Fgf10 (fibroblast growth factor 10) - Rat Genome Database

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Gene: Fgf10 (fibroblast growth factor 10) Rattus norvegicus
Analyze
Symbol: Fgf10
Name: fibroblast growth factor 10
RGD ID: 2606
Description: Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including angiogenesis; response to estradiol; and response to lipopolysaccharide. Acts upstream of or within organ induction. Predicted to be located in several cellular components, including cell surface; extracellular space; and nucleus. Predicted to colocalize with collagen-containing extracellular matrix. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGF-10; Fgf5a; fibroblast growth factor 5a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2250,801,171 - 50,878,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl250,800,992 - 50,876,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx257,899,752 - 57,973,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0255,958,474 - 56,031,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0250,887,932 - 50,961,398 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0251,673,480 - 51,747,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl251,672,722 - 51,750,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,046,331 - 70,120,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4250,866,799 - 50,940,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1250,795,031 - 50,868,552 (+)NCBI
Celera246,463,913 - 46,537,376 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
angiogenesis  (IEP)
animal organ formation  (ISO)
animal organ morphogenesis  (IBA,ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
branch elongation involved in salivary gland morphogenesis  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
bronchiole morphogenesis  (ISO)
bud elongation involved in lung branching  (ISO)
bud outgrowth involved in lung branching  (ISO)
cell differentiation  (IBA,IEP)
cell population proliferation  (ISO)
cell-cell signaling  (ISO)
chemotaxis  (ISO)
determination of left/right symmetry  (ISO)
digestive tract development  (ISO)
embryonic camera-type eye development  (ISO)
embryonic digestive tract development  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic genitalia morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endothelial cell proliferation  (ISO)
epidermis development  (ISO)
epidermis morphogenesis  (ISO)
epithelial cell differentiation  (ISO)
epithelial cell proliferation  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of mitotic spindle orientation  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female genitalia morphogenesis  (ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (ISO,TAS)
fibroblast growth factor receptor signaling pathway involved in mammary gland specification  (IBA,ISO)
fibroblast proliferation  (ISO)
hair follicle morphogenesis  (ISO)
Harderian gland development  (ISO)
induction of positive chemotaxis  (ISO)
inner ear morphogenesis  (ISO)
keratinocyte proliferation  (ISO)
lacrimal gland development  (ISO)
limb bud formation  (ISO)
limb development  (IBA,ISO)
limb morphogenesis  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung epithelium development  (ISO)
lung morphogenesis  (ISO)
lung proximal/distal axis specification  (ISO)
lung saccule development  (ISO)
male genitalia morphogenesis  (ISO)
mammary gland bud formation  (ISO)
mammary gland specification  (ISO)
mesenchymal cell differentiation involved in lung development  (ISO)
mesenchymal-epithelial cell signaling involved in lung development  (ISO)
mesonephros development  (ISO)
metanephros development  (ISO)
metanephros morphogenesis  (ISO)
mitotic cell cycle  (ISO)
muscle cell fate commitment  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of stem cell proliferation  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
organ growth  (ISO)
organ induction  (IDA,ISO)
otic vesicle formation  (ISO)
pancreas development  (ISO)
pituitary gland development  (ISO)
positive chemotaxis  (IBA,ISO)
positive regulation of canonical Wnt signaling pathway  (IBA,ISO)
positive regulation of DNA repair  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (IBA,ISO)
positive regulation of epithelial cell proliferation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IBA)
positive regulation of hair follicle cell proliferation  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IBA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urothelial cell proliferation  (ISO,ISS)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
positive regulation of white fat cell proliferation  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
prostatic bud formation  (ISO)
protein localization to cell surface  (ISO)
radial glial cell differentiation  (ISO)
regulation of activin receptor signaling pathway  (ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of gene expression  (ISO)
regulation of saliva secretion  (ISO)
regulation of smoothened signaling pathway  (ISO)
respiratory system development  (ISO)
response to estradiol  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
salivary gland development  (ISO)
salivary gland morphogenesis  (ISO)
secretion by lung epithelial cell involved in lung growth  (IBA,ISO)
semicircular canal fusion  (ISO)
semicircular canal morphogenesis  (ISO)
smooth muscle cell differentiation  (ISO)
somatic stem cell population maintenance  (ISO)
spleen development  (ISO)
stem cell proliferation  (ISO)
submandibular salivary gland formation  (ISO)
tear secretion  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
tissue regeneration  (IEP)
type II pneumocyte differentiation  (ISO)
urothelial cell proliferation  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
white fat cell differentiation  (ISO)
white fat cell proliferation  (ISO)
Wnt signaling pathway  (ISO)
wound healing  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Adult Neurogenesis in the Female Mouse Hypothalamus: Estradiol and High-Fat Diet Alter the Generation of Newborn Neurons Expressing Estrogen Receptor α. Bless EP, etal., eNeuro. 2016 Sep 22;3(4). pii: eN-NWR-0027-16. doi: 10.1523/ENEURO.0027-16.2016. eCollection 2016 Jul-Aug.
2. Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin. Gambichler T, etal., BMC Dermatol. 2002 Apr 12;2:6. doi: 10.1186/1471-5945-2-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Endogenous and ectopic gland induction by FGF-10. Govindarajan V, etal., Dev Biol. 2000 Sep 1;225(1):188-200.
6. Novel xylan-controlled delivery of therapeutic proteins to inflamed colon by the human anaerobic commensal bacterium. Hamady ZZ, Ann R Coll Surg Engl. 2013 May;95(4):235-40. doi: 10.1308/003588413X13511609958217.
7. Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Hamady ZZ, etal., Gut. 2010 Apr;59(4):461-9. doi: 10.1136/gut.2008.176131. Epub 2009 Sep 7.
8. Pten loss induces autocrine FGF signaling to promote skin tumorigenesis. Hertzler-Schaefer K, etal., Cell Rep. 2014 Mar 13;6(5):818-26. doi: 10.1016/j.celrep.2014.01.045. Epub 2014 Feb 27.
9. The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens. Huang L, etal., Dev Biol. 2005 Feb 15;278(2):396-414.
10. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
11. Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Ishiwata T, etal., Exp Mol Pathol 2002 Dec;73(3):181-90.
12. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Kelly RG, etal., Dev Cell 2001 Sep;1(3):435-40.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis. Miceli R, etal., J Pharmacol Exp Ther. 1999 Jul;290(1):464-71.
15. Endotoxin alters early fetal lung morphogenesis. Muratore CS, etal., J Surg Res. 2009 Aug;155(2):225-30. Epub 2008 Aug 9.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. Quantius J, etal., PLoS Pathog. 2016 Jun 20;12(6):e1005544. doi: 10.1371/journal.ppat.1005544. eCollection 2016 Jun.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
25. Fgf10 is essential for limb and lung formation. Sekine K, etal., Nat Genet 1999 Jan;21(1):138-41.
26. In vivo characterization of keratinocyte growth factor-2 as a potential wound healing agent. Soler PM, etal., Wound Repair Regen. 1999 May-Jun;7(3):172-8. doi: 10.1046/j.1524-475x.1999.00172.x.
27. Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. Suzuki K, etal., FEBS Lett 2000 Sep 8;481(1):53-6.
28. MicroRNA-145 promotes the epithelial-mesenchymal transition in peritoneal dialysis-associated fibrosis by suppressing fibroblast growth factor 10. Wu J, etal., J Biol Chem. 2019 Oct 11;294(41):15052-15067. doi: 10.1074/jbc.RA119.007404. Epub 2019 Aug 20.
29. Structure and expression of a novel isoform of mouse FGF homologous factor (FHF)-4. Yamamoto S, etal., Biochim Biophys Acta 1998 May 29;1398(1):38-41.
30. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. Yamasaki M, etal., J Biol Chem 1996 Jul 5;271(27):15918-21.
31. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Zhu YJ, etal., Toxicology. 2009 Jun 16;260(1-3):120-5. Epub 2009 Apr 5.
Additional References at PubMed
PMID:9393979   PMID:9428423   PMID:9740653   PMID:9784490   PMID:10541313   PMID:10804187   PMID:10821755   PMID:11062007   PMID:11287183   PMID:11782400   PMID:11880361   PMID:11896977  
PMID:11923311   PMID:11959839   PMID:12004962   PMID:12615071   PMID:12804770   PMID:12810586   PMID:12837279   PMID:12861530   PMID:12941620   PMID:14530295   PMID:14604677   PMID:14623822  
PMID:14651921   PMID:14697353   PMID:14726452   PMID:14975937   PMID:15017552   PMID:15130516   PMID:15199404   PMID:15234214   PMID:15329346   PMID:15531758   PMID:15654336   PMID:15690149  
PMID:15765517   PMID:15800000   PMID:15843416   PMID:15958512   PMID:15972105   PMID:16086254   PMID:16141225   PMID:16169547   PMID:16308329   PMID:16324690   PMID:16375885   PMID:16597614  
PMID:16618415   PMID:16691564   PMID:16720875   PMID:16956603   PMID:16989802   PMID:17000704   PMID:17071719   PMID:17188682   PMID:17202188   PMID:17213838   PMID:17218409   PMID:17394208  
PMID:17449030   PMID:17471512   PMID:17500053   PMID:17522155   PMID:17560563   PMID:17601531   PMID:17923768   PMID:17959718   PMID:17969154   PMID:18421016   PMID:18437684   PMID:18559345  
PMID:19102732   PMID:19152659   PMID:19224135   PMID:19607792   PMID:20705941   PMID:21136143   PMID:21147086   PMID:21764747   PMID:22261751   PMID:23143078   PMID:26514922   PMID:26869337  
PMID:29758198   PMID:33577857   PMID:35934252  


Genomics

Comparative Map Data
Fgf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2250,801,171 - 50,878,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl250,800,992 - 50,876,866 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx257,899,752 - 57,973,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0255,958,474 - 56,031,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0250,887,932 - 50,961,398 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0251,673,480 - 51,747,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl251,672,722 - 51,750,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,046,331 - 70,120,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4250,866,799 - 50,940,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1250,795,031 - 50,868,552 (+)NCBI
Celera246,463,913 - 46,537,376 (+)NCBICelera
Cytogenetic Map2q14NCBI
FGF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38544,300,247 - 44,389,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl544,300,247 - 44,389,706 (-)EnsemblGRCh38hg38GRCh38
GRCh37544,300,349 - 44,389,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36544,340,854 - 44,424,541 (-)NCBINCBI36Build 36hg18NCBI36
Build 34544,340,853 - 44,424,541NCBI
Celera544,197,375 - 44,281,044 (-)NCBICelera
Cytogenetic Map5p12NCBI
HuRef544,258,055 - 44,341,703 (-)NCBIHuRef
CHM1_1544,306,497 - 44,390,196 (-)NCBICHM1_1
T2T-CHM13v2.0544,553,832 - 44,642,982 (-)NCBIT2T-CHM13v2.0
Fgf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913118,851,199 - 118,928,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13118,806,327 - 118,928,651 (+)EnsemblGRCm39 Ensembl
GRCm3813118,714,699 - 118,792,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13118,669,791 - 118,792,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713119,503,506 - 119,581,380 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613119,833,907 - 119,910,988 (+)NCBIMGSCv36mm8
Celera13123,161,950 - 123,245,519 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1367.14NCBI
Fgf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,163,117 - 18,245,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544618,163,117 - 18,244,840 (+)NCBIChiLan1.0ChiLan1.0
FGF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1564,085,283 - 64,175,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0565,979,443 - 66,069,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1571,028,324 - 71,111,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl571,028,187 - 71,111,706 (+)Ensemblpanpan1.1panPan2
FGF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1465,851,130 - 65,930,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl465,851,069 - 65,928,192 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha465,597,673 - 65,676,839 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0466,343,407 - 66,423,104 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl466,343,839 - 66,423,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,096,317 - 66,176,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0466,218,509 - 66,297,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0466,768,760 - 66,848,396 (+)NCBIUU_Cfam_GSD_1.0
Fgf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,177,124 - 209,259,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,114,204 - 18,195,898 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,114,231 - 18,195,884 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1628,695,470 - 28,777,509 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11628,695,465 - 28,779,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21630,234,658 - 30,317,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1443,080,387 - 43,163,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl443,081,831 - 43,163,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607133,710,353 - 33,794,576 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475910,904,989 - 10,983,574 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475910,904,626 - 10,983,509 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf10
385 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:28
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000016485
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat

Markers in Region
PMC26870P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2250,801,966 - 50,802,211 (+)MAPPERmRatBN7.2
Rnor_6.0251,673,550 - 51,673,794NCBIRnor6.0
Rnor_5.0270,046,401 - 70,046,645UniSTSRnor5.0
RGSC_v3.4250,866,869 - 50,867,113UniSTSRGSC3.4
Celera246,463,983 - 46,464,227UniSTS
Cytogenetic Map2q15-q16UniSTS
G16001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2250,801,927 - 50,802,169 (+)MAPPERmRatBN7.2
Rnor_6.0251,673,511 - 51,673,752NCBIRnor6.0
Rnor_5.0270,046,362 - 70,046,603UniSTSRnor5.0
RGSC_v3.4250,866,830 - 50,867,071UniSTSRGSC3.4
Celera246,463,944 - 46,464,185UniSTS
Cytogenetic Map2q15-q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 6 6 1
Low 2 41 20 6 11 6 5 6 66 27 26 10 5
Below cutoff 1 2 12 10 8 10 3 5 8 2 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016485   ⟹   ENSRNOP00000016485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl250,800,992 - 50,876,866 (+)Ensembl
Rnor_6.0 Ensembl251,672,722 - 51,750,369 (+)Ensembl
RefSeq Acc Id: NM_012951   ⟹   NP_037083
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2250,801,171 - 50,878,218 (+)NCBI
Rnor_6.0251,673,480 - 51,747,533 (+)NCBI
Rnor_5.0270,046,331 - 70,120,384 (+)NCBI
RGSC_v3.4250,866,799 - 50,940,319 (+)RGD
Celera246,463,913 - 46,537,376 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037083 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA11468 (Get FASTA)   NCBI Sequence Viewer  
  EDM10410 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016485
GenBank Protein P70492 (Get FASTA)   NCBI Sequence Viewer  
  VDK10958 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_037083   ⟸   NM_012951
- Peptide Label: precursor
- UniProtKB: P70492 (UniProtKB/Swiss-Prot),   A0A7U3JW83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016485   ⟸   ENSRNOT00000016485

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70492-F1-model_v2 AlphaFold P70492 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691155
Promoter ID:EPDNEW_R1679
Type:single initiation site
Name:Fgf10_1
Description:fibroblast growth factor 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0251,673,115 - 51,673,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2606 AgrOrtholog
BioCyc Gene G2FUF-54297 BioCyc
Ensembl Genes ENSRNOG00000012278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016485 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25443 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf10 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012278 RatGTEx
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7U3JW83 ENTREZGENE, UniProtKB/TrEMBL
  FGF10_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgf10  fibroblast growth factor 10      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease expressed in vascular smooth muscle cells in the pancreas after L-arginine induced pancreatitis 727503
gene_product member of the fibroblast growth factor (FGF) family 69832
gene_protein 215 amino acids; approximately 24 kDa 69832