Klf5 (Kruppel-like transcription factor 5) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Klf5 (Kruppel-like transcription factor 5) Mus musculus
Analyze
Symbol: Klf5
Name: Kruppel-like transcription factor 5
RGD ID: 1551083
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; MRF binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and skeletal muscle tissue regeneration. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human KLF5 (KLF transcription factor 5).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4930520J07Rik; basic transcription element binding protein 2; basic transcription element-binding protein 2; BTE-binding protein 2; Bteb2; CKL; CKLF; IK; IKLF; intestinal-enriched krueppel-like factor; Krueppel-like factor 5; Kruppel-like factor 5; transcription factor BTEB2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm2203   Gm6007  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,536,127 - 99,550,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,536,127 - 99,552,472 (+)EnsemblGRCm39 Ensembl
GRCm381499,298,691 - 99,313,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,298,691 - 99,315,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv371499,697,910 - 99,712,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361498,181,825 - 98,196,546 (+)NCBIMGSCv36mm8
Celera1497,974,632 - 97,989,357 (+)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimonite  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
baicalein  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
boric acid  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
chloroprene  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
cucurbitacin B  (EXP)
cucurbitacin I  (EXP)
cumene  (EXP)
Cuprizon  (ISO)
Curcumol  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
etoposide  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
folic acid  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
inulin  (EXP)
kojic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (EXP)
pioglitazone  (ISO)
progesterone  (ISO)
Ptaquiloside  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
silibinin  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triacsin C  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta wall morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal conjunctival epithelium morphology  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal cornea stroma morphology  (IAGP)
abnormal decidualization  (IAGP)
abnormal embryo attachment  (IAGP)
abnormal extraocular muscle morphology  (IAGP)
abnormal eyelid aperture  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal inner cell mass morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal lacrimal gland morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung saccule morphology  (IAGP)
abnormal Meibomian gland acinus morphology  (IAGP)
abnormal Meibomian gland development  (IAGP)
abnormal Meibomian gland physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal ocular surface morphology  (IAGP)
abnormal palpebral conjunctiva morphology  (IAGP)
abnormal prostate gland anterior lobe morphology  (IAGP)
abnormal prostate gland dorsolateral lobe morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal response to infection  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal trophectoderm morphology  (IAGP)
abnormal type I pneumocyte morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal uterine receptivity  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
absent alveolar lamellar bodies  (IAGP)
absent blastocoele  (IAGP)
absent conjunctiva goblet cells  (IAGP)
anterior iris synechia  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cornea opacity  (IAGP)
decreased angiogenesis  (IAGP)
decreased cornea epithelium thickness  (IAGP)
decreased cornea stroma thickness  (IAGP)
decreased heart weight  (IAGP)
decreased inner cell mass proliferation  (IAGP)
decreased litter size  (IAGP)
decreased prostate gland weight  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased trophectoderm cell proliferation  (IAGP)
decreased type I pneumocyte number  (IAGP)
disorganized secondary lens fibers  (IAGP)
embryonic lethality at implantation, complete penetrance  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged hair follicles  (IAGP)
enlarged sebaceous gland  (IAGP)
eyelid edema  (IAGP)
eyelids fail to open  (IAGP)
failure of blastocyst to hatch from the zona pellucida  (IAGP)
failure of embryo implantation  (IAGP)
female infertility  (IAGP)
impaired embryo implantation  (IAGP)
increased cell proliferation  (IAGP)
increased cornea stroma thickness  (IAGP)
increased cornea thickness  (IAGP)
increased heart left ventricle size  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased susceptibility to induced colitis  (IEA)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased wet-to-dry lung weight ratio  (IAGP)
lacrimal gland inflammation  (IAGP)
lacrimal gland necrosis  (IAGP)
microphthalmia  (IAGP)
narrow eye opening  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
posterior iris synechia  (IAGP)
prostate gland hyperplasia  (IAGP)
pulmonary alveolar edema  (IAGP)
pulmonary edema  (IAGP)
pulmonary vascular congestion  (IAGP)
reduced female fertility  (IAGP)
respiratory distress  (IAGP)
small lens  (IAGP)
small pupil  (IAGP)
thick lung-associated mesenchyme  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Intestinal tumor progression is associated with altered function of KLF5. Bateman NW, etal., J Biol Chem 2004 Mar 26;279(13):12093-101. Epub 2004 Jan 15.
2. microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway. Chang L, etal., Mol Med. 2020 Apr 9;26(1):31. doi: 10.1186/s10020-020-00150-w.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower saponins in rats with metabolic hypertension by inhibiting the activation of the renin-angiotensin-aldosterone system through complement 3. Huang Q, etal., BMC Complement Med Ther. 2023 Jan 18;23(1):13. doi: 10.1186/s12906-022-03828-2.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy. Nagai R, etal., Adv Exp Med Biol 2003;538:57-65; discussion 66.
9. Inducible expression of BTEB2, a member of the zinc-finger family of transcription factors, in cardiac allograft arteriosclerosis. Ogata T, etal., Transplant Proc. 2000 Nov;32(7):2032-3.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2. Sakamoto H, etal., Cardiology. 2003;100(2):80-5.
14. BTEB2, a Kruppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene. Watanabe N, etal., Circ Res. 1999 Jul 23;85(2):182-91.
15. The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. Xu J, etal., Gene. 2018 Dec 30;679:266-273. doi: 10.1016/j.gene.2018.09.010. Epub 2018 Sep 7.
Additional References at PubMed
PMID:9858544   PMID:9973612   PMID:10349636   PMID:10767086   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11134343   PMID:11152667   PMID:11472850   PMID:12101409   PMID:12477932  
PMID:12520002   PMID:14610273   PMID:14660441   PMID:15077182   PMID:15489334   PMID:15581624   PMID:15740636   PMID:15820306   PMID:16054042   PMID:16102021   PMID:16102754   PMID:16141072  
PMID:16141073   PMID:16230531   PMID:16500892   PMID:16912082   PMID:17178721   PMID:17283079   PMID:17299133   PMID:17395897   PMID:17508399   PMID:17576135   PMID:18054006   PMID:18264089  
PMID:18287559   PMID:18395082   PMID:18450752   PMID:18500350   PMID:18554416   PMID:18599506   PMID:18617520   PMID:18653541   PMID:18782761   PMID:18983969   PMID:19268913   PMID:19435907  
PMID:20038803   PMID:20059953   PMID:20298593   PMID:20362541   PMID:20378849   PMID:20412781   PMID:20439489   PMID:20639455   PMID:20719859   PMID:20875108   PMID:20980403   PMID:21056461  
PMID:21078320   PMID:21267068   PMID:21503901   PMID:21600198   PMID:21677750   PMID:21731673   PMID:21763241   PMID:21803035   PMID:21821915   PMID:21873635   PMID:21911492   PMID:22127252  
PMID:22147266   PMID:22219353   PMID:22233806   PMID:22307056   PMID:22675454   PMID:22696295   PMID:22988430   PMID:23024760   PMID:23112162   PMID:23266329   PMID:23293024   PMID:23552075  
PMID:23755247   PMID:23780512   PMID:23790631   PMID:23892456   PMID:24126055   PMID:24440658   PMID:24475213   PMID:24496616   PMID:24626089   PMID:24770696   PMID:24859004   PMID:25069574  
PMID:25100655   PMID:25197166   PMID:25359725   PMID:25425963   PMID:25504335   PMID:25896510   PMID:25896712   PMID:26077572   PMID:26206133   PMID:26212907   PMID:26226504   PMID:26288816  
PMID:26372456   PMID:26483416   PMID:26574507   PMID:26667042   PMID:26681925   PMID:26731538   PMID:26771354   PMID:27207790   PMID:27334059   PMID:27743478   PMID:27856242   PMID:28115390  
PMID:28394333   PMID:28434617   PMID:28711598   PMID:28864500   PMID:28870993   PMID:28942923   PMID:29074464   PMID:29248441   PMID:29472293   PMID:29523685   PMID:29739838   PMID:29896983  
PMID:30101462   PMID:30452437   PMID:30551500   PMID:30905739   PMID:30982802   PMID:31029826   PMID:31049798   PMID:31077711   PMID:31116584   PMID:31320324   PMID:31451021   PMID:31597102  
PMID:31624151   PMID:31778829   PMID:32081850   PMID:32098917   PMID:32208992   PMID:32515350   PMID:32817651   PMID:32913205   PMID:33078455   PMID:33164644   PMID:33539225   PMID:33588625  
PMID:33636159   PMID:33910455   PMID:34117597   PMID:34426497   PMID:34551684   PMID:34925646   PMID:34998785   PMID:35177643   PMID:35393949   PMID:35729116   PMID:35780838   PMID:35803279  
PMID:35883144   PMID:36008138   PMID:36037173   PMID:36074222   PMID:36996816   PMID:37468485   PMID:37506140   PMID:38593669   PMID:38781024   PMID:39289460   PMID:39412062  


Genomics

Comparative Map Data
Klf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,536,127 - 99,550,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,536,127 - 99,552,472 (+)EnsemblGRCm39 Ensembl
GRCm381499,298,691 - 99,313,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,298,691 - 99,315,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv371499,697,910 - 99,712,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361498,181,825 - 98,196,546 (+)NCBIMGSCv36mm8
Celera1497,974,632 - 97,989,357 (+)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.43NCBI
KLF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381373,054,976 - 73,077,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1373,054,976 - 73,077,541 (+)EnsemblGRCh38hg38GRCh38
GRCh371373,629,114 - 73,651,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,531,143 - 72,549,677 (+)NCBINCBI36Build 36hg18NCBI36
Build 341372,531,142 - 72,549,677NCBI
Celera1354,531,627 - 54,550,162 (+)NCBICelera
Cytogenetic Map13q22.1NCBI
HuRef1354,330,388 - 54,348,922 (+)NCBIHuRef
CHM1_11373,600,752 - 73,619,289 (+)NCBICHM1_1
T2T-CHM13v2.01372,276,491 - 72,299,055 (+)NCBIT2T-CHM13v2.0
Klf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,472,081 - 82,487,267 (+)NCBIGRCr8
mRatBN7.21576,060,320 - 76,079,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1580,049,636 - 80,064,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,126,239 - 81,141,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,073,796 - 78,089,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,703,796 - 83,722,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,703,791 - 83,722,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01587,212,719 - 87,231,850 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41583,103,177 - 83,118,363 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11583,121,895 - 83,132,620 (+)NCBI
Celera1575,305,416 - 75,320,302 (+)NCBICelera
Cytogenetic Map15q21NCBI
Klf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,644,077 - 33,658,094 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,642,604 - 33,665,445 (-)NCBIChiLan1.0ChiLan1.0
KLF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,642,536 - 74,661,347 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11373,233,936 - 73,252,670 (+)NCBINHGRI_mPanPan1
KLF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12227,163,179 - 27,185,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2227,162,397 - 27,200,871 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2227,019,480 - 27,041,542 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,495,564 - 27,517,646 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,495,481 - 27,517,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12227,157,251 - 27,179,316 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02227,200,989 - 27,218,613 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02227,268,194 - 27,290,288 (+)NCBIUU_Cfam_GSD_1.0
Klf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,390,448 - 132,412,071 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365117,806,708 - 7,824,992 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365117,806,714 - 7,824,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,369,810 - 45,388,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,370,009 - 45,386,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,866,834 - 49,870,127 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11q13-q14NCBI
KLF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1352,188,139 - 52,210,882 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660468,300,637 - 8,319,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,489,535 - 27,505,494 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475127,488,434 - 27,509,871 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klf5
424 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:169
Count of miRNA genes:166
Interacting mature miRNAs:169
Transcripts:ENSMUST00000005279
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558823Tbbmd6_mtotal body bone mineral density 6 (mouse)Not determined1477073696111073787Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470863768104863926Mouse
4142508Tgq25_mtriglyceride QTL 25 (mouse)Not determined85134068119134068Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1471221224105221344Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474394976108395093Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474352296108352384Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
14928314Manh77_mmandible shape 77 (mouse)1476767790110767790Mouse
13524530Bodwtq11_mbody wweight QTL 11 (mouse)1487767629102538219Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

Markers in Region
Klf5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14E2.2UniSTS
cM Map14 UniSTS
UniSTS:237237  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381499,301,943 - 99,302,112UniSTSGRCm38
MGSCv371499,701,162 - 99,701,331UniSTSGRCm37
Celera1497,977,884 - 97,978,053UniSTS
Cytogenetic Map14E2.2UniSTS
D14Jor1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381499,305,526 - 99,306,106UniSTSGRCm38
MGSCv371499,704,745 - 99,705,325UniSTSGRCm37
Celera1497,981,467 - 97,982,047UniSTS
Cytogenetic Map14E2.2UniSTS
cM Map1448.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000005279   ⟹   ENSMUSP00000005279
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1499,536,127 - 99,552,472 (+)Ensembl
GRCm38.p6 Ensembl1499,298,691 - 99,315,036 (+)Ensembl
Ensembl Acc Id: ENSMUST00000226784   ⟹   ENSMUSP00000154786
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1499,536,590 - 99,542,762 (+)Ensembl
GRCm38.p6 Ensembl1499,299,154 - 99,305,326 (+)Ensembl
RefSeq Acc Id: NM_009769   ⟹   NP_033899
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391499,536,127 - 99,550,848 (+)NCBI
GRCm381499,298,691 - 99,313,412 (+)ENTREZGENE
MGSCv371499,697,910 - 99,712,631 (+)RGD
Celera1497,974,632 - 97,989,357 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033899   ⟸   NM_009769
- UniProtKB: Q9JMI2 (UniProtKB/Swiss-Prot),   Q9Z0Z7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000154786   ⟸   ENSMUST00000226784
Ensembl Acc Id: ENSMUSP00000005279   ⟸   ENSMUST00000005279
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0Z7-F1-model_v2 AlphaFold Q9Z0Z7 1-446 view protein structure

Promoters
RGD ID:8683112
Promoter ID:EPDNEW_M19587
Type:multiple initiation site
Name:Klf5_1
Description:Mus musculus Kruppel-like factor 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381499,298,688 - 99,298,748EPDNEW
RGD ID:6825105
Promoter ID:MM_KWN:17625
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_009769,   UC007UVF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361499,697,586 - 99,698,342 (+)MPROMDB
RGD ID:6847110
Promoter ID:MM_ACW:16896
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   ES_Cell
Transcripts:KLF5.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361499,700,714 - 99,701,214 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338056 AgrOrtholog
Ensembl Genes ENSMUSG00000005148 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005279 ENTREZGENE
  ENSMUST00000005279.8 UniProtKB/Swiss-Prot
  ENSMUST00000226784.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PIBF1 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12224 UniProtKB/Swiss-Prot
MGD MGI:1338056 ENTREZGENE
NCBI Gene 12224 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
  PROGESTERONE-INDUCED BLOCKING FACTOR 1 UniProtKB/TrEMBL
  PTHR18950:SF2 UniProtKB/TrEMBL
  PTHR23235:SF82 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Klf5 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt KLF5_MOUSE UniProtKB/Swiss-Prot
  Q923C0_MOUSE UniProtKB/TrEMBL
  Q9JMI2 ENTREZGENE
  Q9Z0Z7 ENTREZGENE
UniProt Secondary Q9JMI2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-02 Klf5  Kruppel-like transcription factor 5  Klf5  Kruppel-like factor 5  Symbol and/or name change 5135510 APPROVED