Robo1 (roundabout guidance receptor 1) - Rat Genome Database

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Gene: Robo1 (roundabout guidance receptor 1) Rattus norvegicus
Analyze
Symbol: Robo1
Name: roundabout guidance receptor 1
RGD ID: 61941
Description: Enables axon guidance receptor activity. Involved in several processes, including cellular response to hypoxia; negative regulation of synapse assembly; and nervous system development. Located in axon; dendrite; and neuronal cell body. Biomarker of diabetic retinopathy; lung non-small cell carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; combined or isolated pituitary hormone deficiency 8; congenital nystagmus; multiple myeloma; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102551586; LOC683548; roundabout homolog 1; roundabout, axon guidance receptor, homolog 1; similar to roundabout homolog 1; uncharacterized LOC102551586
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Robo1Tn(sb-T2/Bart3)2.327Mcwi  
Genetic Models: F344-Robo1Tn(sb-T2/Bart3)2.327Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81124,067,869 - 25,108,694 (+)NCBIGRCr8
mRatBN7.21110,580,863 - 11,621,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1110,580,908 - 11,620,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1119,201,886 - 20,247,920 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,929,017 - 12,975,115 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01111,103,305 - 12,145,678 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0119,079,291 - 10,146,302 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl119,642,365 - 10,143,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01113,314,508 - 13,808,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41110,784,947 - 11,720,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11110,784,946 - 11,720,646 (+)NCBI
Celera1110,598,877 - 11,659,942 (+)NCBICelera
Cytogenetic Map11p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
androgen antagonist  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Butylparaben  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
DDE  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glyphosate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta development  (ISO)
aortic valve morphogenesis  (ISO)
axon guidance  (IDA,IEA,ISO)
axon midline choice point recognition  (IEA,IEP,ISO)
cell differentiation  (IEA)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cellular response to hypoxia  (IEP)
chemorepulsion involved in postnatal olfactory bulb interneuron migration  (IEA,ISO)
chemotaxis  (IEA)
coronary vasculature development  (ISO)
endocardial cushion formation  (ISO)
heart development  (ISO)
heart induction  (ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IBA,IEA,ISO)
kidney development  (ISO)
mammary duct terminal end bud growth  (ISO)
negative regulation of cell migration  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine-mediated signaling pathway  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of mammary gland epithelial cell proliferation  (IEA,ISO)
negative regulation of negative chemotaxis  (IEA,ISO)
negative regulation of synapse assembly  (IMP)
nervous system development  (IEA)
neuron projection extension  (IMP)
olfactory bulb interneuron development  (ISO)
oligodendrocyte development  (IEP)
outflow tract septum morphogenesis  (ISO)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of Rho protein signal transduction  (IEA,ISO,ISS)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO)
pulmonary valve morphogenesis  (ISO)
regulation of dendrite morphogenesis  (IMP)
Roundabout signaling pathway  (IEA,ISO,ISS)
spinal cord development  (IEP)
synapse organization  (IBA)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component
axolemma  (ISO)
axon  (IBA,IDA,IEA)
cell projection  (IEA)
cell surface  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
dendrite  (IDA)
endoplasmic reticulum-Golgi intermediate compartment membrane  (IEA)
membrane  (IEA)
neuronal cell body  (IBA,IDA)
plasma membrane  (IBA,IEA,ISO,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Presenilin-dependent receptor processing is required for axon guidance. Bai G, etal., Cell. 2011 Jan 7;144(1):106-18. doi: 10.1016/j.cell.2010.11.053.
2. ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment. Bianchi G, etal., Blood Cancer Discov. 2021 Jul;2(4):338-353. doi: 10.1158/2643-3230.BCD-20-0164.
3. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Brose K, etal., Cell 1999 Mar 19;96(6):795-806.
4. A Study Based on the Correlation Between Slit2/Robo1 Signaling Pathway Proteins and Polymyositis/Dermatomyositis. Chai KX, etal., Curr Mol Med. 2020;20(9):717-722. doi: 10.2174/1566524020666200326102837.
5. Cerebral endothelial expression of Robo1 affects brain infiltration of polymorphonuclear neutrophils during mouse stroke recovery. Gangaraju S, etal., Neurobiol Dis. 2013 Jun;54:24-31. doi: 10.1016/j.nbd.2013.02.014. Epub 2013 Mar 5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats. Jin X, etal., Neurochem Res. 2016 Dec;41(12):3373-3385. doi: 10.1007/s11064-016-2072-0. Epub 2016 Sep 29.
8. Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE. Kaur H, etal., Neuropharmacology. 2019 Nov 1;158:107727. doi: 10.1016/j.neuropharm.2019.107727. Epub 2019 Jul 26.
9. Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain. Ke C, etal., Mol Neurobiol. 2017 Jan;54(1):295-307. doi: 10.1007/s12035-015-9564-9. Epub 2016 Jan 6.
10. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Kidd T, etal., Cell 1998 Jan 23;92(2):205-15.
11. Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury. Li Y, etal., Neuroreport. 2017 Jan 18;28(2):75-81. doi: 10.1097/WNR.0000000000000715.
12. Human placental expression of SLIT/ROBO signaling cues: effects of preeclampsia and hypoxia. Liao WX, etal., Biol Reprod. 2012 Apr 12;86(4):111. doi: 10.1095/biolreprod.110.088138. Print 2012 Apr.
13. Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model. Liu D, etal., J Cardiovasc Pharmacol. 2016 May;67(5):433-41. doi: 10.1097/FJC.0000000000000369.
14. Slit2 regulates the dispersal of oligodendrocyte precursor cells via Fyn/RhoA signaling. Liu X, etal., J Biol Chem. 2012 May 18;287(21):17503-17516. doi: 10.1074/jbc.M111.317610. Epub 2012 Mar 20.
15. Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis. Liu Y, etal., ESC Heart Fail. 2021 Feb;8(1):447-460. doi: 10.1002/ehf2.13095. Epub 2020 Nov 24.
16. Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Liu Z, etal., Mol Cell Neurosci 2004 Jun;26(2):232-40.
17. Spatiotemporal expression patterns of slit and robo genes in the rat brain. Marillat V, etal., J Comp Neurol. 2002 Jan 7;442(2):130-55.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Mommersteeg MT, etal., Cardiovasc Res. 2015 Apr 1;106(1):55-66. doi: 10.1093/cvr/cvv040. Epub 2015 Feb 17.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia. Park JH, etal., Brain Res. 2016 Mar 1;1634:45-56. doi: 10.1016/j.brainres.2015.12.056. Epub 2016 Jan 4.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model. Sherchan P, etal., Neurobiol Dis. 2016 Jan;85:164-173. doi: 10.1016/j.nbd.2015.11.003. Epub 2015 Nov 10.
26. Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Tamada A, etal., Neural Dev. 2008 Nov 5;3:29.
27. Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi T, etal., Mol Carcinog. 2004 Aug;40(4):241-6.
28. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Wehrle R, etal., Eur J Neurosci. 2005 Nov;22(9):2134-44.
29. Regulation of cortical dendrite development by Slit-Robo interactions. Whitford KL, etal., Neuron. 2002 Jan 3;33(1):47-61.
30. Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1. Zhao XC, etal., Brain Res. 2013 Nov 6;1537:283-9. doi: 10.1016/j.brainres.2013.08.036. Epub 2013 Aug 28.
31. The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. Zhou W, etal., PLoS One. 2017 Oct 3;12(10):e0185795. doi: 10.1371/journal.pone.0185795. eCollection 2017.
Additional References at PubMed
PMID:10433822   PMID:11222645   PMID:11404413   PMID:11672528   PMID:11748139   PMID:12504588   PMID:15084255   PMID:15091338   PMID:16254601   PMID:16439476   PMID:17360927   PMID:17848514  
PMID:18566128   PMID:18829537   PMID:19351956   PMID:19783284   PMID:21385766   PMID:25807483   PMID:26529257   PMID:34652618  


Genomics

Comparative Map Data
Robo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81124,067,869 - 25,108,694 (+)NCBIGRCr8
mRatBN7.21110,580,863 - 11,621,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1110,580,908 - 11,620,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1119,201,886 - 20,247,920 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,929,017 - 12,975,115 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01111,103,305 - 12,145,678 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0119,079,291 - 10,146,302 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl119,642,365 - 10,143,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01113,314,508 - 13,808,775 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41110,784,947 - 11,720,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11110,784,946 - 11,720,646 (+)NCBI
Celera1110,598,877 - 11,659,942 (+)NCBICelera
Cytogenetic Map11p11NCBI
ROBO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38378,597,239 - 79,767,998 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl378,597,239 - 79,767,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37378,646,389 - 79,817,148 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36378,729,080 - 79,721,751 (-)NCBINCBI36Build 36hg18NCBI36
Build 34378,729,079 - 79,721,751NCBI
Celera379,390,331 - 80,561,510 (-)NCBICelera
Cytogenetic Map3p12.3NCBI
HuRef378,666,127 - 79,837,569 (-)NCBIHuRef
CHM1_1378,599,244 - 79,770,223 (-)NCBICHM1_1
T2T-CHM13v2.0378,652,524 - 79,823,991 (-)NCBIT2T-CHM13v2.0
Robo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391671,824,406 - 72,844,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1672,105,194 - 72,842,983 (+)EnsemblGRCm39 Ensembl
GRCm381672,027,518 - 73,047,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1672,308,306 - 73,046,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371672,663,394 - 73,046,345 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361672,546,574 - 72,928,773 (+)NCBIMGSCv36mm8
Celera1672,912,535 - 73,307,241 (+)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1641.08NCBI
Robo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540713,107,235 - 13,487,053 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540712,593,911 - 13,485,723 (+)NCBIChiLan1.0ChiLan1.0
ROBO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2278,737,606 - 79,904,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1378,741,123 - 79,909,631 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0378,707,802 - 79,876,519 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1380,579,716 - 81,001,219 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl380,581,388 - 81,569,308 (-)Ensemblpanpan1.1panPan2
ROBO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1318,082,363 - 8,594,623 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl317,626,126 - 8,593,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha317,536,253 - 8,593,279 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0317,481,760 - 8,614,235 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl317,640,944 - 8,614,236 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1317,442,809 - 8,564,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0317,499,515 - 8,626,174 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0317,883,361 - 9,008,850 (+)NCBIUU_Cfam_GSD_1.0
Robo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049718,782,876 - 9,791,545 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365054,330,303 - 4,709,655 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365054,329,428 - 4,711,310 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROBO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13175,348,410 - 176,479,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113175,348,223 - 176,479,482 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213186,417,282 - 186,884,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ROBO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12297,178,093 - 98,363,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2298,222,891 - 98,363,219 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604168,583,685 - 69,736,220 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Robo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248744,949,538 - 5,357,690 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248744,234,640 - 5,359,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Robo1
5522 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000042384
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
D11Rat80  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81124,340,388 - 24,340,547 (+)Marker Load Pipeline
mRatBN7.21110,853,326 - 10,853,485 (+)MAPPERmRatBN7.2
Rnor_6.0119,353,931 - 9,354,089NCBIRnor6.0
Rnor_5.01113,033,392 - 13,033,550UniSTSRnor5.0
RGSC_v3.41110,929,300 - 10,929,459RGDRGSC3.4
RGSC_v3.41110,929,301 - 10,929,459UniSTSRGSC3.4
RGSC_v3.11110,929,301 - 10,929,459RGD
Celera1110,738,560 - 10,738,718UniSTS
RH 3.4 Map1155.6RGD
RH 3.4 Map1155.6UniSTS
RH 2.0 Map11699.1RGD
Cytogenetic Map11p11UniSTS
D11Got12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21110,878,704 - 10,878,889 (+)MAPPERmRatBN7.2
Rnor_6.0119,379,473 - 9,379,657NCBIRnor6.0
Rnor_5.01113,058,934 - 13,059,118UniSTSRnor5.0
RGSC_v3.41110,954,676 - 10,954,861RGDRGSC3.4
RGSC_v3.41110,954,677 - 10,954,861UniSTSRGSC3.4
RGSC_v3.11110,954,677 - 10,954,861RGD
Celera1110,763,938 - 10,764,122UniSTS
RH 3.4 Map1157.1UniSTS
RH 3.4 Map1157.1RGD
RH 2.0 Map11691.9RGD
Cytogenetic Map11p11UniSTS
D11Got11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21110,996,010 - 10,996,213 (+)MAPPERmRatBN7.2
Rnor_6.0119,513,253 - 9,513,455NCBIRnor6.0
Rnor_5.01113,186,038 - 13,186,240UniSTSRnor5.0
RGSC_v3.41111,071,150 - 11,071,353RGDRGSC3.4
RGSC_v3.41111,071,151 - 11,071,353UniSTSRGSC3.4
RGSC_v3.11111,071,150 - 11,071,353RGD
Celera1110,880,219 - 10,880,421UniSTS
RH 2.0 Map11701.2RGD
Cytogenetic Map11p11UniSTS
BF386615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21111,123,162 - 11,123,338 (+)MAPPERmRatBN7.2
Rnor_6.0119,627,493 - 9,627,668NCBIRnor6.0
Rnor_5.01113,299,572 - 13,299,747UniSTSRnor5.0
RGSC_v3.41111,199,161 - 11,199,336UniSTSRGSC3.4
Celera1111,000,733 - 11,000,908UniSTS
Cytogenetic Map11p11UniSTS
BF386668  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21111,450,901 - 11,451,076 (+)MAPPERmRatBN7.2
Rnor_6.0119,972,564 - 9,972,738NCBIRnor6.0
Rnor_5.01113,639,815 - 13,639,989UniSTSRnor5.0
RGSC_v3.41111,541,525 - 11,541,699UniSTSRGSC3.4
Celera1111,321,282 - 11,321,456UniSTS
Cytogenetic Map11p11UniSTS
BF390471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21111,353,350 - 11,353,541 (+)MAPPERmRatBN7.2
Rnor_6.0119,873,986 - 9,874,176NCBIRnor6.0
Rnor_5.01113,541,478 - 13,541,668UniSTSRnor5.0
RGSC_v3.41111,442,349 - 11,442,539UniSTSRGSC3.4
Celera1111,229,410 - 11,229,600UniSTS
Cytogenetic Map11p11UniSTS


Genetic Models
This gene Robo1 is modified in the following models/strains:
F344-Robo1Tn(sb-T2/Bart3)2.327Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF041082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042384   ⟹   ENSRNOP00000044134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1110,580,908 - 11,620,203 (+)Ensembl
Rnor_6.0 Ensembl119,642,413 - 10,143,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087080   ⟹   ENSRNOP00000069709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1111,137,915 - 11,617,375 (+)Ensembl
Rnor_6.0 Ensembl119,642,365 - 10,141,977 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104951   ⟹   ENSRNOP00000096544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1111,227,474 - 11,620,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112268   ⟹   ENSRNOP00000082395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1111,227,489 - 11,620,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117698   ⟹   ENSRNOP00000085459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1111,227,258 - 11,620,203 (+)Ensembl
RefSeq Acc Id: NM_001415011   ⟹   NP_001401940
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,714,695 - 25,108,694 (+)NCBI
mRatBN7.21111,227,658 - 11,621,675 (+)NCBI
RefSeq Acc Id: NM_022188   ⟹   NP_071524
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,067,956 - 25,108,694 (+)NCBI
mRatBN7.21110,580,890 - 11,621,675 (+)NCBI
Rnor_6.0119,209,568 - 10,143,317 (+)NCBI
Rnor_5.01113,314,508 - 13,808,775 (+)NCBI
RGSC_v3.41110,784,947 - 11,720,646 (+)RGD
Celera1110,598,877 - 11,659,942 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270740   ⟹   XP_063126810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,277 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270741   ⟹   XP_063126811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,284 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270742   ⟹   XP_063126812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,067,936 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270743   ⟹   XP_063126813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,275 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270744   ⟹   XP_063126814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,282 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270745   ⟹   XP_063126815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,280 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270746   ⟹   XP_063126816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,288 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270748   ⟹   XP_063126818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,714,742 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270749   ⟹   XP_063126819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,275 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270750   ⟹   XP_063126820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,282 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270751   ⟹   XP_063126821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,067,869 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270752   ⟹   XP_063126822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,357,726 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270753   ⟹   XP_063126823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,067,869 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270754   ⟹   XP_063126824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,358,280 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270755   ⟹   XP_063126825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,904,608 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270756   ⟹   XP_063126826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,714,742 - 25,107,436 (+)NCBI
RefSeq Acc Id: XM_063270757   ⟹   XP_063126827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81124,714,742 - 25,107,436 (+)NCBI
RefSeq Acc Id: NP_071524   ⟸   NM_022188
- Peptide Label: isoform 1 precursor
- UniProtKB: O55005 (UniProtKB/Swiss-Prot),   F1LQI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069709   ⟸   ENSRNOT00000087080
Ensembl Acc Id: ENSRNOP00000044134   ⟸   ENSRNOT00000042384
Ensembl Acc Id: ENSRNOP00000082395   ⟸   ENSRNOT00000112268
Ensembl Acc Id: ENSRNOP00000096544   ⟸   ENSRNOT00000104951
Ensembl Acc Id: ENSRNOP00000085459   ⟸   ENSRNOT00000117698
RefSeq Acc Id: NP_001401940   ⟸   NM_001415011
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A8I5ZZ95 (UniProtKB/TrEMBL),   A0A8I6ASP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126821   ⟸   XM_063270751
- Peptide Label: isoform X11
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126823   ⟸   XM_063270753
- Peptide Label: isoform X13
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126812   ⟸   XM_063270742
- Peptide Label: isoform X3
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126822   ⟸   XM_063270752
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZX35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126819   ⟸   XM_063270749
- Peptide Label: isoform X9
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126813   ⟸   XM_063270743
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZX35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126810   ⟸   XM_063270740
- Peptide Label: isoform X1
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126824   ⟸   XM_063270754
- Peptide Label: isoform X14
- UniProtKB: A0A8I5ZX35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126815   ⟸   XM_063270745
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ASP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126820   ⟸   XM_063270750
- Peptide Label: isoform X10
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126814   ⟸   XM_063270744
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZX35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126811   ⟸   XM_063270741
- Peptide Label: isoform X2
- UniProtKB: O55005 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126816   ⟸   XM_063270746
- Peptide Label: isoform X7
- UniProtKB: A0A8I6ASP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126826   ⟸   XM_063270756
- Peptide Label: isoform X16
- UniProtKB: A0A8I5ZX35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126827   ⟸   XM_063270757
- Peptide Label: isoform X17
- UniProtKB: A0A8I5ZX35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126818   ⟸   XM_063270748
- Peptide Label: isoform X8
- UniProtKB: A0A8I6ASP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126825   ⟸   XM_063270755
- Peptide Label: isoform X15
- UniProtKB: A0A8I6ASP5 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55005-F1-model_v2 AlphaFold O55005 1-1651 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61941 AgrOrtholog
BioCyc Gene G2FUF-22257 BioCyc
Ensembl Genes ENSRNOG00000029614 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042384 ENTREZGENE
  ENSRNOT00000087080 ENTREZGENE
  ENSRNOT00000104951 ENTREZGENE
  ENSRNOT00000130873 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Neural/epithelial_adhesion UniProtKB/Swiss-Prot
  Robo1 UniProtKB/Swiss-Prot
KEGG Report rno:58946 UniProtKB/Swiss-Prot
NCBI Gene 58946 ENTREZGENE
PANTHER CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN UniProtKB/Swiss-Prot
  ROUNDABOUT HOMOLOG 1 UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
PhenoGen Robo1 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029614 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  IGv UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
UniProt A0A0G2JW21_RAT UniProtKB/TrEMBL
  A0A8I5ZX35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ95 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASP5 ENTREZGENE, UniProtKB/TrEMBL
  F1LQI2 ENTREZGENE, UniProtKB/TrEMBL
  O55005 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Robo1  roundabout guidance receptor 1  LOC102551586  uncharacterized LOC102551586  Data merged from RGD:7497873 737654 PROVISIONAL
2013-12-17 LOC102551586  uncharacterized LOC102551586      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-17 Robo1  roundabout, axon guidance receptor, homolog 1 (Drosophila)  LOC683548  similar to roundabout homolog 1  Data merged from RGD:1585646 737654 PROVISIONAL
2006-11-19 LOC683548  similar to roundabout homolog 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Robo1  roundabout homolog 1 (Drosophila)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the subfamily of immunoglobulin superfamily proteins 61733