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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621446
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf5
Name: Kruppel-like factor 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf5decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of KLF5 mRNA

PMID:21839799
Klf5decreases expressionISORGD:15510836480464CTDBenzo(a)pyrene results in decreased expression of KLF5 mRNA

PMID:22228805
Klf5increases expressionISORGD:13459276480464CTDBenzo(a)pyrene results in increased expression of KLF5 mRNA

PMID:20064835, PMID:20106945, PMID:22316170
Klf5increases expressionISORGD:15510836480464CTDBenzo(a)pyrene results in increased expression of KLF5 mRNA

PMID:20713471
Klf5multiple interactionsISORGD:15510836480464CTDBenzo(a)pyrene affects the reaction [AHR protein binds to KLF5 promoter]

PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.