Alk (ALK receptor tyrosine kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Alk (ALK receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Alk
Name: ALK receptor tyrosine kinase
RGD ID: 628622
Description: Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and receptor signaling protein tyrosine kinase activator activity. Involved in nervous system development. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human ALK (ALK receptor tyrosine kinase); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALK tyrosine kinase receptor; ALK tyrosine kinase receptor-like; anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; LOC108351182
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8628,631,431 - 29,351,321 (+)NCBIGRCr8
mRatBN7.2622,879,653 - 23,599,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl622,880,625 - 23,598,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx623,211,130 - 23,929,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0623,526,957 - 24,245,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0623,008,575 - 23,732,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,696,415 - 23,203,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,696,397 - 23,203,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,690,337 - 33,703,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0632,580,744 - 33,082,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4623,009,061 - 23,730,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1623,700,711 - 23,727,905 (+)NCBI
Celera622,414,691 - 23,129,629 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. NPM mutations in acute myelogenous leukemia. Grisendi S and Pandolfi PP, N Engl J Med. 2005 Jan 20;352(3):291-2.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway. Souttou B, etal., J Biol Chem 2001 Mar 23;276(12):9526-31.
Additional References at PubMed
PMID:9174053   PMID:15886198   PMID:16880530   PMID:17487225   PMID:19056867   PMID:19200234   PMID:23382219   PMID:25326243   PMID:25517749   PMID:30497772  


Genomics

Comparative Map Data
Alk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8628,631,431 - 29,351,321 (+)NCBIGRCr8
mRatBN7.2622,879,653 - 23,599,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl622,880,625 - 23,598,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx623,211,130 - 23,929,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0623,526,957 - 24,245,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0623,008,575 - 23,732,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,696,415 - 23,203,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,696,397 - 23,203,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,690,337 - 33,703,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0632,580,744 - 33,082,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4623,009,061 - 23,730,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1623,700,711 - 23,727,905 (+)NCBI
Celera622,414,691 - 23,129,629 (+)NCBICelera
Cytogenetic Map6q14NCBI
ALK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38229,192,774 - 29,921,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl229,192,774 - 29,921,586 (-)EnsemblGRCh38hg38GRCh38
GRCh37229,415,640 - 30,144,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36229,269,144 - 29,997,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 34229,327,292 - 30,056,083NCBI
Celera229,260,042 - 29,988,141 (-)NCBICelera
Cytogenetic Map2p23.2-p23.1NCBI
HuRef229,156,646 - 29,883,927 (-)NCBIHuRef
CHM1_1229,345,879 - 30,074,503 (-)NCBICHM1_1
T2T-CHM13v2.0229,236,229 - 29,965,553 (-)NCBIT2T-CHM13v2.0
Alk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391772,174,206 - 72,911,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1772,175,967 - 72,911,622 (-)EnsemblGRCm39 Ensembl
GRCm381771,868,988 - 72,604,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1771,868,972 - 72,604,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv371772,218,328 - 72,953,647 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361771,009,971 - 71,745,160 (-)NCBIMGSCv36mm8
MGSCv361771,773,845 - 72,508,684 (-)NCBIMGSCv36mm8
Celera1776,136,594 - 76,877,724 (-)NCBICelera
Cytogenetic Map17E1.3NCBI
cM Map1743.77NCBI
Alk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546911,047,048 - 11,548,233 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546911,049,373 - 11,751,235 (-)NCBIChiLan1.0ChiLan1.0
ALK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21296,583,820 - 97,316,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A96,587,794 - 97,320,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A29,196,195 - 29,930,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A29,276,041 - 30,007,687 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A29,276,041 - 30,006,735 (-)Ensemblpanpan1.1panPan2
ALK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11723,010,308 - 23,688,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1723,010,308 - 23,688,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,797,195 - 23,482,846 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01723,570,633 - 24,250,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,572,834 - 24,250,519 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,869,939 - 23,549,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,932,402 - 23,612,861 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01723,038,591 - 23,719,569 (-)NCBIUU_Cfam_GSD_1.0
Alk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629267,167,996 - 67,810,992 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364933,028,608 - 3,671,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364933,624,288 - 3,671,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13109,411,146 - 110,105,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23116,847,214 - 116,923,998 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11477,632,809 - 78,408,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604533,719,552 - 34,471,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473811,095,134 - 11,288,891 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473811,094,699 - 12,010,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alk
3495 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:165
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000011630
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat

Markers in Region
D6Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2622,959,009 - 22,959,164 (-)MAPPERmRatBN7.2
Rnor_6.0623,764,495 - 23,764,649NCBIRnor6.0
Rnor_5.0633,624,543 - 33,624,697UniSTSRnor5.0
RGSC_v3.4623,089,262 - 23,089,417RGDRGSC3.4
RGSC_v3.4623,089,263 - 23,089,417UniSTSRGSC3.4
RGSC_v3.1623,092,215 - 23,092,370RGD
Celera622,493,624 - 22,493,778UniSTS
RH 2.0 Map6192.5RGD
FHH x ACI Map620.5099RGD
Cytogenetic Map6q13UniSTS
D6Got14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,557,699 - 23,557,984 (+)MAPPERmRatBN7.2
Rnor_6.0623,164,038 - 23,164,322NCBIRnor6.0
Rnor_5.0633,043,224 - 33,043,508UniSTSRnor5.0
RGSC_v3.4623,690,605 - 23,690,890RGDRGSC3.4
RGSC_v3.4623,690,606 - 23,690,890UniSTSRGSC3.4
RGSC_v3.1623,693,558 - 23,693,843RGD
Celera623,089,298 - 23,089,582UniSTS
RH 2.0 Map6188.6RGD
Cytogenetic Map6q13UniSTS
D6Got12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,153,282 - 23,153,430 (+)MAPPERmRatBN7.2
Rnor_6.0622,757,499 - 22,757,646NCBIRnor6.0
Rnor_5.0632,642,231 - 32,642,378UniSTSRnor5.0
RGSC_v3.4623,285,110 - 23,285,258RGDRGSC3.4
RGSC_v3.4623,285,111 - 23,285,258UniSTSRGSC3.4
RGSC_v3.1623,288,063 - 23,288,211RGD
Celera622,687,007 - 22,687,154UniSTS
RH 2.0 Map6191.3RGD
Cytogenetic Map6q13UniSTS
RH131901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,592,890 - 23,593,106 (+)MAPPERmRatBN7.2
Rnor_6.0623,198,633 - 23,198,848NCBIRnor6.0
Rnor_5.0633,077,819 - 33,078,034UniSTSRnor5.0
RGSC_v3.4623,725,781 - 23,725,996UniSTSRGSC3.4
Celera623,124,471 - 23,124,686UniSTS
Cytogenetic Map6q13UniSTS
AU048193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,137,820 - 23,137,970 (+)MAPPERmRatBN7.2
Rnor_6.0622,742,038 - 22,742,187NCBIRnor6.0
Rnor_5.0632,626,770 - 32,626,919UniSTSRnor5.0
RGSC_v3.4623,269,650 - 23,269,799UniSTSRGSC3.4
Celera622,671,544 - 22,671,693UniSTS
Cytogenetic Map6q13UniSTS
RH136724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,597,413 - 23,597,546 (+)MAPPERmRatBN7.2
Rnor_6.0623,203,155 - 23,203,287NCBIRnor6.0
Rnor_5.0633,082,341 - 33,082,473UniSTSRnor5.0
RGSC_v3.4623,730,303 - 23,730,435UniSTSRGSC3.4
Celera623,128,993 - 23,129,125UniSTS
Cytogenetic Map6q13UniSTS
RH138197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,198,095 - 23,198,238 (+)MAPPERmRatBN7.2
Rnor_6.0622,800,737 - 22,800,879NCBIRnor6.0
Rnor_5.0632,685,469 - 32,685,611UniSTSRnor5.0
RGSC_v3.4623,329,524 - 23,329,666UniSTSRGSC3.4
Celera622,731,709 - 22,731,851UniSTS
Cytogenetic Map6q13UniSTS
AlkWKYc42g04_r1_396  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4623,316,677 - 23,316,677 (+)RGDRGSC3.4


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 41 113 54 53 25 22 25 6 158 82 93 35 58 28

Sequence


Ensembl Acc Id: ENSRNOT00000011630   ⟹   ENSRNOP00000011630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl622,880,625 - 23,598,034 (+)Ensembl
Rnor_6.0 Ensembl622,696,397 - 23,203,775 (+)Ensembl
RefSeq Acc Id: NM_001169101   ⟹   NP_001162572
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8628,631,477 - 29,349,737 (+)NCBI
mRatBN7.2622,879,706 - 23,598,050 (+)NCBI
Rnor_6.0622,696,415 - 23,203,791 (+)NCBI
Rnor_5.0632,580,744 - 33,082,977 (+)NCBI
Rnor_5.0633,690,337 - 33,703,521 (-)NCBI
RGSC_v3.4623,009,061 - 23,730,939 (+)RGD
Celera622,414,691 - 23,129,629 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111819   ⟹   XP_038967747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8629,093,154 - 29,351,321 (+)NCBI
mRatBN7.2623,350,304 - 23,599,636 (+)NCBI
RefSeq Acc Id: XM_063261571   ⟹   XP_063117641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8629,314,513 - 29,351,321 (+)NCBI
RefSeq Acc Id: XR_005505446
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8628,631,431 - 29,316,620 (+)NCBI
mRatBN7.2622,879,653 - 23,564,923 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001162572 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967747 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117641 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC21663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011630.7
RefSeq Acc Id: NP_001162572   ⟸   NM_001169101
- Peptide Label: precursor
- UniProtKB: F1LRZ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011630   ⟸   ENSRNOT00000011630
RefSeq Acc Id: XP_038967747   ⟸   XM_039111819
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117641   ⟸   XM_063261571
- Peptide Label: isoform X2
Protein Domains
MAM   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LRZ0-F1-model_v2 AlphaFold F1LRZ0 1-1396 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628622 AgrOrtholog
BioCyc Gene G2FUF-38404 BioCyc
Ensembl Genes ENSRNOG00000008683 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011630.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ConA-like_dom UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
  Tyr_prot_kinase_rcpt_2_CS UniProtKB/TrEMBL
KEGG Report rno:266802 UniProtKB/TrEMBL
NCBI Gene 266802 ENTREZGENE
PANTHER PTHR24416:SF276 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Gly_rich UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Alk PhenoGen
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE MAM_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008683 RatGTEx
SMART TyrKc UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt F1LRZ0 ENTREZGENE, UniProtKB/TrEMBL
  Q8CJH1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Alk  ALK receptor tyrosine kinase  LOC108351182  ALK tyrosine kinase receptor-like  Data merged from RGD:11485359 737654 PROVISIONAL
2017-03-09 Alk  ALK receptor tyrosine kinase  Alk  anaplastic lymphoma receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 LOC108351182  ALK tyrosine kinase receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-13 Alk  anaplastic lymphoma receptor tyrosine kinase  Alk  anaplastic lymphoma kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Alk  anaplastic lymphoma kinase      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Alk  anaplastic lymphoma kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease rearrangement and truncation of the human homolog occurs in some cases of non-Hodgkin lymphoma 634542