2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene multiple interactions ISO RGD:1353820 6480464 [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2 more ... CTD PMID:19422813 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1553242 6480464 Tetrachlorodibenzodioxin results in decreased expression of ALK mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1553242 6480464 Tetrachlorodibenzodioxin affects the expression of ALK mRNA CTD PMID:21570461 , PMID:26377647 2,4-diaminopyridine multiple interactions ISO RGD:1353820 6480464 2, 4-diaminopyridine analog binds to and results in decreased activity of ALK protein CTD PMID:22564207 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ALK mRNA CTD PMID:24780913 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of ALK mRNA CTD PMID:30047161 aflatoxin B1 decreases methylation ISO RGD:1353820 6480464 Aflatoxin B1 results in decreased methylation of ALK intron CTD PMID:30157460 Aflatoxin B2 alpha decreases methylation ISO RGD:1353820 6480464 aflatoxin B2 results in decreased methylation of ALK intron CTD PMID:30157460 aldrin multiple interactions ISO RGD:1353820 6480464 [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2 more ... CTD PMID:19422813 , PMID:28263720 alectinib affects response to substance ISO RGD:1353820 6480464 ALK protein affects the susceptibility to alectinib CTD PMID:29458018 alectinib decreases activity ISO RGD:1353820 6480464 alectinib results in decreased activity of ALK protein CTD PMID:26144315 all-trans-retinoic acid multiple interactions ISO RGD:1353820 6480464 [Tretinoin co-treated with ALK gene mutant form] results in increased cleavage of CASP3 protein CTD PMID:20576349 all-trans-retinoic acid increases expression ISO RGD:1353820 6480464 Tretinoin results in increased expression of ALK mRNA CTD PMID:23724009 all-trans-retinoic acid decreases expression ISO RGD:1353820 6480464 Tretinoin results in decreased expression of ALK mRNA, Tretinoin results in decreased expression of ALK protein CTD PMID:20576349 amiodarone increases expression ISO RGD:1353820 6480464 Amiodarone results in increased expression of ALK mRNA CTD PMID:19774075 amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of ALK mRNA CTD PMID:30047161 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ALK mRNA CTD PMID:16483693 amphotericin B increases expression ISO RGD:1353820 6480464 Amphotericin B results in increased expression of ALK mRNA CTD PMID:28534445 arsane affects methylation ISO RGD:1353820 6480464 Arsenic affects the methylation of ALK gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1353820 6480464 Arsenic affects the methylation of ALK gene CTD PMID:25304211 ATP affects binding ISO RGD:1353820 6480464 ALK protein binds to Adenosine Triphosphate CTD PMID:22072639 ATP multiple interactions ISO RGD:1353820 6480464 [ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib, ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate] CTD PMID:22072639 atrazine decreases expression ISO RGD:1353820 6480464 Atrazine results in decreased expression of ALK mRNA CTD PMID:22378314 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of ALK mRNA CTD PMID:36841081 benzo[a]pyrene increases methylation ISO RGD:1353820 6480464 Benzo(a)pyrene results in increased methylation of ALK 5' UTR more ... CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:1553242 6480464 Benzo(a)pyrene results in increased methylation of ALK intron CTD PMID:27901495 benzo[e]pyrene decreases methylation ISO RGD:1353820 6480464 benzo(e)pyrene results in decreased methylation of ALK intron CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ALK mRNA CTD PMID:25181051 more ... bisphenol A multiple interactions ISO RGD:1353820 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of ALK gene CTD PMID:31601247 ceritinib affects response to substance ISO RGD:1353820 6480464 ALK protein affects the susceptibility to ceritinib CTD PMID:29458018 ceritinib decreases phosphorylation ISO RGD:1353820 6480464 ceritinib analog results in decreased phosphorylation of ALK protein CTD PMID:35803438 ceritinib decreases activity ISO RGD:1353820 6480464 ceritinib results in decreased activity of ALK protein CTD PMID:26144315 chlorpyrifos increases expression ISO RGD:1553242 6480464 Chlorpyrifos results in increased expression of ALK mRNA CTD PMID:20350560 choline multiple interactions ISO RGD:1553242 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALK gene CTD PMID:20938992 crizotinib decreases response to substance ISO RGD:1353820 6480464 ALK gene mutant form results in decreased susceptibility to crizotinib more ... CTD PMID:20979473 more ... crizotinib affects response to substance ISO RGD:1353820 6480464 ALK protein affects the susceptibility to crizotinib CTD PMID:29458018 crizotinib increases mutagenesis ISO RGD:1353820 6480464 crizotinib results in increased mutagenesis of ALK gene mutant form, crizotinib results in increased mutagenesis of ALK protein mutant form CTD PMID:20979473 more ... crizotinib decreases activity ISO RGD:1553242 6480464 crizotinib results in decreased activity of ALK protein mutant form CTD PMID:21838707 crizotinib decreases stability ISO RGD:1353820 6480464 crizotinib results in decreased stability of ALK protein mutant form CTD PMID:22912387 crizotinib decreases phosphorylation ISO RGD:1353820 6480464 crizotinib results in decreased phosphorylation of ALK protein, crizotinib results in decreased phosphorylation of ALK protein mutant form CTD PMID:20979473 more ... crizotinib decreases activity ISO RGD:1353820 6480464 Crizotinib results in decreased activity of ALK protein, Crizotinib results in decreased activity of ALK protein mutant form CTD PMID:21030459 more ... crizotinib multiple interactions ISO RGD:1353820 6480464 [ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib more ... CTD PMID:20979473 more ... DDD multiple interactions ISO RGD:1353820 6480464 [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2 more ... CTD PMID:19422813 , PMID:28263720 DDE multiple interactions ISO RGD:1353820 6480464 [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2 more ... CTD PMID:19422813 , PMID:28263720 DDT multiple interactions ISO RGD:1353820 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 dieldrin multiple interactions ISO RGD:1353820 6480464 [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2 more ... CTD PMID:19422813 , PMID:28263720 endrin multiple interactions ISO RGD:1353820 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 epoxiconazole increases expression ISO RGD:1553242 6480464 epoxiconazole results in increased expression of ALK mRNA CTD PMID:35436446 ethanol increases expression ISO RGD:1553242 6480464 Ethanol results in increased expression of ALK mRNA CTD PMID:30319688 folic acid multiple interactions ISO RGD:1553242 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALK gene CTD PMID:20938992 fonofos increases methylation ISO RGD:1353820 6480464 Fonofos results in increased methylation of ALK promoter CTD PMID:22847954 fulvestrant multiple interactions ISO RGD:1353820 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of ALK gene CTD PMID:31601247 gamma-hexachlorocyclohexane multiple interactions ISO RGD:1353820 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 genistein affects expression ISO RGD:1553242 6480464 Genistein affects the expression of ALK mRNA CTD PMID:32186404 hydrogen peroxide increases phosphorylation ISO RGD:1353820 6480464 Hydrogen Peroxide results in increased phosphorylation of ALK protein mutant form CTD PMID:19503098 L-methionine multiple interactions ISO RGD:1553242 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALK gene CTD PMID:20938992 lorlatinib multiple interactions ISO RGD:1353820 6480464 lorlatinib results in decreased phosphorylation of and results in decreased activity of ALK protein, lorlatinib results in decreased phosphorylation of and results in decreased activity of ALK protein mutant form CTD PMID:26144315 masoprocol multiple interactions ISO RGD:1353820 6480464 Masoprocol affects the phosphorylation of and affects the activity of ALK protein mutant form CTD PMID:19503098 masoprocol decreases activity ISO RGD:1353820 6480464 Masoprocol results in decreased activity of ALK protein CTD PMID:19503098 methapyrilene decreases methylation ISO RGD:1353820 6480464 Methapyrilene results in decreased methylation of ALK intron CTD PMID:30157460 methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of ALK gene CTD PMID:35440735 N-acetyl-L-cysteine multiple interactions ISO RGD:1353820 6480464 Acetylcysteine affects the phosphorylation of and affects the activity of ALK protein mutant form CTD PMID:19503098 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1353820 6480464 Ethylnitrosourea results in increased mutagenesis of ALK protein CTD PMID:21948233 , PMID:22034911 N-ethyl-N-nitrosourea multiple interactions ISO RGD:1353820 6480464 [Ethylnitrosourea results in increased mutagenesis of ALK protein] inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein] more ... CTD PMID:22034911 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of ALK mRNA CTD PMID:33387578 parathion increases methylation ISO RGD:1353820 6480464 Parathion results in increased methylation of ALK promoter CTD PMID:22847954 pemetrexed affects response to substance ISO RGD:1353820 6480464 ALK gene mutant form affects the susceptibility to Pemetrexed CTD PMID:21336183 propiconazole decreases expression EXP 6480464 propiconazole results in decreased expression of ALK mRNA CTD PMID:30047161 pyrimidine-2,4-diamine decreases response to substance ISO RGD:1353820 6480464 ALK gene SNP results in decreased susceptibility to 2, 4-diaminopyrimidine analog CTD PMID:20979473 pyrimidine-2,4-diamine multiple interactions ISO RGD:1353820 6480464 ALK gene SNP inhibits the reaction [2, 4-diaminopyrimidine analog results in decreased phosphorylation of ALK protein mutant form] CTD PMID:20979473 pyrimidine-2,4-diamine decreases phosphorylation ISO RGD:1353820 6480464 2, 4-diaminopyrimidine analog results in decreased phosphorylation of ALK protein mutant form CTD PMID:20979473 simvastatin multiple interactions ISO RGD:1353820 6480464 [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 tanespimycin decreases activity ISO RGD:1353820 6480464 tanespimycin results in decreased activity of ALK protein mutant form CTD PMID:21030459 tanespimycin decreases expression ISO RGD:1353820 6480464 tanespimycin results in decreased expression of ALK protein, tanespimycin results in decreased expression of ALK protein modified form CTD PMID:21502504 terbufos increases methylation ISO RGD:1353820 6480464 terbufos results in increased methylation of ALK promoter CTD PMID:22847954 trimellitic anhydride increases expression ISO RGD:1553242 6480464 trimellitic anhydride results in increased expression of ALK mRNA CTD PMID:19042947 vanadium atom decreases expression ISO RGD:1353820 6480464 Vanadium results in decreased expression of ALK mRNA CTD PMID:19000753 vanadium(0) decreases expression ISO RGD:1353820 6480464 Vanadium results in decreased expression of ALK mRNA CTD PMID:19000753 vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of ALK gene CTD PMID:31079544 , PMID:31682807
