Nek2 (NIMA-related kinase 2) - Rat Genome Database

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Gene: Nek2 (NIMA-related kinase 2) Rattus norvegicus
Analyze
Symbol: Nek2 (Ensembl: Nek2l1)
Name: NIMA-related kinase 2 (Ensembl:NIMA (never in mitosis gene a)-related kinase 2-like 1)
RGD ID: 619792
Description: Predicted to enable protein kinase activity and protein phosphatase binding activity. Predicted to be involved in centrosome separation; positive regulation of telomere maintenance; and regulation of cell cycle process. Predicted to act upstream of or within blastocyst development and mitotic spindle assembly. Predicted to be located in several cellular components, including condensed chromosome; microtubule cytoskeleton; and midbody. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NIMA (never in mitosis gene a)-related expressed kinase 2; NIMA (never in mitosis gene a)-related kinase 2; serine/threonine-protein kinase Nek2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Nek2l1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,936,809 - 105,950,054 (+)NCBIGRCr8
mRatBN7.213103,405,818 - 103,419,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,405,819 - 103,419,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,925,762 - 105,939,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,309,612 - 107,322,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,524,711 - 104,537,957 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,511,546 - 110,524,750 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,511,668 - 110,522,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,071,708 - 115,084,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,895,671 - 107,908,904 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,084,908 - 108,096,196 (+)NCBI
Celera13102,845,789 - 102,858,739 (+)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
digitonin  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
MeIQx  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle. Ha Kim Y, etal., Biochem Biophys Res Commun 2002 Jan 18;290(2):730-6.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10880350   PMID:14668482   PMID:14697346   PMID:14978040   PMID:15479717   PMID:17621308   PMID:17626005   PMID:18086858   PMID:18297113   PMID:19117032   PMID:21076410   PMID:21399614  
PMID:21531765   PMID:24554434   PMID:26220856  


Genomics

Comparative Map Data
Nek2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,936,809 - 105,950,054 (+)NCBIGRCr8
mRatBN7.213103,405,818 - 103,419,063 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13103,405,819 - 103,419,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,925,762 - 105,939,011 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013107,309,612 - 107,322,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013104,524,711 - 104,537,957 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013110,511,546 - 110,524,750 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13110,511,668 - 110,522,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013115,071,708 - 115,084,946 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,895,671 - 107,908,904 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113108,084,908 - 108,096,196 (+)NCBI
Celera13102,845,789 - 102,858,739 (+)NCBICelera
Cytogenetic Map13q27NCBI
NEK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381211,658,256 - 211,675,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1211,658,657 - 211,675,630 (-)EnsemblGRCh38hg38GRCh38
GRCh371211,831,598 - 211,848,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361209,902,745 - 209,915,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 341208,224,516 - 208,237,362NCBI
Celera1185,063,198 - 185,076,042 (-)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1182,509,044 - 182,526,419 (-)NCBIHuRef
CHM1_11213,104,002 - 213,121,393 (-)NCBICHM1_1
T2T-CHM13v2.01210,904,362 - 210,921,749 (-)NCBIT2T-CHM13v2.0
Nek2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391191,553,622 - 191,565,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1191,553,556 - 191,565,162 (+)EnsemblGRCm39 Ensembl
GRCm381191,821,449 - 191,833,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,821,444 - 191,833,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv371193,645,352 - 193,656,928 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361193,522,177 - 193,533,657 (+)NCBIMGSCv36mm8
Celera1198,772,491 - 198,784,119 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.94NCBI
Nek2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,553,819 - 5,566,361 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,553,661 - 5,563,648 (+)NCBIChiLan1.0ChiLan1.0
NEK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2137,726,246 - 37,744,856 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1137,690,783 - 37,709,409 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01187,225,947 - 187,243,605 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,088,393 - 192,105,737 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,092,885 - 192,105,737 (-)Ensemblpanpan1.1panPan2
NEK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,039,617 - 10,052,511 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,040,187 - 10,052,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha79,617,334 - 9,630,223 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.079,745,394 - 9,758,577 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl79,745,398 - 9,758,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.179,668,208 - 9,681,172 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.079,770,376 - 9,783,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.079,894,933 - 9,908,005 (-)NCBIUU_Cfam_GSD_1.0
Nek2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934464,442,747 - 64,455,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365571,682,984 - 1,695,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365571,683,027 - 1,695,410 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9131,547,069 - 131,561,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19131,547,044 - 131,560,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29144,585,644 - 144,599,144 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12517,816,929 - 17,847,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2517,829,546 - 17,842,463 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605518,353,967 - 18,371,748 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477117,334,681 - 17,352,259 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477117,334,782 - 17,351,609 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek2
86 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
UniSTS:465399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2813,946,926 - 13,947,427 (+)MAPPERmRatBN7.2
Rnor_6.0815,941,209 - 15,941,709NCBIRnor6.0
Rnor_5.0816,016,439 - 16,016,939UniSTSRnor5.0
RGSC_v3.4814,245,570 - 14,246,070UniSTSRGSC3.4
Celera815,406,473 - 15,406,973UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map13q27UniSTS


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000006235   ⟹   ENSRNOP00000006235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13103,405,819 - 103,419,051 (+)Ensembl
Rnor_6.0 Ensembl13110,511,668 - 110,522,769 (+)Ensembl
RefSeq Acc Id: NM_053691   ⟹   NP_446143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,936,809 - 105,950,054 (+)NCBI
mRatBN7.213103,405,818 - 103,419,063 (+)NCBI
Rnor_6.013110,511,546 - 110,524,750 (+)NCBI
Rnor_5.013115,071,708 - 115,084,946 (+)NCBI
RGSC_v3.413107,895,671 - 107,908,904 (+)RGD
Celera13102,845,789 - 102,858,739 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446143 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK71134 (Get FASTA)   NCBI Sequence Viewer  
  EDL95009 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006235
  ENSRNOP00000006235.3
RefSeq Acc Id: NP_446143   ⟸   NM_053691
- UniProtKB: A6JH03 (UniProtKB/TrEMBL),   G3V6L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006235   ⟸   ENSRNOT00000006235
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699121
Promoter ID:EPDNEW_R9646
Type:initiation region
Name:Nek2_1
Description:NIMA-related kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013110,511,568 - 110,511,628EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619792 AgrOrtholog
BioCyc Gene G2FUF-16824 BioCyc
Ensembl Genes ENSRNOG00000004487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006235 ENTREZGENE
  ENSRNOT00000006235.6 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:114482 UniProtKB/TrEMBL
  rno:690209 UniProtKB/TrEMBL
NCBI Gene 114482 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/TrEMBL
  NIMA-RELATED KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Nek2 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004487 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6JH03 ENTREZGENE, UniProtKB/TrEMBL
  G3V6L2 ENTREZGENE, UniProtKB/TrEMBL
  Q91XQ1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-21 Nek2  NIMA-related kinase 2  Nek2  NIMA (never in mitosis gene a)-related expressed kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nek2  NIMA (never in mitosis gene a)-related expressed kinase 2    NIMA (never in mitosis gene a)-related kinase 2  Name updated 1299863 APPROVED
2002-08-07 Nek2  NIMA (never in mitosis gene a)-related kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL