Nek2 (NIMA related kinase 2) - Rat Genome Database

Name: Nek2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Nek2 (NIMA related kinase 2) Chinchilla lanigera

Analyze

Symbol:

Nek2

Name:

NIMA related kinase 2

RGD ID:

8976483

Description:

ENCODES a protein that exhibits protein kinase activity (ortholog); protein phosphatase binding (ortholog); INVOLVED IN blastocyst development (ortholog); centrosome separation (ortholog); chromosome segregation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); fundus dystrophy (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN centrosome (ortholog); condensed nuclear chromosome (ortholog); kinetochore (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NIMA-related kinase 2; serine/threonine-protein kinase Nek2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,553,819 - 5,566,361 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,553,661 - 5,563,648 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

fundus dystrophy (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

lung non-small cell carcinoma (ISO)

Neoplasm Invasiveness (ISO)

parathyroid carcinoma (ISO)

retinitis pigmentosa 67 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst development (ISO)

centrosome separation (ISO)

chromosome segregation (ISO)

mitotic sister chromatid segregation (ISO)

mitotic spindle assembly (ISO)

negative regulation of centriole-centriole cohesion (ISO)

positive regulation of telomere capping (ISO)

positive regulation of telomere maintenance via telomerase (ISO)

regulation of attachment of spindle microtubules to kinetochore (ISO)

regulation of mitotic centrosome separation (ISO)

Cellular Component

centrosome (ISO)

condensed nuclear chromosome (ISO)

kinetochore (ISO)

midbody (ISO)

nucleoplasm (ISO)

protein-containing complex (ISO)

spindle pole (ISO)

Molecular Function

protein binding (ISO)

protein kinase activity (ISO)

protein phosphatase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Nek2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,553,819 - 5,566,361 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,553,661 - 5,563,648 (+)	NCBI	ChiLan1.0	ChiLan1.0

NEK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	211,658,256 - 211,675,621 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	211,658,657 - 211,675,630 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	211,831,598 - 211,848,963 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	209,902,745 - 209,915,590 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	208,224,516 - 208,237,362	NCBI
Celera	1	185,063,198 - 185,076,042 (-)	NCBI		Celera
Cytogenetic Map	1	q32.3	NCBI
HuRef	1	182,509,044 - 182,526,419 (-)	NCBI		HuRef
CHM1_1	1	213,104,002 - 213,121,393 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	210,904,362 - 210,921,749 (-)	NCBI		T2T-CHM13v2.0

Nek2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	191,553,622 - 191,565,161 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	191,553,556 - 191,565,162 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	191,821,449 - 191,833,049 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,821,444 - 191,833,050 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	193,645,352 - 193,656,928 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	193,522,177 - 193,533,657 (+)	NCBI		MGSCv36	mm8
Celera	1	198,772,491 - 198,784,119 (+)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	96.94	NCBI

Nek2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,936,809 - 105,950,054 (+)	NCBI		GRCr8
mRatBN7.2	13	103,405,818 - 103,419,063 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	103,405,819 - 103,419,051 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	105,925,762 - 105,939,011 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	107,309,612 - 107,322,857 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	104,524,711 - 104,537,957 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	110,511,546 - 110,524,750 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,511,668 - 110,522,769 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	115,071,708 - 115,084,946 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	107,895,671 - 107,908,904 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	108,084,908 - 108,096,196 (+)	NCBI
Celera	13	102,845,789 - 102,858,739 (+)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

NEK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	37,726,246 - 37,744,856 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	37,690,783 - 37,709,409 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	187,225,947 - 187,243,605 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	192,088,393 - 192,105,737 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	192,092,885 - 192,105,737 (-)	Ensembl	panpan1.1		panPan2

NEK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	10,039,617 - 10,052,511 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	10,040,187 - 10,052,512 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	9,617,334 - 9,630,223 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	9,745,394 - 9,758,577 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	9,745,398 - 9,758,560 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	9,668,208 - 9,681,172 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	9,770,376 - 9,783,529 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	9,894,933 - 9,908,005 (-)	NCBI		UU_Cfam_GSD_1.0

Nek2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	64,442,747 - 64,455,130 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	1,682,984 - 1,695,414 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	1,683,027 - 1,695,410 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	131,547,069 - 131,561,095 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	131,547,044 - 131,560,527 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	144,585,644 - 144,599,144 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	17,816,929 - 17,847,348 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	17,829,546 - 17,842,463 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	18,353,967 - 18,371,748 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nek2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,334,681 - 17,352,259 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	17,334,782 - 17,351,609 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005374754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01005731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01356788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000015989 ⟹ ENSCLAP00000015825

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955406	5,553,819 - 5,566,361 (+)	Ensembl

RefSeq Acc Id:

XM_005374754 ⟹ XP_005374811

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955406	5,553,661 - 5,563,648 (+)	NCBI

Sequence:

show sequence

TTAGCCAATCAGAGACGCAGGGCGGCTTCGCAGGCGGCCAATGGATCGCCAGGATAGAGCCCGC
GGCGGTTAAACGTGGCTGAGGCCGGGGCAGTGCGGCGCTGTGCGGCGGCCGAGCGAGGGCGGCT
GCGGCTCCGTGCGTGCGGCGCGGCCCCGCCATGCCTTCCCGAGTGGAGGACTACGAAGTGCTGT
ACACCATCGGCACGGGCTCGTACGGCCGCTGCCAGAAGATCCGGAGGAGGAGCGACGGCAAGAT
ACTGGTTTGGAAAGAACTTGACTATGGATCCATGACAGAGGCCGAAAAACAGATGCTTGTTTCT
GAAGTGAATCTGCTCCGTGAATTGAAACATCCGAACATCGTCCGTTACTACGATCGAATTATTG
ACCGAACAAACACAACCCTGTACATCGTGATGGAATACTGTGAAGGAGGGGACCTGGCTAGTGT
GATCACAAAGGGAACCAGGGAAAGACAATACTTAGAGGAAGAGTTCGTTCTTCGAGTGATGACG
CAGCTGACCCTGGCCCTGAAAGAATGTCACAGGCGAAGTGATGGCGGTCACACGGTGCTTCATC
GAGATCTGAAACCAGCCAACGTTTTCTTGGACGGCAAGCATAATGTCAAGCTCGGAGACTTCGG
GCTAGCGAGAATATTAAACCAGGACACGAGCTTTGCAAAAACATTTGTGGGCACACCGTACTAC
ATGTCTCCAGAACAAATGAATCGCCTGTCCTACAATGAGAAATCCGACATCTGGTCCCTGGGTT
GTTTGCTGTATGAACTGTGTGCGCTGATGCCTCCCTTTACAGCTTTCAACCAAAAAGAACTTGC
TGGGAAGATCAGGGAAGGCAAATTCCGGCGGATCCCTTACCGCTTCTCTGACGAGCTGAATGAC
CTTATTACGAGGATGTTAAATTTAAAGGACTACCATCGGCCTTCCGTCGAGGAAATCCTTGAGA
ACCCTCTGATAGCAGACTTGGTTGCAGAGGAGCAGAGAGGACAGCTTGAGCGGCGTGGGCGCAG
AGTGGCAGGCGTGGAAGAGCCCGAGAAGCCGGGGGACCCCAGCCCCGTGCTGAGCGAGCTGCGG
CTGAAGGAGCTGCAGCTGCAGGAGCGAGAGCGGGCCCTCAAGGCGCGGGAGGAGACGCTGGAGC
AGAAGGAGCGCGAGCTGTGTGTGCGGGAGAGGCTGGCGGAGGACAAGCTGGCCCGCGCCGAGGG
GCTGCTGAAGAGCTGCGGGCTGCTGCGGGAGCAGAGGCTGCTGTCCCTGGCCAGCACTCCAGAA
CTTCTTGATCTACCATCCTCAACAATTAAGAAGAAGGTTCACTTCAGCCGGGAGAGCAAAGAGA
ACACAGTGAGGAACGAGAACTCGGAGAGCCAGCTCACTGCTAAGTCCAAGTGCAAGGACCTGAA
GAAGAGGCTTCATGCTGCGCAGCTGCGGGCACAGGCGCTGTCGGACCTAGAGAAGAACTACCAG
CTCAAGAGCAGGCAGATCCTGGGCATGCGCTAGCCTGGGAGCCGCGGGGGAGCCTGGGAGCCGC
GGGGGAGCCTGGGAGCCGCGGGGGCGCCTGGGAGCCGCGGGGGCGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005374811	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000015825
	ENSCLAP00000015825.1

RefSeq Acc Id:

XP_005374811 ⟸ XM_005374754

- UniProtKB:

A0A8C2VN95 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPSRVEDYEVLYTIGTGSYGRCQKIRRRSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH
PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTRERQYLEEEFVLRVMTQLTLALKECH
RRSDGGHTVLHRDLKPANVFLDGKHNVKLGDFGLARILNQDTSFAKTFVGTPYYMSPEQMNRLS
YNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGKFRRIPYRFSDELNDLITRMLNLKD
YHRPSVEEILENPLIADLVAEEQRGQLERRGRRVAGVEEPEKPGDPSPVLSELRLKELQLQERE
RALKAREETLEQKERELCVRERLAEDKLARAEGLLKSCGLLREQRLLSLASTPELLDLPSSTIK
KKVHFSRESKENTVRNENSESQLTAKSKCKDLKKRLHAAQLRAQALSDLEKNYQLKSRQILGMR

hide sequence

RefSeq Acc Id:

ENSCLAP00000015825 ⟸ ENSCLAT00000015989

Protein Domains

Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010880	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000015989	ENTREZGENE
	ENSCLAT00000015989.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Nek2	ENTREZGENE
PANTHER	CAMK FAMILY PROTEIN KINASE	UniProtKB/TrEMBL
	NIMA-RELATED KINASE 2	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2VN95	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Nek2	NIMA related kinase 2		NIMA-related kinase 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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