Gene: Med12 (mediator complex subunit 12) Rattus norvegicus
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Symbol: Med12
Name: mediator complex subunit 12
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity; chromatin binding (ortholog); protein C-terminus binding (ortholog); INVOLVED IN protein ubiquitination; axis elongation involved in somitogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); angiosarcoma (ortholog); FOUND IN ubiquitin ligase complex; mediator complex (ortholog); nucleus (ortholog); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 3-isobutyl-1-methyl-7H-xanthine (ortholog)
AGR Description: Contributes to ubiquitin protein ligase activity; involved in protein ubiquitination; localizes to the ubiquitin ligase complex; orthologous to human MED12 (mediator complex subunit 12).
Merged Description: Contributes to ubiquitin protein ligase activity; involved in protein ubiquitination; localizes to the ubiquitin ligase complex; orthologous to human MED12 (mediator complex subunit 12); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 3-isobutyl-1-methyl-7H-xanthine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC679693; mediator of RNA polymerase II transcription subunit 12; similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...
Orthologs:
Homo sapiens (human) : MED12 (mediator complex subunit 12)  HGNC  Alliance
Mus musculus (house mouse) : Med12 (mediator complex subunit 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Med12 (mediator complex subunit 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MED12 (mediator complex subunit 12)
Canis lupus familiaris (dog) : MED12 (mediator complex subunit 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Med12 (mediator complex subunit 12)
Sus scrofa (pig) : MED12 (mediator complex subunit 12)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X71,174,653 - 71,197,812 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X72,027,135 - 72,050,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,351,546 - 89,374,489 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX66,760,730 - 66,783,673 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Med12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1585896
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.