NKX2-1 (NK2 homeobox 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: NKX2-1 (NK2 homeobox 1) Canis lupus familiaris
Analyze
Symbol: NKX2-1
Name: NK2 homeobox 1
RGD ID: 12350577
Description: ENCODES a protein that exhibits core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); animal organ morphogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH Benign Familial Chorea (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); choreatic disease (ortholog); FOUND IN nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein Nkx-2.1; thyroid nuclear factor 1; thyroid transcription factor 1; TITF1; TTF-1; TTF1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha814,886,591 - 14,888,646 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0815,197,690 - 15,202,516 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl815,197,699 - 15,201,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,896,830 - 14,898,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0814,963,572 - 14,965,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0815,253,618 - 15,255,673 (-)NCBIUU_Cfam_GSD_1.0


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
axon guidance  (IEA,ISO)
brain development  (IEA,ISO)
cell differentiation  (IBA)
cellular response to leptin stimulus  (ISO)
cerebral cortex cell migration  (IEA,ISO)
cerebral cortex GABAergic interneuron differentiation  (IEA,ISO)
cerebral cortex neuron differentiation  (IEA,ISO)
circadian rhythm  (ISO)
club cell differentiation  (IEA,ISO)
development of primary female sexual characteristics  (ISO)
developmental induction  (IEA,ISO)
embryonic lung development  (ISO)
endoderm development  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA)
feeding behavior  (ISO)
forebrain development  (IEA)
forebrain dorsal/ventral pattern formation  (IEA,ISO)
forebrain neuron differentiation  (IEA,ISO)
forebrain neuron fate commitment  (IEA,ISO)
GABAergic neuron differentiation  (IEA,ISO)
gene expression  (IEA)
globus pallidus development  (IEA,ISO)
hippocampus development  (IEA,ISO)
hypothalamus development  (IEA)
interneuron migration  (IEA,ISO)
Leydig cell differentiation  (IEA,ISO)
locomotory behavior  (IEA,ISO)
lung development  (IEA,ISO)
lung saccule development  (IEA,ISO)
negative regulation of cell migration  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial to mesenchymal transition  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
neuron fate commitment  (IEA,ISO)
neuron migration  (IEA,ISO)
oligodendrocyte differentiation  (IEA,ISO)
pattern specification process  (IEA,ISO)
phospholipid metabolic process  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive regulation of circadian rhythm  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to ethanol  (ISO)
response to hormone  (IEA)
response to lipopolysaccharide  (ISO)
telencephalon cell migration  (IEA,ISO)
telencephalon development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
type II pneumocyte differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7589789   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NKX2-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha814,886,591 - 14,888,646 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0815,197,690 - 15,202,516 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl815,197,699 - 15,201,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,896,830 - 14,898,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0814,963,572 - 14,965,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0815,253,618 - 15,255,673 (-)NCBIUU_Cfam_GSD_1.0
NKX2-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381436,516,397 - 36,520,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1436,516,392 - 36,521,149 (-)EnsemblGRCh38hg38GRCh38
GRCh371436,985,602 - 36,989,437 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361436,055,353 - 36,059,167 (-)NCBINCBI36Build 36hg18NCBI36
Build 341436,055,352 - 36,058,654NCBI
Celera1416,849,149 - 16,852,977 (-)NCBICelera
Cytogenetic Map14q13.3NCBI
HuRef1417,100,276 - 17,104,039 (-)NCBIHuRef
CHM1_11436,984,732 - 36,988,564 (-)NCBICHM1_1
T2T-CHM13v2.01430,705,671 - 30,709,516 (-)NCBIT2T-CHM13v2.0
Nkx2-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391256,578,741 - 56,583,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1256,578,743 - 56,583,693 (-)EnsemblGRCm39 Ensembl
GRCm381256,531,935 - 56,536,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1256,531,958 - 56,536,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371257,632,922 - 57,637,895 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361257,449,970 - 57,454,920 (-)NCBIMGSCv36mm8
Celera1257,681,286 - 57,686,296 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.42NCBI
Nkx2-1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8679,731,677 - 79,735,952 (-)NCBIGRCr8
mRatBN7.2673,996,601 - 74,001,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl673,996,601 - 73,999,791 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx674,392,972 - 74,396,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0674,699,372 - 74,702,565 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,126,847 - 74,130,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0677,418,096 - 77,423,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl677,418,096 - 77,421,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0686,945,224 - 86,950,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4676,916,943 - 76,920,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1676,920,108 - 76,923,259 (-)NCBI
Celera672,803,847 - 72,807,046 (-)NCBICelera
RH 3.4 Map6523.61RGD
Cytogenetic Map6q23NCBI
Nkx2-1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540924,612,635 - 24,616,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540924,612,490 - 24,616,360 (+)NCBIChiLan1.0ChiLan1.0
LOC100983103
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21537,786,124 - 37,826,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11437,002,629 - 37,043,203 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01417,224,870 - 17,273,252 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11435,403,557 - 35,627,438 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1435,404,127 - 35,626,722 (-)Ensemblpanpan1.1panPan2
Nkx2-1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864047,011,599 - 47,015,298 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649410,517,488 - 10,520,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649410,517,488 - 10,520,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl763,487,807 - 63,491,575 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1763,487,200 - 63,491,580 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2768,395,821 - 68,400,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12413,274,118 - 13,317,533 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2413,310,846 - 13,317,056 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660532,266,777 - 2,311,899 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkx2-1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624838300,458 - 305,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624838300,902 - 304,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845004672   ⟹   ENSCAFP00845003731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl815,197,699 - 15,201,982 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845004687   ⟹   ENSCAFP00845003742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl815,197,699 - 15,201,462 (-)Ensembl
RefSeq Acc Id: NM_001003260   ⟹   NP_001003260
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha814,886,591 - 14,888,646 (-)NCBI
ROS_Cfam_1.0815,198,589 - 15,200,644 (-)NCBI
UMICH_Zoey_3.1814,896,830 - 14,898,885 (-)NCBI
UNSW_CanFamBas_1.0814,963,572 - 14,965,627 (-)NCBI
UU_Cfam_GSD_1.0815,253,618 - 15,255,673 (-)NCBI
RefSeq Acc Id: XM_038672849   ⟹   XP_038528777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0815,197,690 - 15,202,510 (-)NCBI
RefSeq Acc Id: XM_038672850   ⟹   XP_038528778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0815,197,690 - 15,202,515 (-)NCBI
RefSeq Acc Id: XM_038672851   ⟹   XP_038528779
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0815,197,690 - 15,202,510 (-)NCBI
RefSeq Acc Id: XM_038672852   ⟹   XP_038528780
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0815,197,690 - 15,202,516 (-)NCBI
RefSeq Acc Id: XM_038672853   ⟹   XP_038528781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0815,197,690 - 15,202,512 (-)NCBI
RefSeq Acc Id: XM_038672854   ⟹   XP_038528782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0815,197,690 - 15,202,510 (-)NCBI
RefSeq Acc Id: NP_001003260   ⟸   NM_001003260
- UniProtKB: P43698 (UniProtKB/Swiss-Prot),   A0A8C0LD94 (UniProtKB/TrEMBL),   A0A8I3MMM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528780   ⟸   XM_038672852
- Peptide Label: isoform X4
- UniProtKB: A0A8I3MMM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528778   ⟸   XM_038672850
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MMM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528781   ⟸   XM_038672853
- Peptide Label: isoform X5
- UniProtKB: A0A8I3MMM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528782   ⟸   XM_038672854
- Peptide Label: isoform X6
- UniProtKB: P43698 (UniProtKB/Swiss-Prot),   A0A8C0LD94 (UniProtKB/TrEMBL),   A0A8I3MMM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528779   ⟸   XM_038672851
- Peptide Label: isoform X3
- UniProtKB: A0A8I3MJN5 (UniProtKB/TrEMBL),   A0A8P0PN74 (UniProtKB/TrEMBL),   A0A8I3MMM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528777   ⟸   XM_038672849
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCAFP00845003731   ⟸   ENSCAFT00845004672
Ensembl Acc Id: ENSCAFP00845003742   ⟸   ENSCAFT00845004687
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000049032 UniProtKB/TrEMBL
  ENSCAFG00030002878 UniProtKB/Swiss-Prot
  ENSCAFG00040021917 UniProtKB/Swiss-Prot
  ENSCAFG00845002630 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000083974.2 UniProtKB/TrEMBL
  ENSCAFT00030005352.1 UniProtKB/Swiss-Prot
  ENSCAFT00040040686.1 UniProtKB/Swiss-Prot
  ENSCAFT00845004672 ENTREZGENE
  ENSCAFT00845004672.1 UniProtKB/TrEMBL
  ENSCAFT00845004687 ENTREZGENE
  ENSCAFT00845004687.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_NK-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403940 UniProtKB/Swiss-Prot
NCBI Gene NKX2-1 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-2.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0LD94 ENTREZGENE
  A0A8I3MJN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MMM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PN74 ENTREZGENE, UniProtKB/TrEMBL
  P43698 ENTREZGENE, UniProtKB/Swiss-Prot