Mir223 (microRNA 223) - Rat Genome Database

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Gene: Mir223 (microRNA 223) Rattus norvegicus
Symbol: Mir223
Name: microRNA 223
RGD ID: 2325543
Description: Predicted to enable lncRNA binding activity; mRNA 3'-UTR binding activity; and mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of cytokine production. Located in blood microparticle. Used to study acute myocardial infarction; brain ischemia; pulmonary hypertension; thrombophlebitis; and transient cerebral ischemia. Biomarker of artery disease (multiple); brain infarction (multiple); peptic esophagitis; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human MIR223 (microRNA 223); INTERACTS WITH 2,5-hexanedione; acetic acid; aflatoxin B1.
Type: ncrna (Ensembl: miRNA)
Previously known as: microRNA mir-223; rno-mir-223
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X65,151,383 - 65,151,492 (+)NCBIGRCr8
mRatBN7.2X61,141,887 - 61,141,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX61,141,887 - 61,141,996 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,615,555 - 62,615,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X66,116,079 - 66,116,188 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,673,322 - 63,673,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,367,812 - 65,367,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,367,812 - 65,367,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X66,205,958 - 66,206,067 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX61,554,814 - 61,554,923 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Hepatitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IEP,ISO)
acute myocardial infarction  (IMP)
adult respiratory distress syndrome  (ISO)
Alcoholic Liver Diseases  (ISO)
aortic atherosclerosis  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Barrett's esophagus  (ISO)
Binge Drinking  (ISO)
brain infarction  (IEP)
brain ischemia  (IMP)
Cardiac Fibrosis  (IMP)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (IEP)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
diabetes mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Febrile Seizures  (IDA,IEP)
hepatocellular carcinoma  (ISO)
Hypercholesterolemia  (ISO)
Intervertebral Disc Displacement  (ISO)
Knee Osteoarthritis  (IEP)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
myocardial infarction  (IEP)
Neuralgia  (IDA)
obesity  (ISO)
peptic esophagitis  (IEP)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (IDA,IEP,ISO)
Schistosomiasis Japonica  (ISO)
Sepsis  (ISO)
Sleep Deprivation  (IEP)
stomach cancer  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
thrombophlebitis  (IMP)
transient cerebral ischemia  (IMP)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell proliferation in bone marrow  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to hypoxia  (IEP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
granulocyte differentiation  (ISO)
inflammatory response  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of autophagy  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (IDA)
negative regulation of cell size  (IDA)
negative regulation of high-density lipoprotein particle clearance  (ISO)
negative regulation of interleukin-1 beta production  (IMP)
negative regulation of interleukin-18 production  (IMP)
negative regulation of pyroptosis  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IDA,ISO)
physiological cardiac muscle hypertrophy  (IMP)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of fibroblast chemotaxis  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of granulocyte differentiation  (ISO)
positive regulation of myofibroblast differentiation  (IMP)
positive regulation of protein localization to plasma membrane  (ISO)
regulation of gene expression  (ISO)
regulation of vasculature development  (ISO)
response to bacterium  (ISO)
response to gravity  (IEP)
response to hypoxia  (ISO)
response to oxygen levels  (ISO)
response to psychosocial stress  (IEP)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Cytokine and microRNA levels during different periods of paradoxical sleep deprivation and sleep recovery in rats. Brianza-Padilla M, etal., PeerJ. 2018 Sep 13;6:e5567. doi: 10.7717/peerj.5567. eCollection 2018.
2. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. Calvente CJ, etal., J Clin Invest. 2019 Jul 11;130:4091-4109. doi: 10.1172/JCI122258.
3. BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis. Chen L, etal., Mol Immunol. 2018 Jan;93:38-46. doi: 10.1016/j.molimm.2017.11.008. Epub 2017 Nov 13.
4. Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity. Chen Y, etal., Exp Mol Med. 2017 Jun 23;49(6):e348. doi: 10.1038/emm.2017.80.
5. Association of plasma miR-223 and platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy: A preliminary report. Chyrchel B, etal., Platelets. 2015;26(6):593-7. doi: 10.3109/09537104.2014.974527. Epub 2014 Oct 28.
6. Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats. Cuomo O, etal., Mol Ther Nucleic Acids. 2019 Dec 6;18:1063-1071. doi: 10.1016/j.omtn.2019.10.022. Epub 2019 Oct 28.
7. miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small Cell Lung Cancer by Targeting E2F8. Dou L, etal., Oncol Res. 2019 Feb 5;27(2):261-268. doi: 10.3727/096504018X15219188894056. Epub 2018 Apr 3.
8. Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. Giray BG, etal., Mol Biol Rep. 2014 Jul;41(7):4513-9. doi: 10.1007/s11033-014-3322-3. Epub 2014 Mar 5.
9. 2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension through regulating microRNA-223. Hao S, etal., J Cell Physiol. 2019 May;234(5):6324-6335. doi: 10.1002/jcp.27363. Epub 2018 Sep 24.
10. Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy. He X, etal., Parasit Vectors. 2013 Sep 20;6:272. doi: 10.1186/1756-3305-6-272.
11. MicroRNA-223 Ameliorates Nonalcoholic Steatohepatitis and Cancer by Targeting Multiple Inflammatory and Oncogenic Genes in Hepatocytes. He Y, etal., Hepatology. 2019 Oct;70(4):1150-1167. doi: 10.1002/hep.30645. Epub 2019 Jun 5.
12. Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9. Hyrina A, etal., EBioMedicine. 2017 Sep;23:68-78. doi: 10.1016/j.ebiom.2017.08.020. Epub 2017 Aug 24.
13. miR-223 and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma. Imura S, etal., Anticancer Res. 2017 Oct;37(10):5877-5883. doi: 10.21873/anticanres.12033.
14. Exposure to workplace bullying, microRNAs and pain; evidence of a moderating effect of miR-30c rs928508 and miR-223 rs3848900. Jacobsen DP, etal., Stress. 2020 Jan;23(1):77-86. doi: 10.1080/10253890.2019.1642320. Epub 2019 Jul 24.
15. Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Ji D, etal., Aging (Albany NY). 2020 Jan 29;12(2):1643-1655. doi: 10.18632/aging.102705. Epub 2020 Jan 29.
16. MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. Jimenez Calvente C, etal., Mol Ther. 2020 Feb 5;28(2):653-663. doi: 10.1016/j.ymthe.2019.09.013. Epub 2019 Sep 13.
17. Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. Kawashita Y, etal., J Hepatobiliary Pancreat Sci. 2017 Oct;24(10):576-583. doi: 10.1002/jhbp.500. Epub 2017 Oct 12.
18. Expression profiling of microRNAs in lipopolysaccharide-induced acute lung injury after hypothermia treatment. Lee W, etal., Mol Cell Toxicol. 2016;12(3):243-253. doi: 10.1007/s13273-016-0029-7. Epub 2016 Oct 7.
19. Effect of miR-223 on thrombophlebitis rats through regulating Toll-like receptor signaling pathway. Li HL, etal., Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2020-2027. doi: 10.26355/eurrev_202002_20380.
20. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. Li M, etal., Gut. 2017 Apr;66(4):705-715. doi: 10.1136/gutjnl-2016-311861. Epub 2016 Sep 27.
21. miRNA-223-3p and let-7b-3p as potential blood biomarkers associated with the ischemic penumbra in rats. Li S, etal., Acta Neurobiol Exp (Wars). 2019;79(2):205-216.
22. MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways. Li Y, etal., J Biol Chem. 2019 Jul 5;294(27):10438-10448. doi: 10.1074/jbc.RA119.007755. Epub 2019 May 22.
23. Role of miR-223-3p in pulmonary arterial hypertension via targeting ITGB3 in the ECM pathway. Liu A, etal., Cell Prolif. 2019 Mar;52(2):e12550. doi: 10.1111/cpr.12550. Epub 2018 Dec 3.
24. MicroRNA-223 Regulates Cardiac Fibrosis After Myocardial Infarction by Targeting RASA1. Liu X, etal., Cell Physiol Biochem. 2018;46(4):1439-1454. doi: 10.1159/000489185. Epub 2018 Apr 19.
25. MicroRNA-223 protects neonatal rat cardiomyocytes and H9c2 cells from hypoxia-induced apoptosis and excessive autophagy via the Akt/mTOR pathway by targeting PARP-1. Liu X, etal., J Mol Cell Cardiol. 2018 May;118:133-146. doi: 10.1016/j.yjmcc.2018.03.018. Epub 2018 Mar 31.
26. The Expression of microRNA-223 and FAM5C in Cerebral Infarction Patients with Diabetes Mellitus. Long Y, etal., Cardiovasc Toxicol. 2017 Jan;17(1):42-48. doi: 10.1007/s12012-015-9354-7.
27. Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p. Lu FB, etal., Mol Cells. 2019 Dec 31;42(12):906-918. doi: 10.14348/molcells.2019.2283.
28. miR-223 reverses experimental pulmonary arterial hypertension. Meloche J, etal., Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C363-72. doi: 10.1152/ajpcell.00149.2015. Epub 2015 Jun 17.
29. MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. Moen A, etal., J Transl Med. 2017 May 1;15(1):89. doi: 10.1186/s12967-017-1194-8.
30. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Neudecker V, etal., Sci Transl Med. 2017 Sep 20;9(408). pii: 9/408/eaah5360. doi: 10.1126/scitranslmed.aah5360.
31. Serum microRNAs; miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma. Oksuz Z, etal., Mol Biol Rep. 2015 Mar;42(3):713-20. doi: 10.1007/s11033-014-3819-9. Epub 2014 Nov 13.
32. miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor. Qadir XV, etal., Am J Pathol. 2015 Dec;185(12):3141-51. doi: 10.1016/j.ajpath.2015.08.020.
33. Expression and significance of miR-223 in rats with pulmonary fibrosis. Qu SJ, etal., Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3951-3958. doi: 10.26355/eurrev_202004_20864.
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. miR-223 represents a biomarker in acute and chronic liver injury. Schueller F, etal., Clin Sci (Lond). 2017 Jul 13;131(15):1971-1987. doi: 10.1042/CS20170218. Print 2017 Aug 1.
36. Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway. Sha R, etal., Med Sci Monit. 2019 Jun 25;25:4723-4733. doi: 10.12659/MSM.917213.
37. Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients. Shaker OG and Senousy MA, J Viral Hepat. 2017 Aug;24(8):636-644. doi: 10.1111/jvh.12696. Epub 2017 Mar 13.
38. An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells: Role of MicroRNA-223 in Smooth Muscle Function and Atherogenesis. Shan Z, etal., J Am Coll Cardiol. 2015 Jun 16;65(23):2526-37. doi: 10.1016/j.jacc.2015.03.570.
39. Downregulation of miR-223 and miR-153 mediates mechanical stretch-stimulated proliferation of venous smooth muscle cells via activation of the insulin-like growth factor-1 receptor. Song L, etal., Arch Biochem Biophys. 2012 Dec 15;528(2):204-11. doi: 10.1016/j.abb.2012.08.015. Epub 2012 Oct 6.
40. MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1. Streppel MM, etal., Clin Cancer Res. 2013 Aug 1;19(15):4067-78. doi: 10.1158/1078-0432.CCR-13-0601. Epub 2013 Jun 11.
41. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
42. Expression of Serum Exosomal and Esophageal MicroRNA in Rat Reflux Esophagitis. Uemura R, etal., Int J Mol Sci. 2017 Jul 25;18(8). pii: ijms18081611. doi: 10.3390/ijms18081611.
43. MicroRNA-223 coordinates cholesterol homeostasis. Vickers KC, etal., Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14518-23. doi: 10.1073/pnas.1215767111. Epub 2014 Sep 22.
44. Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway. Wang B, etal., Biomed Pharmacother. 2019 Jun;114:108683. doi: 10.1016/j.biopha.2019.108683. Epub 2019 Apr 1.
45. MicroRNA-223 inhibits lipopolysaccharide-induced inflammatory response by directly targeting Irak1 in the nucleus pulposus cells of intervertebral disc. Wang H, etal., IUBMB Life. 2018 Jun;70(6):479-490. doi: 10.1002/iub.1747. Epub 2018 Apr 29.
46. MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. Wang X, etal., PLoS One. 2017 Sep 8;12(9):e0184292. doi: 10.1371/journal.pone.0184292. eCollection 2017.
47. [Relationship between expression of microRNA and inflammatory cytokines plasma level in pediatric patients with sepsis]. Wu Y, etal., Zhonghua Er Ke Za Zhi. 2014 Jan;52(1):28-33.
48. Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain. Xie XJ, etal., Mol Pain. 2017 Jan-Dec;13:1744806917706582. doi: 10.1177/1744806917706582.
49. Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Xu J, etal., Mol Carcinog. 2011 Feb;50(2):136-42. doi: 10.1002/mc.20712. Epub 2010 Dec 10.
50. NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression. Yang F, etal., Cell Death Dis. 2018 Jan 9;9(1):12. doi: 10.1038/s41419-017-0020-9.
51. MicroRNA-223 acts as an important regulator to Kupffer cells activation at the early stage of Con A-induced acute liver failure via AIM2 signaling pathway. Yang F, etal., Cell Physiol Biochem. 2014;34(6):2137-52. doi: 10.1159/000369658. Epub 2014 Dec 2.
52. Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy. Yang L, etal., J Biol Chem. 2016 Jul 22;291(30):15700-13. doi: 10.1074/jbc.M116.715805. Epub 2016 May 20.
53. Association of MicroRNA-223 expression with hepatic ischemia/reperfusion injury in mice. Yu CH, etal., Dig Dis Sci. 2009 Nov;54(11):2362-6. doi: 10.1007/s10620-008-0629-8. Epub 2008 Dec 23.
54. EPO-cyclosporine combination therapy reduced brain infarct area in rat after acute ischemic stroke: role of innate immune-inflammatory response, micro-RNAs and MAPK family signaling pathway. Yuen CM, etal., Am J Transl Res. 2017 Apr 15;9(4):1651-1666. eCollection 2017.
55. SOX2-mediated inhibition of miR-223 contributes to STIM1 activation in phenylephrine-induced hypertrophic cardiomyocytes. Zhao ZH, etal., Mol Cell Biochem. 2018 Jun;443(1-2):47-56. doi: 10.1007/s11010-017-3209-4. Epub 2017 Nov 7.
56. Differential miRNAomics of the synovial membrane in knee osteoarthritis induced by bilateral anterior cruciate ligament transection in rats. Zhou J, etal., Mol Med Rep. 2018 Oct;18(4):4051-4057. doi: 10.3892/mmr.2018.9385. Epub 2018 Aug 13.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:18278031   PMID:18723672   PMID:18762567   PMID:18791161   PMID:19147652   PMID:20403161   PMID:20439489   PMID:21247879   PMID:24205035   PMID:25313822  
PMID:25792377   PMID:25875646   PMID:27322747   PMID:27979484   PMID:27999792   PMID:29663740   PMID:31210320   PMID:31212858   PMID:31799641   PMID:32337949   PMID:32926923   PMID:33155218  
PMID:33608866   PMID:33999393   PMID:35042119   PMID:36861147   PMID:37549514   PMID:37660209   PMID:37899695   PMID:37991531   PMID:38059448  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X65,151,383 - 65,151,492 (+)NCBIGRCr8
mRatBN7.2X61,141,887 - 61,141,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX61,141,887 - 61,141,996 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX62,615,555 - 62,615,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X66,116,079 - 66,116,188 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X63,673,322 - 63,673,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X65,367,812 - 65,367,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX65,367,812 - 65,367,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X66,205,958 - 66,206,067 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX61,554,814 - 61,554,923 (+)NCBICelera
Cytogenetic MapXq22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X66,018,870 - 66,018,979 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX66,018,870 - 66,018,979 (+)EnsemblGRCh38hg38GRCh38
GRCh37X65,238,712 - 65,238,821 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X65,155,436 - 65,155,545 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX65,585,857 - 65,585,966 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX59,065,818 - 59,065,927 (+)NCBIHuRef
CHM1_1X65,131,742 - 65,131,851 (+)NCBICHM1_1
T2T-CHM13v2.0X64,445,366 - 64,445,475 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X95,286,423 - 95,286,532 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX95,286,423 - 95,286,532 (+)EnsemblGRCm39 Ensembl
GRCm38X96,242,817 - 96,242,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX96,242,817 - 96,242,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X93,438,156 - 93,438,265 (+)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX83,247,617 - 83,247,726 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.69NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X50,838,131 - 50,838,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX50,838,131 - 50,838,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX41,675,998 - 41,676,100 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X51,802,379 - 51,802,481 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X49,766,866 - 49,766,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X51,114,791 - 51,114,893 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X51,030,133 - 51,030,235 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-miR-223-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:12615
Count of gene targets:7052
Count of transcripts:7639
Interacting mature miRNAs:rno-miR-223-3p, rno-miR-223-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 2 6
Low 7 37 21 11 21 6 6 3 5 13 5 6
Below cutoff 10 8 8 8 1 1 1 3 3 1


Nucleotide Sequences
RefSeq Transcripts NR_031936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053628
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX61,141,887 - 61,141,996 (+)Ensembl
Rnor_6.0 EnsemblX65,367,812 - 65,367,921 (+)Ensembl
RefSeq Acc Id: NR_031936
Rat AssemblyChrPosition (strand)Source
GRCr8X65,151,383 - 65,151,492 (+)NCBI
mRatBN7.2X61,141,887 - 61,141,996 (+)NCBI
Rnor_6.0X65,367,812 - 65,367,921 (+)NCBI
Rnor_5.0X66,205,958 - 66,206,067 (+)NCBI
CeleraX61,554,814 - 61,554,923 (+)NCBI

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325543 AgrOrtholog
BioCyc Gene G2FUF-2186 BioCyc
Ensembl Genes ENSRNOG00000035505 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053628 ENTREZGENE
miRBase MI0000963 ENTREZGENE
NCBI Gene 100314060 ENTREZGENE
PhenoGen Mir223 PhenoGen
RatGTEx ENSRNOG00000035505 RatGTEx
RNAcentral URS00000D5CE2 RNACentral
  URS00000F11D1 RNACentral
  URS00006291D1 RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir223  microRNA 223  Mir223  microRNA mir-223  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir223  microRNA mir-223      Symbol and Name status set to provisional 70820 PROVISIONAL