RGD Reference Report - Prognostic impact of serum albumin levels on the recurrence of stage I non-small cell lung cancer. - Rat Genome Database

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Prognostic impact of serum albumin levels on the recurrence of stage I non-small cell lung cancer.

Authors: Jin, Y  Zhao, L  Peng, F 
Citation: Jin Y, etal., Clinics (Sao Paulo). 2013 May;68(5):686-93. doi: 10.6061/clinics/2013(05)17.
RGD ID: 11036091
Pubmed: PMID:23778417   (View Abstract at PubMed)
PMCID: PMC3654299   (View Article at PubMed Central)
DOI: DOI:10.6061/clinics/2013(05)17   (Journal Full-text)

OBJECTIVE: Patients with stage I non-small cell lung cancer who have undergone complete surgical resection harbor a 30% risk for tumor recurrence. Thus, the identification of factors that are predictive for tumor recurrence is urgently needed. The aim of this study was to test the prognostic value of serum albumin levels on tumor recurrence in patients with stage I non-small cell lung cancer. METHODS: Stage I non-small cell lung cancer patients who underwent complete surgical resection of the primary tumor at Zhejiang Hospital were analyzed in this study. Serum albumin levels were measured before surgery and once again after surgery in 101 histologically diagnosed non-small cell lung cancer patients. Correlations between the pre- and post-operative serum albumin levels and various clinical demographics and recurrence-free survival rates were analyzed. RESULTS: Patients with pre-operative hypoalbuminemia (<3.5 g/dl) had a significantly worse survival rate than patients with normal pre-operative serum albumin levels (>/=3.5 g/dl) (p=0.008). Patients with post-operative hypoalbuminemia had a worse survival rate when compared with patients with normal post-operative serum albumin levels (p=0.001). Cox multivariate analysis identified pre-operative hypoalbuminemia, post-operative hypoalbuminemia and tumor size over 3 cm as independent negative prognostic factors for recurrence. CONCLUSION: Serum albumin levels appear to be a significant independent prognostic factor for tumor recurrence in patients with stage I non-small cell lung cancer who have undergone complete resection. Patient pre-treatment and post-treatment serum albumin levels provide an easy and early means of discrimination between patients with a higher risk for recurrence and patients with a low risk of recurrence.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ALBHumanlung non-small cell carcinoma disease_progressionIEP  RGD 
AlbRatlung non-small cell carcinoma disease_progressionISOALB (Homo sapiens) RGD 
AlbMouselung non-small cell carcinoma disease_progressionISOALB (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alb  (albumin)

Genes (Mus musculus)
Alb  (albumin)

Genes (Homo sapiens)
ALB  (albumin)


Additional Information