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Gene: L1cam (L1 cell adhesion molecule) Rattus norvegicus
Symbol: L1cam
Name: L1 cell adhesion molecule
Description: Exhibits PDZ domain binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and generation of neurons. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; growth cone; and membrane raft. Used to study hydrocephalus. Biomarker of anxiety disorder; hypothyroidism; and mental depression. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
Also known as: Hsas; Hyd; L1; L1 cell adhesion molecule (mapped); L1cam_mapped; N-CAM L1; N-CAM-L1; NCAM-L1; NCAML1; nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; neuron-glia cell adhesion molecule; NgCAM; NILE
Homo sapiens (human) : L1CAM (L1 cell adhesion molecule)  HGNC  Alliance
Mus musculus (house mouse) : L1cam (L1 cell adhesion molecule)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : L1cam (L1 cell adhesion molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : L1CAM (L1 cell adhesion molecule)
Canis lupus familiaris (dog) : L1CAM (L1 cell adhesion molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : L1cam (L1 cell adhesion molecule)
Sus scrofa (pig) : L1CAM (L1 cell adhesion molecule)
Chlorocebus sabaeus (African green monkey) : L1CAM (L1 cell adhesion molecule)
Heterocephalus glaber (naked mole-rat) : L1cam (L1 cell adhesion molecule)
more info ...
Allele / Splice: L1cam_v1   L1cam_v2   L1camem2Jgn  
Genetic Models: SD-L1camem2Jgn
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X156,901,244 - 156,928,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,909,913 - 156,928,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,649,353 - 152,676,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,784,792 - 159,801,553 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1136,279,868 - 136,293,057 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on L1cam
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619777
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.