Slc4a7 (solute carrier family 4 member 7) - Rat Genome Database

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Gene: Slc4a7 (solute carrier family 4 member 7) Rattus norvegicus
Analyze
Symbol: Slc4a7
Name: solute carrier family 4 member 7
RGD ID: 621208
Description: Enables sodium:bicarbonate symporter activity. Predicted to be involved in several processes, including bicarbonate transport; locomotory exploration behavior; and nucleotide biosynthetic process. Predicted to act upstream of or within cochlear nucleus development; eye development; and visual perception. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and stereocilium. Orthologous to human SLC4A7 (solute carrier family 4 member 7); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: electroneutral sodium bicarbonate cotransporter 1; NBC-like protein; NBC3; NBCn1; sodium bicarbonate cotransporter 3; solute carrier family 4 sodium bicarbonate cotransporter member 7 variant NBCn1-G; solute carrier family 4 sodium bicarbonate cotransporter member 7 variant NBCn1-I; solute carrier family 4 sodium bicarbonate cotransporter member 7 variant NBCn1-J; solute carrier family 4, sodium bicarbonate cotransporter, member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81513,015,854 - 13,095,485 (-)NCBIGRCr8
mRatBN7.21510,585,307 - 10,664,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1510,588,979 - 10,664,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1512,726,247 - 12,801,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01513,633,596 - 13,709,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01511,939,509 - 12,015,197 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01511,832,611 - 11,912,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1511,836,286 - 11,912,916 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01515,871,621 - 15,950,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41512,071,975 - 12,125,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11512,071,974 - 12,125,841 (-)NCBI
Celera1510,601,042 - 10,672,302 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
levetiracetam  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
naphthalene  (EXP)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sotorasib  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Choi I, etal., Nature 2000 Jun 1;405(6786):571-5.
2. Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons. Cooper DS, etal., J Biol Chem. 2005 May 6;280(18):17823-30. Epub 2005 Feb 17.
3. An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells. Damkier HH, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H172-80. doi: 10.1152/ajpheart.00713.2005. Epub 2005 Aug 26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Immunolocalization of electroneutral Na(+)-HCO cotransporters in human and rat salivary glands. Gresz V, etal., Am J Physiol Gastrointest Liver Physiol 2002 Aug;283(2):G473-80.
7. Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice. Kim YH, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1262-72. Epub 2005 Sep 6.
8. Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1. Kwon TH, etal., Am J Physiol Renal Physiol 2002 Feb;282(2):F341-51.
9. Immunoelectron microscopic localization of NBC3 sodium-bicarbonate cotransporter in rat kidney. Kwon TH, etal., Am J Physiol Renal Physiol. 2000 Feb;278(2):F327-36. doi: 10.1152/ajprenal.2000.278.2.F327.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3- influx in rat medullary thick ascending limb. Odgaard E, etal., J Physiol. 2004 Feb 15;555(Pt 1):205-18. doi: 10.1113/jphysiol.2003.046474. Epub 2003 Dec 12.
13. Trafficking, localization and degradation of the Na+,HCO3- co-transporter NBCn1 in kidney and breast epithelial cells. Olesen CW, etal., Sci Rep. 2018 May 9;8(1):7435. doi: 10.1038/s41598-018-25059-7.
14. NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts. Praetorius J, etal., Am J Physiol Renal Physiol. 2004 May;286(5):F903-12. Epub 2004 Jan 13.
15. Immunolocalization of NBC3 and NHE3 in the rat epididymis: colocalization of NBC3 and the vacuolar H+-ATPase. Pushkin A, etal., J Androl. 2000 Sep-Oct;21(5):708-20.
16. Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2. Reiners J, etal., Hum Mol Genet. 2005 Dec 15;14(24):3933-43. Epub 2005 Nov 21.
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Immunolocalization of electroneutral Na-HCO(3)(-) cotransporter in rat kidney. Vorum H, etal., Am J Physiol Renal Physiol. 2000 Nov;279(5):F901-9. doi: 10.1152/ajprenal.2000.279.5.F901.
Additional References at PubMed
PMID:12403779   PMID:12808454   PMID:17068143   PMID:17416604   PMID:17715183   PMID:18508879   PMID:18815229   PMID:19170751   PMID:19638364   PMID:20147654   PMID:20591978   PMID:20962104  
PMID:21571816   PMID:21705333   PMID:23183381   PMID:23382378   PMID:23500099   PMID:27717805   PMID:28087731   PMID:37039101  


Genomics

Comparative Map Data
Slc4a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81513,015,854 - 13,095,485 (-)NCBIGRCr8
mRatBN7.21510,585,307 - 10,664,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1510,588,979 - 10,664,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1512,726,247 - 12,801,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01513,633,596 - 13,709,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01511,939,509 - 12,015,197 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01511,832,611 - 11,912,923 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1511,836,286 - 11,912,916 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01515,871,621 - 15,950,530 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41512,071,975 - 12,125,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11512,071,974 - 12,125,841 (-)NCBI
Celera1510,601,042 - 10,672,302 (-)NCBICelera
Cytogenetic Map15p16NCBI
SLC4A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38327,372,723 - 27,484,384 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl327,372,723 - 27,484,420 (-)EnsemblGRCh38hg38GRCh38
GRCh37327,414,214 - 27,525,875 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36327,389,218 - 27,473,249 (-)NCBINCBI36Build 36hg18NCBI36
Build 34327,389,217 - 27,473,249NCBI
Celera327,350,593 - 27,434,523 (-)NCBICelera
Cytogenetic Map3p24.1NCBI
HuRef327,357,387 - 27,468,725 (-)NCBIHuRef
CHM1_1327,364,200 - 27,475,895 (-)NCBICHM1_1
T2T-CHM13v2.0327,374,872 - 27,486,481 (-)NCBIT2T-CHM13v2.0
Slc4a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39147,669,819 - 7,766,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl147,669,823 - 7,767,484 (-)EnsemblGRCm39 Ensembl
GRCm381414,703,011 - 14,799,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1414,702,279 - 14,799,940 (+)EnsemblGRCm38mm10GRCm38
MGSCv371415,535,539 - 15,632,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361413,496,292 - 13,568,779 (+)NCBIMGSCv36mm8
Celera1410,380,221 - 10,477,911 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Slc4a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543018,991,301 - 19,067,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543018,991,615 - 19,059,590 (-)NCBIChiLan1.0ChiLan1.0
SLC4A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2227,319,507 - 27,430,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1327,324,273 - 27,435,750 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0327,261,155 - 27,373,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1327,587,592 - 27,697,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl327,591,639 - 27,670,815 (-)Ensemblpanpan1.1panPan2
SLC4A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12316,710,649 - 16,788,277 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2316,710,701 - 16,785,541 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2316,671,583 - 16,781,327 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02316,973,595 - 17,083,572 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2316,973,651 - 17,081,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12316,797,783 - 16,907,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02316,911,058 - 17,020,946 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02316,975,473 - 17,085,305 (+)NCBIUU_Cfam_GSD_1.0
Slc4a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118185,411,916 - 185,506,897 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647318,550,484 - 18,645,628 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647318,550,489 - 18,645,470 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1313,933,711 - 14,043,058 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11313,933,552 - 14,043,108 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21315,479,010 - 15,753,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC4A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11571,942,498 - 72,047,781 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1571,961,350 - 72,047,617 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604145,130,894 - 45,235,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc4a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247885,243,807 - 5,355,073 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247885,239,858 - 5,355,186 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc4a7
421 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000008759, ENSRNOT00000049771, ENSRNOT00000068171
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat

Markers in Region
D15Got201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21510,621,877 - 10,621,994 (+)MAPPERmRatBN7.2
Rnor_6.01511,869,185 - 11,869,301NCBIRnor6.0
Rnor_5.01515,908,198 - 15,908,314UniSTSRnor5.0
RGSC_v3.41512,105,216 - 12,105,332UniSTSRGSC3.4
Celera1510,633,818 - 10,633,934UniSTS
Cytogenetic Map15p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 4 19 4 19 4 57 25 40 8
Low 2 39 38 37 37 8 11 17 10 1 3 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001413732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001413733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_058211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF069511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF080106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP721460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP721461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP721462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000008759   ⟹   ENSRNOP00000008759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,589,103 - 10,664,781 (-)Ensembl
Rnor_6.0 Ensembl1511,836,407 - 11,912,916 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000049771   ⟹   ENSRNOP00000047758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,589,103 - 10,649,233 (-)Ensembl
Rnor_6.0 Ensembl1511,836,407 - 11,912,916 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068171   ⟹   ENSRNOP00000063542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,588,979 - 10,664,764 (-)Ensembl
Rnor_6.0 Ensembl1511,836,286 - 11,912,806 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101025   ⟹   ENSRNOP00000097556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,588,979 - 10,642,235 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108026   ⟹   ENSRNOP00000081091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,588,979 - 10,644,273 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118797   ⟹   ENSRNOP00000078594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1510,589,217 - 10,664,764 (-)Ensembl
RefSeq Acc Id: NM_001270860   ⟹   NP_001257789
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,015,854 - 13,095,292 (-)NCBI
mRatBN7.21510,585,307 - 10,664,747 (-)NCBI
Rnor_6.01511,836,407 - 11,912,916 (-)NCBI
Rnor_5.01515,871,621 - 15,950,530 (-)NCBI
Celera1510,601,042 - 10,672,302 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270861   ⟹   NP_001257790
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,015,854 - 13,095,292 (-)NCBI
mRatBN7.21510,585,307 - 10,664,747 (-)NCBI
Rnor_6.01511,836,407 - 11,912,916 (-)NCBI
Rnor_5.01515,871,621 - 15,950,530 (-)NCBI
Celera1510,601,042 - 10,672,302 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001413732   ⟹   NP_001400661
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,015,854 - 13,095,292 (-)NCBI
mRatBN7.21510,585,307 - 10,664,747 (-)NCBI
RefSeq Acc Id: NM_001413733   ⟹   NP_001400662
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,015,854 - 13,095,292 (-)NCBI
mRatBN7.21510,585,307 - 10,664,747 (-)NCBI
RefSeq Acc Id: NM_058211   ⟹   NP_478118
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,015,854 - 13,095,292 (-)NCBI
mRatBN7.21510,585,307 - 10,664,747 (-)NCBI
Rnor_6.01511,836,407 - 11,912,916 (-)NCBI
Rnor_5.01515,871,621 - 15,950,530 (-)NCBI
RGSC_v3.41512,071,975 - 12,125,840 (-)RGD
Celera1510,601,042 - 10,672,302 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092959   ⟹   XP_038948887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,015,854 - 13,095,485 (-)NCBI
mRatBN7.21510,585,307 - 10,664,780 (-)NCBI
RefSeq Acc Id: XM_039092960   ⟹   XP_038948888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,035,043 - 13,095,333 (-)NCBI
mRatBN7.21510,604,512 - 10,664,780 (-)NCBI
RefSeq Acc Id: XM_039092961   ⟹   XP_038948889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,044,101 - 13,095,333 (-)NCBI
mRatBN7.21510,613,554 - 10,664,780 (-)NCBI
RefSeq Acc Id: XM_063273919   ⟹   XP_063129989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81513,044,101 - 13,095,333 (-)NCBI
RefSeq Acc Id: NP_478118   ⟸   NM_058211
- Peptide Label: isoform 1
- UniProtKB: A0A8L2Q3F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257789   ⟸   NM_001270860
- Peptide Label: isoform 2
- UniProtKB: A0A8L2Q3F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257790   ⟸   NM_001270861
- Peptide Label: isoform 3
- UniProtKB: Q9QYD5 (UniProtKB/Swiss-Prot),   Q9R1L1 (UniProtKB/Swiss-Prot),   Q9R1N3 (UniProtKB/Swiss-Prot),   A0A8L2UM25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008759   ⟸   ENSRNOT00000008759
RefSeq Acc Id: ENSRNOP00000063542   ⟸   ENSRNOT00000068171
RefSeq Acc Id: ENSRNOP00000047758   ⟸   ENSRNOT00000049771
RefSeq Acc Id: XP_038948887   ⟸   XM_039092959
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QV99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948888   ⟸   XM_039092960
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948889   ⟸   XM_039092961
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000097556   ⟸   ENSRNOT00000101025
RefSeq Acc Id: ENSRNOP00000078594   ⟸   ENSRNOT00000118797
RefSeq Acc Id: ENSRNOP00000081091   ⟸   ENSRNOT00000108026
RefSeq Acc Id: NP_001400662   ⟸   NM_001413733
- Peptide Label: isoform 5
- UniProtKB: A0A0K0WYI6 (UniProtKB/TrEMBL),   A0A8L2QV99 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400661   ⟸   NM_001413732
- Peptide Label: isoform 4
- UniProtKB: F1M0J3 (UniProtKB/TrEMBL),   A0A8L2QV99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129989   ⟸   XM_063273919
- Peptide Label: isoform X4
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1N3-F1-model_v2 AlphaFold Q9R1N3 1-1218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699584
Promoter ID:EPDNEW_R10105
Type:multiple initiation site
Name:Slc4a7_1
Description:solute carrier family 4 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01511,912,882 - 11,912,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621208 AgrOrtholog
BioCyc Gene G2FUF-14398 BioCyc
Ensembl Genes ENSRNOG00000005957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008759 ENTREZGENE
  ENSRNOT00000008759.8 UniProtKB/TrEMBL
  ENSRNOT00000049771 ENTREZGENE
  ENSRNOT00000049771.5 UniProtKB/TrEMBL
  ENSRNOT00000068171 ENTREZGENE
  ENSRNOT00000068171.4 UniProtKB/TrEMBL
  ENSRNOT00000101025.1 UniProtKB/TrEMBL
  ENSRNOT00000108026 ENTREZGENE
  ENSRNOT00000108026.1 UniProtKB/TrEMBL
  ENSRNOT00000118797.1 UniProtKB/TrEMBL
Gene3D-CATH Helical hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band3_cytoplasmic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/HCO3_transpt UniProtKB/TrEMBL
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117955 UniProtKB/Swiss-Prot
NCBI Gene 117955 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM BICARBONATE COTRANSPORTER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_3_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_cotransp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc4a7 PhenoGen
PRINTS HCO3TRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAHCO3TRSPRT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005957 RatGTEx
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0K0WYG5_RAT UniProtKB/TrEMBL
  A0A0K0WYI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL51_RAT UniProtKB/TrEMBL
  A0A8I5ZRP7_RAT UniProtKB/TrEMBL
  A0A8I6AV46_RAT UniProtKB/TrEMBL
  A0A8L2Q3F3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QV99 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UM25 ENTREZGENE, UniProtKB/TrEMBL
  A6K061_RAT UniProtKB/TrEMBL
  A6K062_RAT UniProtKB/TrEMBL
  A6K063_RAT UniProtKB/TrEMBL
  A6K064_RAT UniProtKB/TrEMBL
  F1M0J3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYD5 ENTREZGENE
  Q9R1L1 ENTREZGENE
  Q9R1N3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9QYD5 UniProtKB/Swiss-Prot
  Q9R1L1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc4a7  solute carrier family 4 member 7  Slc4a7  solute carrier family 4, sodium bicarbonate cotransporter, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc4a7  solute carrier family 4, sodium bicarbonate cotransporter, member 7      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc4a7  solute carrier family 4, sodium bicarbonate cotransporter, member 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to apical membranes of acinar and duct cells 625654
gene_disease chronic metabolic acidosis increases protein level in kidney 70580
gene_expression expressed in smooth muscle and basolateral domains of thick ascending limb (TAL) cells in the outer medulla 70580
gene_expression mRNA and protein expressed in acinar and duct cells of the parotid and submandibular glands 625654
gene_homology amino acid sequence is 89-92% identical to human 625654
gene_process may play a role in ductal HCO3- secretion 625654
gene_transcript contains three spliced variants 625654