Gene: L1cam (L1 cell adhesion molecule) Rattus norvegicus
Analyze
Symbol:
L1cam
Name:
L1 cell adhesion molecule
Description:
Exhibits PDZ domain binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and generation of neurons. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; growth cone; and membrane raft. Used to study hydrocephalus. Biomarker of anxiety disorder; hypothyroidism; and mental depression. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Hsas; Hyd; L1; L1 cell adhesion molecule (mapped); L1cam_mapped; N-CAM L1; N-CAM-L1; NCAM-L1; NCAML1; nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; neuron-glia cell adhesion molecule; NgCAM; NILE
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
L1CAM (L1 cell adhesion molecule) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
L1cam (L1 cell adhesion molecule) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
L1cam (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
L1CAM (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
L1CAM (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
L1cam (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
L1CAM (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
L1CAM (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
L1cam (L1 cell adhesion molecule) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
L1cam (L1 cell adhesion molecule)
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
L1CAM (L1 cell adhesion molecule)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Nrg
Alliance
DIOPT (OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
lad-2
Alliance
DIOPT (Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector)
Caenorhabditis elegans (roundworm):
sax-7
Alliance
DIOPT (OMA|PhylomeDB|OrthoFinder|Hieranoid)
Danio rerio (zebrafish):
l1camb
Alliance
DIOPT (PhylomeDB|OrthoFinder|Hieranoid)
Allele / Splice:
L1cam_v1
L1cam_v2
L1camem2Jgn
Genetic Models:
SD-L1camem2Jgn
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 156,901,244 - 156,928,064 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 156,909,913 - 156,928,057 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 152,649,353 - 152,676,124 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 159,784,792 - 159,801,553 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 1 136,279,868 - 136,293,057 (+) NCBI Celera Cytogenetic Map X q37 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Alzheimer's disease ISO RGD:1352608 6483456 protein:increased expression:cerebrospinal fluid (human) RGD anxiety disorder IEP 6483075 protein:increased expression: brain, multiple (rat) RGD autistic disorder ISO RGD:10850 11570405 RGD bipolar disorder ISO RGD:1352608 6483084 associated with Depressive Disorder, mRNA:increased expression:blood (human) RGD colorectal cancer severity ISO RGD:1352608 6483011 protein:increased expression:colon (human) RGD glioblastoma multiforme ISO RGD:1352608 6483067 mRNA:decreased expression:brain, temporal lobe (human) RGD Hirschsprung's disease ISO RGD:10850 6483043 RGD Huntington's disease ISO RGD:10850 6483035 RGD hypothyroidism IEP 11570514 mRNA, protein:increased expression: cerebral cortex: RGD lung non-small cell carcinoma disease_progression ISO RGD:1352608 11570503 RGD MASA syndrome ISO RGD:1352608 6483061 DNA:missense mutations, deletion:cds, intron:p.H191Q, p.D598N, IVS27_3'utrdel (human) RGD MASA syndrome ISO RGD:1352608 11570406 DNA:deletion:exon: RGD MASA syndrome ISO RGD:1352608 11064095 DNA:mutation:cds:924C>T(human) RGD mental depression IEP 6483073 mRNA:decreased expression:hippocampus (rat) RGD Neoplasm Metastasis treatment ISO RGD:1352608 11570404 associated with Pancreatic Neoplasms RGD Neoplasm Metastasis treatment ISO RGD:1352608 11570503 associated with Lung Neoplasms RGD ovarian carcinoma severity ISO RGD:1352608 6483445 protein:increased expression:ovary, serum (human) RGD ovarian carcinoma ISO RGD:1352608 6483449 human cells, mouse model RGD pancreatic cancer treatment ISO RGD:1352608 11570404 RGD pancreatic ductal carcinoma severity ISO RGD:1352608 6483447 protein:increased expression:pancreas (human) RGD Parkinson's disease ISO RGD:10850 6483033 RGD Peripheral Nerve Injuries ISO RGD:10850 6483044 RGD Peripheral Nerve Injuries IDA 6483092 RGD pheochromocytoma ISO RGD:1352608 11570409 mRNA, protein:increased expression:adrenal medulla: RGD Posthemorrhagic Hydrocephalus ISO RGD:1352608 6483013 protein:increased expression:cerebrospinal fluid (human) RGD schizophrenia susceptibility ISO RGD:1352608 11570408 associated with male, DNA:mutation:intron:13504 C > T(human) RGD Spinal Cord Compression ISO RGD:10850 6483029 RGD uterine cancer severity ISO RGD:1352608 6483445 protein:increased expression:uterus, serum (human) RGD X-Linked Hydrocephalus ISO RGD:10850 6483078 C57BL/6J background RGD X-Linked Hydrocephalus IMP 14695001 RGD X-Linked Hydrocephalus ISO RGD:1352608 6483012 DNA:snps:cds:multiple (human) RGD
Imported Annotations - ClinVar
adrenoleukodystrophy ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Adrenoleukodystrophy ClinVar PMID:28492532 autistic disorder ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 creatine transporter deficiency ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Creatine transporter deficiency ClinVar PMID:18047645 more ... Hirschsprung's disease ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Hirschsprung disease ClinVar MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: SPASTIC PARAPLEGIA 1, X-LINKED ClinVar PMID:11772994 more ... MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: L1 syndrome ClinVar PMID:25741868 , PMID:31319225 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: SPASTIC PARAPLEGIA 1, X-LINKED ClinVar PMID:25741868 , PMID:26467025 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: SPASTIC PARAPLEGIA 1, X-LINKED ClinVar PMID:25741868 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: SPASTIC PARAPLEGIA 1, X-LINKED ClinVar PMID:25644381 , PMID:25741868 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:9643285 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:8401576 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:1303258 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by OMIM:303350 ClinVar PMID:7920659 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by OMIM:303350 ClinVar PMID:7920660 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by OMIM:303350 ClinVar PMID:7881431 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by OMIM:303350 ClinVar PMID:1870106 , PMID:7562969 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:10469653 more ... MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:13889294 more ... MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:21271669 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:16650080 , PMID:8929944 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus syndrome ClinVar PMID:1303258 , PMID:8401593 MASA syndrome ISO RGD:1352608 8554872 ClinVar Annotator: match by OMIM:303350 ClinVar PMID:3460961 , PMID:7920659 Neonatal Severe Encephalopathy due to MECP2 Mutations ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Encephalopathy, neonatal severe, due to MECP2 mutations ClinVar PMID:15351775 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:28492532 paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:11772994 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:15148591 , PMID:28492532 paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:26467025 , PMID:28492532 paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:28492532 , PMID:8069317 paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:10469653 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:10797421 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:19846429 , PMID:28492532 paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:25741868 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:10797421 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:18414213 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:20447653 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:18414213 , PMID:28492532 paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:10469653 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:18414213 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:19846429 more ... paraplegia ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:25741868 , PMID:28492532 Partial Agenesis of Corpus Callosum, X-Linked ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Corpus callosum, partial agenesis of, X-linked ClinVar PMID:25741868 Partial Agenesis of Corpus Callosum, X-Linked ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Corpus callosum, partial agenesis of, X-linked ClinVar PMID:29706646 Partial Agenesis of Corpus Callosum, X-Linked ISO RGD:1352608 8554872 ClinVar Annotator: match by OMIM:304100 ClinVar PMID:16650080 , PMID:8929944 syndromic X-linked intellectual disability Lubs type ISO RGD:1352608 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 X-linked Emery-Dreifuss muscular dystrophy 1 ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Emery-Dreifuss muscular dystrophy 1, X-linked ClinVar PMID:28492532 X-Linked Hydrocephalus ISO RGD:1352608 8554872 ClinVar Annotator: match by term: X-linked hydrocephalus ClinVar PMID:10469653 more ... X-Linked Hydrocephalus ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Hydrocephalus due to aqueductal stenosis ClinVar PMID:18414213 , PMID:28492532 X-Linked Hydrocephalus ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Hydrocephalus due to aqueductal stenosis ClinVar PMID:25741868 X-Linked Hydrocephalus, with Congenital Idiopathic Intestinal Pseudoobstruction ISO RGD:1352608 8554872 ClinVar Annotator: match by term: HYDROCEPHALUS, X-LINKED, WITH HIRSCHSPRUNG DISEASE ClinVar PMID:11857550 X-Linked Hydrocephalus, with Congenital Idiopathic Intestinal Pseudoobstruction ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Hydrocephalus, X-linked, with hirschsprung disease ClinVar PMID:15148591 , PMID:28492532 X-Linked Hydrocephalus, with Congenital Idiopathic Intestinal Pseudoobstruction ISO RGD:1352608 8554872 ClinVar Annotator: match by term: Hydrocephalus, X-linked, with hirschsprung disease ClinVar PMID:9279760 X-Linked Hydrocephalus, with Congenital Idiopathic Intestinal Pseudoobstruction ISO RGD:1352608 8554872 ClinVar Annotator: match by null ClinVar PMID:12650797 , PMID:15368500
Imported Annotations - CTD
aphasia ISO RGD:1352608 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7920660 Congenital Hand Deformities ISO RGD:1352608 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7920660 MASA syndrome ISO RGD:1352608 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7920659 , PMID:7920660 Neurologic Gait Disorders ISO RGD:1352608 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7920660 renal cell carcinoma ISO RGD:1352608 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21097529 X-Linked Hydrocephalus ISO RGD:1352608 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7920659 , PMID:7920660 Imported Annotations - MGI
hydrocephalus ISS RGD:1352608 13592920 OMIM:123155 more ... MouseDO Imported Annotations - OMIM
MASA syndrome ISO RGD:1352608 7240710 OMIM Partial Agenesis of Corpus Callosum, X-Linked ISO RGD:1352608 7240710 OMIM X-Linked Hydrocephalus ISO RGD:1352608 7240710 OMIM
1,1-dichloroethene decreases expression ISO RGD:10850 6480464 vinylidene chloride results in decreased expression of L1CAM mRNA CTD PMID:26682919 1,2-dichloroethane increases expression ISO RGD:10850 6480464 ethylene dichloride results in increased expression of L1CAM mRNA CTD PMID:28960355 17beta-estradiol decreases expression ISO RGD:1352608 6480464 Estradiol results in decreased expression of L1CAM mRNA CTD PMID:16474171 , PMID:19167446 17beta-estradiol multiple interactions ISO RGD:1352608 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of L1CAM mRNA CTD PMID:30165855 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:10850 6480464 Trinitrobenzenesulfonic Acid results in increased expression of L1CAM mRNA CTD PMID:17982090 3,4-methylenedioxymethamphetamine increases expression ISO RGD:10850 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of L1CAM mRNA CTD PMID:20188158 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of L1CAM mRNA CTD PMID:28522335 4-hydroxyphenyl retinamide decreases expression ISO RGD:10850 6480464 Fenretinide results in decreased expression of L1CAM mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1352608 6480464 Decitabine inhibits the reaction [Smoke results in decreased expression of L1CAM mRNA] CTD PMID:21095227 5-fluorouracil decreases expression ISO RGD:1352608 6480464 Fluorouracil results in decreased expression of L1CAM protein CTD PMID:15352031 5-fluorouracil affects response to substance ISO RGD:1352608 6480464 L1CAM protein affects the susceptibility to Fluorouracil CTD PMID:15352031 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of L1CAM mRNA CTD PMID:24780913 aflatoxin B1 increases methylation ISO RGD:1352608 6480464 Aflatoxin B1 results in increased methylation of L1CAM intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:1352608 6480464 aflatoxin B2 results in increased methylation of L1CAM intron CTD PMID:30157460 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of L1CAM mRNA CTD PMID:20488242 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of L1CAM mRNA CTD PMID:30779732 atrazine increases expression ISO RGD:1352608 6480464 Atrazine results in increased expression of L1CAM mRNA CTD PMID:22378314 benzo[a]pyrene affects methylation ISO RGD:1352608 6480464 Benzo(a)pyrene affects the methylation of L1CAM intron CTD PMID:30157460 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1352608 6480464 7 more ... CTD PMID:20018196 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1352608 6480464 Diethylhexyl Phthalate results in increased expression of L1CAM mRNA CTD PMID:31163220 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of L1CAM mRNA CTD PMID:31199487 bisphenol A increases expression ISO RGD:10850 6480464 bisphenol A results in increased expression of L1CAM mRNA CTD PMID:16902998 bisphenol A decreases expression ISO RGD:10850 6480464 bisphenol A results in decreased expression of L1CAM mRNA CTD PMID:25594700 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of L1CAM mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1352608 6480464 bisphenol A results in decreased expression of L1CAM mRNA CTD PMID:16474171 butanal increases expression ISO RGD:1352608 6480464 butyraldehyde results in increased expression of L1CAM mRNA CTD PMID:26079696 Butylbenzyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of L1CAM mRNA CTD PMID:31199487 cadmium atom multiple interactions ISO RGD:1352608 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of L1CAM mRNA CTD PMID:31738976 cadmium dichloride multiple interactions ISO RGD:1352608 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of L1CAM mRNA CTD PMID:31738976 carbamazepine affects expression ISO RGD:1352608 6480464 Carbamazepine affects the expression of L1CAM mRNA CTD PMID:25979313 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of L1CAM mRNA CTD PMID:18668222 choline multiple interactions ISO RGD:10850 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of L1CAM mRNA CTD PMID:20938992 cisplatin affects response to substance ISO RGD:1352608 6480464 L1CAM affects the susceptibility to Cisplatin CTD PMID:21097529 cisplatin decreases expression ISO RGD:1352608 6480464 Cisplatin results in decreased expression of L1CAM mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1352608 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of L1CAM mRNA CTD PMID:27392435 copper atom multiple interactions ISO RGD:1352608 6480464 [NSC 689534 binds to Copper] which results in increased expression of L1CAM mRNA CTD PMID:20971185 copper atom multiple interactions ISO RGD:10850 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of L1CAM mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:1352608 6480464 [NSC 689534 binds to Copper] which results in increased expression of L1CAM mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:10850 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of L1CAM mRNA CTD PMID:15467011 coumestrol multiple interactions ISO RGD:1352608 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol decreases expression ISO RGD:1352608 6480464 Coumestrol results in decreased expression of L1CAM mRNA CTD PMID:19167446 cyclosporin A increases expression ISO RGD:1352608 6480464 Cyclosporine results in increased expression of L1CAM mRNA CTD PMID:25562108 dextran sulfate multiple interactions ISO RGD:10850 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of L1CAM mRNA CTD PMID:29950665 diallyl trisulfide multiple interactions ISO RGD:1352608 6480464 diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of L1CAM mRNA], diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of L1CAM protein] CTD PMID:28574600 dibutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of L1CAM mRNA CTD PMID:31199487 diethyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of L1CAM mRNA CTD PMID:31199487 diisobutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of L1CAM mRNA CTD PMID:31199487 diisononyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of L1CAM mRNA CTD PMID:31199487 dioxygen multiple interactions ISO RGD:1352608 6480464 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of L1CAM mRNA] more ... CTD PMID:28574600 dioxygen increases expression ISO RGD:1352608 6480464 Oxygen deficiency results in increased expression of L1CAM mRNA, Oxygen deficiency results in increased expression of L1CAM protein CTD PMID:28574600 dorsomorphin multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Enterolactone multiple interactions ISO RGD:1352608 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of L1CAM mRNA CTD PMID:19167446 entinostat increases expression ISO RGD:1352608 6480464 entinostat results in increased expression of L1CAM mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA CTD PMID:27188386 ethanol decreases expression ISO RGD:10850 6480464 Ethanol results in decreased expression of L1CAM mRNA CTD PMID:29018328 ethanol increases expression ISO RGD:10850 6480464 Ethanol results in increased expression of L1CAM mRNA CTD PMID:30319688 ethanol affects expression ISO RGD:10850 6480464 Ethanol affects the expression of L1CAM mRNA CTD PMID:30319688 ethanol increases response to substance ISO RGD:1352608 6480464 L1CAM protein modified form results in increased susceptibility to Ethanol CTD PMID:29109170 ethanol increases response to substance ISO RGD:10850 6480464 L1CAM protein modified form results in increased susceptibility to Ethanol CTD PMID:29109170 ethanol decreases activity ISO RGD:1352608 6480464 Ethanol results in decreased activity of L1CAM protein CTD PMID:8609170 ethanol multiple interactions ISO RGD:1352608 6480464 Ethanol binds to and results in decreased activity of L1CAM protein, Octanols analog inhibits the reaction [Ethanol binds to and results in decreased activity of L1CAM protein] CTD PMID:18165316 , PMID:29109170 fluoxetine multiple interactions EXP 6480464 Ondansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein] CTD PMID:16900104 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of L1CAM protein CTD PMID:16900104 folic acid multiple interactions ISO RGD:10850 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of L1CAM mRNA CTD PMID:20938992 genistein decreases expression ISO RGD:1352608 6480464 Genistein results in decreased expression of L1CAM mRNA CTD PMID:16474171 L-methionine multiple interactions ISO RGD:10850 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of L1CAM mRNA CTD PMID:20938992 methanol decreases activity ISO RGD:1352608 6480464 Methanol results in decreased activity of L1CAM protein CTD PMID:29109170 methanol increases response to substance ISO RGD:1352608 6480464 L1CAM protein modified form results in increased susceptibility to Methanol CTD PMID:29109170 methylmercury chloride increases expression ISO RGD:1352608 6480464 methylmercuric chloride results in increased expression of L1CAM mRNA CTD PMID:26272509 methylmercury chloride multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA CTD PMID:27188386 mitomycin C affects response to substance ISO RGD:1352608 6480464 L1CAM protein affects the susceptibility to Mitomycin CTD PMID:16217747 Ondansetron multiple interactions EXP 6480464 Ondansetron inhibits the reaction [Fluoxetine results in increased expression of L1CAM protein] CTD PMID:16900104 panobinostat multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1352608 6480464 panobinostat results in increased expression of L1CAM mRNA CTD PMID:26272509 paracetamol decreases expression ISO RGD:1352608 6480464 Acetaminophen results in decreased expression of L1CAM mRNA CTD PMID:26690555 pentanal increases expression ISO RGD:1352608 6480464 pentanal results in increased expression of L1CAM mRNA CTD PMID:26079696 phenylmercury acetate multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA CTD PMID:27188386 pirinixic acid decreases expression ISO RGD:10850 6480464 pirinixic acid results in decreased expression of L1CAM mRNA CTD PMID:17426115 potassium chromate increases expression ISO RGD:1352608 6480464 potassium chromate(VI) results in increased expression of L1CAM mRNA CTD PMID:22714537 progesterone decreases expression ISO RGD:1352608 6480464 Progesterone results in decreased expression of L1CAM mRNA CTD PMID:18070364 propanal increases expression ISO RGD:1352608 6480464 propionaldehyde results in increased expression of L1CAM mRNA CTD PMID:26079696 resveratrol multiple interactions ISO RGD:1352608 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of L1CAM mRNA CTD PMID:19167446 SB 431542 multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1352608 6480464 Silicon Dioxide analog results in increased expression of L1CAM mRNA CTD PMID:25895662 sirolimus affects response to substance ISO RGD:1352608 6480464 L1CAM affects the susceptibility to Sirolimus CTD PMID:21097529 sodium arsenite multiple interactions ISO RGD:1352608 6480464 sodium arsenite results in decreased expression of and affects the splicing of L1CAM mRNA CTD PMID:25879800 sodium arsenite decreases expression ISO RGD:1352608 6480464 sodium arsenite results in decreased expression of L1CAM mRNA CTD PMID:12016162 titanium dioxide increases expression ISO RGD:10850 6480464 titanium dioxide results in increased expression of L1CAM mRNA CTD PMID:29128614 , PMID:29264374 titanium dioxide multiple interactions ISO RGD:10850 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of L1CAM mRNA CTD PMID:29950665 trichostatin A increases expression ISO RGD:1352608 6480464 trichostatin A results in increased expression of L1CAM mRNA CTD PMID:24935251 more ... trichostatin A multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA CTD PMID:27188386 triclosan increases expression ISO RGD:1352608 6480464 Triclosan results in increased expression of L1CAM mRNA CTD PMID:30510588 valproic acid affects expression ISO RGD:1352608 6480464 Valproic Acid affects the expression of L1CAM mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1352608 6480464 Valproic Acid results in increased expression of L1CAM mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1352608 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of L1CAM mRNA CTD PMID:27188386 vorinostat increases expression ISO RGD:1352608 6480464 vorinostat results in increased expression of L1CAM mRNA CTD PMID:26272509
Biological Process axon development ISO RGD:1352608 1624291 (PMID:20621658) RGD PMID:20621658 axon development ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 axon guidance ISO RGD:1352608 1624291 (PMID:24155914) RGD PMID:24155914 axon guidance ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 axon guidance ISO RGD:10850 1624291 MGI:MGI:104518 more ... RGD MGI:MGI:2449891 more ... axon guidance IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 axonal fasciculation IMP 11570517 RGD cell migration ISO RGD:1352608 1624291 (PMID:22973895) RGD PMID:22973895 cell migration ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell migration IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell surface receptor signaling pathway ISO RGD:10850 1624291 (MGI:MGI:74049, PMID:7613634) RGD MGI:MGI:74049 , PMID:7613634 cell-cell adhesion mediated by integrin ISO RGD:10850 1624291 (MGI:MGI:3757617, PMID:8557754) RGD MGI:MGI:3757617 , PMID:8557754 cell-matrix adhesion ISO RGD:1352608 1624291 (PMID:22973895) RGD PMID:22973895 cell-matrix adhesion ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell-matrix adhesion IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to dexamethasone stimulus IEP 11570520 RGD cellular response to ethanol NOT IEP 11570516 RGD cellular response to ethanol IEP 6483018 RGD cellular response to nerve growth factor stimulus IEP 11570521 RGD cellular response to thyroxine stimulus IEP 11570514 RGD cellular response to transforming growth factor beta stimulus IEP 6483452 RGD dopaminergic neuron differentiation IEP 11570519 RGD heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO RGD:10850 1624291 (MGI:MGI:3757617, PMID:8557754) RGD MGI:MGI:3757617 , PMID:8557754 homophilic cell adhesion via plasma membrane adhesion molecules ISO RGD:10850 1624291 (MGI:MGI:3757619, PMID:7669058) RGD MGI:MGI:3757619 , PMID:7669058 homophilic cell adhesion via plasma membrane adhesion molecules IBA FB:FBgn0017590 more ... 13792537 PMID:21873635 GO_Central homotypic cell-cell adhesion ISO RGD:10850 1624291 (MGI:MGI:74049, PMID:7613634) RGD MGI:MGI:74049 , PMID:7613634 leukocyte cell-cell adhesion ISO RGD:10850 1624291 (MGI:MGI:3757617 more ... RGD MGI:MGI:3757617 more ... modulation of chemical synaptic transmission EXP 13702438 PMID:7997264 SynGO neuron differentiation IEP 11570515 RGD neuron projection development ISO RGD:1352608 1624291 (PMID:22973895) RGD PMID:22973895 neuron projection development ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 neuron projection development ISO RGD:10850 1624291 MGI:MGI:2181735 (MGI:MGI:3706622 , PMID:11283023) RGD MGI:MGI:3706622 , PMID:11283023 positive regulation of axon extension IMP 10054086 PMID:18519736 UniProt positive regulation of calcium-mediated signaling ISO RGD:10850 1624291 (MGI:MGI:74049, PMID:7613634) RGD MGI:MGI:74049 , PMID:7613634 positive regulation of cell-cell adhesion ISO RGD:10850 1624291 (MGI:MGI:3757619, PMID:7669058) RGD MGI:MGI:3757619 , PMID:7669058 positive regulation of cell-substrate adhesion IDA 11570518 RGD regulation of ERK1 and ERK2 cascade IDA 11570403 RGD response to activity IEP 11570528 RGD response to thyroid hormone IEP 11570514 RGD synapse organization ISO RGD:1352608 1624291 (PMID:24155914) RGD PMID:24155914 synapse organization IBA PANTHER:PTN002895063 , UniProtKB:P32004 13792537 PMID:21873635 GO_Central synapse organization ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 synapse organization IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component axon ISO RGD:1352608 1624291 (PMID:20621658) RGD PMID:20621658 axon IBA PANTHER:PTN002895063 more ... 13792537 PMID:21873635 GO_Central axon IDA 9850091 RGD axon IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 axonal growth cone IDA 11570505 RGD axonal growth cone IDA 10054086 PMID:18519736 UniProt cell surface ISO RGD:1352608 1624291 (PMID:22973895) RGD PMID:22973895 cell surface IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell surface IDA 9850091 RGD cell surface ISO RGD:10850 1624291 (MGI:MGI:3032463, PMID:12514225) RGD MGI:MGI:3032463 , PMID:12514225 dendrite IDA 9850091 RGD dendritic growth cone IDA 11570505 RGD endosome IDA 9850091 RGD endosome TAS 1600115 Reactome:R-NUL-445082 Reactome Reactome:R-NUL-445082 external side of plasma membrane ISO RGD:10850 1624291 (MGI:MGI:65397 more ... RGD MGI:MGI:65397 more ... integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 membrane ISO RGD:10850 1624291 (MGI:MGI:3706622, PMID:11283023) RGD MGI:MGI:3706622 , PMID:11283023 membrane raft IDA 6483018 RGD neuronal cell body ISO RGD:1352608 1624291 (PMID:20621658) RGD PMID:20621658 neuronal cell body IBA PANTHER:PTN002895063 more ... 13792537 PMID:21873635 GO_Central neuronal cell body IDA 9850091 RGD neuronal cell body IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISO RGD:1352608 1624291 (PMID:20621658) RGD PMID:20621658 plasma membrane IBA MGI:MGI:96721 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISS UniProtKB:P32004 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane TAS 1600115 Reactome:R-RNO-443768 Reactome Reactome:R-RNO-443768 plasma membrane TAS 1600115 Reactome:R-RNO-373735 Reactome Reactome:R-RNO-373735 plasma membrane TAS 1600115 Reactome:R-NUL-445082 Reactome Reactome:R-NUL-445082 plasma membrane IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 presynaptic membrane ISO RGD:10850 1624291 (MGI:MGI:3619851, PMID:16537644) RGD MGI:MGI:3619851 , PMID:16537644 Schaffer collateral - CA1 synapse EXP 13702438 PMID:7997264 SynGO terminal bouton ISO RGD:10850 1624291 (MGI:MGI:3619851, PMID:16537644) RGD MGI:MGI:3619851 , PMID:16537644 Molecular Function axon guidance receptor activity IBA PANTHER:PTN002895063 , RGD:61941 13792537 PMID:21873635 GO_Central identical protein binding ISO RGD:10850 1624291 (MGI:MGI:3757617 more ... RGD MGI:MGI:3757617 more ... integrin binding ISO RGD:10850 1624291 (MGI:MGI:3757617, PMID:8557754) RGD MGI:MGI:3757617 , PMID:8557754 PDZ domain binding IPI RGD:621497 633988 RGD protein binding ISO RGD:1352608 1624291 UniProtKB:P26040 , UniProtKB:P84091 (PMID:18321067) RGD PMID:18321067 protein binding ISO RGD:10850 1624291 PR:B9EKR1 more ... RGD MGI:MGI:2665215 more ... protein binding IPI UniProtKB:A0MZ67 10054086 PMID:18519736 UniProt protein domain specific binding IEA UniProtKB:P32004 , ensembl:ENSP000003590771600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein domain specific binding ISO RGD:1352608 1624291 (PMID:18321067) RGD PMID:18321067 protein self-association ISO RGD:10850 1624291 PR:P11627 (MGI:MGI:3801368, PMID:18550718) RGD MGI:MGI:3801368 , PMID:18550718 sialic acid binding ISO RGD:10850 1624291 (MGI:MGI:3706622 more ... RGD MGI:MGI:3706622 more ...
Gene-Chemical Interaction Annotations
