Mir665 (microRNA 665) - Rat Genome Database

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Gene: Mir665 (microRNA 665) Rattus norvegicus
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Symbol: Mir665
Name: microRNA 665
RGD ID: 2325437
Description: Predicted to enable lncRNA binding activity; mRNA 3'-UTR binding activity; and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including miRNA-mediated gene silencing by mRNA destabilization; negative regulation of canonical Wnt signaling pathway; and negative regulation of vascular associated smooth muscle cell migration. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and cellular response to mechanical stimulus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human MIR665 (microRNA 665); INTERACTS WITH 2,5-hexanedione; atrazine; bisphenol A.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-665; rno-mir-665
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,321,679 - 134,321,772 (+)NCBIGRCr8
mRatBN7.26128,539,440 - 128,539,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,539,440 - 128,539,533 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,680,145 - 128,680,238 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,975,983 - 128,976,076 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,336,916 - 128,337,009 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,706,457 - 133,706,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,706,457 - 133,706,550 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,868,634 - 142,868,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,087,867 - 126,087,960 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir665Rathepatocellular carcinoma disease_progressionISOMIR665 (Homo sapiens)151361293mRNA:increased expression:liver (human)RGD 
Mir665Rathepatocellular carcinoma  ISOMIR665 (Homo sapiens)151361293associated with metastasis and human cells in mouse modelRGD 
Mir665Ratlung non-small cell carcinoma  ISOMIR665 (Homo sapiens)151361291 RGD 
Mir665Ratlung non-small cell carcinoma disease_progressionISOMIR665 (Homo sapiens)151361291associated with metastasis and mRNA:increased expression:lung (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir665RatKagami-Ogata syndrome  ISOMIR665 (Homo sapiens)8554872ClinVar Annotator: match by term: Paternal uniparental disomy 14ClinVarPMID:18176563
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir665RatCocaine-Related Disorders  ISOMIR665 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20643829

1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir665Rat2,5-hexanedione increases expressionEXP 64804642 and 5-hexanedione results in increased expression of MIR665 mRNACTDPMID:31760062
Mir665Ratatrazine increases expressionEXP 6480464Atrazine results in increased expression of MIR665 mRNACTDPMID:31185338
Mir665Ratatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of MIR665 mRNACTDPMID:34030342
Mir665Ratbenzo[a]pyrene increases methylationISOMIR665 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of MIR665 promoterCTDPMID:27901495
Mir665Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of MIR665 geneCTDPMID:28505145
Mir665Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Genistein] results in increased methylation of MIR665 geneCTDPMID:28505145
Mir665Ratcocaine multiple interactionsISOMir665 (Mus musculus)6480464AGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]CTDPMID:20643829
Mir665Ratcocaine increases expressionISOMir665 (Mus musculus)6480464Cocaine results in increased expression of MIR665 mRNACTDPMID:20643829
Mir665Ratdecabromodiphenyl ether decreases expressionISOMIR665 (Homo sapiens)6480464decabromobiphenyl ether results in decreased expression of MIR665 mRNACTDPMID:34166751
Mir665RatDiosbulbin B decreases expressionISOMir665 (Mus musculus)6480464diosbulbin B results in decreased expression of MIR665 mRNACTDPMID:30145177
Mir665Ratgenistein multiple interactionsEXP 6480464[bisphenol A co-treated with Genistein] results in increased methylation of MIR665 geneCTDPMID:28505145
Mir665Ratparacetamol increases expressionEXP 6480464Acetaminophen results in increased expression of MIR665 mRNACTDPMID:27397436
Mir665Ratphenobarbital affects expressionISOMir665 (Mus musculus)6480464Phenobarbital affects the expression of MIR665 mRNACTDPMID:23091169
Mir665Ratpropofol increases expressionEXP 6480464Propofol results in increased expression of MIR665 mRNACTDPMID:26254736
Mir665Ratradon atom affects expressionISOMIR665 (Homo sapiens)6480464Radon affects the expression of MIR665 mRNACTDPMID:23294299
Mir665Ratradon(0) affects expressionISOMIR665 (Homo sapiens)6480464Radon affects the expression of MIR665 mRNACTDPMID:23294299
Mir665Ratsodium fluoride decreases expressionISOMIR665 (Homo sapiens)6480464Sodium Fluoride results in decreased expression of MIR665 mRNACTDPMID:26339601

1 to 17 of 17 rows

Molecular Function

  


#
Reference Title
Reference Citation
1. miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB. Hu Y, etal., Cell Death Dis. 2018 Sep 20;9(10):954. doi: 10.1038/s41419-018-0978-y.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Upregulated miR-665 expression independently predicts poor prognosis of lung cancer and facilitates tumor cell proliferation, migration and invasion. Xia J, etal., Oncol Lett. 2020 May;19(5):3578-3586. doi: 10.3892/ol.2020.11457. Epub 2020 Mar 11.
PMID:16381832   PMID:18215311   PMID:20403161   PMID:20439489   PMID:25959411   PMID:37507642  



Mir665
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,321,679 - 134,321,772 (+)NCBIGRCr8
mRatBN7.26128,539,440 - 128,539,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,539,440 - 128,539,533 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,680,145 - 128,680,238 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,975,983 - 128,976,076 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,336,916 - 128,337,009 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,706,457 - 133,706,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,706,457 - 133,706,550 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,868,634 - 142,868,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,087,867 - 126,087,960 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR665
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,875,033 - 100,875,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,875,033 - 100,875,104 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,341,370 - 101,341,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,411,122 - 100,411,193 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,395,190 - 81,395,261 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1481,523,036 - 81,523,107 (+)NCBIHuRef
CHM1_114101,279,557 - 101,279,628 (+)NCBICHM1_1
T2T-CHM13v2.01495,110,469 - 95,110,540 (+)NCBIT2T-CHM13v2.0
Mir665
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,552,748 - 109,552,841 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,552,748 - 109,552,841 (+)EnsemblGRCm39 Ensembl
GRCm3812109,586,314 - 109,586,407 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,586,314 - 109,586,407 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,824,524 - 110,824,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,780,719 - 110,780,812 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.37NCBI
MIR665
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,097,904 - 69,097,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,615,583 - 68,615,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,381,314 - 69,381,381 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,043,023 - 69,043,090 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,108,894 - 69,108,961 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,507,069 - 69,507,136 (+)NCBIUU_Cfam_GSD_1.0

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Variants in Mir665
1 total Variants

Predicted Targets
Summary Value
Count of predictions:8742
Count of gene targets:5851
Count of transcripts:6316
Interacting mature miRNAs:rno-miR-665
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

1 to 10 of 27 rows



appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 3 38 14 9 6 6 20 11 30 14 3


RefSeq Transcripts NR_032757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000062108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6128,539,440 - 128,539,533 (+)Ensembl
Rnor_6.0 Ensembl6133,706,457 - 133,706,550 (+)Ensembl
RefSeq Acc Id: NR_032757
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,321,679 - 134,321,772 (+)NCBI
mRatBN7.26128,539,440 - 128,539,533 (+)NCBI
Rnor_6.06133,706,457 - 133,706,550 (+)NCBI
Rnor_5.06142,868,634 - 142,868,727 (+)NCBI
Celera6126,087,867 - 126,087,960 (+)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 9 of 9 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36243 BioCyc
Ensembl Genes ENSRNOG00000040355 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000062108 ENTREZGENE
miRBase MI0012606 ENTREZGENE
NCBI Gene 100314180 ENTREZGENE
PhenoGen Mir665 PhenoGen
RatGTEx ENSRNOG00000040355 RatGTEx
RNAcentral URS000036883B RNACentral
  URS00006424F3 RNACentral
1 to 9 of 9 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Mir665  microRNA 665  Mir665  microRNA mir-665  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir665  microRNA mir-665      Symbol and Name status set to provisional 70820 PROVISIONAL