MIR381 (microRNA 381) - Rat Genome Database

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Gene: MIR381 (microRNA 381) Homo sapiens
Analyze
Symbol: MIR381
Name: microRNA 381
RGD ID: 1346769
HGNC Page HGNC:31874
Description: Predicted to be involved in energy homeostasis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; and long-term synaptic potentiation. Located in extracellular space. Implicated in lung non-small cell carcinoma.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-381; mir-381; MIRN381
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,045,920 - 101,045,994 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,045,920 - 101,045,994 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,512,257 - 101,512,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,582,009 - 100,582,083 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,568,314 - 81,568,388 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,695,623 - 81,695,697 (+)NCBIHuRef
CHM1_114101,451,279 - 101,451,353 (+)NCBICHM1_1
T2T-CHM13v2.01495,281,297 - 95,281,371 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. microRNA-381 suppresses the growth and increases cisplatin sensitivity in non-small cell lung cancer cells through inhibition of nuclear factor-¿B signaling. Huang RS, etal., Biomed Pharmacother. 2017 Dec 26;98:538-544. doi: 10.1016/j.biopha.2017.12.092.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4. Zhan LY, etal., Biomed Pharmacother. 2018 Nov;107:818-823. doi: 10.1016/j.biopha.2018.08.053. Epub 2018 Aug 22.
5. MicroRNA-381-induced down-regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. Zheng GH, etal., J Cell Biochem. 2018 Apr;119(4):3149-3161. doi: 10.1002/jcb.26466. Epub 2018 Jan 2.
Additional References at PubMed
PMID:16274478   PMID:16381832   PMID:17604727   PMID:20167074   PMID:20889907   PMID:21037258   PMID:21435336   PMID:22282338   PMID:22592211   PMID:23816136   PMID:24166498   PMID:24303078  
PMID:24404152   PMID:25605243   PMID:26184031   PMID:26320179   PMID:26320367   PMID:26450928   PMID:26646931   PMID:26677080   PMID:26688820   PMID:26768613   PMID:27223121   PMID:27229532  
PMID:27296666   PMID:27312547   PMID:27612424   PMID:28012397   PMID:28193228   PMID:29207112   PMID:29257334   PMID:29295724   PMID:29303411   PMID:29523223   PMID:29540663   PMID:29956737  
PMID:30138038   PMID:30161290   PMID:30266665   PMID:30382579   PMID:30444043   PMID:30483755   PMID:30542723   PMID:30875931   PMID:31173154   PMID:31209205   PMID:31299041   PMID:31347326  
PMID:31378900   PMID:31545430   PMID:31646571   PMID:31797734   PMID:31864017   PMID:32016478   PMID:32196601   PMID:32492888   PMID:32633375   PMID:32712160   PMID:32902022   PMID:32938467  
PMID:33040796   PMID:33086148   PMID:33137708   PMID:33313944   PMID:33352510   PMID:33407350   PMID:33737493   PMID:34308746   PMID:34362391   PMID:34631883   PMID:34749366   PMID:34753384  
PMID:34784841   PMID:34806925   PMID:34931867   PMID:35014178   PMID:35029520   PMID:35184652   PMID:35430713   PMID:35753353   PMID:36046375   PMID:36658407  


Genomics

Comparative Map Data
MIR381
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,045,920 - 101,045,994 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,045,920 - 101,045,994 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,512,257 - 101,512,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,582,009 - 100,582,083 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,568,314 - 81,568,388 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,695,623 - 81,695,697 (+)NCBIHuRef
CHM1_114101,451,279 - 101,451,353 (+)NCBICHM1_1
T2T-CHM13v2.01495,281,297 - 95,281,371 (+)NCBIT2T-CHM13v2.0
Mir381
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,693,256 - 109,693,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,693,256 - 109,693,330 (+)EnsemblGRCm39 Ensembl
GRCm3812109,726,822 - 109,726,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,726,822 - 109,726,896 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,965,032 - 110,965,106 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,924,052 - 110,924,126 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
Mir381
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,562,381 - 134,562,441 (+)NCBIGRCr8
mRatBN7.26128,740,976 - 128,741,036 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6128,920,215 - 128,920,275 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,216,047 - 129,216,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,577,670 - 128,577,730 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,876,615 - 133,876,675 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,876,586 - 133,876,693 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,038,972 - 143,039,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,325,355 - 126,325,415 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR381
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,274,983 - 69,275,057 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,793,130 - 68,793,204 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,556,631 - 69,556,705 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,220,176 - 69,220,250 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,286,271 - 69,286,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,684,270 - 69,684,344 (+)NCBIUU_Cfam_GSD_1.0
MIR381
(Sus scrofa - pig)		 No map positions available.


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33		 pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ID1hsa-miR-381-3pOncomiRDBexternal_infoNANA22592211
LRRC4hsa-miR-381-3pOncomiRDBexternal_infoNANA21435336

Predicted Targets
Summary Value
Count of predictions:21690
Count of gene targets:9497
Count of transcripts:17780
Interacting mature miRNAs:hsa-miR-381-3p, hsa-miR-381-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 2 1
Low 4 1 6 1 7 1 8 8 24 8 5 1 3 2
Below cutoff 2 5 5 5 8 17 5 9 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000362150
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl14101,045,920 - 101,045,994 (+)Ensembl
RefSeq Acc Id: NR_029873
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,045,920 - 101,045,994 (+)NCBI
GRCh3714101,512,257 - 101,512,331 (+)RGD
Celera1481,568,314 - 81,568,388 (+)RGD
HuRef1481,695,623 - 81,695,697 (+)ENTREZGENE
CHM1_114101,451,279 - 101,451,353 (+)NCBI
T2T-CHM13v2.01495,281,297 - 95,281,371 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31874 AgrOrtholog
COSMIC MIR381 COSMIC
Ensembl Genes ENSG00000199020 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362150 ENTREZGENE
GTEx ENSG00000199020 GTEx
HGNC ID HGNC:31874 ENTREZGENE
Human Proteome Map MIR381 Human Proteome Map
miRBase MI0000789 ENTREZGENE
NCBI Gene 494330 ENTREZGENE
PharmGKB PA164722700 PharmGKB
RNAcentral URS00001FFA8C RNACentral
  URS00004A35E2 RNACentral
  URS000075A1A8 RNACentral