Gnpnat1 (glucosamine-phosphate N-acetyltransferase 1) - Rat Genome Database

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Gene: Gnpnat1 (glucosamine-phosphate N-acetyltransferase 1) Rattus norvegicus
Analyze
Symbol: Gnpnat1
Name: glucosamine-phosphate N-acetyltransferase 1
RGD ID: 1563144
Description: Exhibits glucosamine 6-phosphate N-acetyltransferase activity and monosaccharide binding activity. Involved in N-acetylglucosamine metabolic process; glucosamine metabolic process; and liver development. Predicted to localize to several cellular components, including Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; amino sugar metabolic pathway; french type sialuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glucosamine 6-phosphate N-acetyltransferase; LOC498486; RGD1563144; similar to EMeg32 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21518,596,180 - 18,608,854 (-)NCBI
Rnor_6.0 Ensembl1519,721,293 - 19,733,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01519,721,292 - 19,734,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01523,685,448 - 23,698,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41521,272,165 - 21,284,459 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1519,024,815 - 19,037,109 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10777580   PMID:12477932   PMID:18675810   PMID:20439489   PMID:25416956  


Genomics

Comparative Map Data
Gnpnat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21518,596,180 - 18,608,854 (-)NCBI
Rnor_6.0 Ensembl1519,721,293 - 19,733,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01519,721,292 - 19,734,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01523,685,448 - 23,698,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41521,272,165 - 21,284,459 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1519,024,815 - 19,037,109 (-)NCBICelera
Cytogenetic Map15p14NCBI
GNPNAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1452,775,193 - 52,791,668 (-)EnsemblGRCh38hg38GRCh38
GRCh381452,775,193 - 52,791,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371453,241,911 - 53,258,325 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361452,311,661 - 52,328,133 (-)NCBINCBI36hg18NCBI36
Build 341452,311,661 - 52,328,133NCBI
Celera1433,291,588 - 33,308,063 (-)NCBI
Cytogenetic Map14q22.1NCBI
HuRef1433,402,899 - 33,420,411 (-)NCBIHuRef
CHM1_11453,180,808 - 53,197,284 (-)NCBICHM1_1
Gnpnat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,613,878 - 45,626,444 (-)NCBIGRCm39mm39
GRCm39 Ensembl1445,613,791 - 45,642,370 (-)Ensembl
GRCm381445,376,421 - 45,388,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1445,376,334 - 45,404,913 (-)EnsemblGRCm38mm10GRCm38
MGSCv371445,996,096 - 46,008,471 (-)NCBIGRCm37mm9NCBIm37
MGSCv361444,298,298 - 44,310,673 (-)NCBImm8
Celera1441,556,350 - 41,568,784 (-)NCBICelera
Cytogenetic Map14C1NCBI
Gnpnat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,406,723 - 10,424,431 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540910,406,248 - 10,424,431 (+)NCBIChiLan1.0ChiLan1.0
GNPNAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11451,655,182 - 51,671,617 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,655,182 - 51,671,619 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01433,371,603 - 33,388,098 (-)NCBIMhudiblu_PPA_v0panPan3
GNPNAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1828,992,173 - 29,005,511 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl828,993,227 - 29,005,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha828,736,462 - 28,749,813 (-)NCBI
ROS_Cfam_1.0829,158,602 - 29,171,970 (-)NCBI
UMICH_Zoey_3.1828,832,502 - 28,845,853 (-)NCBI
UNSW_CanFamBas_1.0828,904,894 - 28,918,244 (-)NCBI
UU_Cfam_GSD_1.0829,233,507 - 29,247,101 (-)NCBI
Gnpnat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,301,693 - 76,312,369 (+)NCBI
SpeTri2.0NW_0049366972,079,396 - 2,087,602 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNPNAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1182,407,215 - 182,423,443 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11182,404,460 - 182,423,453 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,680,394 - 202,694,010 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNPNAT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,862,903 - 29,878,050 (-)NCBI
ChlSab1.1 Ensembl2429,863,956 - 29,878,135 (-)Ensembl
Gnpnat1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473116,334,347 - 16,346,107 (+)NCBI

Position Markers
D15Got25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,613,974 - 18,614,158 (+)MAPPER
Rnor_6.01519,739,203 - 19,739,386NCBIRnor6.0
Rnor_5.01523,703,359 - 23,703,542UniSTSRnor5.0
RGSC_v3.41521,289,694 - 21,289,878RGDRGSC3.4
RGSC_v3.41521,289,695 - 21,289,878UniSTSRGSC3.4
RGSC_v3.11521,289,695 - 21,289,878RGD
Celera1519,042,360 - 19,042,543UniSTS
RH 3.4 Map15153.4UniSTS
RH 3.4 Map15153.4RGD
RH 2.0 Map15103.3RGD
Cytogenetic Map15p14UniSTS
AA960555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,683,058 - 18,683,155 (+)MAPPER
Rnor_6.01519,807,938 - 19,808,034NCBIRnor6.0
Rnor_5.01523,771,948 - 23,772,044UniSTSRnor5.0
RGSC_v3.41521,358,543 - 21,358,639UniSTSRGSC3.4
Celera1519,110,421 - 19,110,517UniSTS
Cytogenetic Map15p14UniSTS
RH131692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,596,635 - 18,596,816 (+)MAPPER
Rnor_6.01519,721,483 - 19,721,663NCBIRnor6.0
Rnor_5.01523,685,639 - 23,685,819UniSTSRnor5.0
RGSC_v3.41521,272,356 - 21,272,536UniSTSRGSC3.4
Celera1519,025,006 - 19,025,186UniSTS
RH 3.4 Map15150.0UniSTS
Cytogenetic Map15p14UniSTS
RH134534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,683,035 - 18,683,246 (+)MAPPER
Rnor_6.01519,807,915 - 19,808,125NCBIRnor6.0
Rnor_5.01523,771,925 - 23,772,135UniSTSRnor5.0
RGSC_v3.41521,358,520 - 21,358,730UniSTSRGSC3.4
Celera1519,110,398 - 19,110,608UniSTS
RH 3.4 Map15149.4UniSTS
Cytogenetic Map15p14UniSTS
RH140108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,596,241 - 18,596,411 (+)MAPPER
Rnor_6.01519,721,089 - 19,721,258NCBIRnor6.0
Rnor_5.01523,685,245 - 23,685,414UniSTSRnor5.0
RGSC_v3.41521,271,962 - 21,272,131UniSTSRGSC3.4
Celera1519,024,612 - 19,024,781UniSTS
RH 3.4 Map15158.7UniSTS
Cytogenetic Map15p14UniSTS
AI179101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21518,683,992 - 18,684,087 (+)MAPPER
Rnor_6.01519,808,872 - 19,808,966NCBIRnor6.0
Rnor_5.01523,772,882 - 23,772,976UniSTSRnor5.0
RGSC_v3.41521,359,477 - 21,359,571UniSTSRGSC3.4
Celera1519,111,355 - 19,111,449UniSTS
RH 3.4 Map15156.3UniSTS
Cytogenetic Map15p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151582824233657761Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:171
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000012036
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 57 41 19 41 3 3 74 35 40 11 3
Low 17 5 8 1 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012036   ⟹   ENSRNOP00000012036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1519,721,293 - 19,733,967 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078850   ⟹   ENSRNOP00000071110
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1519,721,293 - 19,729,598 (-)Ensembl
RefSeq Acc Id: NM_001134756   ⟹   NP_001128228
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21518,596,445 - 18,608,739 (-)NCBI
Rnor_6.01519,721,292 - 19,733,586 (-)NCBI
Rnor_5.01523,685,448 - 23,698,244 (-)NCBI
RGSC_v3.41521,272,165 - 21,284,459 (-)RGD
Celera1519,024,815 - 19,037,109 (-)RGD
Sequence:
RefSeq Acc Id: NM_001134757   ⟹   NP_001128229
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21518,596,445 - 18,604,751 (-)NCBI
Rnor_6.01519,721,292 - 19,729,598 (-)NCBI
Rnor_5.01523,685,448 - 23,698,244 (-)NCBI
RGSC_v3.41521,272,165 - 21,284,459 (-)RGD
Celera1519,024,815 - 19,033,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251782   ⟹   XP_006251844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01519,721,292 - 19,733,606 (-)NCBI
Rnor_5.01523,685,448 - 23,698,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251783   ⟹   XP_006251845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01519,721,292 - 19,734,032 (-)NCBI
Rnor_5.01523,685,448 - 23,698,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251784   ⟹   XP_006251846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21518,596,180 - 18,608,854 (-)NCBI
Rnor_6.01519,721,292 - 19,733,998 (-)NCBI
Rnor_5.01523,685,448 - 23,698,244 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001128228 (Get FASTA)   NCBI Sequence Viewer  
  NP_001128229 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251846 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI60861 (Get FASTA)   NCBI Sequence Viewer  
  EDL88303 (Get FASTA)   NCBI Sequence Viewer  
  EDL88304 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001128228   ⟸   NM_001134756
- UniProtKB: B1H249 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128229   ⟸   NM_001134757
- UniProtKB: B1H249 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251845   ⟸   XM_006251783
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006251846   ⟸   XM_006251784
- Peptide Label: isoform X1
- UniProtKB: B1H249 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251844   ⟸   XM_006251782
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000012036   ⟸   ENSRNOT00000012036
RefSeq Acc Id: ENSRNOP00000071110   ⟸   ENSRNOT00000078850
Protein Domains
N-acetyltransferase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699605
Promoter ID:EPDNEW_R10121
Type:multiple initiation site
Name:Gnpnat1_1
Description:glucosamine-phosphate N-acetyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01519,733,935 - 19,733,995EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 23686561 23686562 A T snv HTX/Kyo (KyushuU), LE/OrlBarth (UDEL), SDLEF7/Barth (UDEL), Crl:SD (UDEL), HWY/Slc (KyushuU), BDIX/NemOda (KyushuU)
15 23686594 23686595 A G snv HTX/Kyo (KyushuU), SDLEF7/Barth (UDEL), Crl:SD (UDEL), LE/OrlBarth (UDEL)
15 23690257 23690258 A G snv F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), LEC/Tj (KyushuU), HWY/Slc (KyushuU), F344/Stm (KyushuU), RCS/Kyo (KyushuU), HTX/Kyo (KyushuU), NIG-III/Hok (KyushuU), BUF/MNa (KyushuU), Crl:SD (UDEL), LE/OrlBarth (UDEL), ZF (KyushuU), SDLEF7/Barth (UDEL)
15 23690290 23690291 C T snv SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), RCS/Kyo (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), LEC/Tj (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), DOB/Oda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), ZFDM (KyushuU)
15 23690350 23690351 T C snv NIG-III/Hok (KyushuU), ZF (KyushuU), KFRS3B/Kyo (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), DOB/Oda (KyushuU), BDIX/NemOda (KyushuU), F344/Jcl (KyushuU), LEC/Tj (KyushuU), RCS/Kyo (KyushuU), F344/NSlc (KyushuU), HTX/Kyo (KyushuU), LE/Stm (KyushuU), F344/DuCrlCrlj (KyushuU), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), BUF/MNa (KyushuU), ZFDM (KyushuU)
15 23690359 23690360 A C snv SDLEF7/Barth (UDEL)
15 23693520 23693521 C T snv SDLEF7/Barth (UDEL)
15 23693534 23693535 G A snv SDLEF7/Barth (UDEL), Crl:SD (UDEL)
15 23693535 23693536 G A snv Crl:SD (UDEL), SDLEF7/Barth (UDEL)
15 23693580 23693581 G A snv KFRS3B/Kyo (KyushuU), Crl:SD (UDEL), SDLEF7/Barth (UDEL)
15 23693622 23693623 G A snv SDLEF7/Barth (UDEL), KFRS3B/Kyo (KyushuU), Crl:SD (UDEL)
15 23693659 23693660 C T snv SDLEF7/Barth (UDEL)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
15 19722405 19722406 A T snv ACI/EurMcwi (MCW), CDS, CDR, SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), SBN/Ygl (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), SBH/Ygl (MCW), WKY/Gcrc (RGD), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW)
15 19722438 19722439 A G snv SS/JrHsdMcwi (MCW), GH/OmrMcwi (MCW), CDR, COP/CrCrl (MCW & UW), CDS, ACI/EurMcwi (MCW)
15 19726101 19726102 A G snv GH/OmrMcwi (MCW), CDR, CDS
15 19726134 19726135 C T snv ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDR, CDS
15 19726194 19726195 T C snv ACI/EurMcwi (MCW), SR/JrHsd (MCW), COP/CrCrl (MCW & UW), SBN/Ygl (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), SBH/Ygl (MCW), GH/OmrMcwi (MCW), SS/JrHsdMcwi (MCW)
15 19726203 19726204 A C snv SR/JrHsd (MCW), SBH/Ygl (MCW), GH/OmrMcwi (MCW), SBN/Ygl (MCW), COP/CrCrl (MCW & UW), FHL/EurMcwi (MCW), SS/JrHsdMcwi (MCW)
15 19729364 19729365 C T snv CDS, SHRSP/Gcrc (RGD), CDR
15 19729378 19729379 G A snv CDS, CDR
15 19729379 19729380 G A snv CDR, CDS
15 19729424 19729425 G A snv GH/OmrMcwi (MCW), CDS, ACI/EurMcwi (MCW), CDR, COP/CrCrl (MCW & UW)
15 19729466 19729467 G A snv CDS, CDR, SR/JrHsd (MCW), SBN/Ygl (MCW), FHL/EurMcwi (MCW), SBH/Ygl (MCW), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW)
15 19729503 19729504 C T snv SBH/Ygl (MCW), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), CDS, CDR


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563144 AgrOrtholog
Ensembl Genes ENSRNOG00000008641 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012036 UniProtKB/TrEMBL
  ENSRNOP00000071110 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012036 UniProtKB/TrEMBL
  ENSRNOT00000078850 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322586 IMAGE-MGC_LOAD
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  GCN5-rel_AcTrfase UniProtKB/TrEMBL
  GNPNAT1 UniProtKB/TrEMBL
KEGG Report rno:498486 UniProtKB/TrEMBL
MGC_CLONE MGC:188219 IMAGE-MGC_LOAD
NCBI Gene 498486 ENTREZGENE
PANTHER PTHR13355 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PhenoGen Gnpnat1 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
Superfamily-SCOP Acyl_CoA_acyltransferase UniProtKB/TrEMBL
UniProt B1H249 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Gnpnat1  glucosamine-phosphate N-acetyltransferase 1  RGD1563144_predicted  similar to EMeg32 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563144_predicted  similar to EMeg32 protein (predicted)  LOC498486  similar to EMeg32 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498486  similar to EMeg32 protein      Symbol and Name status set to provisional 70820 PROVISIONAL