RGD Reference Report - Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. - Rat Genome Database

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Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence.

Authors: Nanjundan, M  Byers, LA  Carey, MS  Siwak, DR  Raso, MG  Diao, L  Wang, J  Coombes, KR  Roth, JA  Mills, GB  Wistuba, II  Minna, JD  Heymach, JV 
Citation: Nanjundan M, etal., J Thorac Oncol. 2010 Dec;5(12):1894-904.
RGD ID: 5131640
Pubmed: PMID:21124077   (View Abstract at PubMed)
PMCID: PMC3374718   (View Article at PubMed Central)
DOI: DOI:10.1097/JTO.0b013e3181f2a266   (Journal Full-text)

INTRODUCTION: The identification of key pathways dysregulated in non-small cell lung cancer (NSCLC) is an important step toward understanding lung pathogenesis and developing new therapeutic approaches. METHODS: Toward this goal, reverse-phase protein lysate arrays (RPPA) were used to compare signaling pathways between NSCLC tumors and paired normal lung tissue from 46 patients and assess their association with clinical outcome. RESULTS: After RPPA quantification of 63 proteins and phosphoproteins, tissue pairs were randomized to a training set (n = 25 pairs) and test set (n = 21 pairs). In the training set, 15 protein markers were differentially expressed between tumors and normal lung (p

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung non-small cell carcinoma susceptibilityIEP 5131640protein:decreased expression:tumor (human)RGD 
lung non-small cell carcinoma susceptibilityISOEGFR (Homo sapiens)5131640; 5131640protein:decreased expression:tumor (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Egfr  (epidermal growth factor receptor)

Genes (Mus musculus)
Egfr  (epidermal growth factor receptor)

Genes (Homo sapiens)
EGFR  (epidermal growth factor receptor)


Additional Information