Mre11 (MRE11 homolog, double strand break repair nuclease)

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Gene: Mre11 (MRE11 homolog, double strand break repair nuclease) Rattus norvegicus

Analyze

Symbol:

Mre11

Name:

MRE11 homolog, double strand break repair nuclease

RGD ID:

69263

Description:

Predicted to enable identical protein binding activity and nuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and negative regulation of viral entry into host cell. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Lynch syndrome; breast carcinoma; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

double-strand break repair protein MRE11; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; meiotic recombination 11 homolog A (S. cerevisiae); MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Mre11a

RGD Orthologs

Human

Mouse

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	11,618,876 - 11,680,451 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	11,632,354 - 11,678,279 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	15,618,017 - 15,661,868 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	13,915,762 - 13,959,614 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	11,891,307 - 11,935,517 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	13,304,355 - 13,350,329 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,305,152 - 13,352,489 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	13,244,991 - 13,290,976 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	11,588,409 - 11,632,483 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	11,588,411 - 11,632,483 (+)	NCBI
Celera	8	13,102,879 - 13,146,939 (+)	NCBI		Celera
Cytogenetic Map	8	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Animal Disease Models (ISO)

ataxia telangiectasia (ISO)

Ataxia Telangiectasia Like Disorder (ISO)

Ataxia-Telangiectasia-Like Disorder 1 (ISO)

breast carcinoma (ISO)

colon cancer (ISO)

Colonic Neoplasms (ISO)

dystonia (ISO)

endometrial cancer (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

intellectual disability (ISO)

lung adenocarcinoma (ISO)

Lynch syndrome (ISO)

malignant astrocytoma (ISO)

Neurocutaneous Syndromes (ISO)

Ovarian Neoplasms (ISO)

primary ovarian insufficiency (ISO)

Prostatic Neoplasms (ISO)

rectum cancer (ISO)

stomach carcinoma (ISO)

Triple Negative Breast Neoplasms (ISO)

urinary bladder cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroperoxycyclophosphamide (EXP)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromoacetate (ISO)

caffeine (ISO)

camptothecin (ISO)

capecitabine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

doxifluridine (ISO)

doxorubicin (EXP,ISO)

Enterolactone (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

ferroheme b (ISO)

folic acid (ISO)

heme b (ISO)

hydrogen peroxide (ISO)

imiquimod (ISO)

isocyanates (ISO)

ivermectin (ISO)

L-methionine (ISO)

Lasiocarpine (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

monocrotaline (ISO)

myristicin (ISO)

N,N-dimethylformamide (ISO)

N-nitrosodiethylamine (ISO)

Nonidet P-40 (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

pentamidine (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

resveratrol (EXP,ISO)

riddelliine (ISO)

rotenone (ISO)

sunitinib (ISO)

T-2 toxin (ISO)

testosterone (ISO)

thioacetamide (EXP)

topotecan (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

veliparib (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (IEA,ISO)

cellular response to DNA damage stimulus (ISO,ISS)

chromosome organization (ISO)

DNA duplex unwinding (IEA,ISO)

DNA strand resection involved in replication fork processing (IEA,ISO,ISS)

double-strand break repair (IEA,ISO)

double-strand break repair via homologous recombination (IBA,IEA,ISO,ISS)

double-strand break repair via nonhomologous end joining (IBA,IEA,ISO)

heart development (IEP)

homologous chromosome pairing at meiosis (IEA,ISO)

meiotic cell cycle (IEA)

meiotic DNA double-strand break formation (IBA)

mitochondrial double-strand break repair via homologous recombination (IBA)

mitotic G2 DNA damage checkpoint signaling (IBA,IEA,ISO)

mitotic intra-S DNA damage checkpoint signaling (IBA,IEA,ISO)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of viral entry into host cell (IMP)

nucleic acid phosphodiester bond hydrolysis (IEA)

positive regulation of kinase activity (IEA,ISO)

positive regulation of protein autophosphorylation (IEA,ISO)

positive regulation of telomere maintenance (IEA,ISO)

sister chromatid cohesion (IEA,ISO)

telomere maintenance (IBA)

telomeric 3' overhang formation (IEA,ISO)

Cellular Component

BRCA1-C complex (IEA,ISO)

chromatin (IDA)

chromosome, telomeric region (IEA,ISO)

condensed nuclear chromosome (IDA)

cytoplasm (IEA,ISO)

Mre11 complex (IBA,IEA,ISO)

nucleoplasm (IDA,ISO)

nucleus (IDA,ISO)

perinuclear region of cytoplasm (IDA)

PML body (IEA,ISO)

replication fork (IEA,ISO,ISS)

site of double-strand break (IBA,IEA,ISO,ISS)

Molecular Function

3'-5' exonuclease activity (ISO)

3'-5'-DNA exonuclease activity (IEA)

5'-3' exonuclease activity (IEA,ISO,ISS)

DNA binding (IEA,ISO)

DNA endonuclease activity (IEA,ISO)

DNA helicase activity (IEA,ISO)

identical protein binding (IEA,ISO)

manganese ion binding (IEA)

obsolete protein C-terminus binding (IEA,ISO)

protein binding (IPI,ISO)

single-stranded DNA endodeoxyribonuclease activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered p53 signaling pathway (ISO)

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

homologous recombination pathway of double-strand break repair (IEA,ISO,ISS)

non-homologous end joining pathway of double-strand break repair (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.	Angele S, etal., Histopathology. 2003 Oct;43(4):347-53.
2.	Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.	Bartkova J, etal., Mol Oncol. 2008 Dec;2(4):296-316. Epub 2008 Oct 7.
3.	ATM protein kinase: the linchpin of cellular defenses to stress.	Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
4.	Analysis of variants in DNA damage signalling genes in bladder cancer.	Choudhury A, etal., BMC Med Genet. 2008 Jul 18;9:69.
5.	Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation.	Crowe SL, etal., Eur J Neurosci. 2006 May;23(9):2351-61.
6.	A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts.	Donahue SL and Campbell C, Nucleic Acids Res 2004 Jun 15;32(10):3248-57. Print 2004.
7.	Localisation of RAD50 and MRE11 in spermatocyte nuclei of mouse and rat.	Eijpe M, etal., Chromosoma. 2000;109(1-2):123-32.
8.	Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.	Fernet M, etal., Hum Mol Genet. 2005 Jan 15;14(2):307-18. Epub 2004 Dec 1.
9.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10.	Human MRE11 is inactivated in mismatch repair-deficient cancers.	Giannini G, etal., EMBO Rep. 2002 Mar;3(3):248-54. Epub 2002 Feb 15.
11.	Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.	Giannini G, etal., Oncogene. 2004 Apr 8;23(15):2640-7.
12.	Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription.	Hartl B, etal., Oncogene. 2008 Jun 12;27(26):3673-84. Epub 2008 Jan 21.
13.	Regulation of homologous recombination in eukaryotes.	Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
14.	Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains.	Jacobsen E, etal., Brain Res Mol Brain Res. 2004 Sep 10;128(1):1-7.
15.	Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.	Jiang Z, etal., Neurosci Lett. 2006 Dec 1;409(2):112-7. Epub 2006 Oct 10.
16.	The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.	Lanson NA Jr, etal., Nucleic Acids Res 2000 Aug 1;28(15):2882-92.
17.	Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins.	Lovric J, etal., Mol Ther. 2012 Nov;20(11):2087-97. doi: 10.1038/mt.2012.144. Epub 2012 Jul 31.
18.	Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome.	Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
19.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
20.	p53 mutations in cancer.	Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
21.	Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.	Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
22.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
23.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
24.	MRE11 expression is impaired in gastric cancer with microsatellite instability.	Ottini L, etal., Carcinogenesis. 2004 Dec;25(12):2337-43. Epub 2004 Aug 19.
25.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
26.	GOA pipeline	RGD automated data pipeline
27.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
29.	DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.	Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.

Additional References at PubMed

PMID:9224597	PMID:9590181	PMID:9651580	PMID:9705271	PMID:10811102	PMID:12687013	PMID:14690604	PMID:15149599	PMID:15364958	PMID:15790808	PMID:15916964	PMID:15917200
PMID:16374507	PMID:17291760	PMID:17500065	PMID:18614044	PMID:19135898	PMID:19151086	PMID:22078559	PMID:23444137	PMID:24270157	PMID:25468996	PMID:29290612	PMID:29670289
PMID:30612738

Genomics

Comparative Map Data

Mre11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	11,618,876 - 11,680,451 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	11,632,354 - 11,678,279 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	15,618,017 - 15,661,868 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	8	13,915,762 - 13,959,614 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	8	11,891,307 - 11,935,517 (+)	NCBI	Rnor_WKY
Rnor_6.0	8	13,304,355 - 13,350,329 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,305,152 - 13,352,489 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	13,244,991 - 13,290,976 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	11,588,409 - 11,632,483 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	11,588,411 - 11,632,483 (+)	NCBI
Celera	8	13,102,879 - 13,146,939 (+)	NCBI		Celera
Cytogenetic Map	8	q12	NCBI

MRE11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	94,415,570 - 94,512,412 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	94,415,570 - 94,493,885 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	94,148,736 - 94,227,010 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	93,790,114 - 93,866,688 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	93,790,120 - 93,866,688	NCBI
Celera	11	91,438,299 - 91,514,850 (-)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI
HuRef	11	90,216,033 - 90,292,535 (-)	NCBI		HuRef
CHM1_1	11	94,033,481 - 94,110,055 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	94,422,612 - 94,500,884 (-)	NCBI		T2T-CHM13v2.0

Mre11a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	14,695,939 - 14,753,639 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	14,695,950 - 14,748,419 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	14,784,654 - 14,837,125 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	14,784,654 - 14,837,123 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	14,589,151 - 14,638,861 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	14,535,100 - 14,584,812 (+)	NCBI		MGSCv36	mm8
Celera	9	12,065,444 - 12,115,180 (+)	NCBI		Celera
Cytogenetic Map	9	A2	NCBI

MRE11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	92,908,403 - 92,985,966 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	92,918,549 - 92,985,966 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	89,418,537 - 89,500,705 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MRE11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	6,448,909 - 6,528,185 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	6,449,822 - 6,527,119 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	6,459,592 - 6,538,889 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	6,629,575 - 6,708,953 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	6,630,485 - 6,708,909 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	6,416,396 - 6,489,663 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	6,479,470 - 6,558,763 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	6,528,550 - 6,608,693 (+)	NCBI		UU_Cfam_GSD_1.0

Mre11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	79,363,444 - 79,439,016 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	466,456 - 530,317 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936674	466,495 - 528,072 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MRE11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	26,572,361 - 26,634,567 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	26,572,352 - 26,634,596 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	30,330,565 - 30,388,455 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MRE11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	85,615,448 - 85,694,247 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	85,610,819 - 85,694,269 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	40,060,929 - 40,162,758 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mre11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	39,092,781 - 39,153,920 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	39,095,559 - 39,153,936 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mre11
246 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	115
Count of miRNA genes:	96
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000012940
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	24597739	Rat
2317882	Alcrsp24	Alcohol response QTL 24	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	8	1	25902202	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	9712463	41866876	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	41	25	19	25	1	1	74	33	38	11	1
Low	1	17	16	16		16	7	10		2	3		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005487915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005487916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF218574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000012940 ⟹ ENSRNOP00000012940

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	11,634,427 - 11,673,675 (+)	Ensembl
Rnor_6.0 Ensembl	8	13,305,152 - 13,352,489 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100883 ⟹ ENSRNOP00000086786

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	11,632,354 - 11,678,279 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105497 ⟹ ENSRNOP00000092951

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	11,632,354 - 11,678,279 (+)	Ensembl

RefSeq Acc Id:

NM_022279 ⟹ NP_071615

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,633,195 - 11,677,268 (+)	NCBI
Rnor_6.0	8	13,305,239 - 13,349,311 (+)	NCBI
Rnor_5.0	8	13,244,991 - 13,290,976 (+)	NCBI
RGSC_v3.4	8	11,588,409 - 11,632,483 (+)	RGD
Celera	8	13,102,879 - 13,146,939 (+)	RGD

Sequence:

show sequence

ACTATAAAAATGAGCCCCACAGATCCGCTTGATGATGAAGACACATTTAAAATCCTGGTTGCCA
CTGATATTCATCTTGGATTTATGGAAAAAGATGCAGTTAGAGGAAATGACACATTTGTGACATT
TGATGAAATTTTAAGACTTGCCCTGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTT
TTCCATGAAAACAAGCCCTCAAGGAAAACCCTGCACAGCTGCTTAGAGCTGCTTAGGAAGTACT
GTATGGGTGACCGCCCTGTGCAATTTGAGATCATCAGTGACCAGTCAGTCAACTTTGGTTTTAG
TAAGTTTCCATGGGTGAACTACCGGGATGGCAATCTCAACATCTCCATTCCAGTGTTTAGTATC
CACGGCAACCATGATGATCCCACAGGGGCAGATGCCCTCTGTGCCCTGGATGTTTTAAGCTGTG
CTGGGTTTGTGAATCACTTTGGACGGTCAATGTCTGTGGAGAAGGTTGACATTAGTCCAGTTCT
GCTGCAGAAAGGAAGCACAAAACTCGCTCTGTACGGCTTAGGGTCCATTCCAGATGAAAGGCTC
TATCGGATGTTTGTCAATAAGAAAGTAACGATGTTGAGGCCTAAGGAAGACGAGAACTCATGGT
TTAACTTATTCGTGATTCATCAGAACAGGAGTAAACACGGAAGCACCAACTTCATCCCAGAGCA
GTTTTTGGATGACTTCATTGACCTGGTCATCTGGGGCCATGAACATGAGTGTAAAATCGGCCCA
ACCAGGAATGAGCAGCAGCTCTTCTATGTGTCTCAGCCCGGAAGCTCGGTGGTGACAGCCCTTT
CCCCTGGAGAAACTGTGAAGAAACATGTAGGCCTGCTACGCGTTAAAGGGAGAAAGATGAACAT
GCAGAAGCTGCCTCTCCGCACAGTGCGACAGTTCTTCATGGAAGATGTGGTCCTGGCTAACCAC
CCAAGCCTGTTCAACCCTGACAATCCTAAGGTGACCCAGGCCATCCAGAGCTTCTGTTTGGAGA
AGATTGAAGAAATGCTTGACAGTGCTGAGCGGGAACGGCTGGGGAATCCTCAGCAGCCGGAGAA
GCCTCTCATCCGACTACGGGTGGACTACAGTGGAGGCTTTGAACCTTTCAACGTTCTTCGTTTT
AGCCAGAAGTTTGTGGATCGGGTTGCTAACCCAAAAGATGTCATCCACTTTTTCAGACACAGGG
AACAAAAAGGAAAAACAGGAGAAGAGATCAACTTTGGGAAGCTCATCATAAAACCTGCTTCAGA
AGGGACGACGCTCAGAGTAGAAGACCTTGTAAAGCAGTATTTCCAAACTGCAGAGAAGAATGTT
CAGCTCTCACTGCTGACAGAAAGAGGGATGGGTGAAGCAGTTCAAGAGTTTGTGGACAAGGAAG
AGAAAGATGCCATCGAGGAATTAGTGAAGTACCAGTTGGAGAAAACGCAGCGGTTTCTTAAGGA
GCGCCACATCGATGCTCTAGAAGACAAGATTGATGAAGAGGTCCGGCGTTTCAGAGAAAGCAGA
CAGAGAAATACCAACGAAGAAGACGATGAAGTTCGAGAGGCCATGAGCAGGGCCCGGGCCCTCA
GGTCACAGTCGGAGAACGCCGCCTCAGCCTTCAGTGCAGATGACCTGAGTTTTGATATAACAGA
GCAGACAGCAGATGACTCTGACGATAGCCAGTCAGCAGTGCCGAGCCGAGGCCGAGGTCGAGGC
CGAGGACGAAGAGGAGGCAGAGGGCAGAGCACTGCACCCAGAGGAGGCTCTCAGAGAGGCCGAG
ACACTGGGCTGGGGATCTCTACTCGGGGCAGGAGCTCAAAGGCCACTGCGTCAACATCTAGAAA
TATGTCCATTATAGATGCTTTCAGATCTACCCGACAGCAGCCTTCCAGAAATGTAGCCACTAAG
AATTACTCAGAGACCATTGAGGTGGATGAATCTGATGACGATGACAGTTTTCCTACCAGCTCCA
GGGCTGATCAAAGGTGGTCGGGCACAGCACCTAGCAAACGGATGTCCCAGAGCCAGACAGCCAA
AGGGGTGGACTTTGAATCAGACGAGGACGATGACGACGACCCTTTCATGAGTGGTAGTTGCCCA
AGAAGAAACCGAAGATAATGT

hide sequence

RefSeq Acc Id:

XM_006242532 ⟹ XP_006242594

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,632,293 - 11,680,451 (+)	NCBI
Rnor_6.0	8	13,304,355 - 13,350,329 (+)	NCBI
Rnor_5.0	8	13,244,991 - 13,290,976 (+)	NCBI

Sequence:

show sequence

AGTACGGATGCGTTTCTCCCGCGCCCAATTTAGGTTTCTGGTAGCGGTTTTCTTCTCGTTCTGA
CGACTCCTGCCCCTTTTCCCCGAGAGTTTGGAATCGGGTGTTTTTTTTTCTGACGTACCTGAAC
ACAGAACCCCAGGGTACTTGGAGAGGAACCTGGTCCTAGAGGAACTCTACCATAAAAATGAGCC
CCGCAGATCCGCTTGATGATGAAGACACATTTAAAATCCTGGTTGCCACTGATATTCATCTTGG
ATTTATGGAAAAAGATGCAGTTAGAGGAAATGACACATTTGTGACATTTGATGAAATTTTAAGA
CTTGCCCTGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTCCATGAAAACAAGC
CCTCAAGGAAAACCCTGCACAGCTGCTTAGAGCTGCTTAGGAAGTACTGTATGGGTGACCGCCC
TGTGCAATTTGAGATCATCAGTGACCAGTCAGTCAACTTTGGTTTTAGTAAGTTTCCATGGGTG
AACTACCAGGATGGCAATCTCAACATCTCCATTCCAGTGTTTAGTATCCACGGCAACCATGATG
ATCCCACAGGGGCAGATGCCCTCTGTGCCCTGGATGTTTTAAGCTGTGCTGGGTTTGTGAATCA
CTTTGGACGGTCAATGTCTGTGGAGAAGGTTGACATTAGTCCAGTTCTGCTGCAGAAAGGAAGC
ACAAAACTCGCTCTGTACGGCTTAGGGTCCATTCCAGATGAAAGGCTCTATCGGATGTTTGTCA
ATAAGAAAGTAACGATGTTGAGGCCTAAGGAAGACGAGAACTCATGGTTTAACTTATTCGTGAT
TCATCAGAACAGGAGTAAACACGGAAGCACCAACTTCATCCCAGAGCAGTTTTTGGATGACTTC
ATTGACCTGGTCATCTGGGGCCATGAACATGAGTGTAAAATCGGCCCAACCAGGAATGAGCAGC
AGCTCTTCTATGTGTCTCAGCCCGGAAGCTCGGTGGTGACAGCCCTTTCCCCTGGAGAAACTGT
GAAGAAACATGTAGGCCTGCTACGCGTTAAAGGGAGAAAGATGAACATGCAGAAGCTGCCTCTC
CGCACAGTGCGACAGTTCTTCATGGAAGATGTGGTCCTGGCTAACCACCCAAGCCTGTTCAACC
CTGACAATCCTAAGGTGACCCAGGCCATCCAGAGCTTCTGTTTGGAGAAGATTGAAGAAATGCT
TGACAGTGCTGAGCGGGAACGGCTGGGGAATCCTCAGCAGCCGGAGAAGCCTCTCATCCGACTA
CGGGTGGACTACAGTGGAGGCTTTGAACCTTTCAACGTTCTTCGTTTTAGCCAGAAGTTTGTGG
ATCGGGTTGCTAACCCAAAAGATGTCATCCACTTTTTCAGACACAGGGAACAAAAAGGAAAAAC
AGGAGAAGAGATCAACTTTGGGAAGCTCATCATAAAACCTGCTTCAGAAGGGACGACGCTCAGA
GTAGAAGACCTTGTAAAGCAGTATTTCCAAACTGCAGAGAAGAATGTTCAGCTCTCACTGCTGA
CAGAAAGAGGGATGGGTGAAGCAGTTCAAGAGTTTGTGGACAAGGAAGAGAAAGATGCCATCGA
GGAATTAGTGAAGTACCAGCTGGAGAAAACGCAGCGGTTTCTTAAGGAGCGCCACATCGATGCT
CTAGAAGACAAGATTGATGAAGAGGTCCGGCGTTTCAGAGAAAGCAGACAGAGAAATACCAACG
AAGAAGACGATGAAGTTCGAGAGGCCATGAGCAGGGCCCGGGCCCTCAGGTCACAGTCGGAGAA
CGCCGCCTCAGCCTTCAGTGCAGATGACCTGAGTTTTGATATAACGGAGCAGACAGCAGATGAC
TCTGACGATAGCCAGTCAGCAGTGCCGAGCCGAGGCCGAGGTCGAGGCCGAGGACGAAGAGGAG
GCAGAGGGCAGAGCACTGCACCCAGAGGAGGCTCTCAGAGAGGCCGAGACACTGGGCTGGGGAT
CTCTACTCGGGGCAGGAGCTCAAAGGCCACTGCGTCAACATCTAGAAATATGTCCATTATAGAT
GCTTTCAGATCTACCCGACAGCAGCCTTCCAGAAATGTAGCCACTAAGAATTACTCAGAGACCA
TTGAGGTGGATGAATCTGATGACGATGACAGTTTTCCTACCAGCTCCAGGGCTGATCAAAGGTG
GTCGGGCACAGCACCTAGCAAACGGATGTCCCAGAGCCAGACAGCCAAAGGGGTGGACTTTGAA
TCAGACGAGGACGATGATGACGACCCTTTCATGAGTGGTAGTTGCCCAAGAAGAAACCGAAGAT
AATGTTGTTAGTAGAACTTAAAAGTTGTCCCGCTGCAGGAAGAAATCGCAGCAGCGTATGCTAA
CTTTACAGCTGGCGGTGTTTTATCGCTGCAGCACTACAGGAGTCTGAAAAGCCTGGGATTCTAT
TTTAAAATATTGTTTCCTGAAGGTGACTCTCTTAAGCCATTTCCTAGGCGGGTGGTAAGGAGAT
TGCTGCTTCTCCTTAGCCTTTAATCTGCTTGTTATCATTGTCTGGGGCTGCTTTAAGAATGTTA
ATTTCCTGACATAACTGTGTTTCCTGCTTGTAAGAACTTTGCTAAAATTCCATTGTTGAATGAA
GATTAGAGAAAACCCTCCATTATCCATTCCTGCTTCTGATCAGAGACTGTCAGCCTCCAGTGCC
TCAGCTAGCAGAGTTGATGTGACAGCTTACCGGGGCTGTAACCATTTCCTGTCTCCCCAGGAAG
CAAGGCCCTCCTGTGTGTGTGGTGGGGGGAGCAGTCTGAGCTCCCTGGTTGTTAGCAAGTGTGT
GGATTTCAGAGTGTGCTGGAGGACGGTCCACTAGGGCCAGAAGGGCCTTATATTTCAGTAATTA
GTATAAGGTTTTTGTTGAAACCATTTTGGTTGTTTTGGTTTTGGTCTTTATTCACGTTGTAGCA
GAGACTCAGATCCTGTCCCCACTGAGCAGTAGTCATTTTCTTGATCACTCTGTCATTCATGACA
AGCTCTTTTTCTCTCTCAACTCTTGTCAGGGAGAAAAGCTTAATAGGATTTTTCTGTTTCTTAA
AGATAGTGAAAAAGCTTTCTTAGGCCAAACAGCCAGCTGACCTTGTGGTTAGTTCAGGCTGACA
TACCACAGTTCAGTTTCTGCCCGGAGTCGGGGCCAGGCCTCCTTGACCAGCAGCAGCACTGTAC
CATGGCTTTGGTTGCTATAAACATCTCTGAATACACGGTTCCAAAACTGACGGAAACAGCAAGC
TTACATTTTCTTACTTGTTTTAGGAAGAAAATAAAAATGTAATCCTTTCAGAGTTGAGTTAAA

hide sequence

RefSeq Acc Id:

XM_006242533 ⟹ XP_006242595

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,632,312 - 11,680,451 (+)	NCBI
Rnor_6.0	8	13,304,402 - 13,350,329 (+)	NCBI
Rnor_5.0	8	13,244,991 - 13,290,976 (+)	NCBI

Sequence:

show sequence

TTTTCTTCTCGTTCTGACGACTCCTGCCCCTTTTCCCCGAGGTAGAGATAGCCTGTGGCCTCGC
TGGTCGGCTCTGACAAGTTCAGAGTTTGGAATCGGGTGTTTTTTTTTCTGACGTACCTGAACAC
AGAACCCCAGGGTACTTGGAGAGGAACCTGGTCCTAGAGGAACTCTACCATAAAAATGAGCCCC
GCAGATCCGCTTGATGATGAAGACACATTTAAAATCCTGGTTGCCACTGATATTCATCTTGGAT
TTATGGAAAAAGATGCAGTTAGAGGAAATGACACATTTGTGACATTTGATGAAATTTTAAGACT
TGCCCTGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTCCATGAAAACAAGCCC
TCAAGGAAAACCCTGCACAGCTGCTTAGAGCTGCTTAGGAAGTACTGTATGGGTGACCGCCCTG
TGCAATTTGAGATCATCAGTGACCAGTCAGTCAACTTTGGTTTTAGTAAGTTTCCATGGGTGAA
CTACCAGGATGGCAATCTCAACATCTCCATTCCAGTGTTTAGTATCCACGGCAACCATGATGAT
CCCACAGGGGCAGATGCCCTCTGTGCCCTGGATGTTTTAAGCTGTGCTGGGTTTGTGAATCACT
TTGGACGGTCAATGTCTGTGGAGAAGGTTGACATTAGTCCAGTTCTGCTGCAGAAAGGAAGCAC
AAAACTCGCTCTGTACGGCTTAGGGTCCATTCCAGATGAAAGGCTCTATCGGATGTTTGTCAAT
AAGAAAGTAACGATGTTGAGGCCTAAGGAAGACGAGAACTCATGGTTTAACTTATTCGTGATTC
ATCAGAACAGGAGTAAACACGGAAGCACCAACTTCATCCCAGAGCAGTTTTTGGATGACTTCAT
TGACCTGGTCATCTGGGGCCATGAACATGAGTGTAAAATCGGCCCAACCAGGAATGAGCAGCAG
CTCTTCTATGTGTCTCAGCCCGGAAGCTCGGTGGTGACAGCCCTTTCCCCTGGAGAAACTGTGA
AGAAACATGTAGGCCTGCTACGCGTTAAAGGGAGAAAGATGAACATGCAGAAGCTGCCTCTCCG
CACAGTGCGACAGTTCTTCATGGAAGATGTGGTCCTGGCTAACCACCCAAGCCTGTTCAACCCT
GACAATCCTAAGGTGACCCAGGCCATCCAGAGCTTCTGTTTGGAGAAGATTGAAGAAATGCTTG
ACAGTGCTGAGCGGGAACGGCTGGGGAATCCTCAGCAGCCGGAGAAGCCTCTCATCCGACTACG
GGTGGACTACAGTGGAGGCTTTGAACCTTTCAACGTTCTTCGTTTTAGCCAGAAGTTTGTGGAT
CGGGTTGCTAACCCAAAAGATGTCATCCACTTTTTCAGACACAGGGAACAAAAAGGAAAAACAG
GAGAAGAGATCAACTTTGGGAAGCTCATCATAAAACCTGCTTCAGAAGGGACGACGCTCAGAGT
AGAAGACCTTGTAAAGCAGTATTTCCAAACTGCAGAGAAGAATGTTCAGCTCTCACTGCTGACA
GAAAGAGGGATGGGTGAAGCAGTTCAAGAGTTTGTGGACAAGGAAGAGAAAGATGCCATCGAGG
AATTAGTGAAGTACCAGCTGGAGAAAACGCAGCGGTTTCTTAAGGAGCGCCACATCGATGCTCT
AGAAGACAAGATTGATGAAGAGGTCCGGCGTTTCAGAGAAAGCAGACAGAGAAATACCAACGAA
GAAGACGATGAAGTTCGAGAGGCCATGAGCAGGGCCCGGGCCCTCAGGTCACAGTCGGAGAACG
CCGCCTCAGCCTTCAGTGCAGATGACCTGAGTTTTGATATAACGGAGCAGACAGCAGATGACTC
TGACGATAGCCAGTCAGCAGTGCCGAGCCGAGGCCGAGGTCGAGGCCGAGGACGAAGAGGAGGC
AGAGGGCAGAGCACTGCACCCAGAGGAGGCTCTCAGAGAGGCCGAGACACTGGGCTGGGGATCT
CTACTCGGGGCAGGAGCTCAAAGGCCACTGCGTCAACATCTAGAAATATGTCCATTATAGATGC
TTTCAGATCTACCCGACAGCAGCCTTCCAGAAATGTAGCCACTAAGAATTACTCAGAGACCATT
GAGGTGGATGAATCTGATGACGATGACAGTTTTCCTACCAGCTCCAGGGCTGATCAAAGGTGGT
CGGGCACAGCACCTAGCAAACGGATGTCCCAGAGCCAGACAGCCAAAGGGGTGGACTTTGAATC
AGACGAGGACGATGATGACGACCCTTTCATGAGTGGTAGTTGCCCAAGAAGAAACCGAAGATAA
TGTTGTTAGTAGAACTTAAAAGTTGTCCCGCTGCAGGAAGAAATCGCAGCAGCGTATGCTAACT
TTACAGCTGGCGGTGTTTTATCGCTGCAGCACTACAGGAGTCTGAAAAGCCTGGGATTCTATTT
TAAAATATTGTTTCCTGAAGGTGACTCTCTTAAGCCATTTCCTAGGCGGGTGGTAAGGAGATTG
CTGCTTCTCCTTAGCCTTTAATCTGCTTGTTATCATTGTCTGGGGCTGCTTTAAGAATGTTAAT
TTCCTGACATAACTGTGTTTCCTGCTTGTAAGAACTTTGCTAAAATTCCATTGTTGAATGAAGA
TTAGAGAAAACCCTCCATTATCCATTCCTGCTTCTGATCAGAGACTGTCAGCCTCCAGTGCCTC
AGCTAGCAGAGTTGATGTGACAGCTTACCGGGGCTGTAACCATTTCCTGTCTCCCCAGGAAGCA
AGGCCCTCCTGTGTGTGTGGTGGGGGGAGCAGTCTGAGCTCCCTGGTTGTTAGCAAGTGTGTGG
ATTTCAGAGTGTGCTGGAGGACGGTCCACTAGGGCCAGAAGGGCCTTATATTTCAGTAATTAGT
ATAAGGTTTTTGTTGAAACCATTTTGGTTGTTTTGGTTTTGGTCTTTATTCACGTTGTAGCAGA
GACTCAGATCCTGTCCCCACTGAGCAGTAGTCATTTTCTTGATCACTCTGTCATTCATGACAAG
CTCTTTTTCTCTCTCAACTCTTGTCAGGGAGAAAAGCTTAATAGGATTTTTCTGTTTCTTAAAG
ATAGTGAAAAAGCTTTCTTAGGCCAAACAGCCAGCTGACCTTGTGGTTAGTTCAGGCTGACATA
CCACAGTTCAGTTTCTGCCCGGAGTCGGGGCCAGGCCTCCTTGACCAGCAGCAGCACTGTACCA
TGGCTTTGGTTGCTATAAACATCTCTGAATACACGGTTCCAAAACTGACGGAAACAGCAAGCTT
ACATTTTCTTACTTGTTTTAGGAAGAAAATAAAAATGTAATCCTTTCAGAGTTGAGTTAAA

hide sequence

RefSeq Acc Id:

XM_006242534 ⟹ XP_006242596

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,632,457 - 11,680,451 (+)	NCBI
Rnor_6.0	8	13,304,625 - 13,350,329 (+)	NCBI
Rnor_5.0	8	13,244,991 - 13,290,976 (+)	NCBI

Sequence:

show sequence

CTCGGGTAGAAGGTCGTCTGTAGTGGCAGCACTCGCCTTCGCAGAGTGACCACTCTGAGCTGTC
TGTCACCGTGGATCCGAAAGAGTTTGGAATCGGGTGTTTTTTTTTCTGACGTACCTGAACACAG
AACCCCAGGGTACTTGGAGAGGAACCTGGTCCTAGAGGAACTCTACCATAAAAATGAGCCCCGC
AGATCCGCTTGATGATGAAGACACATTTAAAATCCTGGTTGCCACTGATATTCATCTTGGATTT
ATGGAAAAAGATGCAGTTAGAGGAAATGACACATTTGTGACATTTGATGAAATTTTAAGACTTG
CCCTGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTCCATGAAAACAAGCCCTC
AAGGAAAACCCTGCACAGCTGCTTAGAGCTGCTTAGGAAGTACTGTATGGGTGACCGCCCTGTG
CAATTTGAGATCATCAGTGACCAGTCAGTCAACTTTGGTTTTAGTAAGTTTCCATGGGTGAACT
ACCAGGATGGCAATCTCAACATCTCCATTCCAGTGTTTAGTATCCACGGCAACCATGATGATCC
CACAGGGGCAGATGCCCTCTGTGCCCTGGATGTTTTAAGCTGTGCTGGGTTTGTGAATCACTTT
GGACGGTCAATGTCTGTGGAGAAGGTTGACATTAGTCCAGTTCTGCTGCAGAAAGGAAGCACAA
AACTCGCTCTGTACGGCTTAGGGTCCATTCCAGATGAAAGGCTCTATCGGATGTTTGTCAATAA
GAAAGTAACGATGTTGAGGCCTAAGGAAGACGAGAACTCATGGTTTAACTTATTCGTGATTCAT
CAGAACAGGAGTAAACACGGAAGCACCAACTTCATCCCAGAGCAGTTTTTGGATGACTTCATTG
ACCTGGTCATCTGGGGCCATGAACATGAGTGTAAAATCGGCCCAACCAGGAATGAGCAGCAGCT
CTTCTATGTGTCTCAGCCCGGAAGCTCGGTGGTGACAGCCCTTTCCCCTGGAGAAACTGTGAAG
AAACATGTAGGCCTGCTACGCGTTAAAGGGAGAAAGATGAACATGCAGAAGCTGCCTCTCCGCA
CAGTGCGACAGTTCTTCATGGAAGATGTGGTCCTGGCTAACCACCCAAGCCTGTTCAACCCTGA
CAATCCTAAGGTGACCCAGGCCATCCAGAGCTTCTGTTTGGAGAAGATTGAAGAAATGCTTGAC
AGTGCTGAGCGGGAACGGCTGGGGAATCCTCAGCAGCCGGAGAAGCCTCTCATCCGACTACGGG
TGGACTACAGTGGAGGCTTTGAACCTTTCAACGTTCTTCGTTTTAGCCAGAAGTTTGTGGATCG
GGTTGCTAACCCAAAAGATGTCATCCACTTTTTCAGACACAGGGAACAAAAAGGAAAAACAGGA
GAAGAGATCAACTTTGGGAAGCTCATCATAAAACCTGCTTCAGAAGGGACGACGCTCAGAGTAG
AAGACCTTGTAAAGCAGTATTTCCAAACTGCAGAGAAGAATGTTCAGCTCTCACTGCTGACAGA
AAGAGGGATGGGTGAAGCAGTTCAAGAGTTTGTGGACAAGGAAGAGAAAGATGCCATCGAGGAA
TTAGTGAAGTACCAGCTGGAGAAAACGCAGCGGTTTCTTAAGGAGCGCCACATCGATGCTCTAG
AAGACAAGATTGATGAAGAGGTCCGGCGTTTCAGAGAAAGCAGACAGAGAAATACCAACGAAGA
AGACGATGAAGTTCGAGAGGCCATGAGCAGGGCCCGGGCCCTCAGGTCACAGTCGGAGAACGCC
GCCTCAGCCTTCAGTGCAGATGACCTGAGTTTTGATATAACGGAGCAGACAGCAGATGACTCTG
ACGATAGCCAGTCAGCAGTGCCGAGCCGAGGCCGAGGTCGAGGCCGAGGACGAAGAGGAGGCAG
AGGGCAGAGCACTGCACCCAGAGGAGGCTCTCAGAGAGGCCGAGACACTGGGCTGGGGATCTCT
ACTCGGGGCAGGAGCTCAAAGGCCACTGCGTCAACATCTAGAAATATGTCCATTATAGATGCTT
TCAGATCTACCCGACAGCAGCCTTCCAGAAATGTAGCCACTAAGAATTACTCAGAGACCATTGA
GGTGGATGAATCTGATGACGATGACAGTTTTCCTACCAGCTCCAGGGCTGATCAAAGGTGGTCG
GGCACAGCACCTAGCAAACGGATGTCCCAGAGCCAGACAGCCAAAGGGGTGGACTTTGAATCAG
ACGAGGACGATGATGACGACCCTTTCATGAGTGGTAGTTGCCCAAGAAGAAACCGAAGATAATG
TTGTTAGTAGAACTTAAAAGTTGTCCCGCTGCAGGAAGAAATCGCAGCAGCGTATGCTAACTTT
ACAGCTGGCGGTGTTTTATCGCTGCAGCACTACAGGAGTCTGAAAAGCCTGGGATTCTATTTTA
AAATATTGTTTCCTGAAGGTGACTCTCTTAAGCCATTTCCTAGGCGGGTGGTAAGGAGATTGCT
GCTTCTCCTTAGCCTTTAATCTGCTTGTTATCATTGTCTGGGGCTGCTTTAAGAATGTTAATTT
CCTGACATAACTGTGTTTCCTGCTTGTAAGAACTTTGCTAAAATTCCATTGTTGAATGAAGATT
AGAGAAAACCCTCCATTATCCATTCCTGCTTCTGATCAGAGACTGTCAGCCTCCAGTGCCTCAG
CTAGCAGAGTTGATGTGACAGCTTACCGGGGCTGTAACCATTTCCTGTCTCCCCAGGAAGCAAG
GCCCTCCTGTGTGTGTGGTGGGGGGAGCAGTCTGAGCTCCCTGGTTGTTAGCAAGTGTGTGGAT
TTCAGAGTGTGCTGGAGGACGGTCCACTAGGGCCAGAAGGGCCTTATATTTCAGTAATTAGTAT
AAGGTTTTTGTTGAAACCATTTTGGTTGTTTTGGTTTTGGTCTTTATTCACGTTGTAGCAGAGA
CTCAGATCCTGTCCCCACTGAGCAGTAGTCATTTTCTTGATCACTCTGTCATTCATGACAAGCT
CTTTTTCTCTCTCAACTCTTGTCAGGGAGAAAAGCTTAATAGGATTTTTCTGTTTCTTAAAGAT
AGTGAAAAAGCTTTCTTAGGCCAAACAGCCAGCTGACCTTGTGGTTAGTTCAGGCTGACATACC
ACAGTTCAGTTTCTGCCCGGAGTCGGGGCCAGGCCTCCTTGACCAGCAGCAGCACTGTACCATG
GCTTTGGTTGCTATAAACATCTCTGAATACACGGTTCCAAAACTGACGGAAACAGCAAGCTTAC
ATTTTCTTACTTGTTTTAGGAAGAAAATAAAAATGTAATCCTTTCAGAGTTGAGTTAAA

hide sequence

RefSeq Acc Id:

XM_039082071 ⟹ XP_038937999

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,618,876 - 11,680,451 (+)	NCBI

RefSeq Acc Id:

XM_039082072 ⟹ XP_038938000

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,637,354 - 11,680,451 (+)	NCBI

RefSeq Acc Id:

XM_039082073 ⟹ XP_038938001

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,637,354 - 11,680,451 (+)	NCBI

RefSeq Acc Id:

XR_005487915

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,632,293 - 11,677,346 (+)	NCBI

RefSeq Acc Id:

XR_005487916

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	11,632,293 - 11,659,008 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071615	(Get FASTA)	NCBI Sequence Viewer
	XP_006242594	(Get FASTA)	NCBI Sequence Viewer
	XP_006242595	(Get FASTA)	NCBI Sequence Viewer
	XP_006242596	(Get FASTA)	NCBI Sequence Viewer
	XP_038937999	(Get FASTA)	NCBI Sequence Viewer
	XP_038938000	(Get FASTA)	NCBI Sequence Viewer
	XP_038938001	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF91227	(Get FASTA)	NCBI Sequence Viewer
	EDL78461	(Get FASTA)	NCBI Sequence Viewer
	EDL78462	(Get FASTA)	NCBI Sequence Viewer
	EDL78463	(Get FASTA)	NCBI Sequence Viewer
	Q9JIM0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_071615 ⟸ NM_022279

- UniProtKB:

Q9JIM0 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHE
NKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYRDGNLNISIPVFSIHGN
HDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRM
FVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRN
EQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSL
FNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQK
FVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLS
LLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRN
TNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGR
RGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYS
ETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRN
RR

hide sequence

RefSeq Acc Id:	XP_006242594 ⟸ XM_006242532
- Peptide Label:	isoform X1
- UniProtKB:	G3V781 (UniProtKB/TrEMBL), A0A8I6A2X5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPADPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHE NKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGN HDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRM FVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRN EQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSL FNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQK FVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLS LLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRN TNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGR RGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYS ETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRN RR hide sequence

RefSeq Acc Id:	XP_006242595 ⟸ XM_006242533
- Peptide Label:	isoform X1
- UniProtKB:	G3V781 (UniProtKB/TrEMBL), A0A8I6A2X5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPADPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHE NKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGN HDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRM FVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRN EQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSL FNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQK FVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLS LLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRN TNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGR RGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYS ETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRN RR hide sequence

RefSeq Acc Id:	XP_006242596 ⟸ XM_006242534
- Peptide Label:	isoform X1
- UniProtKB:	G3V781 (UniProtKB/TrEMBL), A0A8I6A2X5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSPADPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHE NKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGN HDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRM FVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRN EQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSL FNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQK FVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLS LLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRN TNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGR RGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYS ETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRN RR hide sequence

RefSeq Acc Id:

ENSRNOP00000012940 ⟸ ENSRNOT00000012940

RefSeq Acc Id:	XP_038937999 ⟸ XM_039082071
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A2X5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938000 ⟸ XM_039082072
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038938001 ⟸ XM_039082073
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000086786 ⟸ ENSRNOT00000100883

RefSeq Acc Id:

ENSRNOP00000092951 ⟸ ENSRNOT00000105497

Protein Domains

Mre11_DNA_bind

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JIM0-F1-model_v2	AlphaFold	Q9JIM0	1-706	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69263	AgrOrtholog
BioCyc Gene	G2FUF-31683	BioCyc
Ensembl Genes	ENSRNOG00000009506	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012940.3	UniProtKB/TrEMBL
	ENSRNOP00000086786	ENTREZGENE
	ENSRNOP00000086786.1	UniProtKB/TrEMBL
	ENSRNOP00000092951.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012940.5	UniProtKB/TrEMBL
	ENSRNOT00000100883	ENTREZGENE
	ENSRNOT00000100883.1	UniProtKB/TrEMBL
	ENSRNOT00000105497.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.110.110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.60.21.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mre11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mre11_DNA-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mre11_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mre11_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64046	UniProtKB/Swiss-Prot
NCBI Gene	64046	ENTREZGENE
Pfam	Metallophos	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mre11_DNA_bind	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mre11	PhenoGen
PIRSF	DSB_repair_MRE11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Mre11_DNA_bind	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	mre11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A2X5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AEW0_RAT	UniProtKB/TrEMBL
	G3V781	ENTREZGENE, UniProtKB/TrEMBL
	MRE11_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-08	Mre11	MRE11 homolog, double strand break repair nuclease	Mre11a	MRE11 homolog A, double strand break repair nuclease	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-30	Mre11a	MRE11 homolog A, double strand break repair nuclease	Mre11a	MRE11 homolog, double strand break repair nuclease A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-09	Mre11a	MRE11 homolog, double strand break repair nuclease A	Mre11a	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Mre11a	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	Mre11a	meiotic recombination 11 homolog A (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Mre11a	meiotic recombination 11 homolog A (S. cerevisiae)			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA is expressed in immortalized cardiomyocytes and in testis	68816

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)