Klf5 (KLF transcription factor 5) - Rat Genome Database

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Gene: Klf5 (KLF transcription factor 5) Rattus norvegicus
Analyze
Symbol: Klf5
Name: KLF transcription factor 5
RGD ID: 621446
Description: Enables sequence-specific DNA binding activity. Involved in cellular response to organic cyclic compound; cellular response to peptide; and positive regulation of cell population proliferation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of transcription regulator complex. Used to study transient cerebral ischemia. Orthologous to human KLF5 (KLF transcription factor 5); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic transcription element binding protein 2; basic transcription element binding protein BTEB2; Bteb2; IKLF; Krueppel-like factor 5; Kruppel-like factor 5; Kruppel-like factor 5 (intestinal)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Klf5-ps1   Klf5-ps2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,472,081 - 82,487,267 (+)NCBIGRCr8
mRatBN7.21576,060,320 - 76,079,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1580,049,636 - 80,064,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,126,239 - 81,141,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,073,796 - 78,089,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,703,796 - 83,722,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,703,791 - 83,722,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01587,212,719 - 87,231,850 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41583,103,177 - 83,118,363 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11583,121,895 - 83,132,620 (+)NCBI
Celera1575,305,416 - 75,320,302 (+)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
Curcumol  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
etoposide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pioglitazone  (EXP)
progesterone  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Intestinal tumor progression is associated with altered function of KLF5. Bateman NW, etal., J Biol Chem 2004 Mar 26;279(13):12093-101. Epub 2004 Jan 15.
2. microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway. Chang L, etal., Mol Med. 2020 Apr 9;26(1):31. doi: 10.1186/s10020-020-00150-w.
3. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Cheng Y, etal., Circ Res. 2009 Jul 17;105(2):158-66. doi: 10.1161/CIRCRESAHA.109.197517. Epub 2009 Jun 18.
4. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy. Nagai R, etal., Adv Exp Med Biol 2003;538:57-65; discussion 66.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Inducible expression of BTEB2, a member of the zinc-finger family of transcription factors, in cardiac allograft arteriosclerosis. Ogata T, etal., Transplant Proc. 2000 Nov;32(7):2032-3.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2. Sakamoto H, etal., Cardiology. 2003;100(2):80-5.
13. Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation. Sun R, etal., J Biol Chem 2001 Mar 9;276(10):6897-900.
14. BTEB2, a Kruppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene. Watanabe N, etal., Circ Res. 1999 Jul 23;85(2):182-91.
15. The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. Xu J, etal., Gene. 2018 Dec 30;679:266-273. doi: 10.1016/j.gene.2018.09.010. Epub 2018 Sep 7.
16. HDAC2 phosphorylation-dependent Klf5 deacetylation and RARalpha acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. Zheng B, etal., Cell Res. 2011 Oct;21(10):1487-508. doi: 10.1038/cr.2011.34. Epub 2011 Mar 8.
Additional References at PubMed
PMID:12101409   PMID:12477932   PMID:12568725   PMID:14711826   PMID:15581624   PMID:16595680   PMID:18095165   PMID:18178156   PMID:19628677   PMID:20037604   PMID:20439489   PMID:20719859  
PMID:21468585   PMID:21503901   PMID:22147266   PMID:23266329   PMID:24770868   PMID:25205373   PMID:25323860   PMID:26102029   PMID:26702149   PMID:27743478   PMID:27764756   PMID:29211809  
PMID:30322616   PMID:36135378  


Genomics

Comparative Map Data
Klf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,472,081 - 82,487,267 (+)NCBIGRCr8
mRatBN7.21576,060,320 - 76,079,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1580,049,636 - 80,064,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,126,239 - 81,141,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,073,796 - 78,089,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,703,796 - 83,722,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,703,791 - 83,722,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01587,212,719 - 87,231,850 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41583,103,177 - 83,118,363 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11583,121,895 - 83,132,620 (+)NCBI
Celera1575,305,416 - 75,320,302 (+)NCBICelera
Cytogenetic Map15q21NCBI
KLF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381373,054,976 - 73,077,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1373,054,976 - 73,077,541 (+)EnsemblGRCh38hg38GRCh38
GRCh371373,629,114 - 73,651,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,531,143 - 72,549,677 (+)NCBINCBI36Build 36hg18NCBI36
Build 341372,531,142 - 72,549,677NCBI
Celera1354,531,627 - 54,550,162 (+)NCBICelera
Cytogenetic Map13q22.1NCBI
HuRef1354,330,388 - 54,348,922 (+)NCBIHuRef
CHM1_11373,600,752 - 73,619,289 (+)NCBICHM1_1
T2T-CHM13v2.01372,276,491 - 72,299,055 (+)NCBIT2T-CHM13v2.0
Klf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,536,127 - 99,550,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,536,127 - 99,552,472 (+)EnsemblGRCm39 Ensembl
GRCm381499,298,691 - 99,313,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,298,691 - 99,315,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv371499,697,910 - 99,712,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361498,181,825 - 98,196,546 (+)NCBIMGSCv36mm8
Celera1497,974,632 - 97,989,357 (+)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.43NCBI
Klf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,644,077 - 33,658,094 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,642,604 - 33,665,445 (-)NCBIChiLan1.0ChiLan1.0
KLF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,642,536 - 74,661,347 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11373,233,936 - 73,252,670 (+)NCBINHGRI_mPanPan1
KLF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12227,163,179 - 27,185,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2227,162,397 - 27,200,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2227,019,480 - 27,041,542 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,495,564 - 27,517,646 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,495,481 - 27,517,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12227,157,251 - 27,179,316 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02227,200,989 - 27,218,613 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02227,268,194 - 27,290,288 (+)NCBIUU_Cfam_GSD_1.0
Klf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,390,448 - 132,412,071 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365117,806,708 - 7,824,992 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365117,806,714 - 7,824,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,369,810 - 45,388,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,370,009 - 45,386,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,866,834 - 49,870,127 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11q13-q14NCBI
KLF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1352,188,139 - 52,210,882 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660468,300,637 - 8,319,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,489,535 - 27,505,494 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475127,488,434 - 27,509,871 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klf5
105 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir31rno-miR-31a-5pMirtarbaseexternal_infoReporter assayFunctional MTI19542014
Mir145rno-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19542014

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:121
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000057843
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat

Markers in Region
UniSTS:237237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21576,067,436 - 76,067,606 (+)MAPPERmRatBN7.2
mRatBN7.2319,788,432 - 19,788,601 (+)MAPPERmRatBN7.2
Rnor_6.0315,772,895 - 15,773,063NCBIRnor6.0
Rnor_6.01583,710,914 - 83,711,083NCBIRnor6.0
Rnor_5.01587,219,842 - 87,220,011UniSTSRnor5.0
Rnor_5.0321,067,659 - 21,067,827UniSTSRnor5.0
RGSC_v3.4315,671,010 - 15,671,178UniSTSRGSC3.4
RGSC_v3.41583,106,356 - 83,106,525UniSTSRGSC3.4
Celera1575,308,294 - 75,308,463UniSTS
Celera314,499,987 - 14,500,155UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 17 11
Low 36 40 24 19 24 8 11 74 31 24 8
Below cutoff 7 17 17 17

Sequence


RefSeq Acc Id: ENSRNOT00000057843   ⟹   ENSRNOP00000054653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)Ensembl
Rnor_6.0 Ensembl1583,707,735 - 83,722,921 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090637   ⟹   ENSRNOP00000075155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1583,703,791 - 83,721,398 (+)Ensembl
RefSeq Acc Id: NM_053394   ⟹   NP_445846
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,472,081 - 82,487,267 (+)NCBI
mRatBN7.21576,064,258 - 76,079,445 (+)NCBI
Rnor_6.01583,707,735 - 83,722,921 (+)NCBI
Rnor_5.01587,212,719 - 87,231,850 (+)NCBI
RGSC_v3.41583,103,177 - 83,118,363 (+)RGD
Celera1575,305,416 - 75,320,302 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445846 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG16894 (Get FASTA)   NCBI Sequence Viewer  
  AAH81758 (Get FASTA)   NCBI Sequence Viewer  
  BAC57493 (Get FASTA)   NCBI Sequence Viewer  
  EDM02422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054653
  ENSRNOP00000054653.2
RefSeq Acc Id: NP_445846   ⟸   NM_053394
- UniProtKB: F1LSL7 (UniProtKB/TrEMBL),   Q66HP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054653   ⟸   ENSRNOT00000057843
RefSeq Acc Id: ENSRNOP00000075155   ⟸   ENSRNOT00000090637
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LSL7-F1-model_v2 AlphaFold F1LSL7 1-443 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699860
Promoter ID:EPDNEW_R10384
Type:multiple initiation site
Name:Klf5_1
Description:Kruppel-like factor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01583,707,722 - 83,707,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621446 AgrOrtholog
BioCyc Gene G2FUF-12785 BioCyc
Ensembl Genes ENSRNOG00000008785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057843 ENTREZGENE
  ENSRNOT00000057843.3 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132572 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:84410 UniProtKB/TrEMBL
MGC_CLONE MGC:93308 IMAGE-MGC_LOAD
NCBI Gene 84410 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  PTHR23235:SF82 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf5 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008785 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt F1LSL7 ENTREZGENE, UniProtKB/TrEMBL
  Q66HP1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf5  KLF transcription factor 5  Klf5  Kruppel-like factor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Klf5  Kruppel-like factor 5    Kruppel-like factor 5 (intestinal)  Name updated 1299863 APPROVED
2002-08-07 Klf5  Kruppel-like factor 5 (intestinal)      Symbol and Name status set to provisional 70820 PROVISIONAL