Mir381 (microRNA 381) - Rat Genome Database

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Gene: Mir381 (microRNA 381) Rattus norvegicus
Analyze
Symbol: Mir381
Name: microRNA 381
RGD ID: 2325521
Description: Predicted to be involved in energy homeostasis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; and long-term synaptic potentiation. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human MIR381 (microRNA 381); INTERACTS WITH cadmium dichloride; hexanal; mechlorethamine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-381; rno-mir-381
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,562,381 - 134,562,441 (+)NCBIGRCr8
mRatBN7.26128,740,976 - 128,741,036 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6128,920,215 - 128,920,275 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,216,047 - 129,216,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,577,670 - 128,577,730 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,876,615 - 133,876,675 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,876,586 - 133,876,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,038,972 - 143,039,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,325,355 - 126,325,415 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir381RatHyperalgesia treatmentIDA 13838658 RGD 
Mir381RatKidney Reperfusion Injury  IEP 13825150RNA:decreased expression:kidneyRGD 
Mir381Ratlung non-small cell carcinoma treatmentISOMIR381 (Homo sapiens)13464271 RGD 
Mir381Ratsciatic neuropathy  IEP 13838658RNA:decreased expression:spinal cordRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir381RatKagami-Ogata syndrome  ISOMIR381 (Homo sapiens)8554872ClinVar Annotator: match by term: Paternal uniparental disomy 14ClinVarPMID:18176563
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir381RatExperimental Neoplasms  ISOMIR381 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816
Mir381RatHearing Loss, Noise-Induced  ISOMIR381 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23472202
Mir381Ratpapillary thyroid carcinoma  ISOMIR381 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir381Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMIR381 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MIR381 mRNACTDPMID:30096437
Mir381Ratarsane decreases expressionISOMIR381 (Homo sapiens)6480464Arsenic results in decreased expression of MIR381CTDPMID:30114287
Mir381Ratarsenic atom decreases expressionISOMIR381 (Homo sapiens)6480464Arsenic results in decreased expression of MIR381CTDPMID:30114287
Mir381Ratbisphenol F multiple interactionsISOMIR381 (Homo sapiens)6480464[bisphenol F co-treated with Fulvestrant] results in increased methylation of MIR381 geneCTDPMID:31601247
Mir381Ratcadmium dichloride increases expressionISOMir381 (Mus musculus)6480464Cadmium Chloride results in increased expression of MIR381 mRNACTDPMID:35183672
Mir381Ratcadmium dichloride affects expressionEXP 6480464Cadmium Chloride affects the expression of MIR381 mRNACTDPMID:35525383
Mir381Ratdexmedetomidine multiple interactionsISOMir381 (Mus musculus)6480464[Dexmedetomidine co-treated with Lipopolysaccharides] results in increased expression of MIR381 mRNA more ...CTDPMID:30102002
Mir381Ratdiphenylmethane-4,4'-diisocyanate multiple interactionsISOMir381 (Mus musculus)6480464[[4 and 4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNACTDPMID:31609387
Mir381Ratdiphenylmethane-4,4'-diisocyanate decreases expressionISOMir381 (Mus musculus)64804644 and 4'-diphenylmethane diisocyanate results in decreased expression of MIR381CTDPMID:31609387
Mir381Ratfulvestrant multiple interactionsISOMIR381 (Homo sapiens)6480464[bisphenol F co-treated with Fulvestrant] results in increased methylation of MIR381 geneCTDPMID:31601247
Mir381Rathexanal decreases expressionEXP 6480464n-hexanal results in decreased expression of MIR381 mRNACTDPMID:26403475
Mir381Ratlipopolysaccharide multiple interactionsISOMir381 (Mus musculus)6480464[Dexmedetomidine co-treated with Lipopolysaccharides] results in increased expression of MIR381 mRNA more ...CTDPMID:30102002
Mir381Ratmechlorethamine increases expressionEXP 6480464Mechlorethamine results in increased expression of MIR381 mRNACTDPMID:33971176
Mir381Ratphenobarbital affects expressionISOMir381 (Mus musculus)6480464Phenobarbital affects the expression of MIR381 mRNACTDPMID:23091169
Mir381Ratsodium arsenite decreases expressionISOMIR381 (Homo sapiens)6480464sodium arsenite results in decreased expression of MIR381 mRNACTDPMID:25879800
Mir381Ratsodium arsenite increases expressionISOMIR381 (Homo sapiens)6480464sodium arsenite results in increased expression of MIR381 mRNACTDPMID:34032870
Mir381Ratvalproic acid increases expressionISOMIR381 (Homo sapiens)6480464Valproic Acid results in increased expression of MIR381 mRNACTDPMID:29154799

1 to 17 of 17 rows

Biological Process

  


#
Reference Title
Reference Citation
1. microRNA-381 suppresses the growth and increases cisplatin sensitivity in non-small cell lung cancer cells through inhibition of nuclear factor-¿B signaling. Huang RS, etal., Biomed Pharmacother. 2017 Dec 26;98:538-544. doi: 10.1016/j.biopha.2017.12.092.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4. Zhan LY, etal., Biomed Pharmacother. 2018 Nov;107:818-823. doi: 10.1016/j.biopha.2018.08.053. Epub 2018 Aug 22.
5. MicroRNA-381-induced down-regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. Zheng GH, etal., J Cell Biochem. 2018 Apr;119(4):3149-3161. doi: 10.1002/jcb.26466. Epub 2018 Jan 2.
PMID:16274478   PMID:16381832   PMID:20403161   PMID:20439489   PMID:21247879   PMID:25858512   PMID:27312547   PMID:29633273   PMID:29750292   PMID:30229813   PMID:36734386   PMID:39152444  



Mir381
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,562,381 - 134,562,441 (+)NCBIGRCr8
mRatBN7.26128,740,976 - 128,741,036 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6128,920,215 - 128,920,275 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,216,047 - 129,216,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,577,670 - 128,577,730 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,876,615 - 133,876,675 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,876,586 - 133,876,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,038,972 - 143,039,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,325,355 - 126,325,415 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR381
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,045,920 - 101,045,994 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,045,920 - 101,045,994 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,512,257 - 101,512,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,582,009 - 100,582,083 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,568,314 - 81,568,388 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,695,623 - 81,695,697 (+)NCBIHuRef
CHM1_114101,451,279 - 101,451,353 (+)NCBICHM1_1
T2T-CHM13v2.01495,281,297 - 95,281,371 (+)NCBIT2T-CHM13v2.0
Mir381
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,693,256 - 109,693,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,693,256 - 109,693,330 (+)EnsemblGRCm39 Ensembl
GRCm3812109,726,822 - 109,726,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,726,822 - 109,726,896 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,965,032 - 110,965,106 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,924,052 - 110,924,126 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
MIR381
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,274,983 - 69,275,057 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,793,130 - 68,793,204 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,556,631 - 69,556,705 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,220,176 - 69,220,250 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,286,271 - 69,286,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,684,270 - 69,684,344 (+)NCBIUU_Cfam_GSD_1.0
MIR381
(Sus scrofa - pig)		 No map positions available.

.

Predicted Targets
Summary Value
Count of predictions:8788
Count of gene targets:5329
Count of transcripts:5722
Interacting mature miRNAs:rno-miR-381-3p, rno-miR-381-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat

1 to 10 of 25 rows



appendage
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
3 20 15 6 6 6 17 8 12 5


RefSeq Transcripts NR_032129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6133,876,586 - 133,876,693 (+)Ensembl
RefSeq Acc Id: NR_032129
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,562,381 - 134,562,441 (+)NCBI
mRatBN7.26128,740,976 - 128,741,036 (+)NCBI
Rnor_6.06133,876,615 - 133,876,675 (+)NCBI
Rnor_5.06143,038,972 - 143,039,032 (+)NCBI
Celera6126,325,355 - 126,325,415 (+)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 9 of 9 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35963 BioCyc
Ensembl Genes ENSRNOG00000035493 Ensembl
miRBase MI0003546 ENTREZGENE
NCBI Gene 100314084 ENTREZGENE
PhenoGen Mir381 PhenoGen
RatGTEx ENSRNOG00000035493 RatGTEx
RNAcentral URS00004A35E2 RNACentral
  URS000075A8F4 RNACentral
  URS000075B13E RNACentral
1 to 9 of 9 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-29 Mir381  microRNA 381  Mir381  microRNA mir-381  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir381  microRNA mir-381      Symbol and Name status set to provisional 70820 PROVISIONAL