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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. | Alvarez-Dolado M, etal., Mol Cell Neurosci. 2000 Oct;16(4):499-514. |
| 2. | Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. | Arlt MJ, etal., Cancer Res. 2006 Jan 15;66(2):936-43. |
| 3. | Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. | Ben QW, etal., Ann Surg Oncol. 2010 Aug;17(8):2213-21. Epub 2010 Feb 17. |
| 4. | Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum. | Bernreuther C, etal., J Neurosci. 2006 Nov 8;26(45):11532-9. |
| 5. | Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice. | Cui YF, etal., Brain. 2010 Jan;133(Pt 1):189-204. Epub 2009 Dec 7. |
| 6. | A silent mutation, C924T (G308G), in the L1CAM gene results in X linked hydrocephalus (HSAS). | Du YZ, etal., J Med Genet. 1998 Jun;35(6):456-62. |
| 7. | miR-29a modulates neuronal differentiation through targeting REST in mesenchymal stem cells. | Duan P, etal., PLoS One. 2014 May 19;9(5):e97684. doi: 10.1371/journal.pone.0097684. eCollection 2014. |
| 8. | Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. | Emmert AS, etal., J Neurosurg. 2019 Feb 8:1-14. doi: 10.3171/2018.10.JNS181015. |
| 9. | L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. | Fogel M, etal., Lancet. 2003 Sep 13;362(9387):869-75. |
| 10. | Nerve growth factor enhances expression of neuron-glia cell adhesion molecule in PC12 cells. | Friedlander DR, etal., J Cell Biol. 1986 Feb;102(2):413-9. |
| 11. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 12. | Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice. | Guseva D, etal., Exp Neurol. 2011 Jun;229(2):339-52. Epub 2011 Mar 2. |
| 13. | Binding partners L1 cell adhesion molecule and the ezrin-radixin-moesin (ERM) proteins are involved in development and the regenerative response to injury of hippocampal and cortical neurons. | Haas MA, etal., Eur J Neurosci. 2004 Sep;20(6):1436-44. |
| 14. | L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer. | Hai J, etal., Clin Cancer Res. 2012 Apr 1;18(7):1914-24. doi: 10.1158/1078-0432.CCR-11-2893. Epub 2012 Feb 3. |
| 15. | Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons. | Hoffman EJ, etal., Neuroscience. 2008 Dec 2;157(3):556-65. doi: 10.1016/j.neuroscience.2008.08.071. Epub 2008 Sep 25. |
| 16. | Antidepressant-like effects of 3,6'-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. | Hu Y, etal., Neurochem Int. 2010 Feb;56(3):461-5. Epub 2009 Dec 14. |
| 17. | Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. | Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119. |
| 18. | X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. | Jouet M, etal., Nat Genet. 1994 Jul;7(3):402-7. |
| 19. | L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. | Kaifi JT, etal., Mod Pathol. 2007 Nov;20(11):1183-90. Epub 2007 Sep 14. |
| 20. | The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. | Koroll M, etal., J Biol Chem 2001 Apr 6;276(14):10646-54. |
| 21. | An association study between polymorphism of L1CAM gene and schizophrenia in a Japanese sample. | Kurumaji A, etal., Am J Med Genet. 2001 Jan 8;105(1):99-104. |
| 22. | Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. | Lin B, etal., PLoS One. 2010 Apr 19;5(4):e10210. |
| 23. | Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. | Lüthl A, etal., Nature. 1994 Dec 22-29;372(6508):777-9. doi: 10.1038/372777a0. |
| 24. | Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response. | Macias M, etal., Neuroreport. 2002 Dec 20;13(18):2527-30. |
| 25. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 26. | Transforming growth factor beta1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells. | Miller MW, etal., J Neurochem. 2006 May;97(4):1182-90. |
| 27. | Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing. | Miura M, etal., FEBS Lett 1991 Sep 2;289(1):91-5. |
| 28. | Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. | Molatore S, etal., Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18493-8. doi: 10.1073/pnas.1003956107. Epub 2010 Oct 11. |
| 29. | Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3. | Montgomery AM, etal., J Cell Biol. 1996 Feb;132(3):475-85. |
| 30. | Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with post-hemorrhagic hydrocephalus of prematurity. | Morales DM, etal., Mol Cell Proteomics. 2011 Dec 20. |
| 31. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 32. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 33. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 34. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 35. | Heterozygous L1-deficient mice express an autism-like phenotype. | Sauce B, etal., Behav Brain Res. 2015 Oct 1;292:432-42. doi: 10.1016/j.bbr.2015.05.040. Epub 2015 Jun 14. |
| 36. | Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. | Schafer H, etal., Carcinogenesis. 2012 Jan;33(1):84-93. doi: 10.1093/carcin/bgr262. Epub 2011 Nov 17. |
| 37. | TGF-beta1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells. | Schafer H, etal., Oncogene. 2012 Feb 20. doi: 10.1038/onc.2012.44. |
| 38. | Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth. | Shimada T, etal., J Cell Biol. 2008 Jun 2;181(5):817-29. doi: 10.1083/jcb.200712138. |
| 39. | Mesostriatal dopaminergic axons transiently express high levels of NILE during development. | Shults CW, etal., Exp Neurol. 1992 Jun;116(3):275-85. |
| 40. | Involvement of the nerve growth factor-inducible large external glycoprotein (NILE) in neurite fasciculation in primary cultures of rat brain. | Stallcup WB and Beasley L, Proc Natl Acad Sci U S A. 1985 Feb;82(4):1276-80. |
| 41. | Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes. | Strekalova H, etal., Neurobiol Aging. 2006 Jan;27(1):1-9. |
| 42. | A deletion of five nucleotides in the L1CAM gene in a Japanese family with X-linked hydrocephalus. | Takechi T, etal., Hum Genet. 1996 Mar;97(3):353-6. |
| 43. | Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases. | Tang N, etal., J Neurochem. 2006 Mar;96(5):1480-90. |
| 44. | Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts. | Tang N, etal., J Neurochem. 2011 Nov;119(4):859-67. doi: 10.1111/j.1471-4159.2011.07467.x. Epub 2011 Oct 11. |
| 45. | A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. | Tapanes-Castillo A, etal., Neurogenetics. 2010 Feb;11(1):53-71. Epub 2009 Jun 30. |
| 46. | Neurotrophins 3 and 4 differentially regulate NCAM, L1 and N-cadherin expression during peripheral nerve regeneration. | Thornton MR, etal., Biotechnol Appl Biochem. 2008 Feb;49(Pt 2):165-74. |
| 47. | Effect of dexamethasone on the nerve growth factor-induced increase in the NILE glycoprotein in PC12 cells. | Tocco MD, etal., J Neurosci Res. 1992 Jan;31(1):28-32. |
| 48. | "Juvenile stress" alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stress-related psychopathologies. | Tsoory MM, etal., J Neurosci Res. 2010 Feb 1;88(2):369-80. |
| 49. | MASA syndrome is due to mutations in the neural cell adhesion gene L1CAM. | Vits L, etal., Nat Genet. 1994 Jul;7(3):408-13. |
| 50. | State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. | Wakabayashi Y, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1199-205. Epub 2008 Mar 15. |
| 51. | L1cam acts as a modifier gene for members of the endothelin signalling pathway during enteric nervous system development. | Wallace AS, etal., Neurogastroenterol Motil. 2011 Nov;23(11):e510-22. doi: 10.1111/j.1365-2982.2011.01692.x. Epub 2011 Mar 14. |
| 52. | Toluene disruption of the functions of L1 cell adhesion molecule at concentrations associated with occupational exposures. | White KM, etal., Pediatr Res. 2016 Jul;80(1):145-50. doi: 10.1038/pr.2016.40. Epub 2016 Mar 8. |
| 53. | Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury. | Xu JC, etal., J Neurotrauma. 2011 Sep;28(9):1921-37. Epub 2011 Aug 31. |
| 54. | The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. | Yap CC, etal., J Cell Biol. 2008 Feb 25;180(4):827-42. doi: 10.1083/jcb.200707143. |
Additional References at PubMed
| PMID:2466966 | PMID:2723751 | PMID:7613634 | PMID:7669058 | PMID:8117278 | PMID:8125140 | PMID:8557754 | PMID:9048906 | PMID:11283023 | PMID:11948808 | PMID:12070130 | PMID:12453492 |
| PMID:12514225 | PMID:12533613 | PMID:12900915 | PMID:14608600 | PMID:14705138 | PMID:15803510 | PMID:15880726 | PMID:15905095 | PMID:15911348 | PMID:16022864 | PMID:16537644 | PMID:16554297 |
| PMID:17151951 | PMID:17234591 | PMID:18321067 | PMID:18464795 | PMID:18478542 | PMID:18550718 | PMID:18650339 | PMID:19185025 | PMID:19458237 | PMID:19581412 | PMID:20124415 | PMID:20463227 |
| PMID:20621658 | PMID:20964729 | PMID:21423176 | PMID:22815787 | PMID:22973895 | PMID:23050935 | PMID:24155914 | PMID:24223996 | PMID:27559042 | PMID:31426714 | PMID:38728789 |
Genomics
Comparative Map Data
| L1cam (Rattus norvegicus - Norway rat) |
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| L1CAM (Homo sapiens - human) |
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| L1cam (Mus musculus - house mouse) |
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| L1cam (Chinchilla lanigera - long-tailed chinchilla) |
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| L1CAM (Pan paniscus - bonobo/pygmy chimpanzee) |
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| L1CAM (Canis lupus familiaris - dog) |
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| L1cam (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| L1CAM (Sus scrofa - pig) |
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| L1CAM (Chlorocebus sabaeus - green monkey) |
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| L1cam (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in L1cam
37 total Variants 
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