RGD Reference Report - Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. - Rat Genome Database

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Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.

Authors: Guazzi, S  Price, M  De Felice, M  Damante, G  Mattei, MG  Di Lauro, R 
Citation: Guazzi S, etal., EMBO J 1990 Nov;9(11):3631-9.
RGD ID: 729951
Pubmed: PMID:1976511   (View Abstract at PubMed)
PMCID: PMC552115   (View Article at PubMed Central)

The cDNA for TTF-1, a thyroid nuclear factor that binds to the promoter of thyroid specific genes, has been cloned. The protein encoded by the cDNA shows binding properties indistinguishable from those of TTF-1 present in nuclear extracts of differentiated rat thyroid cells. The DNA binding domain of TTF-1 is a novel mammalian homeodomain that shows considerable sequence homology to the Drosophila NK-2 homeodomain. TTF-1 mRNA and corresponding binding activity are detected in thyroid and lung. The chromosomal localization of the TTF-1 gene has been determined in humans and mice and corresponds to chromosomes 14 and 12, respectively, demonstrating that the TTF-1 gene is not located within previously described clusters of homeobox-containing genes.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nkx2-1RatDNA binding  IDA  RGD 
Nkx2-1RatDNA binding  TAS  RGD 
Nkx2-1RatRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIDA PMID:1976511NTNU_SB 

Objects Annotated

Genes (Rattus norvegicus)
Nkx2-1  (NK2 homeobox 1)

Objects referenced in this article
Gene NKX2-1 NK2 homeobox 1 Homo sapiens

Additional Information