Naa10 (N(alpha)-acetyltransferase 10, NatA catalytic subunit) - Rat Genome Database

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Gene: Naa10 (N(alpha)-acetyltransferase 10, NatA catalytic subunit) Rattus norvegicus
Analyze
Symbol: Naa10
Name: N(alpha)-acetyltransferase 10, NatA catalytic subunit
RGD ID: 1565315
Description: Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Predicted to contribute to peptide alpha-N-acetyltransferase activity and ribosome binding activity. Predicted to be involved in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Predicted to be located in cytosol and nucleolus. Predicted to be part of NatA complex. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit); INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-N-acetyltransferase 1A; Ard1; ARD1 homolog A, N-acetyltransferase; ARD1 homolog A, N-acetyltransferase (S. cerevisiae); Ard1a; LOC363518; N-acetyltransferase ARD1 homolog; N-acetyltransferase ARD1 homolog (S. cerevisiae) ; N-alpha-acetyltransferase 10; N-alpha-acetyltransferase 10, NatA catalytic subunit; RGD1565315; similar to N-acetyltransferase ARD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,656,056 - 151,661,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,656,056 - 151,661,252 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,797,221 - 153,802,417 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,360,437 - 157,365,635 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,032,270 - 155,037,466 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,863,655 - 156,868,950 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,863,754 - 156,868,950 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,611,704 - 152,617,018 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,843,948 - 159,849,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,230,914 - 136,236,046 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
NatA complex  (IBA,ISO)
nucleolus  (IEA,ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12888564   PMID:15496142   PMID:19480662   PMID:19946888   PMID:25376646   PMID:25489052   PMID:25732826   PMID:27422821   PMID:27708256   PMID:33872734  


Genomics

Comparative Map Data
Naa10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,656,056 - 151,661,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,656,056 - 151,661,252 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,797,221 - 153,802,417 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,360,437 - 157,365,635 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,032,270 - 155,037,466 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,863,655 - 156,868,950 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,863,754 - 156,868,950 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,611,704 - 152,617,018 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,843,948 - 159,849,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,230,914 - 136,236,046 (+)NCBICelera
Cytogenetic MapXq37NCBI
NAA10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,929,225 - 153,935,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,929,225 - 153,935,080 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,194,678 - 153,200,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,848,571 - 152,853,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,716,223 - 152,721,315NCBI
CeleraX153,429,094 - 153,434,185 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,847,939 - 141,853,239 (-)NCBIHuRef
CHM1_1X153,069,735 - 153,075,062 (-)NCBICHM1_1
T2T-CHM13v2.0X152,202,942 - 152,208,754 (-)NCBIT2T-CHM13v2.0
Naa10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,960,476 - 72,965,550 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,960,479 - 72,965,550 (-)EnsemblGRCm39 Ensembl
GRCm38X73,916,870 - 73,921,944 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,916,873 - 73,921,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,162,209 - 71,167,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,169,595 - 70,174,633 (-)NCBIMGSCv36mm8
CeleraX65,169,303 - 65,174,378 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.49NCBI
Naa10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580603,331 - 612,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580604,805 - 609,978 (-)NCBIChiLan1.0ChiLan1.0
NAA10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X153,977,213 - 153,983,495 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,484,008 - 143,489,904 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,371,135 - 153,376,027 (-)NCBIpanpan1.1PanPan1.1panPan2
NAA10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,777,658 - 121,782,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,727,573 - 121,788,860 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,106,419 - 107,110,858 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,918,940 - 124,923,379 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,918,987 - 124,930,159 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,688,217 - 120,692,656 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,203,614 - 123,208,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,964,950 - 122,969,389 (-)NCBIUU_Cfam_GSD_1.0
Naa10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,074,683 - 119,079,358 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809812,390 - 817,288 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809812,454 - 817,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAA10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,658,158 - 124,662,702 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,658,429 - 124,662,744 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,223,246 - 142,227,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAA10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,353,262 - 128,359,222 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,352,634 - 128,359,085 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,225,260 - 66,230,466 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naa10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946559,710 - 570,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla_female_1.0 EnsemblNW_004624946565,212 - 570,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946560,924 - 570,340 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000051254
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
REN88218  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,659,063 - 151,659,289 (-)MAPPERmRatBN7.2
Rnor_6.0X156,865,717 - 156,865,942NCBIRnor6.0
Rnor_5.01152,613,785 - 152,614,010UniSTSRnor5.0
RGSC_v3.4X159,846,956 - 159,847,181UniSTSRGSC3.4
Celera1136,232,877 - 136,233,102UniSTS
Cytogenetic MapXq37UniSTS
REN88217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,658,743 - 151,659,066 (-)MAPPERmRatBN7.2
Rnor_6.0X156,865,940 - 156,866,262NCBIRnor6.0
Rnor_5.01152,614,008 - 152,614,330UniSTSRnor5.0
RGSC_v3.4X159,846,636 - 159,846,958UniSTSRGSC3.4
Celera1136,233,100 - 136,233,422UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 8 11 74 35 34 11 8
Low 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000083611   ⟹   ENSRNOP00000074325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,656,056 - 151,661,252 (-)Ensembl
Rnor_6.0 EnsemblX156,863,754 - 156,868,950 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109479   ⟹   ENSRNOP00000083715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,656,057 - 151,661,236 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116596   ⟹   ENSRNOP00000089199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,656,071 - 151,661,192 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119418   ⟹   ENSRNOP00000084817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,656,881 - 151,661,252 (-)Ensembl
RefSeq Acc Id: NM_001135839   ⟹   NP_001129311
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,656,056 - 151,661,252 (-)NCBI
Rnor_6.0X156,863,754 - 156,868,950 (+)NCBI
Rnor_5.01152,611,704 - 152,617,018 (+)NCBI
RGSC_v3.4X159,843,948 - 159,849,144 (-)RGD
Celera1136,230,914 - 136,236,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229591   ⟹   XP_006229653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,656,066 - 151,661,304 (-)NCBI
Rnor_6.0X156,863,655 - 156,868,948 (+)NCBI
Rnor_5.01152,611,704 - 152,617,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229592   ⟹   XP_006229654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,656,058 - 151,661,244 (-)NCBI
Rnor_6.0X156,863,655 - 156,868,948 (+)NCBI
Rnor_5.01152,611,704 - 152,617,018 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602117   ⟹   XP_017457606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,656,066 - 151,661,230 (-)NCBI
Rnor_6.0X156,863,655 - 156,868,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099914   ⟹   XP_038955842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,657,212 - 151,661,304 (-)NCBI
RefSeq Acc Id: XM_039099915   ⟹   XP_038955843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,657,074 - 151,661,304 (-)NCBI
RefSeq Acc Id: NP_001129311   ⟸   NM_001135839
- UniProtKB: D3ZUQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229653   ⟸   XM_006229591
- Peptide Label: isoform X1
- UniProtKB: D3ZUQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229654   ⟸   XM_006229592
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZXS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457606   ⟸   XM_017602117
- Peptide Label: isoform X3
- UniProtKB: A6KRT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074325   ⟸   ENSRNOT00000083611
RefSeq Acc Id: XP_038955843   ⟸   XM_039099915
- Peptide Label: isoform X5
- UniProtKB: A6KRT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955842   ⟸   XM_039099914
- Peptide Label: isoform X4
- UniProtKB: A6KRT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083715   ⟸   ENSRNOT00000109479
RefSeq Acc Id: ENSRNOP00000089199   ⟸   ENSRNOT00000116596
RefSeq Acc Id: ENSRNOP00000084817   ⟸   ENSRNOT00000119418
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUQ2-F1-model_v2 AlphaFold D3ZUQ2 1-235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702052
Promoter ID:EPDNEW_R12576
Type:initiation region
Name:Naa10_1
Description:N-acetyltransferase 10, NatA catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,863,811 - 156,863,871EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565315 AgrOrtholog
BioCyc Gene G2FUF-653 BioCyc
Ensembl Genes ENSRNOG00000060063 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083611 ENTREZGENE
  ENSRNOT00000083611.2 UniProtKB/TrEMBL
  ENSRNOT00000109479 ENTREZGENE
  ENSRNOT00000109479.1 UniProtKB/TrEMBL
  ENSRNOT00000116596.1 UniProtKB/TrEMBL
  ENSRNOT00000119418.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/TrEMBL
InterPro AcTrfase_GCN5-related UniProtKB/TrEMBL
  Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Ard1-like UniProtKB/TrEMBL
NCBI Gene 363518 ENTREZGENE
PANTHER N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  N-ALPHA-ACETYLTRANSFERASE 10 UniProtKB/TrEMBL
  PTHR23091 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PhenoGen Naa10 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060063 RatGTEx
Superfamily-SCOP Acyl_CoA_acyltransferase UniProtKB/TrEMBL
UniProt A0A8I5ZXS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9B2_RAT UniProtKB/TrEMBL
  A0A8I6GC73_RAT UniProtKB/TrEMBL
  A6KRT5 ENTREZGENE, UniProtKB/TrEMBL
  A6KRT6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUQ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Naa10  N(alpha)-acetyltransferase 10, NatA catalytic subunit  Ard1a  ARD1 homolog A, N-acetyltransferase (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ard1a  ARD1 homolog A, N-acetyltransferase (S. cerevisiae)  Ard1  N-acetyltransferase ARD1 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ard1  N-acetyltransferase ARD1 homolog (S. cerevisiae)   Ard1_predicted  N-acetyltransferase ARD1 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ard1_predicted  N-acetyltransferase ARD1 homolog (S. cerevisiae) (predicted)  RGD1565315_predicted  similar to N-acetyltransferase ARD1 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1565315_predicted  similar to N-acetyltransferase ARD1 (predicted)  LOC363518  similar to N-acetyltransferase ARD1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363518  similar to N-acetyltransferase ARD1      Symbol and Name status set to provisional 70820 PROVISIONAL