Gpr135 (G protein-coupled receptor 135) - Rat Genome Database

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Gene: Gpr135 (G protein-coupled receptor 135) Rattus norvegicus
Analyze
Symbol: Gpr135
Name: G protein-coupled receptor 135
RGD ID: 727844
Description: Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR135 (G protein-coupled receptor 135); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor 135; probable G-protein coupled receptor 135
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8696,363,466 - 96,366,594 (-)NCBIGRCr8
mRatBN7.2690,627,533 - 90,630,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl690,629,178 - 90,630,551 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx690,999,916 - 91,001,289 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0691,299,380 - 91,300,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0690,738,936 - 90,740,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0694,816,976 - 94,818,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl694,816,976 - 94,818,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06104,261,635 - 104,263,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4694,262,988 - 94,264,361 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1694,266,443 - 94,267,817 (-)NCBI
Celera689,094,054 - 89,095,427 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endosome  (IBA,ISO)
endosome membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, etal., FEBS Lett 2003 Nov 20;554(3):381-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28827538   PMID:31038027  


Genomics

Comparative Map Data
Gpr135
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8696,363,466 - 96,366,594 (-)NCBIGRCr8
mRatBN7.2690,627,533 - 90,630,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl690,629,178 - 90,630,551 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx690,999,916 - 91,001,289 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0691,299,380 - 91,300,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0690,738,936 - 90,740,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0694,816,976 - 94,818,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl694,816,976 - 94,818,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06104,261,635 - 104,263,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4694,262,988 - 94,264,361 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1694,266,443 - 94,267,817 (-)NCBI
Celera689,094,054 - 89,095,427 (-)NCBICelera
Cytogenetic Map6q24NCBI
GPR135
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381459,452,783 - 59,465,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1459,429,022 - 59,465,380 (-)EnsemblGRCh38hg38GRCh38
GRCh371459,927,477 - 59,932,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361458,999,993 - 59,001,812 (-)NCBINCBI36Build 36hg18NCBI36
Build 341458,965,492 - 59,001,812NCBI
Celera1439,979,309 - 39,981,128 (-)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1440,094,106 - 40,095,925 (-)NCBIHuRef
CHM1_11459,868,393 - 59,870,212 (-)NCBICHM1_1
T2T-CHM13v2.01453,659,699 - 53,672,299 (-)NCBIT2T-CHM13v2.0
Gpr135
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391272,114,748 - 72,117,875 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1272,114,750 - 72,117,899 (-)EnsemblGRCm39 Ensembl
GRCm381272,067,974 - 72,071,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1272,067,976 - 72,071,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv371273,170,605 - 73,171,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361272,988,202 - 72,989,575 (-)NCBIMGSCv36mm8
Celera1273,180,633 - 73,182,006 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.2NCBI
Gpr135
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546613,188,710 - 13,192,314 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546613,188,710 - 13,194,054 (-)NCBIChiLan1.0ChiLan1.0
GPR135
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21560,594,838 - 60,603,442 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11459,811,352 - 59,819,941 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01440,064,817 - 40,071,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11458,329,664 - 58,332,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1458,331,046 - 58,332,449 (-)Ensemblpanpan1.1panPan2
GPR135
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1834,683,841 - 34,685,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha834,444,248 - 34,446,877 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0834,919,401 - 34,922,039 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl834,919,001 - 34,922,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1834,536,642 - 34,539,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0834,605,685 - 34,608,329 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0834,972,929 - 34,975,567 (-)NCBIUU_Cfam_GSD_1.0
Gpr135
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864070,377,446 - 70,378,904 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364953,813,078 - 3,814,256 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364953,812,825 - 3,814,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR135
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1188,580,947 - 188,582,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11188,580,016 - 188,582,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GPR135
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12436,693,214 - 36,695,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2436,694,048 - 36,695,547 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605324,947,818 - 24,950,265 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr135
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473441,641,813 - 41,643,929 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr135
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:88
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000005933
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 24 4 3 3 1 1 72 35 35 4 1
Below cutoff 2 19 38 28 10 28 7 8 2 6 7 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005933   ⟹   ENSRNOP00000005933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl690,629,178 - 90,630,551 (-)Ensembl
Rnor_6.0 Ensembl694,816,976 - 94,818,349 (-)Ensembl
RefSeq Acc Id: NM_181771   ⟹   NP_861436
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8696,363,466 - 96,366,594 (-)NCBI
mRatBN7.2690,627,533 - 90,630,661 (-)NCBI
Rnor_6.0694,816,976 - 94,818,349 (-)NCBI
Rnor_5.06104,261,635 - 104,263,008 (-)NCBI
RGSC_v3.4694,262,988 - 94,264,361 (-)RGD
Celera689,094,054 - 89,095,427 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_861436 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP72139 (Get FASTA)   NCBI Sequence Viewer  
  EDM03583 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005933
  ENSRNOP00000005933.2
  ENSRNOP00055013640
GenBank Protein Q7TQN7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_861436   ⟸   NM_181771
- UniProtKB: Q7TQN7 (UniProtKB/Swiss-Prot),   A6HC28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005933   ⟸   ENSRNOT00000005933
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQN7-F1-model_v2 AlphaFold Q7TQN7 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727844 AgrOrtholog
BioCyc Gene G2FUF-37157 BioCyc
Ensembl Genes ENSRNOG00000004499 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010048 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005933 ENTREZGENE
  ENSRNOT00000005933.3 UniProtKB/Swiss-Prot
  ENSRNOT00055016949 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314213 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 314213 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr135 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004499 RatGTEx
  ENSRNOG00055010048 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HC28 ENTREZGENE, UniProtKB/TrEMBL
  GP135_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gpr135  G protein-coupled receptor 135      Symbol and Name status set to approved 1299863 APPROVED