458 - 305,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624838300,902 - 304,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nkx2-1
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:478
Count of miRNA genes:185
Interacting mature miRNAs:190
Transcripts:ENSMUST00000001536, ENSMUST00000178477
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12904004Opfaq11_mopen field activity QTL 11 (mouse)125315562457276756Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
12903999Opfaq8_mopen field activity QTL 8 (mouse)125490765357870585Mouse

Markers in Region
Titf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,533,692 - 56,534,761UniSTSGRCm38
MGSCv371257,634,679 - 57,635,748UniSTSGRCm37
Celera1257,683,047 - 57,684,116UniSTS
Cytogenetic Map12C1-C3UniSTS
cM Map1228.0UniSTS
cM Map1228.0UniSTS
Nkx2-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,535,030 - 56,536,356UniSTSGRCm38
MGSCv371257,634,031 - 57,634,462UniSTSGRCm37
Celera1257,684,385 - 57,685,744UniSTS
Cytogenetic Map12C1-C3UniSTS
AA858694  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,532,121 - 56,532,317UniSTSGRCm38
MGSCv371257,633,108 - 57,633,304UniSTSGRCm37
Celera1257,681,473 - 57,681,669UniSTS
Cytogenetic Map12C1-C3UniSTS
AV026640  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,532,042 - 56,532,133UniSTSGRCm38
MGSCv371257,633,029 - 57,633,120UniSTSGRCm37
Celera1257,681,394 - 57,681,485UniSTS
Cytogenetic Map12C1-C3UniSTS
Whitehead/MRC_RH12579.31UniSTS
UniSTS:225218  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,535,900 - 56,536,051UniSTSGRCm38
MGSCv371257,636,887 - 57,637,038UniSTSGRCm37
Celera1257,685,288 - 57,685,439UniSTS
Cytogenetic Map12C1-C3UniSTS
PMC152810P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,533,593 - 56,533,801UniSTSGRCm38
MGSCv371257,634,580 - 57,634,788UniSTSGRCm37
Celera1257,682,948 - 57,683,156UniSTS
Cytogenetic Map12C1-C3UniSTS
D6Wox31  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,535,315 - 56,535,523UniSTSGRCm38
MGSCv371257,636,302 - 57,636,510UniSTSGRCm37
Celera1257,684,670 - 57,684,910UniSTS
Cytogenetic Map12C1-C3UniSTS
D6Wox28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,535,371 - 56,535,523UniSTSGRCm38
MGSCv371257,636,358 - 57,636,510UniSTSGRCm37
Celera1257,684,726 - 57,684,910UniSTS
Cytogenetic Map12C1-C3UniSTS
Nkx2-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C1-C3UniSTS
Nkx2-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,533,044 - 56,533,475UniSTSGRCm38
MGSCv371257,634,031 - 57,634,462UniSTSGRCm37
Celera1257,682,399 - 57,682,830UniSTS
Cytogenetic Map12C1-C3UniSTS
Titf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381256,541,308 - 56,541,397UniSTSGRCm38
MGSCv371257,642,295 - 57,642,384UniSTSGRCm37
Celera1257,690,712 - 57,690,801UniSTS
Cytogenetic Map12C1-C3UniSTS
cM Map1228.0UniSTS
Nkx2-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C1-C3UniSTS
Titf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C1-C3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000001536   ⟹   ENSMUSP00000001536
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1256,578,743 - 56,583,693 (-)Ensembl
GRCm38.p6 Ensembl1256,531,958 - 56,536,908 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178477   ⟹   ENSMUSP00000136103
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1256,578,743 - 56,581,891 (-)Ensembl
GRCm38.p6 Ensembl1256,531,958 - 56,535,106 (-)Ensembl
RefSeq Acc Id: NM_001403580   ⟹   NP_001390509
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391256,578,743 - 56,582,767 (-)NCBI
RefSeq Acc Id: NM_009385   ⟹   NP_033411
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391256,578,743 - 56,583,570 (-)NCBI
GRCm381256,531,935 - 56,536,908 (-)NCBI
MGSCv371257,632,922 - 57,637,895 (-)RGD
Celera1257,681,286 - 57,686,296 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515791   ⟹   XP_006515854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391256,578,741 - 56,582,951 (-)NCBI
GRCm381256,531,956 - 56,536,166 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157377   ⟹   XP_036013270
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391256,578,741 - 56,582,951 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033411   ⟸   NM_009385
- Peptide Label: isoform 1
- UniProtKB: P50220 (UniProtKB/Swiss-Prot),   Q6PFE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515854   ⟸   XM_006515791
- Peptide Label: isoform X2
- UniProtKB: Q6PFE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136103   ⟸   ENSMUST00000178477
RefSeq Acc Id: ENSMUSP00000001536   ⟸   ENSMUST00000001536
RefSeq Acc Id: XP_036013270   ⟸   XM_036157377
- Peptide Label: isoform X1
- UniProtKB: Q6PFE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001390509   ⟸   NM_001403580
- Peptide Label: isoform 2
- UniProtKB: Q6PFE0 (UniProtKB/TrEMBL)
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50220-F1-model_v2 AlphaFold P50220 1-372 view protein structure

Promoters
RGD ID:8678310
Promoter ID:EPDNEW_M17186
Type:initiation region
Name:Nkx2-1_1
Description:Mus musculus NK2 homeobox 1 (Nkx2-1), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17187  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381256,535,198 - 56,535,258EPDNEW
RGD ID:8678312
Promoter ID:EPDNEW_M17187
Type:single initiation site
Name:Nkx2-1_2
Description:Mus musculus NK2 homeobox 1 (Nkx2-1), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17186  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381256,536,928 - 56,536,988EPDNEW
RGD ID:6823226
Promoter ID:MM_KWN:11700
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001146198
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361257,635,826 - 57,636,777 (-)MPROMDB
RGD ID:6823227
Promoter ID:MM_KWN:11701
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_009385
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361257,637,526 - 57,638,277 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108067 AgrOrtholog
Ensembl Genes ENSMUSG00000001496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001536 ENTREZGENE
  ENSMUST00000001536.9 UniProtKB/Swiss-Prot
  ENSMUST00000178477.9 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21869 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108067 ENTREZGENE
NCBI Gene 21869 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-2.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nkx2-1 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NKX21_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PFE0 ENTREZGENE, UniProtKB/TrEMBL