Nkx2-1 (NK2 homeobox 1) - Rat Genome Database

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Gene: Nkx2-1 (NK2 homeobox 1) Ictidomys tridecemlineatus
Analyze
Symbol: Nkx2-1
Name: NK2 homeobox 1
RGD ID: 12583738
Description: ENCODES a protein that exhibits core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); animal organ morphogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH Benign Familial Chorea (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); choreatic disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: homeobox protein Nkx-2.1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864047,011,599 - 47,015,298 (-)NCBI
SpeTri2.0NW_00493649410,517,488 - 10,520,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
animal organ morphogenesis  (ISO)
axon guidance  (ISO)
brain development  (ISO)
cellular response to leptin stimulus  (ISO)
cerebral cortex cell migration  (ISO)
cerebral cortex GABAergic interneuron differentiation  (ISO)
cerebral cortex neuron differentiation  (ISO)
circadian rhythm  (ISO)
club cell differentiation  (ISO)
development of primary female sexual characteristics  (ISO)
developmental induction  (ISO)
embryonic lung development  (ISO)
endoderm development  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
feeding behavior  (ISO)
forebrain development  (ISO)
forebrain dorsal/ventral pattern formation  (ISO)
forebrain neuron differentiation  (ISO)
forebrain neuron fate commitment  (ISO)
globus pallidus development  (ISO)
hippocampus development  (ISO)
hyperosmotic salinity response  (ISO)
Leydig cell differentiation  (ISO)
locomotory behavior  (ISO)
lung development  (ISO)
lung saccule development  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron fate commitment  (ISO)
neuron migration  (ISO)
oligodendrocyte differentiation  (ISO)
pattern specification process  (ISO)
phospholipid metabolic process  (ISO)
pituitary gland development  (ISO)
positive regulation of circadian rhythm  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to ethanol  (ISO)
response to hormone  (ISO)
response to lipopolysaccharide  (ISO)
telencephalon cell migration  (ISO)
telencephalon development  (ISO)
thyroid gland development  (ISO)
type II pneumocyte differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Nkx2-1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864047,011,599 - 47,015,298 (-)NCBI
SpeTri2.0NW_00493649410,517,488 - 10,520,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1436,516,392 - 36,521,149 (-)EnsemblGRCh38hg38GRCh38
GRCh381436,516,397 - 36,520,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371436,985,602 - 36,989,437 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361436,055,353 - 36,059,167 (-)NCBINCBI36hg18NCBI36
Build 341436,055,352 - 36,058,654NCBI
Celera1416,849,149 - 16,852,977 (-)NCBI
Cytogenetic Map14q13.3NCBI
HuRef1417,100,276 - 17,104,039 (-)NCBIHuRef
CHM1_11436,984,732 - 36,988,564 (-)NCBICHM1_1
Nkx2-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391256,578,720 - 56,583,693 (-)NCBIGRCm39mm39
GRCm39 Ensembl1256,578,743 - 56,583,693 (-)Ensembl
GRCm381256,531,935 - 56,536,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1256,531,958 - 56,536,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371257,632,922 - 57,637,895 (-)NCBIGRCm37mm9NCBIm37
MGSCv361257,449,970 - 57,454,920 (-)NCBImm8
Celera1257,681,286 - 57,686,296 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.42NCBI
Nkx2-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2673,996,601 - 74,001,483 (-)NCBI
Rnor_6.0 Ensembl677,418,096 - 77,421,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0677,418,096 - 77,423,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0686,945,224 - 86,950,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4676,916,943 - 76,920,133 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1676,920,108 - 76,923,259 (-)NCBI
Celera672,803,847 - 72,807,046 (-)NCBICelera
RH 3.4 Map6523.61RGD
Cytogenetic Map6q23NCBI
Nkx2-1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540924,612,635 - 24,616,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540924,612,490 - 24,616,360 (+)NCBIChiLan1.0ChiLan1.0
NKX2-1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11435,403,557 - 35,627,438 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1435,404,127 - 35,626,722 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01417,224,870 - 17,273,252 (-)NCBIMhudiblu_PPA_v0panPan3
NKX2-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha814,886,591 - 14,888,646 (-)NCBI
ROS_Cfam_1.0815,197,690 - 15,202,516 (-)NCBI
UMICH_Zoey_3.1814,896,830 - 14,898,885 (-)NCBI
UNSW_CanFamBas_1.0814,963,572 - 14,965,627 (-)NCBI
UU_Cfam_GSD_1.0815,253,618 - 15,255,673 (-)NCBI
NKX2-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl763,487,807 - 63,491,575 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1763,487,200 - 63,491,580 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2768,395,821 - 68,400,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12413,274,118 - 13,317,533 (-)NCBI
ChlSab1.1 Ensembl2413,310,846 - 13,317,056 (-)Ensembl
Nkx2-1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624838300,902 - 304,944 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005322695   ⟹   XP_005322752
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_00493649410,517,488 - 10,520,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005322696   ⟹   XP_005322753
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864047,011,599 - 47,014,913 (-)NCBI
SpeTri2.0NW_00493649410,517,488 - 10,520,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040274017   ⟹   XP_040129951
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864047,011,599 - 47,014,153 (-)NCBI
RefSeq Acc Id: XM_040274018   ⟹   XP_040129952
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864047,011,599 - 47,015,298 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005322753 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129951 (Get FASTA)   NCBI Sequence Viewer  
  XP_040129952 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005322753   ⟸   XM_005322696
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005322752   ⟸   XM_005322695
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040129952   ⟸   XM_040274018
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040129951   ⟸   XM_040274017
- Peptide Label: isoform X1
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023264 UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000022097 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029292 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
NCBI Gene Nkx2-1 ENTREZGENE
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt I3NCK0_ICTTR UniProtKB/TrEMBL